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Protein Page:
CTNNB1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CTNNB1 a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Actin binding protein; Cell adhesion; Nuclear receptor co-regulator; Motility/polarity/chemotaxis
Cellular Component: centrosome; desmosome; basolateral plasma membrane; zonula adherens; fascia adherens; intercellular junction; beta-catenin destruction complex; cytosol; transcription factor complex; cell-cell adherens junction; membrane; lamellipodium; cell projection membrane; perinuclear region of cytoplasm; cytoplasm; synapse; dendritic shaft; lateral plasma membrane; apical junction complex; neuron projection; internal side of plasma membrane; protein complex; tight junction; cell; cell cortex; catenin complex; Z disc; adherens junction; cytoskeleton; apical part of cell; microvillus membrane; plasma membrane; cell junction; nucleus
Molecular Function: protein C-terminus binding; transcription coactivator activity; protein kinase binding; transcription factor binding; protein phosphatase binding; ionotropic glutamate receptor binding; protein binding; enzyme binding; DNA binding; cadherin binding; double-stranded DNA binding; protein complex binding; estrogen receptor binding; chromatin binding; nitric-oxide synthase binding; structural molecule activity; SMAD binding; kinase binding; transcription factor activity; nuclear hormone receptor binding; alpha-catenin binding
Biological Process: skin development; cellular morphogenesis during differentiation; regulation of myelination; regulation of centriole-centriole cohesion; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; cell maturation; negative regulation of chondrocyte differentiation; positive regulation of fibroblast growth factor receptor signaling pathway; cell fate determination; morphogenesis of embryonic epithelium; embryonic foregut morphogenesis; positive regulation of mesenchymal cell proliferation; male genitalia development; synapse organization and biogenesis; kidney development; T cell differentiation; hindbrain development; positive regulation of neuroblast proliferation; regulation of smooth muscle cell proliferation; transcription, DNA-dependent; regulation of osteoblast differentiation; regulation of transcription from RNA polymerase II promoter; regulation of gene expression; response to estrogen stimulus; regulation of epithelial cell differentiation; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; embryonic digit morphogenesis; limb development; embryonic forelimb morphogenesis; neuron migration; dorsal/ventral axis specification; cardiac muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; forebrain development; pancreas development; vasculogenesis; proximal/distal pattern formation; Wnt receptor signaling pathway; in utero embryonic development; cytoskeletal anchoring; neural plate development; gastrulation with mouth forming second; odontogenesis of dentine-containing teeth; regulation of cell proliferation; positive regulation of osteoblast differentiation; cell proliferation; Schwann cell proliferation; negative regulation of cell differentiation; dorsal/ventral pattern formation; ureteric bud branching; embryonic heart tube development; lens morphogenesis in camera-type eye; anterior/posterior axis specification; lung development; protein heterooligomerization; heart development; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; osteoclast differentiation; regulation of apoptosis; hair cycle process; cell-cell adhesion; positive regulation of endothelial cell differentiation; organ development; ectoderm development; positive regulation of epithelial cell differentiation; cell adhesion; bone resorption; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of protein sumoylation; genitalia morphogenesis; patterning of blood vessels; endoderm formation; negative regulation of transcription, DNA-dependent; cellular process; oocyte development; negative regulation of osteoclast differentiation; glial cell fate determination; endodermal cell fate commitment; cell-matrix adhesion; cell fate specification; embryonic hindlimb morphogenesis; response to estradiol stimulus; synaptic transmission; central nervous system vasculogenesis; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; regulation of cell differentiation; hemopoiesis; cell differentiation; fallopian tube development; skeletal development; layer formation in the cerebral cortex; hair follicle morphogenesis; thymus development; regulation of T cell proliferation; embryonic axis specification; synaptic vesicle transport; liver development; negative regulation of oligodendrocyte differentiation; response to cytokine stimulus
Reference #:  Q02248 (UniProtKB)
Alt. Names/Synonyms: Beta-catenin; catenin (cadherin associated protein), beta 1; Catenin beta-1; Catnb; CTNB1; Ctnnb1; Mesc; OTTMUSP00000017750
Gene Symbols: Ctnnb1
Molecular weight: 85,471 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CTNNB1

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA


Sites Implicated In
cell adhesion, altered: Y142‑p, Y654‑p
cell motility, altered: Y654‑p
cytoskeletal reorganization: Y654‑p
transcription, altered: S33‑p, S552‑p, Y654‑p
activity, induced: S33‑p
intracellular localization: S191‑p, S552‑p, S605‑p, Y654‑p
molecular association, regulation: Y142‑p, Y654‑p
protein degradation: S29‑p, S33‑p, S37‑p, T41‑p, S45‑p
ubiquitination: S29‑p, S33‑p, S37‑p, T41‑p, S45‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 0 K19 MAMEPDRKAAVsHWQ
1 3 K19-ub MAMEPDRkAAVsHWQ
2 0 S23-p PDRkAAVsHWQQQsY
0 1 S23-gl PDRkAAVsHWQQQsY
3 3 S29-p VsHWQQQsYLDsGIH
0 36 Y30 sHWQQQsYLDsGIHs
53 5 S33-p QQQsYLDsGIHsGAT
56 14 S37-p YLDsGIHsGATtTAP
47 2 T41-p GIHsGATtTAPsLSG
24 3 S45-p GATtTAPsLSGkGNP
0 1 S47 TtTAPsLSGkGNPEE
4 0 K49-ac TAPsLSGkGNPEEED
1 0 K49 TAPsLSGKGNPEEED
1 0 Y64 VDTSQVLYEWEQGFS
1 0 S73 WEQGFSQSFTQEQVA
5 23 Y86-p VADIDGQyAMTRAQR
2 0 T102 RAAMFPETLDEGMQI
2 0 T112 EGMQIPSTQFDAAHP
0 1 D115 QIPSTQFDAAHPTNV
3 0 T120 QFDAAHPTNVQRLAE
0 7 K133-ub AEPSQMLkHAVVNLI
10 0 Y142-p AVVNLINyQDDAELA
0 3 K158-ub RAIPELTkLLNDEDQ
0 8 K170-ub EDQVVVNkAAVMVHQ
0 2 S179 AVMVHQLSKKEASRH
0 6 K180 VMVHQLSKKEASRHA
2 35 S191-p SRHAIMRsPQMVSAI
0 1 S196 MRsPQMVSAIVRTMQ
0 13 K233-ub EGLLAIFkSGGIPAL
1 0 S246 ALVKMLGSPVDSVLF
1 1 Y331 LVNIMRTYTYEKLLW
1 0 T332 VNIMRTYTYEKLLWT
2 1 Y333 NIMRTYTYEKLLWTT
0 3 K335 MRTYTYEKLLWTTSR
1 0 K345 WTTSRVLKVLSVCSS
0 1 K345 WTTSRVLKVLSVCSS
1 0 K354 LSVCSSNKPAIVEAG
0 6 K354 LSVCSSNKPAIVEAG
2 0 T393-p RNLSDAAtKQEGMEG
1 0 K394 NLSDAAtKQEGMEGL
0 1 K435 TCNNYKNKMMVCQVG
0 6 K435 TCNNYKNKMMVCQVG
1 1 T472 ICALRHLTSRHQEAE
0 1 S473 CALRHLTSRHQEAEM
1 91 Y489-p QNAVRLHyGLPVVVK
0 30 K508 PSHWPLIKATVGLIR
0 1 T510 HWPLIKATVGLIRNL
0 1 T547 LVRAHQDTQRRtsMG
0 13 T551-p HQDTQRRtsMGGtQQ
9 37 S552-p QDTQRRtsMGGtQQQ
0 17 T556-p RRtsMGGtQQQFVEG
0 2 T574 EEIVEGCTGALHILA
1 0 S605-p LFVQLLYsPIENIQR
0 6 K625-ub LCELAQDkEAAEAIE
0 2 T653-p SRNEGVAtyAAAVLF
13 23 Y654-p RNEGVAtyAAAVLFR
2 15 Y670 SEDKPQDYkKRLsVE
0 4 K671-ub EDKPQDYkKRLsVEL
9 41 S675-p QDYkKRLsVELtssL
0 3 T679-p KRLsVELtssLFRtE
0 1 S680-p RLsVELtssLFRtEP
0 1 S681-p LsVELtssLFRtEPM
0 1 T685-p LtssLFRtEPMAWNE
0 1 T693-p EPMAWNEtADLGLDI
0 1 S715 GYRQDDPSYRSFHSG
0 36 Y716 YRQDDPSYRSFHSGG
1 4 S718 QDDPSYRSFHSGGYG
0 2 S721 PSYRSFHSGGYGQDA
0 1 Y724 RSFHSGGYGQDALGM
0 1 Y748 GHHPGADYPVDGLPD
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
9564 : Phospho-beta-Catenin (Ser45) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
9030 : Acetyl-beta-Catenin (Lys49) (D7C2) Rabbit mAb
9534 : Acetyl-beta-Catenin (Lys49) Antibody
5651 : Phospho-beta-Catenin (Ser552) (D8E11) Rabbit mAb
9566 : Phospho-beta-Catenin (Ser552) Antibody
4176 : Phospho-beta-Catenin (Ser675) (D2F1) XP(TM) Rabbit mAb
9567 : Phospho-beta-Catenin (Ser675) Antibody
  human

 
K19-ac MAMEPDRkAAVsHWQ
K19-ub MAMEPDRkAAVsHWQ
S23-p PDRkAAVsHWQQQsy
S23 PDRkAAVSHWQQQsy
S29-p VsHWQQQsyLDsGIH
Y30-p sHWQQQsyLDsGIHs
S33-p QQQsyLDsGIHsGAT
S37-p yLDsGIHsGATtTAP
T41-p GIHsGATtTAPsLsG
S45-p GATtTAPsLsGkGNP
S47-p TtTAPsLsGkGNPEE
K49-ac TAPsLsGkGNPEEED
K49-ub TAPsLsGkGNPEEED
Y64-p VDTSQVLyEWEQGFS
S73-p WEQGFSQsFTQEQVA
Y86-p VADIDGQyAMTRAQR
T102-p RAAMFPEtLDEGMQI
T112-p EGMQIPStQFdAAHP
D115-ca QIPStQFdAAHPtNV
T120-p QFdAAHPtNVQRLAE
K133-ub AEPSQMLkHAVVNLI
Y142-p AVVNLINyQDDAELA
K158-ub RAIPELTkLLNDEDQ
K170-ub EDQVVVNkAAVMVHQ
S179-p AVMVHQLskKEASRH
K180-ub VMVHQLskKEASRHA
S191-p SRHAIMRsPQMVsAI
S196-p MRsPQMVsAIVRTMQ
K233-ub EGLLAIFkSGGIPAL
S246-p ALVKMLGsPVDSVLF
Y331-p LVNIMRTytyEkLLW
T332-p VNIMRTytyEkLLWT
Y333-p NIMRTytyEkLLWTT
K335-ub MRTytyEkLLWTTSR
K345-ac WTTSRVLkVLSVCSS
K345-ub WTTSRVLkVLSVCSS
K354-ac LSVCSSNkPAIVEAG
K354-ub LSVCSSNkPAIVEAG
T393-p RNLSDAAtkQEGMEG
K394-ub NLSDAAtkQEGMEGL
K435-ac TCNNYKNkMMVCQVG
K435-ub TCNNYKNkMMVCQVG
T472-p ICALRHLtsRHQEAE
S473-p CALRHLtsRHQEAEM
Y489-p QNAVRLHyGLPVVVK
K508-ub PSHWPLIkAtVGLIR
T510-p HWPLIkAtVGLIRNL
T547-p LVRAHQDtQRRtsMG
T551-p HQDtQRRtsMGGtQQ
S552-p QDtQRRtsMGGtQQQ
T556-p RRtsMGGtQQQFVEG
T574-p EEIVEGCtGALHILA
S605 LFVQLLYSPIENIQR
K625-ub LCELAQDkEAAEAIE
T653-p SRNEGVAtyAAAVLF
Y654-p RNEGVAtyAAAVLFR
Y670-p SEDKPQDykKRLsVE
K671-ub EDKPQDykKRLsVEL
S675-p QDykKRLsVELtsSL
T679-p KRLsVELtsSLFRTE
S680-p RLsVELtsSLFRTEP
S681 LsVELtsSLFRTEPM
T685 LtsSLFRTEPMAWNE
T693 EPMAWNETADLGLDI
S715-p GYRQDDPsyRsFHsG
Y716-p YRQDDPsyRsFHsGG
S718-p QDDPsyRsFHsGGyG
S721-p PsyRsFHsGGyGQDA
Y724-p RsFHsGGyGQDALGM
Y748-p GHHPGADyPVDGLPD
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
9564 : Phospho-beta-Catenin (Ser45) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
9030 : Acetyl-beta-Catenin (Lys49) (D7C2) Rabbit mAb
9534 : Acetyl-beta-Catenin (Lys49) Antibody
5651 : Phospho-beta-Catenin (Ser552) (D8E11) Rabbit mAb
9566 : Phospho-beta-Catenin (Ser552) Antibody
4176 : Phospho-beta-Catenin (Ser675) (D2F1) XP(TM) Rabbit mAb
9567 : Phospho-beta-Catenin (Ser675) Antibody
  rat

 
K19 MAMEPDRKAAVSHWQ
K19 MAMEPDRKAAVSHWQ
S23 PDRKAAVSHWQQQSY
S23 PDRKAAVSHWQQQSY
S29 VSHWQQQSYLDsGIH
Y30 SHWQQQSYLDsGIHs
S33-p QQQSYLDsGIHsGAT
S37-p YLDsGIHsGATtTAP
T41-p GIHsGATtTAPsLSG
S45-p GATtTAPsLSGKGNP
S47 TtTAPsLSGKGNPEE
K49 TAPsLSGKGNPEEED
K49 TAPsLSGKGNPEEED
Y64 VDTSQVLYEWEQGFS
S73 WEQGFSQSFTQEQVA
Y86 VADIDGQYAMTRAQR
T102 RAAMFPETLDEGMQI
T112 EGMQIPSTQFDAAHP
D115 QIPSTQFDAAHPTNV
T120 QFDAAHPTNVQRLAE
K133 AEPSQMLKHAVVNLI
Y142-p AVVNLINyQDDAELA
K158 RAIPELTKLLNDEDQ
K170 EDQVVVNKAAVMVHQ
S179 AVMVHQLSKKEASRH
K180 VMVHQLSKKEASRHA
S191-p SRHAIMRsPQMVSAI
S196 MRsPQMVSAIVRTMQ
K233 EGLLAIFKSGGIPAL
S246 ALVKMLGSPVDSVLF
Y331 LVNIMRTYTYEKLLW
T332 VNIMRTYTYEKLLWT
Y333 NIMRTYTYEKLLWTT
K335 MRTYTYEKLLWTTSR
K345 WTTSRVLKVLSVCSS
K345 WTTSRVLKVLSVCSS
K354 LSVCSSNKPAIVEAG
K354 LSVCSSNKPAIVEAG
T393 RNLSDAATKQEGMEG
K394 NLSDAATKQEGMEGL
K435 TCNNYKNKMMVCQVG
K435 TCNNYKNKMMVCQVG
T472 ICALRHLTSRHQEAE
S473 CALRHLTSRHQEAEM
Y489-p QNAVRLHyGLPVVVK
K508 PSHWPLIKATVGLIR
T510 HWPLIKATVGLIRNL
T547 LVRAHQDTQRRtsMG
T551-p HQDTQRRtsMGGTQQ
S552-p QDTQRRtsMGGTQQQ
T556 RRtsMGGTQQQFVEG
T574 EEIVEGCTGALHILA
S605 LFVQLLYSPIENIQR
K625 LCELAQDKEAAEAIE
T653 SRNEGVATyAAAVLF
Y654-p RNEGVATyAAAVLFR
Y670 SEDKPQDYKKRLsVE
K671 EDKPQDYKKRLsVEL
S675-p QDYKKRLsVELTSSL
T679 KRLsVELTSSLFRTE
S680 RLsVELTSSLFRTEP
S681 LsVELTSSLFRTEPM
T685 LTSSLFRTEPMAWNE
T693 EPMAWNETADLGLDI
S715 GYRQDDPSYRSFHSG
Y716 YRQDDPSYRSFHSGG
S718 QDDPSYRSFHSGGYG
S721 PSYRSFHSGGYGQDA
Y724 RSFHSGGYGQDALGM
Y748 GHHPGADYPVDGLPD
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
9030 : Acetyl-beta-Catenin (Lys49) (D7C2) Rabbit mAb
9534 : Acetyl-beta-Catenin (Lys49) Antibody
5651 : Phospho-beta-Catenin (Ser552) (D8E11) Rabbit mAb
9566 : Phospho-beta-Catenin (Ser552) Antibody
4176 : Phospho-beta-Catenin (Ser675) (D2F1) XP(TM) Rabbit mAb
9567 : Phospho-beta-Catenin (Ser675) Antibody
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