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IL2RB (human)

Overview IL2RB Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I. Belongs to the type I cytokine receptor family. Type 4 subfamily. Note: This description may include information from UniProtKB. Protein type: Receptor, cytokine; Membrane protein, integral Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function: interleukin-2 receptor activity; interleukin-2 binding Biological Process: virus-host interaction; cytokine and chemokine mediated signaling pathway; protein complex assembly; signal transduction; negative regulation of apoptosis Reference #:  P14784 (UniProtKB) Alt. Names/Synonyms: CD122; CD122 antigen; high affinity IL-2 receptor beta subunit; High affinity IL-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; IL2RB; interleukin 2 receptor, beta; Interleukin-2 receptor subunit beta; p70-75; p75 Gene Symbols: IL2RB Molecular weight: 61,117 Da Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IL2RB 1ILM - B=31-230 (human) 1ILN - B=31-230 (human) 2B5I - B=27-240 (human) 2ERJ - B/F=25-232 (human) 3QAZ - W/T/N/K/E/B/Z/H/c/Q/f/i=24-240 (human) 4GS7 - B=27-240 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1ILM 1ILN 2B5I 2ERJ 3QAZ 4GS7  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
apoptosis, inhibited: Y418‑p, Y536‑p cell growth, altered: Y418‑p, Y536‑p transcription, altered: Y364‑p molecular association, regulation: Y364‑p, Y418‑p, Y536‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T105-p	LTTVDIVtLRVLCRE
0	1		T282-p	KKVLKCNtPDPSKFF
0	1		S293-p	SKFFSQLsSEHGGDV
4	0		Y364-p	SCFTNQGyFFFHLPD
1	0		Y381-p	EIEACQVyFTyDPyS
1	0		Y384-p	ACQVyFTyDPySEED
1	0		Y387-p	VyFTyDPySEEDPDE
3	0		Y418-p	LSGEDDAyCTFPSRD
0	1		S458-p	GEERMPPsLQERVPR
3	3		Y536-p	LPLNTDAyLSLQELQ

	mouse
D106	LTSVDLLDINVVCWE
I285	KTVLKCHIPDPSEFF
S296	SEFFSQLSSQHGGDL
Y367	SCFTNQGYFFFHLPN
Y384	EIESCQVYFTYDPCV
Y387	SCQVYFTYDPCVEEE
C390	VYFTYDPCVEEEVEE
Y421	LAGEQDDYCAFPPRD
S457	PEERSPLSLHEGLPS
Y524	LTLNTDAYLSLQELQ

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