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Protein Page:
CTNNB1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CTNNB1 a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Actin binding protein; Transcription factor
Cellular Component: desmosome; centrosome; basolateral plasma membrane; intercellular junction; fascia adherens; zonula adherens; cytosol; beta-catenin destruction complex; transcription factor complex; cell-cell adherens junction; membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; synapse; dendritic shaft; lateral plasma membrane; spindle pole; internal side of plasma membrane; catenin complex; cell cortex; Z disc; nucleoplasm; adherens junction; apical part of cell; microvillus membrane; plasma membrane; nucleus; cell junction
Molecular Function: protein C-terminus binding; transcription coactivator activity; protein kinase binding; transcription factor binding; protein phosphatase binding; ionotropic glutamate receptor binding; protein binding; signal transducer activity; enzyme binding; androgen receptor binding; cadherin binding; double-stranded DNA binding; protein complex binding; estrogen receptor binding; chromatin binding; structural molecule activity; SMAD binding; transcription factor activity; kinase binding; nuclear hormone receptor binding; alpha-catenin binding
Biological Process: regulation of myelination; regulation of centriole-centriole cohesion; protein heterooligomerization; positive regulation of apoptosis; regulation of fibroblast proliferation; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; cell maturation; T cell differentiation in the thymus; positive regulation of fibroblast growth factor receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; osteoclast differentiation; cell-cell adhesion; positive regulation of endothelial cell differentiation; embryonic foregut morphogenesis; positive regulation of mesenchymal cell proliferation; ectoderm development; synapse organization and biogenesis; male genitalia development; cell adhesion; hindbrain development; embryonic limb morphogenesis; bone resorption; response to drug; positive regulation of neuroblast proliferation; tongue morphogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of smooth muscle cell proliferation; transcription, DNA-dependent; hair cell differentiation; negative regulation of protein sumoylation; patterning of blood vessels; genitalia morphogenesis; muscle cell differentiation; midgut development; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; oocyte development; embryonic forelimb morphogenesis; negative regulation of osteoclast differentiation; glial cell fate determination; endodermal cell fate commitment; apoptosis; cell-matrix adhesion; neuron migration; dorsal/ventral axis specification; cell fate specification; determination of dorsoventral asymmetry; negative regulation of transcription from RNA polymerase II promoter; embryonic hindlimb morphogenesis; response to estradiol stimulus; negative regulation of cell proliferation; central nervous system vasculogenesis; positive regulation of MAPKKK cascade; pancreas development; positive regulation of interferon type I production; fallopian tube development; proximal/distal pattern formation; layer formation in the cerebral cortex; cell structure disassembly during apoptosis; hair follicle morphogenesis; Wnt receptor signaling pathway; thymus development; cytoskeletal anchoring; in utero embryonic development; neural plate development; embryonic axis specification; regulation of T cell proliferation; synaptic vesicle transport; gastrulation with mouth forming second; liver development; regulation of angiogenesis; odontogenesis of dentine-containing teeth; myoblast differentiation; negative regulation of oligodendrocyte differentiation; Schwann cell proliferation; positive regulation of osteoblast differentiation; response to cadmium ion; ureteric bud branching; response to cytokine stimulus; androgen receptor signaling pathway; positive regulation of muscle cell differentiation; epithelial to mesenchymal transition; innate immune response; embryonic heart tube development; lens morphogenesis in camera-type eye; anterior/posterior axis specification
Reference #:  P35222 (UniProtKB)
Alt. Names/Synonyms: Beta-catenin; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin beta-1; CTNB1; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923
Gene Symbols: CTNNB1
Molecular weight: 85,497 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CTNNB1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: T332‑p, T472‑p, S552‑p
carcinogenesis, induced: Y333‑p
cell adhesion, altered: S33‑p, S37‑p, T41‑p, S45‑p
cell cycle regulation: Y333‑p
cell growth, altered: S33‑p, S37‑p, T41‑p, Y86‑p, Y654‑p, Y670‑p
cell growth, induced: Y333‑p, Y654‑p, Y670‑p
cell growth, inhibited: T112‑p, T120‑p
cell motility, altered: S29‑p, S45‑p, T102‑p, T112‑p, S552‑p
cell motility, inhibited: T112‑p, T120‑p
cytoskeletal reorganization: S33‑p, S37‑p, T41‑p, Y654‑p
transcription, altered: S33‑p, S37‑p, T41‑p, Y86‑p, T393‑p, Y654‑p
transcription, induced: Y86‑p, T112‑p, T120‑p, Y333‑p, T393‑p, Y489‑p, S552‑p, Y654‑p, S675‑p
transcription, inhibited: S33‑p, T120‑p, T332‑p, T472‑p, S552‑p
activity, induced: T393‑p, Y654‑p, Y670‑p, S675‑p
activity, inhibited: S33‑p
intracellular localization: S33‑p, S37‑p, T41‑p, S45‑p, T112‑p, T120‑p, Y142‑p, Y333‑p, Y489‑p, S552‑p, S675‑p
molecular association, regulation: S33‑p, S37‑p, T41‑p, S45‑p, Y86‑p, Y142‑p, S246‑p, Y333‑p, T393‑p, Y489‑p, Y654‑p, Y670‑p, S675‑p
phosphorylation: S45‑p, T393‑p
protein degradation: S29‑p, S33‑p, S37‑p, T41‑p, S45‑p, T102‑p, T112‑p
protein stabilization: Y86‑p, T393‑p, Y654‑p, S675‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K19-a MAMEPDRkAAVsHWQ
1 3 K19-u MAMEPDRkAAVsHWQ
2 0 S23-p PDRkAAVsHWQQQsy
0 1 S23 PDRkAAVSHWQQQsy
3 3 S29-p VsHWQQQsyLDsGIH
0 35 Y30-p sHWQQQsyLDsGIHs
52 5 S33-p QQQsyLDsGIHsGAT
55 4 S37-p yLDsGIHsGATtTAP
47 2 T41-p GIHsGATtTAPsLSG
24 3 S45-p GATtTAPsLSGkGNP
4 0 K49-a TAPsLSGkGNPEEED
1 0 K49-u TAPsLSGkGNPEEED
1 0 Y64-p VDTSQVLyEWEQGFS
1 0 S73-p WEQGFSQsFTQEQVA
5 22 Y86-p VADIDGQyAMTRAQR
2 0 T102-p RAAMFPEtLDEGMQI
2 0 T112-p EGMQIPStQFdAAHP
0 1 D115-ca QIPStQFdAAHPtNV
2 0 T120-p QFdAAHPtNVQRLAE
0 7 K133-u AEPSQMLkHAVVNLI
9 0 Y142-p AVVNLINyQDDAELA
0 3 K158-u RAIPELTkLLNDEDQ
0 8 K170-u EDQVVVNkAAVMVHQ
0 1 S179-p AVMVHQLskKEASRH
0 6 K180-u VMVHQLskKEASRHA
2 32 S191-p SRHAIMRsPQMVsAI
0 1 S196-p MRsPQMVsAIVRTMQ
0 13 K233-u EGLLAIFkSGGIPAL
1 0 S246-p ALVKMLGsPVDSVLF
1 2 Y331-p LVNIMRTytyEkLLW
1 0 T332-p VNIMRTytyEkLLWT
2 1 Y333-p NIMRTytyEkLLWTT
0 3 K335-u MRTytyEkLLWTTSR
1 0 K345-a WTTSRVLkVLSVCSS
0 1 K345-u WTTSRVLkVLSVCSS
1 0 K354-a LSVCSSNkPAIVEAG
0 6 K354-u LSVCSSNkPAIVEAG
2 0 T393-p RNLSDAAtkQEGMEG
1 0 K394-u NLSDAAtkQEGMEGL
0 6 K435-u TCNNYKNkMMVCQVG
1 1 T472-p ICALRHLtsRHQEAE
0 1 S473-p CALRHLtsRHQEAEM
1 88 Y489-p QNAVRLHyGLPVVVK
0 30 K508-u PSHWPLIkATVGLIR
0 1 T547-p LVRAHQDtQRRtsMG
0 13 T551-p HQDtQRRtsMGGtQQ
9 34 S552-p QDtQRRtsMGGtQQQ
0 13 T556-p RRtsMGGtQQQFVEG
0 2 T574-p EEIVEGCtGALHILA
1 0 S605 LFVQLLYSPIENIQR
0 6 K625-u LCELAQDkEAAEAIE
0 1 T653 SRNEGVATyAAAVLF
13 24 Y654-p RNEGVATyAAAVLFR
2 15 Y670-p SEDKPQDykKRLsVE
0 4 K671-u EDKPQDykKRLsVEL
9 38 S675-p QDykKRLsVELTsSL
0 1 T679 KRLsVELTsSLFRTE
0 1 S680-p RLsVELTsSLFRTEP
0 1 S681 LsVELTsSLFRTEPM
0 32 Y716-p YRQDDPSyRsFHsGG
1 3 S718-p QDDPSyRsFHsGGYG
0 2 S721-p PSyRsFHsGGYGQDA
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
9564 : Phospho-beta-Catenin (Ser45) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
9030 : Acetyl-beta-Catenin (Lys49) (D7C2) Rabbit mAb
9534 : Acetyl-beta-Catenin (Lys49) Antibody
5651 : Phospho-beta-Catenin (Ser552) (D8E11) Rabbit mAb
9566 : Phospho-beta-Catenin (Ser552) Antibody
4176 : Phospho-beta-Catenin (Ser675) (D2F1) XP(TM) Rabbit mAb
9567 : Phospho-beta-Catenin (Ser675) Antibody
  mouse

 
K19 MAMEPDRKAAVsHWQ
K19-u MAMEPDRkAAVsHWQ
S23-p PDRkAAVsHWQQQsY
S23-gl PDRkAAVsHWQQQsY
S29-p VsHWQQQsYLDsGIH
Y30 sHWQQQsYLDsGIHs
S33-p QQQsYLDsGIHsGAT
S37-p YLDsGIHsGATtTAP
T41-p GIHsGATtTAPsLSG
S45-p GATtTAPsLSGkGNP
K49-a TAPsLSGkGNPEEED
K49 TAPsLSGKGNPEEED
Y64 VDTSQVLYEWEQGFS
S73 WEQGFSQSFTQEQVA
Y86-p VADIDGQyAMTRAQR
T102 RAAMFPETLDEGMQI
T112 EGMQIPSTQFDAAHP
D115 QIPSTQFDAAHPTNV
T120 QFDAAHPTNVQRLAE
K133-u AEPSQMLkHAVVNLI
Y142-p AVVNLINyQDDAELA
K158-u RAIPELTkLLNDEDQ
K170-u EDQVVVNkAAVMVHQ
S179 AVMVHQLSKKEASRH
K180 VMVHQLSKKEASRHA
S191-p SRHAIMRsPQMVSAI
S196 MRsPQMVSAIVRTMQ
K233-u EGLLAIFkSGGIPAL
S246 ALVKMLGSPVDSVLF
Y331 LVNIMRTYTYEKLLW
T332 VNIMRTYTYEKLLWT
Y333 NIMRTYTYEKLLWTT
K335 MRTYTYEKLLWTTSR
K345 WTTSRVLKVLSVCSS
K345 WTTSRVLKVLSVCSS
K354 LSVCSSNKPAIVEAG
K354 LSVCSSNKPAIVEAG
T393-p RNLSDAAtKQEGMEG
K394 NLSDAAtKQEGMEGL
K435 TCNNYKNKMMVCQVG
T472 ICALRHLTSRHQEAE
S473 CALRHLTSRHQEAEM
Y489-p QNAVRLHyGLPVVVK
K508 PSHWPLIKATVGLIR
T547 LVRAHQDTQRRtsMG
T551-p HQDTQRRtsMGGtQQ
S552-p QDTQRRtsMGGtQQQ
T556-p RRtsMGGtQQQFVEG
T574 EEIVEGCTGALHILA
S605-p LFVQLLYsPIENIQR
K625-u LCELAQDkEAAEAIE
T653-p SRNEGVAtyAAAVLF
Y654-p RNEGVAtyAAAVLFR
Y670 SEDKPQDYkKRLsVE
K671-u EDKPQDYkKRLsVEL
S675-p QDYkKRLsVELtssL
T679-p KRLsVELtssLFRTE
S680-p RLsVELtssLFRTEP
S681-p LsVELtssLFRTEPM
Y716 YRQDDPSYRSFHSGG
S718 QDDPSYRSFHSGGYG
S721 PSYRSFHSGGYGQDA
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
9564 : Phospho-beta-Catenin (Ser45) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
9030 : Acetyl-beta-Catenin (Lys49) (D7C2) Rabbit mAb
9534 : Acetyl-beta-Catenin (Lys49) Antibody
5651 : Phospho-beta-Catenin (Ser552) (D8E11) Rabbit mAb
9566 : Phospho-beta-Catenin (Ser552) Antibody
4176 : Phospho-beta-Catenin (Ser675) (D2F1) XP(TM) Rabbit mAb
9567 : Phospho-beta-Catenin (Ser675) Antibody
  rat

 
K19 MAMEPDRKAAVSHWQ
K19 MAMEPDRKAAVSHWQ
S23 PDRKAAVSHWQQQSY
S23 PDRKAAVSHWQQQSY
S29 VSHWQQQSYLDsGIH
Y30 SHWQQQSYLDsGIHs
S33-p QQQSYLDsGIHsGAT
S37-p YLDsGIHsGATtTAP
T41-p GIHsGATtTAPsLSG
S45-p GATtTAPsLSGKGNP
K49 TAPsLSGKGNPEEED
K49 TAPsLSGKGNPEEED
Y64 VDTSQVLYEWEQGFS
S73 WEQGFSQSFTQEQVA
Y86 VADIDGQYAMTRAQR
T102 RAAMFPETLDEGMQI
T112 EGMQIPSTQFDAAHP
D115 QIPSTQFDAAHPTNV
T120 QFDAAHPTNVQRLAE
K133 AEPSQMLKHAVVNLI
Y142-p AVVNLINyQDDAELA
K158 RAIPELTKLLNDEDQ
K170 EDQVVVNKAAVMVHQ
S179 AVMVHQLSKKEASRH
K180 VMVHQLSKKEASRHA
S191-p SRHAIMRsPQMVSAI
S196 MRsPQMVSAIVRTMQ
K233 EGLLAIFKSGGIPAL
S246 ALVKMLGSPVDSVLF
Y331 LVNIMRTYTYEKLLW
T332 VNIMRTYTYEKLLWT
Y333 NIMRTYTYEKLLWTT
K335 MRTYTYEKLLWTTSR
K345 WTTSRVLKVLSVCSS
K345 WTTSRVLKVLSVCSS
K354 LSVCSSNKPAIVEAG
K354 LSVCSSNKPAIVEAG
T393 RNLSDAATKQEGMEG
K394 NLSDAATKQEGMEGL
K435 TCNNYKNKMMVCQVG
T472 ICALRHLTSRHQEAE
S473 CALRHLTSRHQEAEM
Y489-p QNAVRLHyGLPVVVK
K508 PSHWPLIKATVGLIR
T547 LVRAHQDTQRRtsMG
T551-p HQDTQRRtsMGGTQQ
S552-p QDTQRRtsMGGTQQQ
T556 RRtsMGGTQQQFVEG
T574 EEIVEGCTGALHILA
S605 LFVQLLYSPIENIQR
K625 LCELAQDKEAAEAIE
T653 SRNEGVATyAAAVLF
Y654-p RNEGVATyAAAVLFR
Y670 SEDKPQDYKKRLsVE
K671 EDKPQDYKKRLsVEL
S675-p QDYKKRLsVELTSSL
T679 KRLsVELTSSLFRTE
S680 RLsVELTSSLFRTEP
S681 LsVELTSSLFRTEPM
Y716 YRQDDPSYRSFHSGG
S718 QDDPSYRSFHSGGYG
S721 PSYRSFHSGGYGQDA
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
9030 : Acetyl-beta-Catenin (Lys49) (D7C2) Rabbit mAb
9534 : Acetyl-beta-Catenin (Lys49) Antibody
5651 : Phospho-beta-Catenin (Ser552) (D8E11) Rabbit mAb
9566 : Phospho-beta-Catenin (Ser552) Antibody
4176 : Phospho-beta-Catenin (Ser675) (D2F1) XP(TM) Rabbit mAb
9567 : Phospho-beta-Catenin (Ser675) Antibody
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