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Protein Page:
Ikaros (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Ikaros a transcription factor of the ikaros C2H2-type zinc-finger protein family. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development. Deletions in Ikaros have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Seven alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA binding protein; Transcription factor
Cellular Component: centric heterochromatin; cytoplasm; nucleus
Molecular Function: DNA binding; protein heterodimerization activity; sequence-specific DNA binding; metal ion binding; transcription factor activity
Biological Process: Peyer's patch development; gland development; thymus development; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; positive regulation of multicellular organism growth; cell cycle; lymph node development; positive regulation of neutrophil differentiation; retina development in camera-type eye; natural killer cell differentiation; B cell differentiation; forebrain development; mesoderm development; positive regulation of NK T cell differentiation; positive regulation of transcription from RNA polymerase II promoter; T cell differentiation
Reference #:  Q13422 (UniProtKB)
Alt. Names/Synonyms: CLL-associated antigen KW-6; DNA-binding protein Ikaros; hIk-1; Hs.54452; IK1; IKAROS; Ikaros (zinc finger protein); IKAROS family zinc finger 1 (Ikaros); Ikaros family zinc finger protein 1; IKZF1; LYF1; Lymphoid transcription factor LyF-1; PRO0758; zinc finger protein, subfamily 1A, 1 (Ikaros); ZNFN1A1
Gene Symbols: IKZF1
Molecular weight: 57,528 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Ikaros

Protein Structure Not Found.


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Sites Implicated In
cell differentiation, induced: S361‑p, S364‑p
transcription, induced: S361‑p, S364‑p
intracellular localization: S361‑p, S364‑p
molecular association, regulation: S361‑p, S364‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S13 GQDMSQVSGKESPPV
1 0 T23 ESPPVSDTPDEGDEP
0 2 - gap
1 0 K58 RVVASNVKVEtQsDE
0 1 T61-p ASNVKVEtQsDEENG
2 11 S63-p NVKVEtQsDEENGRA
1 0 S101 GSHRDQGSSALsGVG
0 1 S105-p DQGSSALsGVGGIRL
1 0 T140 MVHKRSHTGERPFQC
2 0 S168 LRHIKLHSGEKPFKC
1 0 S196 TGHLRTHSVGKPHKC
1 0 S214-p GRSYKQRssLEEHKE
1 0 S215-p RSYKQRssLEEHKER
1 0 K241 GTLYPVIKEETNHSE
0 1 S258-p EDLCKIGsERsLVLD
0 3 S261-p CKIGsERsLVLDRLA
0 26 S269-p LVLDRLAsNVAkRKS
0 1 K273-ub RLAsNVAkRKSSMPQ
0 2 S289-p FLGDKGLsDtPyDss
0 2 T291-p GDKGLsDtPyDssAs
0 3 Y293-p KGLsDtPyDssAsyE
1 4 S295-p LsDtPyDssAsyEKE
0 1 S296-p sDtPyDssAsyEKEN
0 1 S298-p tPyDssAsyEKENEM
0 1 Y299-p PyDssAsyEKENEMM
0 3 Y321-p AINNAINyLGAESLR
0 1 S326 INyLGAESLRPLVQt
0 4 T333-p SLRPLVQtPPGGSEV
0 1 G337 LVQtPPGGSEVVPVI
0 1 S338 VQtPPGGSEVVPVIs
0 3 S345-p SEVVPVIsPMyQLHK
0 1 P346 EVVPVIsPMyQLHKP
0 7 Y348-p VPVIsPMyQLHKPLA
0 1 A355 yQLHKPLAEGtPRsN
0 1 T358-p HKPLAEGtPRsNHsA
1 2 S361-p LAEGtPRsNHsAQDs
1 3 S364-p GtPRsNHsAQDsAVE
0 1 S368-p sNHsAQDsAVENLLL
0 2 S377-p VENLLLLsKAKLVPS
1 5 S389-p VPSEREAsPsNsCQD
1 3 S391-p SEREAsPsNsCQDst
1 4 S393-p REAsPsNsCQDstDT
1 2 S397-p PsNsCQDstDTEsNN
1 5 T398-p sNsCQDstDTEsNNE
0 1 T400 sCQDstDTEsNNEEQ
0 5 S402-p QDstDTEsNNEEQRS
0 2 S409 sNNEEQRSGLIyLtN
0 92 Y413-p EQRSGLIyLtNHIAP
0 3 T415-p RSGLIyLtNHIAPHA
0 1 S427-p PHARNGLsLkEEHRA
0 1 K429-ub ARNGLsLkEEHRAyD
0 20 Y435-p LkEEHRAyDLLRAAs
0 35 S442-p yDLLRAAsENsQDAL
0 24 S445-p LRAAsENsQDALRVV
  mouse

► Hide Isoforms
 
S13-p GQDMSQVsGKESPPV
T23-p ESPPVSDtPDEGDEP
- gap
K58-sm RGMGSNVkVETQsDE
T61 GSNVkVETQsDEENG
S63-p NVkVETQsDEENGRA
S101-p GSHRDQGsSALSGVG
S105 DQGsSALSGVGGIRL
T140-p MVHKRSHtERPFQCN
S167-p LRHIKLHsGEKPFKC
S195-p TGHLRTHsVGKPHKC
S213-p GRSYKQRssLEEHKE
S214-p RSYKQRssLEEHKER
K239-sm PGVCPVIkEETNHNE
A256 EDLCKIGAERSLVLD
S259 CKIGAERSLVLDRLA
S267-p LVLDRLAsNVAKRKS
K271 RLAsNVAKRKSSMPQ
S287 FLGDKCLSDMPYDsA
M289 GDKCLSDMPYDsANY
Y291 KCLSDMPYDsANYEK
S293-p LSDMPYDsANYEKED
- gap
N295 DMPYDsANYEKEDMM
Y296 MPYDsANYEKEDMMT
Y317-p AINNAINyLGAEsLR
S322-p INyLGAEsLRPLVQt
T329-p sLRPLVQtPPGssEV
S333-p LVQtPPGssEVVPVI
S334-p VQtPPGssEVVPVIs
S341-p sEVVPVIssMyQLHK
S342-p EVVPVIssMyQLHKP
Y344-p VPVIssMyQLHKPPs
S351-p yQLHKPPsDGPPRsN
P354 HKPPsDGPPRsNHsA
S357-p PsDGPPRsNHsAQDA
S360-p GPPRsNHsAQDAVDN
- gap
S372-p VDNLLLLsKAKSVSS
S384-p VSSEREAsPsNsCQD
S386-p SEREAsPsNsCQDst
S388-p REAsPsNsCQDstDt
S392-p PsNsCQDstDtEsNA
T393-p sNsCQDstDtEsNAE
T395-p sCQDstDtEsNAEEQ
S397-p QDstDtEsNAEEQRs
S404-p sNAEEQRsGLIYLTN
Y408 EQRsGLIYLTNHINP
T410 RsGLIYLTNHINPHA
A422 PHARNGLALKEEQRA
K424 ARNGLALKEEQRAYE
Y430 LKEEQRAYEVLRAAs
S437-p YEVLRAAsENsQDAF
S440-p LRAAsENsQDAFRVV
  Ikaros iso9  
S13 GQDMSQVSGKESPPV
T23 ESPPVSDTPDEGDEP
S73-p AIIPKSFsPSNVKVE
K78 SFsPSNVKVETQsDE
T81 PSNVKVETQsDEENG
S83-p NVKVETQsDEENGRA
S121 GSHRDQGSSALSGVG
S125 DQGSSALSGVGGIRL
T160 MVHKRSHTGERPFQC
S188 LRHIKLHSGEKPFKC
S216 TGHLRTHSVGKPHKC
S234 GRSYKQRSSLEEHKE
S235 RSYKQRSSLEEHKER
K260 PGMYPVIKEETNHNE
A277 EDLCKIGAERSLVLD
S280 CKIGAERSLVLDRLA
S288 LVLDRLASNVAKRKS
K292 RLASNVAKRKSSMPQ
S308 FLGDKCLSDMPYDSA
M310 GDKCLSDMPYDSANY
Y312 KCLSDMPYDSANYEK
S314 LSDMPYDSANYEKED
- gap
N316 DMPYDSANYEKEDMM
Y317 MPYDSANYEKEDMMT
Y338 AINNAINYLGAESLR
S343 INYLGAESLRPLVQT
T350 SLRPLVQTPPGSSEV
S354 LVQTPPGSSEVVPVI
S355 VQTPPGSSEVVPVIS
S362 SEVVPVISSMYQLHK
S363 EVVPVISSMYQLHKP
Y365 VPVISSMYQLHKPPS
S372 YQLHKPPSDGPPRSN
P375 HKPPSDGPPRSNHSA
S378 PSDGPPRSNHSAQDA
S381 GPPRSNHSAQDAVDN
- gap
S393 VDNLLLLSKAKSVSS
S405 VSSEREASPSNSCQD
S407 SEREASPSNSCQDST
S409 REASPSNSCQDSTDT
S413 PSNSCQDSTDTESNA
T414 SNSCQDSTDTESNAE
T416 SCQDSTDTESNAEEQ
S418 QDSTDTESNAEEQRS
S425 SNAEEQRSGLIYLTN
Y429 EQRSGLIYLTNHINP
T431 RSGLIYLTNHINPHA
A443 PHARNGLALKEEQRA
K445 ARNGLALKEEQRAYE
Y451 LKEEQRAYEVLRAAS
S458 YEVLRAASENSQDAF
S461 LRAASENSQDAFRVV
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