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RXRA
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. Homodimer. Heterodimer with RARA; required for ligand- dependent retinoic acid receptor transcriptional activity. Heterodimer with PPARA (via the leucine-like zipper in the LBD); the interaction is required for PPARA transcriptional activity. Also heterodimerizes with PPARG. Interacts with NCOA3 and NCOA6 coactivators. Interacts with FAM120B. Interacts with PELP1, SENP6, SFPQ, DNTTIP2 and RNF8. Interacts (via the DNA binding domain) with HCV core protein; the interaction enhances the transcriptional activities of the RXRA/RARA and the RXRA/PPARA heterodimers. Interacts with PRMT2. Interacts with ASXL1 and NCOA1. Highly expressed in liver, also found in lung, kidney and heart. Belongs to the nuclear hormone receptor family. NR2 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; DNA binding protein; Nuclear receptor |
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Cellular Component: nucleoplasm; axon; nuclear chromatin; nucleus
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Molecular Function: ligand-dependent nuclear receptor activity; zinc ion binding; chromatin DNA binding; transcription coactivator activity; protein binding; enzyme binding; DNA binding; vitamin D receptor binding; retinoid-X receptor activity; sequence-specific DNA binding; protein heterodimerization activity; double-stranded DNA binding; steroid hormone receptor activity; retinoic acid receptor activity; transcription factor activity
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Biological Process: retinoic acid receptor signaling pathway; positive regulation of apoptosis; response to glucocorticoid stimulus; ventricular cardiac muscle cell differentiation; cardiac muscle cell proliferation; cellular lipid metabolic process; female pregnancy; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; response to selenium ion; response to vitamin D; ventricular cardiac muscle morphogenesis; inflammatory response; placenta development; aging; transcription initiation from RNA polymerase II promoter; cholesterol metabolic process; vitamin metabolic process; response to retinoic acid; axon regeneration; liver development; response to ethanol; cellular response to insulin stimulus; virus-host interaction; midgut development; gene expression; positive regulation of transcription from RNA polymerase II promoter
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Reference #:
P19793 (UniProtKB)
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| Alt. Names/Synonyms: FLJ00280; FLJ00318; FLJ16020; FLJ16733; MGC102720; NR2B1; Nuclear receptor subfamily 2 group B member 1; Retinoic acid receptor RXR-alpha; Retinoid X receptor alpha; retinoid X receptor, alpha; RXR-alpha; RXRA |
| Gene Symbols: RXRA |
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Molecular weight: 50,811 Da
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Basal Isoelectric point: 7.92
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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