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Protein Page:
FXR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FXR1 RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. Interacts with FMR1 and FXR2. Interacts with TDRD3, and with CYFIP2 but not with CYFIP1. Expressed in all tissues examined including heart, brain, kidney and testis. Belongs to the FMR1 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein; Translation
Chromosomal Location of Human Ortholog: 3q28
Cellular Component: polysome; costamere; membrane; cytoplasm; nucleolus
Molecular Function: mRNA 3'-UTR binding; RNA binding
Biological Process: muscle development; apoptosis; negative regulation of translation; cell differentiation
Reference #:  P51114 (UniProtKB)
Alt. Names/Synonyms: Fragile X mental retardation syndrome-related protein 1; fragile X mental retardation, autosomal homolog 1; FXR1; hFXR1p
Gene Symbols: FXR1
Molecular weight: 69,721 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FXR1

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S420‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 K56-ub LPPPPDIkKEISEGD
0 5 Y68-p EGDEVEVySRANDQE
0 1 K83-ub PCGWWLAkVRMMKGE
0 1 Y92 RMMKGEFYVIEYAAC
0 1 Y96 GEFYVIEYAACDATy
0 19 Y103-p YAACDATyNEIVTFE
0 15 K119-ub LRPVNQNkTVKKNTF
0 1 T125 NkTVKKNTFFKCTVD
0 6 K179-ub SASEATVkRVNILSD
0 1 S191-p LSDMHLRsIRTKLML
0 4 K207-ub SRNEEATkHLECTkQ
0 1 K213-ub TkHLECTkQLAAAFH
0 3 K246-ub SNIQQARkVPGVTAI
0 1 Y265-p DTGTFRIyGEsADAV
0 1 S268-p TFRIyGEsADAVkKA
0 3 K273-ub GEsADAVkKARGFLE
0 1 K295 VPRNLVGKVIGKNGK
0 2 K302 KVIGKNGKVIQEIVD
0 5 K310-ub VIQEIVDkSGVVRVR
0 7 K325-ub IEGDNENkLPREDGM
0 1 Y353-p NVQVLLEyHIAyLKE
0 1 Y357-p LLEyHIAyLKEVEQL
0 2 - gap
0 5 - gap
0 2 - gap
0 2 - gap
0 3 - gap
0 3 - gap
0 1 S384 QIGSRSYSGRGRGRR
0 2 T401-p NYTSGYGtNSELsNP
0 20 S406-p YGtNSELsNPsEtES
0 21 S409-p NSELsNPsEtESERK
0 1 T411-p ELsNPsEtESERKDE
1 40 S420-p SERKDELsDWsLAGE
0 41 S423-p KDELsDWsLAGEDDR
0 1 S432-p AGEDDRDsRHQRDsR
0 4 S438-p DsRHQRDsRRRPGGr
0 1 R445-m2 sRRRPGGrGRSVSGG
0 1 K470-ub SSISSVLkDPDSNPy
0 127 Y477-p kDPDSNPysLLDNtE
0 14 S478-p DPDSNPysLLDNtEs
0 17 T483-p PysLLDNtEsDQtAD
0 24 S485-p sLLDNtEsDQtADtD
0 3 T488-p DNtEsDQtADtDAsE
0 10 T491-p EsDQtADtDAsEsHH
0 7 S494-p QtADtDAsEsHHstN
0 3 S496-p ADtDAsEsHHstNRR
0 4 S499-p DAsEsHHstNRRRRs
0 5 T500-p AsEsHHstNRRRRsR
0 18 S506-p stNRRRRsRRRRtDE
0 70 T511-p RRsRRRRtDEDAVLM
0 3 T522 AVLMDGMTESDTASV
0 2 S524 LMDGMTESDTASVNE
0 1 T526 DGMTESDTASVNENG
0 1 S528 MTESDTASVNENGLV
0 1 T557 QRNLPRETLAKNKKE
0 1 S585-p KAINGPTsAsGDDIs
0 13 S587-p INGPTsAsGDDIsKL
0 1 S592-p sAsGDDIsKLQRtPG
0 5 T597-p DIsKLQRtPGEEKIN
0 1 T605-p PGEEKINtLKEENtQ
0 7 T611-p NtLKEENtQEAAVLN
  FXR1 iso2  
K56 LPPPPDIKKEISEGD
Y68 EGDEVEVYSRANDQE
K83 PCGWWLAKVRMMKGE
Y92 RMMKGEFYVIEYAAC
Y96 GEFYVIEYAACDATY
Y103 YAACDATYNEIVTFE
K119 LRPVNQNKTVKKNTF
T125 NKTVKKNTFFKCTVD
K179 SASEATVKRVNILSD
S191 LSDMHLRSIRTKLML
K207 SRNEEATKHLECTKQ
K213 TKHLECTKQLAAAFH
K246 SNIQQARKVPGVTAI
Y265 DTGTFRIYGESADAV
S268 TFRIYGESADAVKKA
K273 GESADAVKKARGFLE
K295 VPRNLVGKVIGKNGK
K302 KVIGKNGKVIQEIVD
K310 VIQEIVDKSGVVRVR
K325 IEGDNENKLPREDGM
Y353 NVQVLLEYHIAYLKE
Y357 LLEYHIAYLKEVEQL
- gap
- gap
- gap
- gap
- gap
- gap
S384 QIGSRSYSGRGRGRR
T401 NYTSGYGTNSELSNP
S406 YGTNSELSNPSETES
S409 NSELSNPSETESERK
T411 ELSNPSETESERKDE
S420 SERKDELSDWSLAGE
S423 KDELSDWSLAGEDDR
S432 AGEDDRDSRHQRDSR
S438 DSRHQRDSRRRPGGR
R445 SRRRPGGRGRSVSGG
K470 SSISSVLKDPDSNPy
Y477-p KDPDSNPySLLDNTE
S478 DPDSNPySLLDNTES
T483 PySLLDNTESDQTAD
S485 SLLDNTESDQTADTD
T488 DNTESDQTADTDASE
T491 ESDQTADTDASESHH
S494 QTADTDASESHHSTN
S496 ADTDASESHHSTNRR
S499 DASESHHSTNRRRRS
T500 ASESHHSTNRRRRSR
S506 STNRRRRSRRRRtDE
T511-p RRSRRRRtDEDAVLM
T522-p AVLMDGMtEsDtAsV
S524-p LMDGMtEsDtAsVNE
T526-p DGMtEsDtAsVNENG
S528-p MtEsDtAsVNENGLG
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  FXR1 iso3  
- gap
- gap
- gap
Y7 _MMKGEFYVIEYAAC
Y11 GEFYVIEYAACDATY
Y18 YAACDATYNEIVTFE
K34 LRPVNQNKTVKKNTF
T40 NKTVKKNTFFKCTVD
K94 SASEATVKRVNILSD
S106 LSDMHLRSIRTKLML
K122 SRNEEATKHLECTKQ
K128 TKHLECTKQLAAAFH
K161 SNIQQARKVPGVTAI
Y180 DTGTFRIYGESADAV
S183 TFRIYGESADAVKKA
K188 GESADAVKKARGFLE
K210 VPRNLVGKVIGKNGK
K217 KVIGKNGKVIQEIVD
K225 VIQEIVDKSGVVRVR
K240 IEGDNENKLPREDGM
Y268 NVQVLLEYHIAYLKE
Y272 LLEYHIAYLKEVEQL
- gap
- gap
- gap
- gap
- gap
- gap
S299 QIGSRSYSGRGRGRR
T316 NYTSGYGTNSELSNP
S321 YGTNSELSNPSETES
S324 NSELSNPSETESERK
T326 ELSNPSETESERKDE
S335 SERKDELSDWSLAGE
S338 KDELSDWSLAGEDDR
S347 AGEDDRDSRHQRDSR
S353 DSRHQRDSRRRPGGR
R360 SRRRPGGRGRSVSGG
K385 SSISSVLKDPDSNPy
Y392-p KDPDSNPySLLDNTE
S393 DPDSNPySLLDNTES
T398 PySLLDNTESDQTAD
S400 SLLDNTESDQTADTD
T403 DNTESDQTADTDASE
T406 ESDQTADTDASESHH
S409 QTADTDASESHHSTN
S411 ADTDASESHHSTNRR
S414 DASESHHSTNRRRRs
T415 ASESHHSTNRRRRsR
S421-p STNRRRRsRRRRtDE
T426-p RRsRRRRtDEDAVLM
T437 AVLMDGMTESDTASV
S439 LMDGMTESDTASVNE
T441 DGMTESDTASVNENG
S443 MTESDTASVNENGLV
T472 QRNLPRETLAKNKKE
S500 KAINGPTSASGDDIS
S502 INGPTSASGDDISKL
S507 SASGDDISKLQRTPG
T512 DISKLQRTPGEEKIN
T520 PGEEKINTLKEENTQ
T526 NTLKEENTQEAAVLN
  FXR1 iso5  
- gap
- gap
- gap
Y7 _MMKGEFYVIEYAAC
Y11 GEFYVIEYAACDATY
Y18 YAACDATYNEIVTFE
K34 LRPVNQNKTVKKNTF
T40 NKTVKKNTFFKCTMD
K94 SASEATVKRVNILSD
S106 LSDMHLRSIRTKLML
K122 SRNEEATKHLECTKQ
K128 TKHLECTKQLAAAFH
K161 SNIQQARKVPGVTAI
Y180 DTGTFRIYGESADAV
S183 TFRIYGESADAVKKA
K188 GESADAVKKARGFLE
K210 VPRNLVGKVIGKNGK
K217 KVIGKNGKVIQEIVD
K225 VIQEIVDKSGVVRVR
K240 IEGDNENKLPREDGM
Y268 NVQVLLEYHIAYLKE
Y272 LLEYHIAYLKEVEQL
K309 TRGPEKEKGYAtDEs
T313-p EKEKGYAtDEstVSS
S316-p KGYAtDEstVSSVQG
T317-p GYAtDEstVSSVQGS
S319 AtDEstVSSVQGSRS
S320 tDEstVSSVQGSRSY
S328 VQGSRSYSGRGRGRR
T345 NYTSGYGTNSELSNP
S350 YGTNSELSNPSETES
S353 NSELSNPSETESERK
T355 ELSNPSETESERKDE
S364 SERKDELSDWSLAGE
S367 KDELSDWSLAGEDDR
S376 AGEDDRDSRHQRDSR
S382 DSRHQRDSRRRPGGR
R389 SRRRPGGRGRSVSGG
K414 SPISSVLKDPDSNPY
Y421 KDPDSNPYSLLDNTE
S422 DPDSNPYSLLDNTES
T427 PYSLLDNTESDQTAD
S429 SLLDNTESDQTADTD
T432 DNTESDQTADTDASE
T435 ESDQTADTDASESHH
S438 QTADTDASESHHSTN
S440 ADTDASESHHSTNRR
S443 DASESHHSTNRRRRS
T444 ASESHHSTNRRRRSR
S450 STNRRRRSRRRRTDE
T455 RRSRRRRTDEDAVLM
T466 AVLMDGMTESDTASV
S468 LMDGMTESDTASVNE
T470 DGMTESDTASVNENG
S472 MTESDTASVNENGLV
T501 QRNLPRETLAKNKKE
S529 KAINGPTSASGDDIS
S531 INGPTSASGDDISKL
S536 SASGDDISKLQRTPG
T541 DISKLQRTPGEEKIN
T549 PGEEKINTLKEENTQ
T555 NTLKEENTQEAAVLN
  mouse

► Hide Isoforms
 
K56 LPPPPDIKKEISEGD
Y68-p EGDEVEVySRANDQE
K83 PCGWWLAKVRMMKGE
Y92-p RMMKGEFyVIEyAAC
Y96-p GEFyVIEyAACDATy
Y103-p yAACDATyNEIVTFE
K119 LRPVNQNKTVKKNtF
T125-p NKTVKKNtFFKCTVD
K179 SASEATVKRVNILSD
S191 LSDMHLRSIRTKLML
K207 SRNEEATKHLECTKQ
K213 TKHLECTKQLAAAFH
K246-ub SNIQQARkVPGVTAI
Y265 DTGTFRIYGESAEAV
S268 TFRIYGESAEAVKKA
K273 GESAEAVKKARGFLE
K295-ac VPRNLVGkVIGKNGk
K302-ub kVIGKNGkVIQEIVD
K310 VIQEIVDKSGVVRVR
K325-ub IEGDNENkLPREDGM
Y353 NVQVLLEYHIAYLKE
Y357 LLEYHIAYLKEVEQL
K394-ub TRGPEREkGYAtDEs
T398-p EREkGYAtDEstVss
S401-p kGYAtDEstVssVQG
T402-p GYAtDEstVssVQGS
S404-p AtDEstVssVQGSRS
S405-p tDEstVssVQGSRSY
S413-p VQGSRSYsGRGRGRR
T430-p NYTSGYGtNSELsNP
S435-p YGtNSELsNPsEtES
S438-p NSELsNPsEtESERK
T440-p ELsNPsEtESERKDE
S449-p SERKDELsDWsLAGE
S452-p KDELsDWsLAGEDDR
T461 AGEDDRETRHQRDSR
S467 ETRHQRDSRRRPGGR
R474 SRRRPGGRGRSVSGG
K499 SSISSVLKDPDSNPy
Y506-p KDPDSNPysLLDNtE
S507-p DPDSNPysLLDNtEs
T512-p PysLLDNtEsDQtAD
S514-p sLLDNtEsDQtADtD
T517-p DNtEsDQtADtDAsE
T520-p EsDQtADtDAsEsHH
S523-p QtADtDAsEsHHstN
S525-p ADtDAsEsHHstNRR
S528-p DAsEsHHstNRRRRS
T529-p AsEsHHstNRRRRSR
S535 stNRRRRSRRRRtDE
T540-p RRSRRRRtDEDAVLM
T551 AVLMDGLTEsDtASV
S553-p LMDGLTEsDtASVNE
T555-p DGLTEsDtASVNENG
S557 LTEsDtASVNENGLD
T613-p QRNLPREtLAKNKKE
S641-p KAINGPTsAsGDEIP
S643-p INGPTsAsGDEIPKL
P648 sAsGDEIPKLPRTLG
T653 EIPKLPRTLGEEKTK
T661 LGEEKTKTLKEDSTQ
T667 KTLKEDSTQEAAVLN
  FXR1 iso2  
K56 LPPPPDIKKEISEGD
Y68 EGDEVEVYSRANDQE
K83 PCGWWLAKVRMMKGE
Y92 RMMKGEFYVIEYAAC
Y96 GEFYVIEYAACDATY
Y103 YAACDATYNEIVTFE
K119 LRPVNQNKTVKKNTF
T125 NKTVKKNTFFKCTVD
K179 SASEATVKRVNILSD
S191 LSDMHLRSIRTKLML
K207 SRNEEATKHLECTKQ
K213 TKHLECTKQLAAAFH
K246 SNIQQARKVPGVTAI
Y265 DTGTFRIYGESAEAV
S268 TFRIYGESAEAVKKA
K273 GESAEAVKKARGFLE
K295 VPRNLVGKVIGKNGK
K302 KVIGKNGKVIQEIVD
K310 VIQEIVDKSGVVRVR
K325 IEGDNENKLPREDGM
Y353 NVQVLLEYHIAYLKE
Y357 LLEYHIAYLKEVEQL
- gap
- gap
- gap
- gap
- gap
- gap
S384 QIGSRSYSGRGRGRR
T401 NYTSGYGTNSELSNP
S406 YGTNSELSNPSETES
S409 NSELSNPSETESERK
T411 ELSNPSETESERKDE
S420 SERKDELSDWSLAGE
S423 KDELSDWSLAGEDDR
T432 AGEDDRETRHQRDSR
S438 ETRHQRDSRRRPGGR
R445 SRRRPGGRGRSVSGG
K470 SSISSVLKDPDSNPY
Y477 KDPDSNPYSLLDNTE
S478 DPDSNPYSLLDNTES
T483 PYSLLDNTESDQTAD
S485 SLLDNTESDQTADTD
T488 DNTESDQTADTDASE
T491 ESDQTADTDASESHH
S494 QTADTDASESHHSTN
S496 ADTDASESHHSTNRR
S499 DASESHHSTNRRRRS
T500 ASESHHSTNRRRRSR
S506 STNRRRRSRRRRtDE
T511-p RRSRRRRtDEDAVLM
T522-p AVLMDGLtEsDTASV
S524-p LMDGLtEsDTASVNE
T526 DGLtEsDTASVNENG
S528 LtEsDTASVNENGLG
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
K56 LPPPPDIKKEISEGD
Y68 EGDEVEVYSRANDQE
K83 PCGWWLAKVRMMKGE
Y92 RMMKGEFYVIEYAAC
Y96 GEFYVIEYAACDATY
Y103 YAACDATYNEIVTFE
K119 LRPVNQNKTVKKNTF
T125 NKTVKKNTFFKCTVD
K179 SASEATVKRVNILSD
S191 LSDMHLRSIRTKLML
K207 SRNEEATKHLECTKQ
K213 TKHLECTKQLAAAFH
K246 SNIQQARKVPGVTAI
Y265 DTGTFRIYGESAEAV
S268 TFRIYGESAEAVKKA
K273 GESAEAVKKARGFLE
K295 VPRNLVGKVIGKNGK
K302 KVIGKNGKVIQEIVD
K310 VIQEIVDKSGVVRVR
K325 IEGDNENKLPREDGM
Y353 NVQVLLEYHIAYLKE
Y357 LLEYHIAYLKEVEQL
K394 TRGPEKEKGYAtDEs
T398-p EKEKGYAtDEsTVSS
S401-p KGYAtDEsTVSSVQG
T402 GYAtDEsTVSSVQGS
S404 AtDEsTVSSVQGSRS
S405 tDEsTVSSVQGSRSY
S413 VQGSRSYSGRGRGRR
T430 NYTSGYGTNSELsNP
S435-p YGTNSELsNPsETES
S438-p NSELsNPsETESERK
T440 ELsNPsETESERKDE
S449-p SERKDELsDWsLAGE
S452-p KDELsDWsLAGEDDR
T461 AGEDDRETRHQRDSR
S467 ETRHQRDSRRRPGGR
R474 SRRRPGGRGRSVSGG
K499 SSISSVLKDPDSNPY
Y506 KDPDSNPYSLLDNtE
S507 DPDSNPYSLLDNtEs
T512-p PYSLLDNtEsDQtAD
S514-p SLLDNtEsDQtADTD
T517-p DNtEsDQtADTDASE
T520 EsDQtADTDASESHH
S523 QtADTDASESHHSTN
S525 ADTDASESHHSTNRR
S528 DASESHHSTNRRRRS
T529 ASESHHSTNRRRRSR
S535 STNRRRRSRRRRtDE
T540-p RRSRRRRtDEDAVLM
T551 AVLMDGMTESDTASV
S553 LMDGMTESDTASVNE
T555 DGMTESDTASVNENG
S557 MTESDTASVNENGLG
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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