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CTNNB1 (human)

Overview CTNNB1 a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Actin binding protein; Transcription factor; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Cellular Component: desmosome; centrosome; basolateral plasma membrane; intercellular junction; fascia adherens; zonula adherens; cytosol; beta-catenin destruction complex; transcription factor complex; cell-cell adherens junction; membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; synapse; dendritic shaft; lateral plasma membrane; spindle pole; internal side of plasma membrane; cell cortex; catenin complex; Z disc; cell-substrate adherens junction; adherens junction; microvillus membrane; apical part of cell; plasma membrane; cell junction; nucleus Molecular Function: protein C-terminus binding; identical protein binding; transcription coactivator activity; protein phosphatase binding; transcription factor binding; protein kinase binding; ionotropic glutamate receptor binding; protein binding; signal transducer activity; enzyme binding; androgen receptor binding; cadherin binding; double-stranded DNA binding; estrogen receptor binding; chromatin binding; SMAD binding; structural molecule activity; transcription factor activity; kinase binding; alpha-catenin binding; nuclear hormone receptor binding Biological Process: skin development; regulation of myelination; regulation of centriole-centriole cohesion; positive regulation of apoptosis; regulation of fibroblast proliferation; positive regulation of transcription, DNA-dependent; cell maturation; negative regulation of chondrocyte differentiation; T cell differentiation in the thymus; positive regulation of fibroblast growth factor receptor signaling pathway; osteoclast differentiation; Wnt receptor signaling pathway through beta-catenin; cell-cell adhesion; positive regulation of endothelial cell differentiation; positive regulation of mesenchymal cell proliferation; embryonic foregut morphogenesis; male genitalia development; ectoderm development; synapse organization and biogenesis; cell adhesion; hindbrain development; embryonic limb morphogenesis; bone resorption; response to drug; positive regulation of neuroblast proliferation; tongue morphogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of smooth muscle cell proliferation; transcription, DNA-dependent; hair cell differentiation; genitalia morphogenesis; patterning of blood vessels; muscle cell differentiation; midgut development; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; oocyte development; negative regulation of apoptosis; negative regulation of osteoclast differentiation; glial cell fate determination; endodermal cell fate commitment; apoptosis; cell-matrix adhesion; neuron migration; dorsal/ventral axis specification; cell fate specification; determination of dorsoventral asymmetry; negative regulation of transcription from RNA polymerase II promoter; embryonic hindlimb morphogenesis; response to estradiol stimulus; negative regulation of cell proliferation; central nervous system vasculogenesis; positive regulation of MAPKKK cascade; forebrain development; pancreas development; fallopian tube development; proximal/distal pattern formation; cell structure disassembly during apoptosis; Wnt receptor signaling pathway; hair follicle morphogenesis; thymus development; cytoskeletal anchoring; in utero embryonic development; regulation of T cell proliferation; embryonic axis specification; synaptic vesicle transport; gastrulation with mouth forming second; liver development; regulation of angiogenesis; odontogenesis of dentine-containing teeth; negative regulation of oligodendrocyte differentiation; myoblast differentiation; positive regulation of osteoblast differentiation; Schwann cell proliferation; response to cadmium ion; ureteric bud branching; response to cytokine stimulus; androgen receptor signaling pathway; epithelial to mesenchymal transition; embryonic heart tube development; positive regulation of muscle cell differentiation; lens morphogenesis in camera-type eye; anterior/posterior axis specification Reference #:  P35222 (UniProtKB) Alt. Names/Synonyms: Beta-catenin; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin beta-1; CTNB1; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923 Gene Symbols: CTNNB1 Molecular weight: 85,497 Da Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CTNNB1 1G3J - A/C=133-664 (human) 1JDH - A=135-663 (human) 1JPW - A/B/C=134-670 (human) 1LUJ - A=150-663 (human) 1P22 - C=19-44 (human) 1QZ7 - A=133-665 (human) 1T08 - A=146-664 (human) 1TH1 - A/B=133-664 (human) 2G57 - A=18-45 (human) 2GL7 - A/D=138-686 (human) 2Z6H - A=138-781 (human) 3DIW - D/C=772-781 (human) 3SL9 - A/G/E/B=141-305 (human) 3SLA - A/D/C/E/B=141-306 (human) 3TX7 - A=138-663 (human) 4DJS - A=148-665 (human) 1DOW - B=118-149 (mouse) 1I7W - A/C=134-671 (mouse) 1I7X - A/C=134-671 (mouse) 1JPP - A/B=134-671 (mouse) 1M1E - A=134-671 (mouse) 1V18 - A=134-671 (mouse) 2BCT - A=150-665 (mouse) 3BCT - A=193-662 (mouse) 3OUW - A=134-671 (mouse) 3OUX - A=134-671 (mouse) 4EV8 - A=134-671 (mouse) 4EV9 - A=134-671 (mouse) 4EVA - A/C=134-671 (mouse) 4EVP - A=134-671 (mouse) 4EVT - A=134-671 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2G57 2GL7 2Z6H 3DIW 3SL9 3SLA 3TX7 4DJS  |  Phospho3D  |  DISEASE 114550 116806 132600 155255 167000  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
carcinogenesis, induced: Y333‑p cell adhesion, altered: S33‑p, S37‑p, T41‑p, S45‑p cell cycle regulation: Y333‑p cell growth, altered: S33‑p, S37‑p, T41‑p, Y86‑p, T112‑p, T120‑p, Y654‑p, Y670‑p cell growth, induced: Y333‑p, Y654‑p, Y670‑p cell motility, altered: S29‑p, S45‑p, T102‑p, T112‑p, T120‑p, S552‑p cytoskeletal reorganization: S33‑p, S37‑p, T41‑p, Y654‑p transcription, altered: S33‑p, S37‑p, T41‑p, Y86‑p, T112‑p, T120‑p, T393‑p, S552‑p, Y654‑p, S675‑p transcription, induced: Y333‑p, Y489‑p, S675‑p transcription, inhibited: T120‑p activation: T393‑p, Y654‑p, Y670‑p, S675‑p inhibition: S33‑p intracellular localization: S33‑p, S37‑p, T41‑p, S45‑p, T112‑p, T120‑p, Y142‑p, Y333‑p, Y489‑p, S552‑p, S675‑p molecular association, regulation: S33‑p, S37‑p, T41‑p, S45‑p, Y86‑p, Y142‑p, S246‑p, Y333‑p, T393‑p, Y489‑p, Y654‑p, Y670‑p, S675‑p phosphorylation: S45‑p, T393‑p protein degradation: S29‑p, S33‑p, S37‑p, T41‑p, S45‑p, T102‑p, T112‑p protein stabilization: Y86‑p, T393‑p, Y654‑p, S675‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		K19-a	MAMEPDRkAAVsHWQ
1	3		K19-u	MAMEPDRkAAVsHWQ
2	0		S23-p	PDRkAAVsHWQQQsy
0	1		S23	PDRkAAVSHWQQQsy
3	3		S29-p	VsHWQQQsyLDsGIH
0	34		Y30-p	sHWQQQsyLDsGIHs
51	5		S33-p	QQQsyLDsGIHsGAT
54	4		S37-p	yLDsGIHsGATtTAP
45	2		T41-p	GIHsGATtTAPsLSG
23	3		S45-p	GATtTAPsLSGkGNP
3	0		K49-a	TAPsLSGkGNPEEED
1	0		K49-u	TAPsLSGkGNPEEED
1	0		Y64-p	VDTSQVLyEWEQGFS
1	0		S73-p	WEQGFSQsFTQEQVA
5	22		Y86-p	VADIDGQyAMTRAQR
2	0		T102-p	RAAMFPEtLDEGMQI
2	0		T112-p	EGMQIPStQFdAAHP
0	1		D115-ca	QIPStQFdAAHPtNV
2	0		T120-p	QFdAAHPtNVQRLAE
0	7		K133-u	AEPSQMLkHAVVNLI
9	0		Y142-p	AVVNLINyQDDAELA
0	3		K158-u	RAIPELTkLLNDEDQ
0	8		K170-u	EDQVVVNkAAVMVHQ
0	1		S179-p	AVMVHQLskKEASRH
0	6		K180-u	VMVHQLskKEASRHA
2	29		S191-p	SRHAIMRsPQMVsAI
0	1		S196-p	MRsPQMVsAIVRTMQ
0	13		K233-u	EGLLAIFkSGGIPAL
1	0		S246-p	ALVKMLGsPVDSVLF
1	2		Y331-p	LVNIMRTyTyEkLLW
2	1		Y333-p	NIMRTyTyEkLLWTT
0	3		K335-u	MRTyTyEkLLWTTSR
1	0		K345-a	WTTSRVLkVLSVCSS
0	1		K345-u	WTTSRVLkVLSVCSS
1	0		K354-a	LSVCSSNkPAIVEAG
0	6		K354-u	LSVCSSNkPAIVEAG
2	0		T393-p	RNLSDAAtKQEGMEG
0	1		K435-a	TCNNYKNkMMVCQVG
0	6		K435-u	TCNNYKNkMMVCQVG
0	1		T472-p	ICALRHLtsRHQEAE
0	1		S473-p	CALRHLtsRHQEAEM
1	85		Y489-p	QNAVRLHyGLPVVVK
0	30		K508-u	PSHWPLIkATVGLIR
0	1		T547-p	LVRAHQDtQRRtsMG
0	13		T551-p	HQDtQRRtsMGGtQQ
8	30		S552-p	QDtQRRtsMGGtQQQ
0	12		T556-p	RRtsMGGtQQQFVEG
0	2		T574-p	EEIVEGCtGALHILA
1	0		S605	LFVQLLYSPIENIQR
0	6		K625-u	LCELAQDkEAAEAIE
0	1		T653	SRNEGVATyAAAVLF
13	24		Y654-p	RNEGVATyAAAVLFR
2	15		Y670-p	SEDKPQDykKRLsVE
0	4		K671-u	EDKPQDykKRLsVEL
8	34		S675-p	QDykKRLsVELTSSL
0	1		T679	KRLsVELTSSLFRTE
0	1		S681	LsVELTSSLFRTEPM
0	1		T685	LTSSLFRTEPMAWNE
0	1		T693	EPMAWNETADLGLDI
0	1		S715-p	GYRQDDPsyRsFHsG
0	32		Y716-p	YRQDDPsyRsFHsGG
1	3		S718-p	QDDPsyRsFHsGGYG
0	2		S721-p	PsyRsFHsGGYGQDA
0	1		Y748-p	GHHPGADyPVDGLPD

	mouse
K19	MAMEPDRKAAVsHWQ
K19-u	MAMEPDRkAAVsHWQ
S23-p	PDRkAAVsHWQQQsY
S23-g	PDRkAAVsHWQQQsY
S29-p	VsHWQQQsYLDsGIH
Y30	sHWQQQsYLDsGIHs
S33-p	QQQsYLDsGIHsGAT
S37-p	YLDsGIHsGATtTAP
T41-p	GIHsGATtTAPsLSG
S45-p	GATtTAPsLSGkGNP
K49-a	TAPsLSGkGNPEEED
K49	TAPsLSGKGNPEEED
Y64	VDTSQVLYEWEQGFS
S73	WEQGFSQSFTQEQVA
Y86-p	VADIDGQyAMTRAQR
T102	RAAMFPETLDEGMQI
T112	EGMQIPSTQFDAAHP
D115	QIPSTQFDAAHPTNV
T120	QFDAAHPTNVQRLAE
K133-u	AEPSQMLkHAVVNLI
Y142-p	AVVNLINyQDDAELA
K158-u	RAIPELTkLLNDEDQ
K170-u	EDQVVVNkAAVMVHQ
S179	AVMVHQLSKKEASRH
K180	VMVHQLSKKEASRHA
S191-p	SRHAIMRsPQMVSAI
S196	MRsPQMVSAIVRTMQ
K233-u	EGLLAIFkSGGIPAL
S246	ALVKMLGSPVDSVLF
Y331	LVNIMRTYTYEKLLW
Y333	NIMRTYTYEKLLWTT
K335	MRTYTYEKLLWTTSR
K345	WTTSRVLKVLSVCSS
K345	WTTSRVLKVLSVCSS
K354	LSVCSSNKPAIVEAG
K354	LSVCSSNKPAIVEAG
T393-p	RNLSDAAtKQEGMEG
K435	TCNNYKNKMMVCQVG
K435	TCNNYKNKMMVCQVG
T472	ICALRHLTSRHQEAE
S473	CALRHLTSRHQEAEM
Y489-p	QNAVRLHyGLPVVVK
K508	PSHWPLIKATVGLIR
T547	LVRAHQDTQRRtsMG
T551-p	HQDTQRRtsMGGtQQ
S552-p	QDTQRRtsMGGtQQQ
T556-p	RRtsMGGtQQQFVEG
T574	EEIVEGCTGALHILA
S605-p	LFVQLLYsPIENIQR
K625-u	LCELAQDkEAAEAIE
T653-p	SRNEGVAtyAAAVLF
Y654-p	RNEGVAtyAAAVLFR
Y670	SEDKPQDYkKRLsVE
K671-u	EDKPQDYkKRLsVEL
S675-p	QDYkKRLsVELtSsL
T679-p	KRLsVELtSsLFRtE
S681-p	LsVELtSsLFRtEPM
T685-p	LtSsLFRtEPMAWNE
T693-p	EPMAWNEtADLGLDI
S715	GYRQDDPSYRSFHSG
Y716	YRQDDPSYRSFHSGG
S718	QDDPSYRSFHSGGYG
S721	PSYRSFHSGGYGQDA
Y748	GHHPGADYPVDGLPD

	rat
K19	MAMEPDRKAAVSHWQ
K19	MAMEPDRKAAVSHWQ
S23	PDRKAAVSHWQQQSY
S23	PDRKAAVSHWQQQSY
S29	VSHWQQQSYLDsGIH
Y30	SHWQQQSYLDsGIHs
S33-p	QQQSYLDsGIHsGAT
S37-p	YLDsGIHsGATtTAP
T41-p	GIHsGATtTAPsLSG
S45-p	GATtTAPsLSGKGNP
K49	TAPsLSGKGNPEEED
K49	TAPsLSGKGNPEEED
Y64	VDTSQVLYEWEQGFS
S73	WEQGFSQSFTQEQVA
Y86	VADIDGQYAMTRAQR
T102	RAAMFPETLDEGMQI
T112	EGMQIPSTQFDAAHP
D115	QIPSTQFDAAHPTNV
T120	QFDAAHPTNVQRLAE
K133	AEPSQMLKHAVVNLI
Y142-p	AVVNLINyQDDAELA
K158	RAIPELTKLLNDEDQ
K170	EDQVVVNKAAVMVHQ
S179	AVMVHQLSKKEASRH
K180	VMVHQLSKKEASRHA
S191-p	SRHAIMRsPQMVSAI
S196	MRsPQMVSAIVRTMQ
K233	EGLLAIFKSGGIPAL
S246	ALVKMLGSPVDSVLF
Y331	LVNIMRTYTYEKLLW
Y333	NIMRTYTYEKLLWTT
K335	MRTYTYEKLLWTTSR
K345	WTTSRVLKVLSVCSS
K345	WTTSRVLKVLSVCSS
K354	LSVCSSNKPAIVEAG
K354	LSVCSSNKPAIVEAG
T393	RNLSDAATKQEGMEG
K435	TCNNYKNKMMVCQVG
K435	TCNNYKNKMMVCQVG
T472	ICALRHLTSRHQEAE
S473	CALRHLTSRHQEAEM
Y489-p	QNAVRLHyGLPVVVK
K508	PSHWPLIKATVGLIR
T547	LVRAHQDTQRRtsMG
T551-p	HQDTQRRtsMGGTQQ
S552-p	QDTQRRtsMGGTQQQ
T556	RRtsMGGTQQQFVEG
T574	EEIVEGCTGALHILA
S605	LFVQLLYSPIENIQR
K625	LCELAQDKEAAEAIE
T653	SRNEGVATyAAAVLF
Y654-p	RNEGVATyAAAVLFR
Y670	SEDKPQDYKKRLsVE
K671	EDKPQDYKKRLsVEL
S675-p	QDYKKRLsVELTSSL
T679	KRLsVELTSSLFRTE
S681	LsVELTSSLFRTEPM
T685	LTSSLFRTEPMAWNE
T693	EPMAWNETADLGLDI
S715	GYRQDDPSYRSFHSG
Y716	YRQDDPSYRSFHSGG
S718	QDDPSYRSFHSGGYG
S721	PSYRSFHSGGYGQDA
Y748	GHHPGADYPVDGLPD

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