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Protein Page:
CTNNB1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CTNNB1 a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cell adhesion; Nuclear receptor co-regulator; Actin-binding; Transcription factor
Cellular Component: apical junction complex; centrosome; protein complex; tight junction; cell; basolateral plasma membrane; intercellular junction; fascia adherens; catenin complex; cytosol; Z disc; beta-catenin destruction complex; transcription factor complex; adherens junction; cell-cell adherens junction; cytoskeleton; membrane; cell projection membrane; lamellipodium; microvillus membrane; apical part of cell; cytoplasm; plasma membrane; cell junction; nucleus; lateral plasma membrane
Molecular Function: protein binding; signal transducer activity; DNA binding; cadherin binding; transcription coactivator activity; double-stranded DNA binding; chromatin binding; protein phosphatase binding; transcription factor activity; transcription factor binding; nuclear hormone receptor binding; alpha-catenin binding
Biological Process: skin development; cellular morphogenesis during differentiation; regulation of myelination; positive regulation of transcription, DNA-dependent; cell maturation; negative regulation of chondrocyte differentiation; positive regulation of fibroblast growth factor receptor signaling pathway; cell fate determination; morphogenesis of embryonic epithelium; chromatin-mediated maintenance of transcription; embryonic foregut morphogenesis; positive regulation of mesenchymal cell proliferation; regulation of cell fate specification; synapse organization and biogenesis; male genitalia development; kidney development; T cell differentiation; positive regulation of neuroblast proliferation; nervous system development; transcription, DNA-dependent; regulation of osteoblast differentiation; regulation of transcription from RNA polymerase II promoter; regulation of gene expression; regulation of epithelial cell differentiation; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; embryonic digit morphogenesis; limb development; embryonic forelimb morphogenesis; neuron migration; dorsal/ventral axis specification; cardiac muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of MAPKKK cascade; forebrain development; positive regulation of cell proliferation; pancreas development; vasculogenesis; proximal/distal pattern formation; negative regulation of mitotic cell cycle, embryonic; Wnt receptor signaling pathway; in utero embryonic development; stem cell maintenance; neural plate development; gastrulation with mouth forming second; positive regulation of telomere maintenance via telomerase; odontogenesis of dentine-containing teeth; regulation of cell proliferation; cell proliferation; positive regulation of osteoblast differentiation; negative regulation of cell differentiation; dorsal/ventral pattern formation; ureteric bud branching; embryonic heart tube development; lens morphogenesis in camera-type eye; lung development; anterior/posterior axis specification; heart development; T cell differentiation in the thymus; osteoclast differentiation; Wnt receptor signaling pathway through beta-catenin; regulation of apoptosis; hair cycle process; cell-cell adhesion; positive regulation of endothelial cell differentiation; organ development; ectoderm development; positive regulation of epithelial cell differentiation; cell adhesion; bone resorption; positive regulation of I-kappaB kinase/NF-kappaB cascade; patterning of blood vessels; genitalia morphogenesis; endoderm formation; negative regulation of transcription, DNA-dependent; cellular process; oocyte development; negative regulation of osteoclast differentiation; glial cell fate determination; endodermal cell fate commitment; cell-matrix adhesion; cell fate specification; embryonic hindlimb morphogenesis; synaptic transmission; regulation of osteoclast differentiation; central nervous system vasculogenesis; regulation of transcription, DNA-dependent; vasculature development; regulation of cell differentiation; hemopoiesis; cell differentiation; fallopian tube development; skeletal development; layer formation in the cerebral cortex; hair follicle morphogenesis; thymus development; regulation of T cell proliferation; embryonic axis specification; synaptic vesicle transport; positive regulation of telomerase activity; negative regulation of oligodendrocyte differentiation
Reference #:  Q02248 (UniProtKB)
Alt. Names/Synonyms: Beta-catenin; catenin (cadherin associated protein), beta 1; Catenin beta-1; Catnb; CTNB1; Ctnnb1; Mesc; OTTMUSP00000017750
Gene Symbols: Ctnnb1
Molecular weight: 85,471 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CTNNB1

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA


Sites Implicated In
cell adhesion, altered: Y142‑p, Y654‑p
cell motility, altered: Y654‑p
cytoskeletal reorganization: Y654‑p
transcription, altered: S33‑p, S552‑p, Y654‑p
activity, induced: S33‑p
intracellular localization: S191‑p, S552‑p, S605‑p, Y654‑p
molecular association, regulation: Y142‑p, Y654‑p
protein degradation: S29‑p, S33‑p, S37‑p, T41‑p, S45‑p
ubiquitination: S29‑p, S33‑p, S37‑p, T41‑p, S45‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 0 K19 MAMEPDRKAAVsHWQ
1 3 K19-ub MAMEPDRkAAVsHWQ
2 0 S23-p PDRkAAVsHWQQQsY
0 1 S23-gl PDRkAAVsHWQQQsY
3 4 S29-p VsHWQQQsYLDsGIH
0 38 Y30 sHWQQQsYLDsGIHs
59 5 S33-p QQQsYLDsGIHsGAT
61 14 S37-p YLDsGIHsGATtTAP
51 2 T41-p GIHsGATtTAPsLSG
27 3 S45-p GATtTAPsLSGkGNP
0 1 S47 TtTAPsLSGkGNPEE
5 0 K49-ac TAPsLSGkGNPEEED
1 0 K49 TAPsLSGKGNPEEED
1 0 Y64 VDTSQVLYEWEQGFS
1 0 S73 WEQGFSQSFTQEQVA
6 23 Y86-p VADIDGQyAMTRAQR
2 0 T102 RAAMFPETLDEGMQI
2 0 T112 EGMQIPSTQFDAAHP
0 1 D115 QIPSTQFDAAHPTNV
3 0 T120 QFDAAHPTNVQRLAE
0 7 K133-ub AEPSQMLkHAVVNLI
11 0 Y142-p AVVNLINyQDDAELA
0 3 K158-ub RAIPELTkLLNDEDQ
0 8 K170-ub EDQVVVNkAAVMVHQ
0 2 S179 AVMVHQLSKKEASRH
0 6 K180 VMVHQLSKKEASRHA
3 41 S191-p SRHAIMRsPQMVSAI
0 1 S196 MRsPQMVSAIVRTMQ
0 13 K233-ub EGLLAIFkSGGIPAL
2 0 S246 ALVKMLGSPVDSVLF
1 1 Y331 LVNIMRTYTYEKLLW
1 0 T332 VNIMRTYTYEKLLWT
2 1 Y333 NIMRTYTYEKLLWTT
0 3 K335 MRTYTYEKLLWTTSR
1 0 K345 WTTSRVLKVLSVCSS
0 1 K345 WTTSRVLKVLSVCSS
1 0 K354 LSVCSSNKPAIVEAG
0 6 K354 LSVCSSNKPAIVEAG
2 0 T393-p RNLSDAAtKQEGMEG
1 0 K394 NLSDAAtKQEGMEGL
0 1 K435 TCNNYKNKMMVCQVG
0 6 K435 TCNNYKNKMMVCQVG
1 1 T472 ICALRHLTSRHQEAE
0 1 S473 CALRHLTSRHQEAEM
1 91 Y489-p QNAVRLHyGLPVVVK
0 30 K508 PSHWPLIKATVGLIR
0 1 T510 HWPLIKATVGLIRNL
0 1 T547 LVRAHQDTQRRtsMG
0 15 T551-p HQDTQRRtsMGGtQQ
12 46 S552-p QDTQRRtsMGGtQQQ
0 18 T556-p RRtsMGGtQQQFVEG
0 2 T574 EEIVEGCTGALHILA
2 0 S605-p LFVQLLYsPIENIQR
0 6 K625-ub LCELAQDkEAAEAIE
0 2 T653-p SRNEGVAtyAAAVLF
15 23 Y654-p RNEGVAtyAAAVLFR
2 15 Y670 SEDKPQDYkKRLsVE
0 4 K671-ub EDKPQDYkKRLsVEL
11 47 S675-p QDYkKRLsVELtssL
0 3 T679-p KRLsVELtssLFRtE
0 1 S680-p RLsVELtssLFRtEP
0 1 S681-p LsVELtssLFRtEPM
0 1 T685-p LtssLFRtEPMAWNE
0 1 T693-p EPMAWNEtADLGLDI
1 1 S715 GYRQDDPSYRSFHSG
0 36 Y716 YRQDDPSYRSFHSGG
1 4 S718 QDDPSYRSFHSGGYG
0 2 S721 PSYRSFHSGGYGQDA
0 1 Y724 RSFHSGGYGQDALGM
0 1 Y748 GHHPGADYPVDGLPD
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
9564 : Phospho-beta-Catenin (Ser45) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
9030 : Acetyl-beta-Catenin (Lys49) (D7C2) Rabbit mAb
9534 : Acetyl-beta-Catenin (Lys49) Antibody
5651 : Phospho-beta-Catenin (Ser552) (D8E11) Rabbit mAb
9566 : Phospho-beta-Catenin (Ser552) Antibody
4176 : Phospho-beta-Catenin (Ser675) (D2F1) XP(TM) Rabbit mAb
9567 : Phospho-beta-Catenin (Ser675) Antibody
  human

 
K19-ac MAMEPDRkAAVsHWQ
K19-ub MAMEPDRkAAVsHWQ
S23-p PDRkAAVsHWQQQsy
S23 PDRkAAVSHWQQQsy
S29-p VsHWQQQsyLDsGIH
Y30-p sHWQQQsyLDsGIHs
S33-p QQQsyLDsGIHsGAT
S37-p yLDsGIHsGATtTAP
T41-p GIHsGATtTAPsLsG
S45-p GATtTAPsLsGkGNP
S47-p TtTAPsLsGkGNPEE
K49-ac TAPsLsGkGNPEEED
K49-ub TAPsLsGkGNPEEED
Y64-p VDTSQVLyEWEQGFS
S73-p WEQGFSQsFTQEQVA
Y86-p VADIDGQyAMTRAQR
T102-p RAAMFPEtLDEGMQI
T112-p EGMQIPStQFdAAHP
D115-ca QIPStQFdAAHPtNV
T120-p QFdAAHPtNVQRLAE
K133-ub AEPSQMLkHAVVNLI
Y142-p AVVNLINyQDDAELA
K158-ub RAIPELTkLLNDEDQ
K170-ub EDQVVVNkAAVMVHQ
S179-p AVMVHQLskKEASRH
K180-ub VMVHQLskKEASRHA
S191-p SRHAIMRsPQMVsAI
S196-p MRsPQMVsAIVRTMQ
K233-ub EGLLAIFkSGGIPAL
S246-p ALVKMLGsPVDSVLF
Y331-p LVNIMRTytyEkLLW
T332-p VNIMRTytyEkLLWT
Y333-p NIMRTytyEkLLWTT
K335-ub MRTytyEkLLWTTSR
K345-ac WTTSRVLkVLSVCSS
K345-ub WTTSRVLkVLSVCSS
K354-ac LSVCSSNkPAIVEAG
K354-ub LSVCSSNkPAIVEAG
T393-p RNLSDAAtkQEGMEG
K394-ub NLSDAAtkQEGMEGL
K435-ac TCNNYKNkMMVCQVG
K435-ub TCNNYKNkMMVCQVG
T472-p ICALRHLtsRHQEAE
S473-p CALRHLtsRHQEAEM
Y489-p QNAVRLHyGLPVVVK
K508-ub PSHWPLIkAtVGLIR
T510-p HWPLIkAtVGLIRNL
T547-p LVRAHQDtQRRtsMG
T551-p HQDtQRRtsMGGtQQ
S552-p QDtQRRtsMGGtQQQ
T556-p RRtsMGGtQQQFVEG
T574-p EEIVEGCtGALHILA
S605-p LFVQLLYsPIENIQR
K625-ub LCELAQDkEAAEAIE
T653-p SRNEGVAtyAAAVLF
Y654-p RNEGVAtyAAAVLFR
Y670-p SEDKPQDykKRLsVE
K671-ub EDKPQDykKRLsVEL
S675-p QDykKRLsVELtsSL
T679-p KRLsVELtsSLFRTE
S680-p RLsVELtsSLFRTEP
S681 LsVELtsSLFRTEPM
T685 LtsSLFRTEPMAWNE
T693 EPMAWNETADLGLDI
S715-p GYRQDDPsyRsFHsG
Y716-p YRQDDPsyRsFHsGG
S718-p QDDPsyRsFHsGGyG
S721-p PsyRsFHsGGyGQDA
Y724-p RsFHsGGyGQDALGM
Y748-p GHHPGADyPVDGLPD
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
9564 : Phospho-beta-Catenin (Ser45) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
9030 : Acetyl-beta-Catenin (Lys49) (D7C2) Rabbit mAb
9534 : Acetyl-beta-Catenin (Lys49) Antibody
5651 : Phospho-beta-Catenin (Ser552) (D8E11) Rabbit mAb
9566 : Phospho-beta-Catenin (Ser552) Antibody
4176 : Phospho-beta-Catenin (Ser675) (D2F1) XP(TM) Rabbit mAb
9567 : Phospho-beta-Catenin (Ser675) Antibody
  rat

 
K19 MAMEPDRKAAVSHWQ
K19 MAMEPDRKAAVSHWQ
S23 PDRKAAVSHWQQQSY
S23 PDRKAAVSHWQQQSY
S29 VSHWQQQSYLDsGIH
Y30 SHWQQQSYLDsGIHs
S33-p QQQSYLDsGIHsGAT
S37-p YLDsGIHsGATtTAP
T41-p GIHsGATtTAPsLSG
S45-p GATtTAPsLSGKGNP
S47 TtTAPsLSGKGNPEE
K49 TAPsLSGKGNPEEED
K49 TAPsLSGKGNPEEED
Y64 VDTSQVLYEWEQGFS
S73 WEQGFSQSFTQEQVA
Y86 VADIDGQYAMTRAQR
T102 RAAMFPETLDEGMQI
T112 EGMQIPSTQFDAAHP
D115 QIPSTQFDAAHPTNV
T120 QFDAAHPTNVQRLAE
K133 AEPSQMLKHAVVNLI
Y142-p AVVNLINyQDDAELA
K158 RAIPELTKLLNDEDQ
K170 EDQVVVNKAAVMVHQ
S179 AVMVHQLSKKEASRH
K180 VMVHQLSKKEASRHA
S191-p SRHAIMRsPQMVSAI
S196 MRsPQMVSAIVRTMQ
K233 EGLLAIFKSGGIPAL
S246 ALVKMLGSPVDSVLF
Y331 LVNIMRTYTYEKLLW
T332 VNIMRTYTYEKLLWT
Y333 NIMRTYTYEKLLWTT
K335 MRTYTYEKLLWTTSR
K345 WTTSRVLKVLSVCSS
K345 WTTSRVLKVLSVCSS
K354 LSVCSSNKPAIVEAG
K354 LSVCSSNKPAIVEAG
T393 RNLSDAATKQEGMEG
K394 NLSDAATKQEGMEGL
K435 TCNNYKNKMMVCQVG
K435 TCNNYKNKMMVCQVG
T472 ICALRHLTSRHQEAE
S473 CALRHLTSRHQEAEM
Y489-p QNAVRLHyGLPVVVK
K508 PSHWPLIKATVGLIR
T510 HWPLIKATVGLIRNL
T547 LVRAHQDTQRRtsMG
T551-p HQDTQRRtsMGGTQQ
S552-p QDTQRRtsMGGTQQQ
T556 RRtsMGGTQQQFVEG
T574 EEIVEGCTGALHILA
S605 LFVQLLYSPIENIQR
K625 LCELAQDKEAAEAIE
T653 SRNEGVATyAAAVLF
Y654-p RNEGVATyAAAVLFR
Y670 SEDKPQDYKKRLsVE
K671 EDKPQDYKKRLsVEL
S675-p QDYKKRLsVELTSSL
T679 KRLsVELTSSLFRTE
S680 RLsVELTSSLFRTEP
S681 LsVELTSSLFRTEPM
T685 LTSSLFRTEPMAWNE
T693 EPMAWNETADLGLDI
S715 GYRQDDPSYRSFHSG
Y716 YRQDDPSYRSFHSGG
S718 QDDPSYRSFHSGGYG
S721 PSYRSFHSGGYGQDA
Y724 RSFHSGGYGQDALGM
Y748 GHHPGADYPVDGLPD
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
9030 : Acetyl-beta-Catenin (Lys49) (D7C2) Rabbit mAb
9534 : Acetyl-beta-Catenin (Lys49) Antibody
5651 : Phospho-beta-Catenin (Ser552) (D8E11) Rabbit mAb
9566 : Phospho-beta-Catenin (Ser552) Antibody
4176 : Phospho-beta-Catenin (Ser675) (D2F1) XP(TM) Rabbit mAb
9567 : Phospho-beta-Catenin (Ser675) Antibody
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