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Protein Page:
PIK3R3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIK3R3 Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Belongs to the PI3K p85 subunit family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Kinase, lipid; Motility/polarity/chemotaxis
Cellular Component: cytosol; phosphoinositide 3-kinase complex
Molecular Function: protein binding; 1-phosphatidylinositol-3-kinase activity; phosphoinositide 3-kinase regulator activity
Biological Process: phospholipid metabolic process; insulin receptor signaling pathway; phosphatidylinositol biosynthetic process; regulation of phosphoinositide 3-kinase activity
Reference #:  Q92569 (UniProtKB)
Alt. Names/Synonyms: 100% homology to SWISS-PROT Q92569; DKFZp686P05226; FLJ41892; p55; p55-GAMMA; P55G; p55PIK; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; Phosphatidylinositol 3-kinase regulatory subunit gamma; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma); phosphoinositide-3-kinase, regulatory subunit 3 (gamma); phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma); phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma); PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; PIK3R3; PtdIns-3-kinase regulatory subunit gamma; PtdIns-3-kinase regulatory subunit p55-gamma
Gene Symbols: PIK3R3
Molecular weight: 54,448 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-├č Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PIK3R3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K106-ac DYTLTLRkGGNNKLI
0 1 K114-ac GGNNKLIkIYHRDGK
0 1 Y158 KLDVKLMYPVSRYQQ
0 19 Y184-p VGKKLQEyHsQyQEK
0 5 S186-p KKLQEyHsQyQEKSK
0 9 Y188-p LQEyHsQyQEKSKEy
0 5 Y195-p yQEKSKEyDRLyEEy
2 710 Y199-p SKEyDRLyEEytRTS
0 37 Y202-p yDRLyEEytRTSQEI
0 15 T203-p DRLyEEytRTSQEIQ
0 3 Y260-p IERIMMNyDKLKSRL
0 1 K282 MRLEQDLKNQALDNR
0 1 N283 RLEQDLKNQALDNRE
1 30 Y341-p NEDADENyFINEEDE
0 2 Y373-p VQAEDLLyGKPDGAF
0 11 Y407-p EVKHCVIySTARGYG
4228 : Phospho-PI3K p85 (Tyr458)/p55 (Tyr199) Antibody
  PIK3R3 iso3  
K152 DYTLTLRKGGNNKLI
K160 GGNNKLIKIYHRDGK
Y204 KLDVKLMYPVSRYQQ
Y230 VGKKLQEYHSQYQEK
S232 KKLQEYHSQYQEKSK
Y234 LQEYHSQYQEKSKEY
Y241 YQEKSKEYDRLYEEY
Y245 SKEYDRLYEEYTRTS
Y248 YDRLYEEYTRTSQEI
T249 DRLYEEYTRTSQEIQ
Y306 IERIMMNYDKLKSRL
K328-m2 MRLEQDLkkQALDNR
K329-m2 RLEQDLkkQALDNRE
Y387 NEDADENYFINEEDE
Y419 VQAEDLLYGKPDGAF
Y453 EVKHCVIYSTARGYG
  mouse

 
K106 DYTLTLRKGGNNKLI
K114 GGNNKLIKIYHRDGK
Y158-p KLDVKLTyPVSRFQQ
F184 VGKNLQEFHSQYQEK
S186 KNLQEFHSQYQEKSK
Y188 LQEFHSQYQEKSKEY
Y195 YQEKSKEYDRLyEEy
Y199-p SKEYDRLyEEytRTS
Y202-p YDRLyEEytRTSQEI
T203-p DRLyEEytRTSQEIQ
Y260 IERIMMNYDKLKSRL
K282 LRLEQDLKKQALDNR
K283 RLEQDLKKQALDNRE
Y341-p NEDSDESyFINEEDE
Y373 VQAEDLLYGKPDGAF
Y407 EVKHCVIYSTARGYG
4228 : Phospho-PI3K p85 (Tyr458)/p55 (Tyr199) Antibody
  rat

 
K106 DYTLTLRKGGNNKLI
K114 GGNNKLIKIYHRDGN
Y158 KLDVKLMYPVSRYQQ
F184 VGKNLQEFHSQYQEK
S186 KNLQEFHSQYQEKSK
Y188 LQEFHSQYQEKSKEY
Y195 YQEKSKEYDRLyEEY
Y199-p SKEYDRLyEEYTRTS
Y202 YDRLyEEYTRTSQEI
T203 DRLyEEYTRTSQEIQ
Y260 IERIMMNYDKLKSRL
K282 VRLEQDLKKQALDNR
K283 RLEQDLKKQALDNRE
Y341 SEDTDESYFINEDDE
Y373 VQAEDLLYGKPDGAF
Y407 EVKPCVIYSPARGYG
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