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Protein Page:
PSD-93 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PSD-93 Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Interacts through its PDZ domains with NETO1. Interacts with NOS1/nNOS through second PDZ domain. Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. Belongs to the MAGUK family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: postsynaptic membrane; postsynaptic density; plasma membrane; cell junction
Molecular Function: guanylate kinase activity; protein binding
Biological Process: synaptic transmission; sensory perception of pain; nucleotide phosphorylation
Reference #:  Q15700 (UniProtKB)
Alt. Names/Synonyms: Channel-associated protein of synapse-110; channel-associated protein of synapses, 110kDa; Chapsyn-110; discs, large homolog 2 (Drosophila); discs, large homolog 2, chapsyn-110; Disks large homolog 2; DKFZp781D1854; DKFZp781E0954; DLG2; FLJ37266; MGC131811; Postsynaptic density protein PSD-93; PSD-93; PSD93
Gene Symbols: DLG2
Molecular weight: 97,552 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSD-93

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 9 S28-p EDAPHDHsLPRLTHE
0 3 S45 GPELVHVSEKNLSQI
0 1 S50 HVSEKNLSQIENVHG
0 41 Y58 QIENVHGYVLQSHIS
0 1 S62 VHGYVLQSHISPLKA
0 6 S65 YVLQSHISPLKASPA
0 2 K131 DPGIFITKIIPGGAA
0 1 K165 VSEVSHSKAVEALKE
0 12 K171 SKAVEALKEAGsIVR
0 9 S175-p EALKEAGsIVRLYVR
0 6 K201 IKLFKGPKGLGFSIA
0 25 Y223 IPGDNSIYVTKIIDG
0 20 K235 IDGGAAQKDGRLQVG
1 4 S323-p KTSLPPIsPGRySPI
0 2 Y327-p PPIsPGRySPIPKHM
0 5 S328 PIsPGRySPIPKHML
0 1 K332 GRySPIPKHMLVDDD
1 120 Y340-p HMLVDDDyTRPPEPV
0 6 T341 MLVDDDyTRPPEPVy
0 1 T341 MLVDDDyTRPPEPVy
1 148 Y348-p TRPPEPVySTVNKLC
0 4 S349 RPPEPVySTVNKLCD
0 5 T350 PPEPVySTVNKLCDK
0 5 K357 TVNKLCDKPASPRHY
0 5 S360 KLCDKPASPRHYsPV
0 2 Y364 KPASPRHYsPVECDK
0 10 S365-p PASPRHYsPVECDKS
0 2 Y382 LSAPYSHYHLGLLPD
0 2 S406 STATRQPSMTLQRAV
0 9 S414 MTLQRAVSLEGEPRK
0 1 Y500 TVTIIAQYQPEDYAR
0 8 Y505 AQYQPEDYARFEAKI
0 3 K511 DYARFEAKIHDLREQ
0 1 S528 NHSMSSGSGSLRTNQ
0 1 S530 SMSSGSGSLRTNQKR
0 1 S550 AMFDYDKSKDSGLPS
0 3 S553 DYDKSKDSGLPSQGL
0 3 S557 SKDSGLPSQGLSFKY
0 2 S561 GLPSQGLSFKYGDIL
0 1 S574 ILHVINASDDEWWQA
0 2 S590 RVMLEGDSEEMGVIP
0 5 K618 KTVKFNAKPGVIDSK
0 1 S624 AKPGVIDSKGsFNDK
0 10 K625 KPGVIDSKGsFNDKR
0 2 S627-p GVIDSKGsFNDKRKK
0 1 S635-p FNDKRKKsFIFSRKF
0 23 - gap
0 1 - gap
0 4 Y719-p TTRPKRDyEVDGRDy
0 26 Y726-p yEVDGRDyHFVISRE
0 23 Y750 KFIEAGQYNDNLYGT
0 23 Y755 GQYNDNLYGTSVQSV
0 1 K809 EPLMEMNKRLTEEQA
0 1 K867 PFIWIPSKEKL____
2930 : Phospho-PSD93 (Tyr340) Antibody
  PSD-93 iso3  
- gap
- gap
- gap
- gap
- gap
- gap
K80 DPGIFITKIIPGGAA
K114 VSEVSHSKAVEALKE
K120 SKAVEALKEAGSIVR
S124 EALKEAGSIVRLYVR
K150 IKLFKGPKGLGFSIA
Y172 IPGDNSIYVTKIIDG
K184 IDGGAAQKDGRLQVG
S272 KTSLPPISPGRYSPI
Y276 PPISPGRYSPIPKHM
S277 PISPGRYSPIPKHML
K281 GRYSPIPKHMLVDDD
Y289 HMLVDDDYTSHSQHS
T290 MLVDDDYTSHSQHST
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S303 STATRQPSMTLQRAV
S311 MTLQRAVSLEGEPRK
Y397 TVTIIAQYQPEDYAR
Y402 AQYQPEDYARFEAKI
K408 DYARFEAKIHDLREQ
S425 NHSMSSGSGSLRTNQ
S427 SMSSGSGSLRTNQKR
S447 AMFDYDKSKDSGLPS
S450 DYDKSKDSGLPSQGL
S454 SKDSGLPSQGLSFKY
S458 GLPSQGLSFKYGDIL
S471 ILHVINASDDEWWQA
S487 RVMLEGDSEEMGVIP
K515 KTVKFNAKPGVIDSK
S521 AKPGVIDSKGDIPGL
K522 KPGVIDSKGDIPGLG
- gap
- gap
Y533-p PGLGDDGyGTKTLRG
K536 GDDGyGTKTLRGQED
Y598 TTRPKRDYEVDGRDY
Y605 YEVDGRDYHFVISRE
Y629 KFIEAGQYNDNLYGT
Y634 GQYNDNLYGTSVQSV
K688 EPLMEMNKRLTEEQA
K746 PFIWIPSKEKL____
  PSD-93 iso4  
- gap
- gap
- gap
- gap
- gap
S104 TCPHGWFSPAQASPA
K170 DPGIFITKIIPGGAA
K204 VSEVSHSKAVEALKE
K210 SKAVEALKEAGSIVR
S214 EALKEAGSIVRLYVR
K240 IKLFKGPKGLGFSIA
Y262 IPGDNSIYVTKIIDG
K274 IDGGAAQKDGRLQVG
S362 KTSLPPISPGRYSPI
Y366 PPISPGRYSPIPKHM
S367 PISPGRYSPIPKHML
K371 GRYSPIPKHMLVDDD
Y379 HMLVDDDYTRPPEPV
T380 MLVDDDYTRPPEPVY
T380 MLVDDDYTRPPEPVY
Y387 TRPPEPVYSTVNKLC
S388 RPPEPVYSTVNKLCD
T389 PPEPVYSTVNKLCDK
K396 TVNKLCDKPASPRHY
S399 KLCDKPASPRHYSPV
Y403 KPASPRHYSPVECDK
S404 PASPRHYSPVECDKS
Y421 LSAPYSHYHLGLLPD
S445 STATRQPSMTLQRAV
S453 MTLQRAVSLEGEPRK
Y539 TVTIIAQYQPEDYAR
Y544 AQYQPEDYARFEAKI
K550 DYARFEAKIHDLREQ
S567 NHSMSSGSGSLRTNQ
S569 SMSSGSGSLRTNQKR
S589 AMFDYDKSKDSGLPS
S592 DYDKSKDSGLPSQGL
S596 SKDSGLPSQGLSFKY
S600 GLPSQGLSFKYGDIL
S613 ILHVINASDDEWWQA
S629 RVMLEGDSEEMGVIP
K657 KTVKFNAKPGVIDSK
S663 AKPGVIDSKGSFNDK
K664 KPGVIDSKGSFNDKR
S666 GVIDSKGSFNDKRKK
S674 FNDKRKKSFIFSRKF
- gap
- gap
Y758 TTRPKRDYEVDGRDY
Y765 YEVDGRDYHFVISRE
Y789 KFIEAGQYNDNLYGT
Y794 GQYNDNLYGTSVQSV
K848 EPLMEMNKRLTEEQA
K906 PFIWIPSKEKL____
  PSD-93 iso8  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
S28-p EDGPHDHsLPRLTHE
S45-p GPELVHVsEKNLsQI
S50-p HVsEKNLsQIENVHG
Y58-p QIENVHGyVLQsHIs
S62-p VHGyVLQsHIsPLKA
S65-p yVLQsHIsPLKASPA
K131-u DPGIFITkIIPGGAA
K165-u VSEVSHSkAVEALkE
K171-u SkAVEALkEAGsIVR
S175-p EALkEAGsIVRLYVR
K201-u IKLFKGPkGLGFSIA
Y223 IPGDNSIYVTKIIDG
K235-u IDGGAAQkDGRLQVG
S323-p KTSLPPIsPGRysPI
Y327-p PPIsPGRysPIPkHM
S328-p PIsPGRysPIPkHML
K332-u GRysPIPkHMLGEDD
Y340-p HMLGEDDytRPPEPV
T341-p MLGEDDytRPPEPVy
T341-gl MLGEDDytRPPEPVy
Y348-p tRPPEPVyStVNKLC
S349 RPPEPVyStVNKLCD
T350-p PPEPVyStVNKLCDk
K357-u tVNKLCDkPAsPRHy
S360-p KLCDkPAsPRHysPV
Y364-p kPAsPRHysPVECDK
S365-p PAsPRHysPVECDKS
Y382 LSTPYPHYHLGLLPD
S406-p STATRQPsVTLQRAI
S414-p VTLQRAIsLEGEPRK
Y500-p TVTIIAQyQPEDyAR
Y505-p AQyQPEDyARFEAkI
K511-u DyARFEAkIHDLREQ
S528-p NHSMSSGsGsLRTNQ
S530-p SMSSGsGsLRTNQKR
S550-p AMFDYDKsKDsGLPs
S553-p DYDKsKDsGLPsQGL
S557-p sKDsGLPsQGLsFKY
S561-p GLPsQGLsFKYGDIL
S574-p ILHVINAsDDEWWQA
S590-p RVTLDGDsEEMGVIP
K618-u KTVKFNAkPGVIDsk
S624-p AkPGVIDskGDIPGL
K625-u kPGVIDskGDIPGLG
- gap
- gap
Y636-p PGLGDDGyGTkTLRG
K639-u GDDGyGTkTLRGQED
Y701 TTRPKRDYEVDGRDy
Y708-p YEVDGRDyHFVISRE
Y732-p KFIEAGQyNDNLyGT
Y737-p GQyNDNLyGTSVQSV
K791-u EPLMEMNkRLTEEQA
K849-u PFIWIPSkEKL____
2930 : Phospho-PSD93 (Tyr340) Antibody
  PSD-93 iso2  
S35 EDGPHDHSLPRLTHE
S52 GPELVHVSEKNLSQI
S57 HVSEKNLSQIENVHG
Y65 QIENVHGYVLQSHIS
S69 VHGYVLQSHISPLKA
S72 YVLQSHISPLKASPA
K138 DPGIFITKIIPGGAA
K172 VSEVSHSKAVEALKE
K178 SKAVEALKEAGSIVR
S182 EALKEAGSIVRLYVR
K208 IKLFKGPKGLGFSIA
Y230 IPGDNSIYVTKIIDG
K242 IDGGAAQKDGRLQVG
P330 KTSLPPIPPGRYSPI
Y334 PPIPPGRYSPIPKHM
S335 PIPPGRYSPIPKHML
K339 GRYSPIPKHMLGEDD
Y347 HMLGEDDYTRPPEPV
T348 MLGEDDYTRPPEPVY
T348 MLGEDDYTRPPEPVY
Y355 TRPPEPVYSTVNKLC
S356 RPPEPVYSTVNKLCD
T357 PPEPVYSTVNKLCDK
K364 TVNKLCDKPASPRHY
S367 KLCDKPASPRHYSPV
Y371 KPASPRHYSPVECDK
S372 PASPRHYSPVECDKS
Y389 LSTPYPHYHLGLLPD
S413 STATRQPSVTLQRAI
S421 VTLQRAISLEGEPRK
Y507 TVTIIAQYQPEDYAR
Y512 AQYQPEDYARFEAKI
K518 DYARFEAKIHDLREQ
S535 NHSMSSGSGSLRTNQ
S537 SMSSGSGSLRTNQKR
S557 AMFDYDKSKDSGLPS
S560 DYDKSKDSGLPSQGL
S564 SKDSGLPSQGLSFKY
S568 GLPSQGLSFKYGDIL
S581 ILHVINASDDEWWQA
S597 RVILDGDSEEMGVIP
K625 KTVKFNAKPGVIDSK
S631 AKPGVIDSKGDIPGL
K632 KPGVIDSKGDIPGLG
- gap
- gap
Y643 PGLGDDGYGTKTLRG
K646 GDDGYGTKTLRGQED
Y708 TTRPKRDYEVDGRDY
Y715 YEVDGRDYHFVISRE
Y739 KFIEAGQYNDNLYGT
Y744 GQYNDNLYGTSVQSV
K798 EPLMEMNKRLTEEQA
K856 PFIWIPSKEKL____
  PSD-93 iso9  
- gap
- gap
- gap
- gap
- gap
S100 ACPHGWFSPAQASPA
K166 DPGIFITKIIPGGAA
K200 VSEVSHSKAVEALKE
K206 SKAVEALKEAGSIVR
S210 EALKEAGSIVRLYVR
K236-u IKLFKGPkGLGFSIA
Y258 IPGDNSIYVTKIIDG
K270 IDGGAAQKDGRLQVG
S358-p KTSLPPIsPGRysPI
Y362-p PPIsPGRysPIPKHM
S363-p PIsPGRysPIPKHML
K367 GRysPIPKHMLGEDD
Y375 HMLGEDDYTRPPEPV
T376 MLGEDDYTRPPEPVY
T376 MLGEDDYTRPPEPVY
Y383 TRPPEPVYSTVNKLC
S384 RPPEPVYSTVNKLCD
T385 PPEPVYSTVNKLCDK
K392 TVNKLCDKPASPRHY
S395 KLCDKPASPRHYSPV
Y399 KPASPRHYSPVECDK
S400 PASPRHYSPVECDKS
Y417 LSTPYPHYHLGLLPD
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

► Hide Isoforms
 
S28 EDGPHDHSLPRLTHE
S45 GPELVHVSEKNLSQI
S50 HVSEKNLSQIENVHG
Y58-p QIENVHGyVLQSHIS
S62 VHGyVLQSHISPLKA
S65 yVLQSHISPLKASPA
K131 DPGIFITKIIPGGAA
K165 VSEVSHSKAVEALkE
K171-u SKAVEALkEAGsIVR
S175-p EALkEAGsIVRLYVR
K201 IKLFKGPKGLGFSIA
Y223-p IPGDNSIyVTKIIDG
K235-u IDGGAAQkDGRLQVG
S323-p KTSLPPIsPGRYsPI
Y327 PPIsPGRYsPIPKHM
S328-p PIsPGRYsPIPKHML
K332 GRYsPIPKHMLVEDD
Y340-p HMLVEDDytRPPEPV
T341-p MLVEDDytRPPEPVy
T341 MLVEDDyTRPPEPVy
Y348-p tRPPEPVystVNKLC
S349-p RPPEPVystVNKLCD
T350-p PPEPVystVNKLCDk
K357-u tVNKLCDkPASPRHY
S360 KLCDkPASPRHYsPV
Y364 kPASPRHYsPVECDK
S365-p PASPRHYsPVECDKS
Y382-p LSTPYPHyHLGLLPD
S406 STATRQPSVTLQRAI
S414 VTLQRAISLEGEPRK
Y500 TVTIIAQYQPEDyAR
Y505-p AQYQPEDyARFEAKI
K511 DyARFEAKIHDLREQ
S528 NHSMSSGSGSLRTNQ
S530 SMSSGSGSLRTNQKR
S550 AMFDYDKSKDSGLPs
S553 DYDKSKDSGLPsQGL
S557-p SKDSGLPsQGLSFKY
S561 GLPsQGLSFKYGDIL
S574 ILHVINASDDEWWQA
S590 RVILDGDSEEMGVIP
K618-u KTVKFNAkPGVIDSK
S624 AkPGVIDSKGDIPGL
K625 kPGVIDSKGDIPGLG
- gap
- gap
Y636-p PGLGDDGyGTKTLRG
K639 GDDGyGTKTLRGQED
Y701-p TTRPKRDyEVDGRDy
Y708-p yEVDGRDyHFVISRE
Y732-p KFIEAGQyNDNLyGT
Y737-p GQyNDNLyGTSVQSV
K791 EPLMEMNKRLTEEQA
K849 PFIWIPSKEKL____
2930 : Phospho-PSD93 (Tyr340) Antibody
  PSD-93 iso7  
S28 EDGPHDHSLPRLTHE
S45 GPELVHVSEKNLSQI
S50 HVSEKNLSQIENVHG
Y58 QIENVHGYVLQSHIS
S62 VHGYVLQSHISPLKA
S65 YVLQSHISPLKASPA
K131 DPGIFITKIIPGGAA
K165 VSEVSHSKAVEALKE
K171 SKAVEALKEAGSIVR
S175 EALKEAGSIVRLYVR
K201 IKLFKGPKGLGFSIA
Y223 IPGDNSIYVTKIIDG
K235 IDGGAAQKDGRLQVG
S323 KTSLPPISPGRYSPI
Y327 PPISPGRYSPIPKHM
S328 PISPGRYSPIPKHML
K332 GRYSPIPKHMLVEDD
Y340 HMLVEDDYTRPPEPV
T341 MLVEDDYTRPPEPVY
T341 MLVEDDYTRPPEPVY
Y348 TRPPEPVYSTVNKLC
S349 RPPEPVYSTVNKLCD
T350 PPEPVYSTVNKLCDK
K357 TVNKLCDKPASPRHY
S360 KLCDKPASPRHYSPV
Y364 KPASPRHYSPVECDK
S365 PASPRHYSPVECDKS
Y382 LSTPYPHYHLGLLPD
S406 STATRQPSVTLQRAI
S414 VTLQRAISLEGEPRK
Y500 TVTIIAQYQPEDYAR
Y505 AQYQPEDYARFEAKI
K511 DYARFEAKIHDLREQ
S528 NHSMSSGSGSLRTNQ
S530 SMSSGSGSLRTNQKR
S550 AMFDYDKSKDSGLPS
S553 DYDKSKDSGLPSQGL
S557 SKDSGLPSQGLSFKY
S561 GLPSQGLSFKYGDIL
S574 ILHVINASDDEWWQA
S590 RVILDGDSEEMGVIP
K618 KTVKFNAKPGVIDSK
S624 AKPGVIDSKGSFNDK
K625 KPGVIDSKGSFNDKR
S627 GVIDSKGSFNDKRKK
S635 FNDKRKKSFIFSRKF
- gap
- gap
Y719 TTRPKRDYEVDGRDY
Y726 YEVDGRDYHFVISRE
Y750 KFIEAGQYNDNLYGT
Y755 GQYNDNLYGTSVQSV
K809 EPLMEMNKRLTEEQA
K867 PFIWIPSKEKL____
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