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CD34
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Belongs to the CD34 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Cell surface |
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Cellular Component: intercellular bridge; lysosome; perinuclear region of cytoplasm; integral to plasma membrane; cytoplasm; apical plasma membrane; basal plasma membrane; plasma membrane; external side of plasma membrane
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Molecular Function: sulfate binding; carbohydrate binding; transcription factor binding
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Biological Process: positive regulation of odontogenesis; regulation of immune response; glutamate metabolic process; negative regulation of nitric oxide biosynthetic process; glomerular filtration; cell motility involved in cell locomotion; negative regulation of blood coagulation; negative regulation of tumor necrosis factor production; signal transduction; positive regulation of interleukin-10 production; cell proliferation; positive regulation of angiogenesis; cell-cell adhesion; regulation of blood pressure; endothelial cell proliferation; tissue homeostasis; hemopoiesis; leukocyte migration
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Reference #:
P28906 (UniProtKB)
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| Alt. Names/Synonyms: CD34; CD34 antigen; CD34 molecule; Hematopoietic progenitor cell antigen CD34 |
| Gene Symbols: CD34 |
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Molecular weight: 40,716 Da
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Basal Isoelectric point: 7
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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