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Protein Page:
Ikaros (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Ikaros a transcription factor of the ikaros C2H2-type zinc-finger protein family. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development. Deletions in Ikaros have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Seven alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA binding protein; Transcription factor
Cellular Component: centric heterochromatin; cytoplasm; nucleus
Molecular Function: DNA binding; zinc ion binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity
Biological Process: Peyer's patch development; gland development; transcription, DNA-dependent; thymus development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of multicellular organism growth; chromatin modification; cell cycle; lymph node development; positive regulation of neutrophil differentiation; natural killer cell differentiation; retina development in camera-type eye; B cell differentiation; forebrain development; mesoderm development; positive regulation of NK T cell differentiation; positive regulation of transcription from RNA polymerase II promoter; T cell differentiation
Reference #:  Q13422 (UniProtKB)
Alt. Names/Synonyms: CLL-associated antigen KW-6; DNA-binding protein Ikaros; hIk-1; Hs.54452; IK1; IKAROS; Ikaros (zinc finger protein); IKAROS family zinc finger 1 (Ikaros); Ikaros family zinc finger protein 1; IKZF1; LYF1; Lymphoid transcription factor LyF-1; PRO0758; zinc finger protein, subfamily 1A, 1 (Ikaros); ZNFN1A1
Gene Symbols: IKZF1
Molecular weight: 57,528 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Ikaros
Protein Structure Not Found.


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Sites Implicated In
cell differentiation, induced: S361‑p, S364‑p
transcription, induced: S361‑p, S364‑p
intracellular localization: S361‑p, S364‑p
molecular association, regulation: S361‑p, S364‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 S10 ADEGQDMSQVSGKES
1 1 S13 GQDMSQVSGKESPPV
1 0 T23 ESPPVSDTPDEGDEP
0 1 - gap
1 0 K58 RVVASNVKVEtQsDE
0 1 T61-p ASNVKVEtQsDEENG
2 11 S63-p NVKVEtQsDEENGRA
1 0 S101 GSHRDQGSSALsGVG
0 1 S105-p DQGSSALsGVGGIRL
1 0 T140 MVHKRSHTGERPFQC
1 0 S168 LRHIKLHSGEKPFKC
1 0 S196 TGHLRTHSVGKPHKC
1 0 K241 GTLYPVIKEETNHSE
0 1 S258-p EDLCKIGsERsLVLD
0 2 S261-p CKIGsERsLVLDRLA
0 25 S269-p LVLDRLAsNVAkRKS
0 1 K273-u RLAsNVAkRKSSMPQ
0 1 S289-p FLGDKGLsDtPyDss
0 2 T291-p GDKGLsDtPyDssAS
0 3 Y293-p KGLsDtPyDssASyE
1 4 S295-p LsDtPyDssASyEKE
0 1 S296-p sDtPyDssASyEKEN
0 1 Y299-p PyDssASyEKENEMM
0 3 Y321-p AINNAINyLGAESLR
0 2 T333-p SLRPLVQtPPGGSEV
0 2 S345-p SEVVPVIsPMyQLHK
0 4 Y348-p VPVIsPMyQLHKPLA
0 1 T358-p HKPLAEGtPRsNHsA
1 1 S361-p LAEGtPRsNHsAQDS
1 1 S364-p GtPRsNHsAQDSAVE
0 1 S377-p VENLLLLsKAKLVPs
0 1 S384-p sKAKLVPsEREAsPs
1 5 S389-p VPsEREAsPsNsCQD
1 4 S391-p sEREAsPsNsCQDst
1 6 S393-p REAsPsNsCQDstDT
1 3 S397-p PsNsCQDstDTEsNN
1 8 T398-p sNsCQDstDTEsNNE
0 7 S402-p QDstDTEsNNEEQRS
0 2 S409 sNNEEQRSGLIyLtN
0 89 Y413-p EQRSGLIyLtNHIAP
0 3 T415-p RSGLIyLtNHIAPHA
0 1 K429-u ARNGLSLkEEHRAyD
0 18 Y435-p LkEEHRAyDLLRAAs
0 22 S442-p yDLLRAAsENsQDAL
0 10 S445-p LRAAsENsQDALRVV
  Ikaros iso12  
S10-p ADEGQDMsQVsVIKE
S13-p GQDMsQVsVIKEETN
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K16 MsQVsVIKEETNHSE
S33 EDLCKIGSERSLVLD
S36 CKIGSERSLVLDRLA
S44 LVLDRLASNVAKRKS
K48 RLASNVAKRKSSMPQ
S64 FLGDKGLSDTPYDSS
T66 GDKGLSDTPYDSSAS
Y68 KGLSDTPYDSSASYE
S70 LSDTPYDSSASYEKE
S71 SDTPYDSSASYEKEN
Y74 PYDSSASYEKENEMM
Y96 AINNAINYLGAESLR
T108 SLRPLVQTPPGGSEV
S120 SEVVPVISPMYQLHK
Y123 VPVISPMYQLHKPLA
T133 HKPLAEGTPRSNHSA
S136 LAEGTPRSNHSAQDS
S139 GTPRSNHSAQDSAVE
S152 VENLLLLSKAKLVPS
S159 SKAKLVPSEREASPS
S164 VPSEREASPSNSCQD
S166 SEREASPSNSCQDST
S168 REASPSNSCQDSTDT
S172 PSNSCQDSTDTESNN
T173 SNSCQDSTDTESNNE
S177 QDSTDTESNNEEQRS
S184 SNNEEQRSGLIYLTN
Y188 EQRSGLIYLTNHIAP
T190 RSGLIYLTNHIAPHA
K204 ARNGLSLKEEHRAYD
Y210 LKEEHRAYDLLRAAS
S217 YDLLRAASENSQDAL
S220 LRAASENSQDALRVV
  mouse

► Hide Isoforms 		 
S10 VDEGQDMSQVsGKES
S13-p GQDMSQVsGKESPPV
T23-p ESPPVSDtPDEGDEP
- gap
K58-s RGMGSNVkVETQsDE
T61 GSNVkVETQsDEENG
S63-p NVkVETQsDEENGRA
S101-p GSHRDQGsSALSGVG
S105 DQGsSALSGVGGIRL
T140-p MVHKRSHtERPFQCN
S167-p LRHIKLHsGEKPFKC
S195-p TGHLRTHsVGKPHKC
K239-s PGVCPVIkEETNHNE
A256 EDLCKIGAERSLVLD
S259 CKIGAERSLVLDRLA
S267 LVLDRLASNVAKRKS
K271 RLASNVAKRKSSMPQ
S287 FLGDKCLSDMPYDsA
M289 GDKCLSDMPYDsANY
Y291 KCLSDMPYDsANYEK
S293-p LSDMPYDsANYEKED
- gap
Y296 MPYDsANYEKEDMMT
Y317 AINNAINYLGAESLR
T329 SLRPLVQTPPGSSEV
S341 SEVVPVISSMYQLHK
Y344 VPVISSMYQLHKPPS
P354 HKPPSDGPPRsNHsA
S357-p PSDGPPRsNHsAQDA
S360-p GPPRsNHsAQDAVDN
S372 VDNLLLLSKAKSVSS
S379 SKAKSVSSEREAsPs
S384-p VSSEREAsPsNsCQD
S386-p SEREAsPsNsCQDst
S388-p REAsPsNsCQDstDT
S392-p PsNsCQDstDTEsNA
T393-p sNsCQDstDTEsNAE
S397-p QDstDTEsNAEEQRs
S404-p sNAEEQRsGLIYLTN
Y408 EQRsGLIYLTNHINP
T410 RsGLIYLTNHINPHA
K424 ARNGLALKEEQRAYE
Y430 LKEEQRAYEVLRAAs
S437-p YEVLRAAsENsQDAF
S440-p LRAAsENsQDAFRVV
  Ikaros iso9  
S10 VDEGQDMSQVSGKES
S13 GQDMSQVSGKESPPV
T23 ESPPVSDTPDEGDEP
S73-p AIIPKSFsPSNVKVE
K78 SFsPSNVKVETQsDE
T81 PSNVKVETQsDEENG
S83-p NVKVETQsDEENGRA
S121 GSHRDQGSSALSGVG
S125 DQGSSALSGVGGIRL
T160 MVHKRSHTGERPFQC
S188 LRHIKLHSGEKPFKC
S216 TGHLRTHSVGKPHKC
K260 PGMYPVIKEETNHNE
A277 EDLCKIGAERSLVLD
S280 CKIGAERSLVLDRLA
S288 LVLDRLASNVAKRKS
K292 RLASNVAKRKSSMPQ
S308 FLGDKCLSDMPYDSA
M310 GDKCLSDMPYDSANY
Y312 KCLSDMPYDSANYEK
S314 LSDMPYDSANYEKED
- gap
Y317 MPYDSANYEKEDMMT
Y338 AINNAINYLGAESLR
T350 SLRPLVQTPPGSSEV
S362 SEVVPVISSMYQLHK
Y365 VPVISSMYQLHKPPS
P375 HKPPSDGPPRSNHSA
S378 PSDGPPRSNHSAQDA
S381 GPPRSNHSAQDAVDN
S393 VDNLLLLSKAKSVSS
S400 SKAKSVSSEREASPS
S405 VSSEREASPSNSCQD
S407 SEREASPSNSCQDST
S409 REASPSNSCQDSTDT
S413 PSNSCQDSTDTESNA
T414 SNSCQDSTDTESNAE
S418 QDSTDTESNAEEQRS
S425 SNAEEQRSGLIYLTN
Y429 EQRSGLIYLTNHINP
T431 RSGLIYLTNHINPHA
K445 ARNGLALKEEQRAYE
Y451 LKEEQRAYEVLRAAS
S458 YEVLRAASENSQDAF
S461 LRAASENSQDAFRVV
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