a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Cell adhesion; Motility/polarity/chemotaxis; Transcription factor; Actin binding protein
Cellular Component: desmosome; centrosome; basolateral plasma membrane; zonula adherens; intercellular junction; fascia adherens; cytosol; beta-catenin destruction complex; transcription factor complex; cell-cell adherens junction; membrane; cell projection membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; synapse; dendritic shaft; lateral plasma membrane; apical junction complex; neuron projection; internal side of plasma membrane; protein complex; tight junction; cell; catenin complex; cell cortex; Z disc; cytoskeleton; adherens junction; apical part of cell; microvillus membrane; plasma membrane; nucleus; cell junction
Molecular Function: protein C-terminus binding; transcription coactivator activity; protein kinase binding; protein phosphatase binding; transcription factor binding; ionotropic glutamate receptor binding; protein binding; enzyme binding; DNA binding; cadherin binding; double-stranded DNA binding; protein complex binding; estrogen receptor binding; chromatin binding; SMAD binding; nitric-oxide synthase binding; structural molecule activity; transcription factor activity; kinase binding; nuclear hormone receptor binding; alpha-catenin binding
Biological Process: skin development; cellular morphogenesis during differentiation; regulation of myelination; regulation of centriole-centriole cohesion; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; cell maturation; negative regulation of chondrocyte differentiation; positive regulation of fibroblast growth factor receptor signaling pathway; cell fate determination; morphogenesis of embryonic epithelium; positive regulation of mesenchymal cell proliferation; embryonic foregut morphogenesis; synapse organization and biogenesis; male genitalia development; kidney development; T cell differentiation; hindbrain development; positive regulation of neuroblast proliferation; transcription, DNA-dependent; regulation of smooth muscle cell proliferation; regulation of osteoblast differentiation; regulation of transcription from RNA polymerase II promoter; regulation of gene expression; response to estrogen stimulus; regulation of epithelial cell differentiation; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; embryonic digit morphogenesis; limb development; embryonic forelimb morphogenesis; neuron migration; cardiac muscle cell proliferation; dorsal/ventral axis specification; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; forebrain development; positive regulation of cell proliferation; pancreas development; vasculogenesis; proximal/distal pattern formation; Wnt receptor signaling pathway; cytoskeletal anchoring; in utero embryonic development; neural plate development; gastrulation with mouth forming second; regulation of cell proliferation; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; Schwann cell proliferation; cell proliferation; negative regulation of cell differentiation; dorsal/ventral pattern formation; ureteric bud branching; embryonic heart tube development; lens morphogenesis in camera-type eye; lung development; anterior/posterior axis specification; protein heterooligomerization; heart development; T cell differentiation in the thymus; osteoclast differentiation; Wnt receptor signaling pathway through beta-catenin; regulation of apoptosis; hair cycle process; cell-cell adhesion; positive regulation of endothelial cell differentiation; organ development; ectoderm development; positive regulation of epithelial cell differentiation; cell adhesion; bone resorption; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of protein sumoylation; genitalia morphogenesis; patterning of blood vessels; endoderm formation; negative regulation of transcription, DNA-dependent; cellular process; oocyte development; cell death; negative regulation of osteoclast differentiation; glial cell fate determination; endodermal cell fate commitment; cell-matrix adhesion; cell fate specification; embryonic hindlimb morphogenesis; response to estradiol stimulus; synaptic transmission; regulation of osteoclast differentiation; central nervous system vasculogenesis; regulation of transcription, DNA-dependent; regulation of cell differentiation; hemopoiesis; cell differentiation; skeletal development; fallopian tube development; layer formation in the cerebral cortex; hair follicle morphogenesis; thymus development; embryonic axis specification; regulation of T cell proliferation; synaptic vesicle transport; liver development; negative regulation of oligodendrocyte differentiation; response to cytokine stimulus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.