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Protein Page:
CD34 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CD34 Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Belongs to the CD34 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell surface
Cellular Component: intercellular bridge; lysosome; integral to plasma membrane; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; basal plasma membrane; plasma membrane; external side of plasma membrane
Molecular Function: sulfate binding; carbohydrate binding; transcription factor binding
Biological Process: positive regulation of odontogenesis; regulation of immune response; glutamate metabolic process; negative regulation of nitric oxide biosynthetic process; glomerular filtration; cell motility involved in cell locomotion; negative regulation of blood coagulation; negative regulation of tumor necrosis factor production; signal transduction; positive regulation of interleukin-10 production; cell proliferation; positive regulation of angiogenesis; cell-cell adhesion; regulation of blood pressure; endothelial cell proliferation; tissue homeostasis; hemopoiesis; leukocyte migration
Reference #:  P28906 (UniProtKB)
Alt. Names/Synonyms: CD34; CD34 antigen; CD34 molecule; Hematopoietic progenitor cell antigen CD34
Gene Symbols: CD34
Molecular weight: 40,716 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD34

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S178 IKAEIKCSGIREVKL
0 1 S282-p FTEQDVAsHQSySQK
0 1 Y286-p DVAsHQSySQKTLIA
1 0 S316 YFLMNRRSWSPTGER
0 33 Y329-p ERLGEDPyytENGGG
0 18 Y330-p RLGEDPyytENGGGQ
0 2 T331-p LGEDPyytENGGGQG
0 15 Y339-p ENGGGQGySsGPGTS
1 1 S340 NGGGQGySsGPGTSP
1 3 S341-p GGGQGySsGPGTSPE
1 6 S346 ySsGPGTSPEAQGKA
0 1 K352 TSPEAQGKASVNRGA
1 0 S374 ATSRNGHSARQHVVA
  mouse

 
S175-p IKGEIKCsGIREVRL
S279 FNKQDIGSHQSYSRK
Y283 DIGSHQSYSRKTLIA
S313-p YFLMNRRsWSPTGER
Y326-p ERLGEDPyyTENGGG
Y327-p RLGEDPyyTENGGGQ
T328 LGEDPyyTENGGGQG
Y336-p ENGGGQGyssGPGAs
S337-p NGGGQGyssGPGAsP
S338-p GGGQGyssGPGAsPE
S343-p yssGPGAsPETQGkA
K349-u AsPETQGkANVTRGA
S371-p ATSRNGHsARQHVVA
  rat

 
S179 IKGDIKCSGIRGVPF
S283 FNKQDLGSHQSYSRK
Y287 DLGSHQSYSRKTLIA
S317 YFLMNRRSWSPTGER
Y330 ERLGEDPYYTENGGG
Y331 RLGEDPYYTENGGGQ
T332 LGEDPYYTENGGGQG
Y340 ENGGGQGYSSGPGTS
S341 NGGGQGYSSGPGTSP
S342 GGGQGYSSGPGTSPE
S347 YSSGPGTSPETQGKA
K353 TSPETQGKANVTRGA
S375 ATSRNGHSARQHVVA
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