Home

PSD-93 (human)

Overview PSD-93 Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Interacts through its PDZ domains with NETO1. Interacts with NOS1/nNOS through second PDZ domain. Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. Belongs to the MAGUK family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: postsynaptic membrane; cell soma; postsynaptic density; cytoplasm; plasma membrane; cell junction Molecular Function: guanylate kinase activity; protein binding; protein heterodimerization activity; PDZ domain binding Biological Process: synaptic transmission; sensory perception of pain; neuronal ion channel clustering; receptor clustering Reference #:  Q15700 (UniProtKB) Alt. Names/Synonyms: Channel-associated protein of synapse-110; channel-associated protein of synapses, 110kDa; Chapsyn-110; discs, large homolog 2 (Drosophila); discs, large homolog 2, chapsyn-110; Disks large homolog 2; DKFZp781D1854; DKFZp781E0954; DLG2; FLJ37266; MGC131811; Postsynaptic density protein PSD-93; PSD-93; PSD93 Gene Symbols: DLG2 Molecular weight: 97,552 Da Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PSD-93 2BYG - A=190-283 (human) 2HE2 - A/B=418-514 (human) 2WL7 - A=95-188 (mouse) 4H11 - A/B=93-188 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2BYG 2HE2  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		Y16	LRTNVKKYRYQDEDA
0	9		S28-p	EDAPHDHsLPRLTHE
0	3		S45	GPELVHVSEKNLSQI
0	1		S50	HVSEKNLSQIENVHG
0	41		Y58-p	QIENVHGyVLQSHIS
0	1		-	gap
0	1		-	gap
0	1		-	gap
0	1		S62	VHGyVLQSHISPLKA
0	6		S65	yVLQSHISPLKASPA
0	2		K131	DPGIFITKIIPGGAA
0	1		K165	VSEVSHSKAVEALkE
0	12		K171-u	SKAVEALkEAGsIVR
0	9		S175-p	EALkEAGsIVRLyVR
0	1		Y180-p	AGsIVRLyVRRRRPI
0	6		K201	IKLFKGPKGLGFSIA
0	25		Y223-p	IPGDNSIyVTKIIDG
0	20		K235	IDGGAAQKDGRLQVG
0	1		T257-p	NYSLEEVtHEEAVAI
1	4		S323-p	KTSLPPIsPGRySPI
0	2		Y327-p	PPIsPGRySPIPKHM
0	5		S328	PIsPGRySPIPKHML
0	1		K332	GRySPIPKHMLVDDD
1	120		Y340-p	HMLVDDDyTRPPEPV
0	6		T341	MLVDDDyTRPPEPVy
0	1		T341	MLVDDDyTRPPEPVy
1	148		Y348-p	TRPPEPVystVNKLC
0	4		S349-p	RPPEPVystVNKLCD
0	5		T350-p	PPEPVystVNKLCDk
0	5		K357-u	tVNKLCDkPASPRHY
0	5		S360	KLCDkPASPRHYsPV
0	2		Y364	kPASPRHYsPVECDK
0	10		S365-p	PASPRHYsPVECDKS
0	1		Y379	SFLLSAPYSHYHLGL
0	2		Y382	LSAPYSHYHLGLLPD
0	2		S406	STATRQPSMTLQRAV
0	9		S414	MTLQRAVSLEGEPRK
0	1		Y500	TVTIIAQYQPEDYAR
0	8		Y505	AQYQPEDYARFEAKI
0	3		K511	DYARFEAKIHDLREQ
0	1		S523-p	REQMMNHsMSSGSGS
0	1		S528	NHsMSSGSGSLRTNQ
0	1		S530	sMSSGSGSLRTNQKR
0	1		Y547	YVRAMFDYDKSKDSG
0	1		S550	AMFDYDKSKDSGLPs
0	3		S553	DYDKSKDSGLPsQGL
0	3		S557-p	SKDSGLPsQGLSFKY
0	2		S561	GLPsQGLSFKYGDIL
0	1		S574	ILHVINASDDEWWQA
0	1		M585	WWQARRVMLEGDSEE
0	2		S590	RVMLEGDSEEMGVIP
0	1		S598-p	EEMGVIPsKRRVERK
0	5		K618	KTVKFNAKPGVIDSK
0	1		S624	AKPGVIDSKGsFNDK
0	10		K625	KPGVIDSKGsFNDKR
0	1		S627-p	GVIDSKGsFNDKRKK
0	23		-	gap
0	1		-	gap
0	1		-	gap
0	1		Y679	VTRQEINYTRPVIIL
0	4		Y719-p	TTRPKRDyEVDGRDy
0	26		Y726-p	yEVDGRDyHFVISRE
0	23		Y750-p	KFIEAGQyNDNLyGT
0	23		Y755-p	GQyNDNLyGTSVQSV
0	1		K809	EPLMEMNKRLTEEQA
0	1		K867	PFIWIPSKEKL____

	PSD-93 iso3
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
K80	DPGIFITKIIPGGAA
K114	VSEVSHSKAVEALKE
K120	SKAVEALKEAGSIVR
S124	EALKEAGSIVRLYVR
Y129	AGSIVRLYVRRRRPI
K150	IKLFKGPKGLGFSIA
Y172	IPGDNSIYVTKIIDG
K184	IDGGAAQKDGRLQVG
T206	NYSLEEVTHEEAVAI
S272	KTSLPPISPGRYSPI
Y276	PPISPGRYSPIPKHM
S277	PISPGRYSPIPKHML
K281	GRYSPIPKHMLVDDD
Y289	HMLVDDDYTSHSQHS
T290	MLVDDDYTSHSQHST
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S303	STATRQPSMTLQRAV
S311	MTLQRAVSLEGEPRK
Y397	TVTIIAQYQPEDYAR
Y402	AQYQPEDYARFEAKI
K408	DYARFEAKIHDLREQ
S420	REQMMNHSMSSGSGS
S425	NHSMSSGSGSLRTNQ
S427	SMSSGSGSLRTNQKR
Y444	YVRAMFDYDKSKDSG
S447	AMFDYDKSKDSGLPS
S450	DYDKSKDSGLPSQGL
S454	SKDSGLPSQGLSFKY
S458	GLPSQGLSFKYGDIL
S471	ILHVINASDDEWWQA
M482	WWQARRVMLEGDSEE
S487	RVMLEGDSEEMGVIP
S495	EEMGVIPSKRRVERK
K515	KTVKFNAKPGVIDSK
S521	AKPGVIDSKGDIPGL
K522	KPGVIDSKGDIPGLG
-	gap
Y533-p	PGLGDDGyGtKTLRG
T535-p	LGDDGyGtKTLRGQE
K536	GDDGyGtKTLRGQED
Y558	VTRQEINYTRPVIIL
Y598	TTRPKRDYEVDGRDY
Y605	YEVDGRDYHFVISRE
Y629	KFIEAGQYNDNLYGT
Y634	GQYNDNLYGTSVQSV
K688	EPLMEMNKRLTEEQA
K746	PFIWIPSKEKL____

	PSD-93 iso4
-	gap
-	gap
-	gap
-	gap
-	gap
Y46-p	RNCQGLGySSQTMPS
S54-p	SSQTMPSsGPGGPAs
S61-p	sGPGGPAsNRTGGSS
-	gap
S104	TCPHGWFSPAQASPA
K170	DPGIFITKIIPGGAA
K204	VSEVSHSKAVEALKE
K210	SKAVEALKEAGSIVR
S214	EALKEAGSIVRLYVR
Y219	AGSIVRLYVRRRRPI
K240	IKLFKGPKGLGFSIA
Y262	IPGDNSIYVTKIIDG
K274	IDGGAAQKDGRLQVG
T296	NYSLEEVTHEEAVAI
S362	KTSLPPISPGRYSPI
Y366	PPISPGRYSPIPKHM
S367	PISPGRYSPIPKHML
K371	GRYSPIPKHMLVDDD
Y379	HMLVDDDYTRPPEPV
T380	MLVDDDYTRPPEPVY
T380	MLVDDDYTRPPEPVY
Y387	TRPPEPVYSTVNKLC
S388	RPPEPVYSTVNKLCD
T389	PPEPVYSTVNKLCDK
K396	TVNKLCDKPASPRHY
S399	KLCDKPASPRHYSPV
Y403	KPASPRHYSPVECDK
S404	PASPRHYSPVECDKS
Y418	SFLLSAPYSHYHLGL
Y421	LSAPYSHYHLGLLPD
S445	STATRQPSMTLQRAV
S453	MTLQRAVSLEGEPRK
Y539	TVTIIAQYQPEDYAR
Y544	AQYQPEDYARFEAKI
K550	DYARFEAKIHDLREQ
S562	REQMMNHSMSSGSGS
S567	NHSMSSGSGSLRTNQ
S569	SMSSGSGSLRTNQKR
Y586	YVRAMFDYDKSKDSG
S589	AMFDYDKSKDSGLPS
S592	DYDKSKDSGLPSQGL
S596	SKDSGLPSQGLSFKY
S600	GLPSQGLSFKYGDIL
S613	ILHVINASDDEWWQA
M624	WWQARRVMLEGDSEE
S629	RVMLEGDSEEMGVIP
S637	EEMGVIPSKRRVERK
K657	KTVKFNAKPGVIDSK
S663	AKPGVIDSKGSFNDK
K664	KPGVIDSKGSFNDKR
S666	GVIDSKGSFNDKRKK
-	gap
-	gap
-	gap
Y718	VTRQEINYTRPVIIL
Y758	TTRPKRDYEVDGRDY
Y765	YEVDGRDYHFVISRE
Y789	KFIEAGQYNDNLYGT
Y794	GQYNDNLYGTSVQSV
K848	EPLMEMNKRLTEEQA
K906	PFIWIPSKEKL____

	PSD-93 iso8
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	mouse ► Hide Isoforms
Y16	LRTNVKKYRYQDEDG
S28-p	EDGPHDHsLPRLTHE
S45-p	GPELVHVsEKNLsQI
S50-p	HVsEKNLsQIENVHG
Y58-p	QIENVHGyVLQsHIs
-	gap
-	gap
-	gap
S62-p	VHGyVLQsHIsPLKA
S65-p	yVLQsHIsPLKASPA
K131-u	DPGIFITkIIPGGAA
K165-u	VSEVSHSkAVEALkE
K171-u	SkAVEALkEAGsIVR
S175-p	EALkEAGsIVRLYVR
Y180	AGsIVRLYVRRRRPI
K201-u	IKLFKGPkGLGFSIA
Y223	IPGDNSIYVTKIIDG
K235-u	IDGGAAQkDGRLQVG
T257	NYSLEEVTHEEAVAI
S323-p	KTSLPPIsPGRysPI
Y327-p	PPIsPGRysPIPkHM
S328-p	PIsPGRysPIPkHML
K332-u	GRysPIPkHMLGEDD
Y340-p	HMLGEDDytRPPEPV
T341-p	MLGEDDytRPPEPVy
T341-g	MLGEDDytRPPEPVy
Y348-p	tRPPEPVyStVNKLC
S349	RPPEPVyStVNKLCD
T350-p	PPEPVyStVNKLCDk
K357-u	tVNKLCDkPAsPRHy
S360-p	KLCDkPAsPRHysPV
Y364-p	kPAsPRHysPVECDK
S365-p	PAsPRHysPVECDKS
Y379	SFLLSTPYPHYHLGL
Y382	LSTPYPHYHLGLLPD
S406-p	STATRQPsVTLQRAI
S414-p	VTLQRAIsLEGEPRK
Y500-p	TVTIIAQyQPEDyAR
Y505-p	AQyQPEDyARFEAkI
K511-u	DyARFEAkIHDLREQ
S523	REQMMNHSMSSGsGs
S528-p	NHSMSSGsGsLRTNQ
S530-p	SMSSGsGsLRTNQKR
Y547	YVRAMFDYDKsKDsG
S550-p	AMFDYDKsKDsGLPs
S553-p	DYDKsKDsGLPsQGL
S557-p	sKDsGLPsQGLsFKY
S561-p	GLPsQGLsFKYGDIL
S574-p	ILHVINAsDDEWWQA
T585-p	WWQARRVtLDGDsEE
S590-p	RVtLDGDsEEMGVIP
S598	EEMGVIPSKRRVERK
K618-u	KTVKFNAkPGVIDsk
S624-p	AkPGVIDskGDIPGL
K625-u	kPGVIDskGDIPGLG
-	gap
Y636-p	PGLGDDGyGTkTLRG
T638	LGDDGyGTkTLRGQE
K639-u	GDDGyGTkTLRGQED
Y661	VTRQEINYTRPVIIL
Y701	TTRPKRDYEVDGRDy
Y708-p	YEVDGRDyHFVISRE
Y732-p	KFIEAGQyNDNLyGT
Y737-p	GQyNDNLyGTSVQSV
K791-u	EPLMEMNkRLTEEQA
K849-u	PFIWIPSkEKL____

	PSD-93 iso2
Y23	LMFGCKKYRYQDEDG
S35	EDGPHDHSLPRLTHE
S52	GPELVHVSEKNLSQI
S57	HVSEKNLSQIENVHG
Y65	QIENVHGYVLQSHIS
-	gap
-	gap
-	gap
S69	VHGYVLQSHISPLKA
S72	YVLQSHISPLKASPA
K138	DPGIFITKIIPGGAA
K172	VSEVSHSKAVEALKE
K178	SKAVEALKEAGSIVR
S182	EALKEAGSIVRLYVR
Y187	AGSIVRLYVRRRRPI
K208	IKLFKGPKGLGFSIA
Y230	IPGDNSIYVTKIIDG
K242	IDGGAAQKDGRLQVG
T264	NYSLEEVTHEEAVAI
P330	KTSLPPIPPGRYSPI
Y334	PPIPPGRYSPIPKHM
S335	PIPPGRYSPIPKHML
K339	GRYSPIPKHMLGEDD
Y347	HMLGEDDYTRPPEPV
T348	MLGEDDYTRPPEPVY
T348	MLGEDDYTRPPEPVY
Y355	TRPPEPVYSTVNKLC
S356	RPPEPVYSTVNKLCD
T357	PPEPVYSTVNKLCDK
K364	TVNKLCDKPASPRHY
S367	KLCDKPASPRHYSPV
Y371	KPASPRHYSPVECDK
S372	PASPRHYSPVECDKS
Y386	SFLLSTPYPHYHLGL
Y389	LSTPYPHYHLGLLPD
S413	STATRQPSVTLQRAI
S421	VTLQRAISLEGEPRK
Y507	TVTIIAQYQPEDYAR
Y512	AQYQPEDYARFEAKI
K518	DYARFEAKIHDLREQ
S530	REQMMNHSMSSGSGS
S535	NHSMSSGSGSLRTNQ
S537	SMSSGSGSLRTNQKR
Y554	YVRAMFDYDKSKDSG
S557	AMFDYDKSKDSGLPS
S560	DYDKSKDSGLPSQGL
S564	SKDSGLPSQGLSFKY
S568	GLPSQGLSFKYGDIL
S581	ILHVINASDDEWWQA
I592	WWQARRVILDGDSEE
S597	RVILDGDSEEMGVIP
S605	EEMGVIPSKRRVERK
K625	KTVKFNAKPGVIDSK
S631	AKPGVIDSKGDIPGL
K632	KPGVIDSKGDIPGLG
-	gap
Y643	PGLGDDGYGTKTLRG
T645	LGDDGYGTKTLRGQE
K646	GDDGYGTKTLRGQED
Y668	VTRQEINYTRPVIIL
Y708	TTRPKRDYEVDGRDY
Y715	YEVDGRDYHFVISRE
Y739	KFIEAGQYNDNLYGT
Y744	GQYNDNLYGTSVQSV
K798	EPLMEMNKRLTEEQA
K856	PFIWIPSKEKL____

	PSD-93 iso 9
-	gap
-	gap
-	gap
-	gap
-	gap
Y46	RNAQGLGYSSQTMPS
S54	SSQTMPSSGPGGPAS
S61	SGPGGPASNRTKLVT
-	gap
S100	ACPHGWFSPAQASPA
K166	DPGIFITKIIPGGAA
K200	VSEVSHSKAVEALKE
K206	SKAVEALKEAGSIVR
S210	EALKEAGSIVRLYVR
Y215	AGSIVRLYVRRRRPI
K236-u	IKLFKGPkGLGFSIA
Y258	IPGDNSIYVTKIIDG
K270	IDGGAAQKDGRLQVG
T292	NYSLEEVTHEEAVAI
S358-p	KTSLPPIsPGRysPI
Y362-p	PPIsPGRysPIPKHM
S363-p	PIsPGRysPIPKHML
K367	GRysPIPKHMLGEDD
Y375	HMLGEDDYTRPPEPV
T376	MLGEDDYTRPPEPVY
T376	MLGEDDYTRPPEPVY
Y383	TRPPEPVYSTVNKLC
S384	RPPEPVYSTVNKLCD
T385	PPEPVYSTVNKLCDK
K392	TVNKLCDKPASPRHY
S395	KLCDKPASPRHYSPV
Y399	KPASPRHYSPVECDK
S400	PASPRHYSPVECDKS
Y414	SFLLSTPYPHYHLGL
Y417	LSTPYPHYHLGLLPD
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	rat
Y16-p	LRTNVKKyRYQDEDG
S28	EDGPHDHSLPRLTHE
S45	GPELVHVSEKNLSQI
S50	HVSEKNLSQIENVHG
Y58-p	QIENVHGyVLQSHIS
-	gap
-	gap
-	gap
S62	VHGyVLQSHISPLKA
S65	yVLQSHISPLKASPA
K131	DPGIFITKIIPGGAA
K165	VSEVSHSKAVEALkE
K171-u	SKAVEALkEAGsIVR
S175-p	EALkEAGsIVRLYVR
Y180	AGsIVRLYVRRRRPI
K201	IKLFKGPKGLGFSIA
Y223-p	IPGDNSIyVTKIIDG
K235-u	IDGGAAQkDGRLQVG
T257	NYSLEEVTHEEAVAI
S323-p	KTSLPPIsPGRYsPI
Y327	PPIsPGRYsPIPKHM
S328-p	PIsPGRYsPIPKHML
K332	GRYsPIPKHMLVEDD
Y340-p	HMLVEDDytRPPEPV
T341-p	MLVEDDytRPPEPVy
T341	MLVEDDyTRPPEPVy
Y348-p	tRPPEPVystVNKLC
S349-p	RPPEPVystVNKLCD
T350-p	PPEPVystVNKLCDk
K357-u	tVNKLCDkPASPRHY
S360	KLCDkPASPRHYsPV
Y364	kPASPRHYsPVECDK
S365-p	PASPRHYsPVECDKS
Y379-p	SFLLSTPyPHyHLGL
Y382-p	LSTPyPHyHLGLLPD
S406	STATRQPSVTLQRAI
S414	VTLQRAISLEGEPRK
Y500	TVTIIAQYQPEDyAR
Y505-p	AQYQPEDyARFEAKI
K511	DyARFEAKIHDLREQ
S523	REQMMNHSMSSGSGS
S528	NHSMSSGSGSLRTNQ
S530	SMSSGSGSLRTNQKR
Y547-p	YVRAMFDyDKSKDSG
S550	AMFDyDKSKDSGLPs
S553	DyDKSKDSGLPsQGL
S557-p	SKDSGLPsQGLSFKY
S561	GLPsQGLSFKYGDIL
S574	ILHVINASDDEWWQA
I585	WWQARRVILDGDSEE
S590	RVILDGDSEEMGVIP
S598	EEMGVIPSKRRVERK
K618-u	KTVKFNAkPGVIDSK
S624	AkPGVIDSKGDIPGL
K625	kPGVIDSKGDIPGLG
-	gap
Y636-p	PGLGDDGyGTKTLRG
T638	LGDDGyGTKTLRGQE
K639	GDDGyGTKTLRGQED
Y661-p	VTRQEINyTRPVIIL
Y701-p	TTRPKRDyEVDGRDy
Y708-p	yEVDGRDyHFVISRE
Y732-p	KFIEAGQyNDNLyGT
Y737-p	GQyNDNLyGTSVQSV
K791	EPLMEMNKRLTEEQA
K849	PFIWIPSKEKL____

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.