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Btk (human)

Overview Btk a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; TK group; Tec family Cellular Component: intracellular membrane-bound organelle; cytoplasm; plasma membrane; cytoplasmic vesicle; cytosol; nucleus; lipid raft Molecular Function: identical protein binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; metal ion binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding Biological Process: I-kappaB kinase/NF-kappaB cascade; adaptive immune response; peptidyl-tyrosine phosphorylation; B cell activation; transcription, DNA-dependent; cell maturation; calcium-mediated signaling; protein amino acid phosphorylation; Toll signaling pathway; toll-like receptor 2 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of B cell apoptosis; regulation of B cell cytokine production; B cell receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; positive regulation of B cell differentiation; mesoderm development; toll-like receptor 4 signaling pathway Reference #:  Q06187 (UniProtKB) Alt. Names/Synonyms: Agammaglobulinaemia tyrosine kinase; AGMX1; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; IMD1; MGC126261; MGC126262; PSCTK1; Tyrosine-protein kinase BTK; XLA Gene Symbols: BTK Molecular weight: 76,281 Da Basal Isoelectric point: 7.83  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Btk 1AWW - A=212-275 (human) 1AWX - A=212-275 (human) 1B55 - A/B=1-170 (human) 1BTK - A/B=1-170 (human) 1BWN - A/B=1-170 (human) 1K2P - A/B=397-659 (human) 1QLY - A=216-273 (human) 2GE9 - A=269-387 (human) 2Z0P - A/D/C/B=2-170 (human) 3GEN - A=382-659 (human) 3K54 - A=382-659 (human) 3OCS - A=393-656 (human) 3OCT - A=393-656 (human) 3P08 - A/B=393-659 (human) 3PIX - A=387-659 (human) 3PIY - A=387-659 (human) 3PIZ - A=387-659 (human) 3PJ1 - A=387-659 (human) 3PJ2 - A=387-659 (human) 3PJ3 - A=387-659 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3  |  ENZYME  |  Phospho3D  |  DISEASE 300300 300755 307200  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell growth, altered: Y223‑p activation: Y551‑p enzymatic activity, induced: Y223‑p, Y551‑p intracellular localization: Y551‑p molecular association, regulation: Y551‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	3		S21-p	SQQKKKTsPLNFKKR
0	26		Y40-p	TVHKLSYyEYDFERG
0	1		S55-p	RRGSKKGsIDVEKIT
1	0		S115	EGPLYVFSPTEELRK
0	1		S179-p	NGSLKPGssHRkTKK
1	2		S180-p	GSLKPGssHRkTKKP
0	1		K183-a	KPGssHRkTKKPLPP
0	1		T191-p	TKKPLPPtPEEDQIL
15	259		Y223-p	LKKVVALyDyMPMNA
0	93		Y225-p	KVVALyDyMPMNAND
0	1		Y263-p	DKNGQEGyIPSNYVT
0	1		Y279-p	AEDSIEMyEWYSKHM
0	1		K300-u	QLLKQEGkEGGFIVR
0	6		K322-u	YTVSVFAkSTGDPQG
0	7		Y334-p	PQGVIRHyVVCSTPQ
0	1		S342-p	VVCSTPQsQyyLAEK
0	190		Y344-p	CSTPQsQyyLAEKHL
0	6		Y345-p	STPQsQyyLAEKHLF
0	106		Y361-p	TIPELINyHQHNsAG
0	3		S366-p	INyHQHNsAGLIsRL
0	1		S371-p	HNsAGLIsRLKyPVS
1	22		Y375-p	GLIsRLKyPVSQQNK
0	13		K406-u	PKDLTFLkELGTGQF
0	1		Y425	YGKWRGQYDVAIKMI
0	1		S436	IKMIKEGSMSEDEFI
0	15		Y461-p	HEKLVQLyGVCTkQR
0	3		K466-u	QLyGVCTkQRPIFII
0	1		Y511-p	DVCEAMEyLESKQFL
0	5		K536-u	VNDQGVVkVSDFGLs
0	2		S543-p	kVSDFGLsRYVLDDE
21	143		Y551-p	RYVLDDEytsSVGSk
0	7		T552-p	YVLDDEytsSVGSkF
0	5		S553-p	VLDDEytsSVGSkFP
0	12		K558-u	ytsSVGSkFPVRWsP
0	1		S564-p	SkFPVRWsPPEVLMY
0	1		T602-p	KMPYERFtNsETAEH
0	1		S604-p	PYERFtNsETAEHIA
1	1		Y617	IAQGLRLYRPHLASE
0	1		S623	LYRPHLASEKVYTIM
0	1		S659-p	LDVMDEEs_______

	mouse
S21-p	SQQKKKTsPLNFKKR
Y40-p	TVHKLSYyEYDFERG
S55	RRGSKKGSIDVEKIT
S115-p	EGPLYVFsPTEELRK
S179	NGSLKPGSsHRKTKK
S180-p	GSLKPGSsHRKTKKP
K183	KPGSsHRKTKKPLPP
T191	TKKPLPPTPEEDQIL
Y223-p	LKKVVALyDyMPMNA
Y225-p	KVVALyDyMPMNAND
Y263	DKNGQEGYIPSNYIT
Y279	AEDSIEMYEWYSKHM
K300	QLLKQEGKEGGFIVR
K322	YTVSVFAKSTGEPQG
Y334-p	PQGVIRHyVVCSTPQ
S342	VVCSTPQSQyyLAEK
Y344-p	CSTPQSQyyLAEKHL
Y345-p	STPQSQyyLAEKHLF
Y361-p	TIPELINyHQHNSAG
S366	INyHQHNSAGLISRL
S371	HNSAGLISRLKyPVS
Y375-p	GLISRLKyPVSKQNK
K406	PKDLTFLKELGTGQF
Y425-p	YGKWRGQyDVAIKMI
S436-p	IKMIREGsMSEDEFI
Y461-p	HEKLVQLyGVCTKQR
K466	QLyGVCTKQRPIFII
Y511	DVCEAMEYLESKQFL
K536	VNDQGVVKVSDFGLs
S543-p	KVSDFGLsRYVLDDE
Y551-p	RYVLDDEyTsSVGSK
T552	YVLDDEyTsSVGSKF
S553-p	VLDDEyTsSVGSKFP
K558	yTsSVGSKFPVRWSP
S564	SKFPVRWSPPEVLMY
T602	KMPYERFTNSETAEH
S604	PYERFTNSETAEHIA
Y617-p	IAQGLRLyRPHLAsE
S623-p	LyRPHLAsERVYTIM
S659	LDVMDEES_______

	rat
S21	SQQKKKTSPLNFKKR
Y40	TVHKLSYYEYDFERG
S55	RRGSKKGSIDVEKIT
S116	EGPLYVFSPTEELRK
S180	NGSLKPGSSHRKTKK
S181	GSLKPGSSHRKTKKP
K184	KPGSSHRKTKKPLPP
T192	TKKPLPPTPEEDQIL
Y224	LKKVVALYDYMPMNA
Y226	KVVALYDYMPMNAND
Y264	DKNGQEGYIPSNYVT
Y280	AEDSIEMYEWYSKHM
K301	QLLKQEGKEGGFIVR
K323	YTVSVFAKSTGEPQG
Y335	PQGVIRHYVVCSTPQ
S343	VVCSTPQSQYYLAEK
Y345	CSTPQSQYYLAEKHL
Y346	STPQSQYYLAEKHLF
Y362	TIPELINYHQHNSAG
S367	INYHQHNSAGLISRL
S372	HNSAGLISRLKYPVS
Y376	GLISRLKYPVSKQNK
K407	PKDLTFLKELGTGQF
Y426	YGKWRGQYDVAIKMI
S437	IKMIREGSMSEDEFI
Y462-p	HEKLVQLyGVCTKQR
K467	QLyGVCTKQRPIFII
Y512	DVCEAMEYLESKQFL
K537	VNDQGVVKVSDFGLS
S544	KVSDFGLSRYVLDDE
Y552	RYVLDDEYTSSVGSK
T553	YVLDDEYTSSVGSKF
S554	VLDDEYTSSVGSKFP
K559	YTSSVGSKFPVRWSP
S565	SKFPVRWSPPEVLMY
T603	KIPYERFTNSETAEH
S605	PYERFTNSETAEHIA
Y618	IAQGLRLYRPHLASD
S624	LYRPHLASDRVYTIM
S660	LDVMDEES_______

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