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Protein Page:
p57Kip2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
p57Kip2 Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life. Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver. Belongs to the CDI family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Inhibitor protein; Nuclear receptor co-regulator
Cellular Component: cytoplasm; nucleus
Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding
Biological Process: negative regulation of kinase activity; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; neuron maturation; negative regulation of cell proliferation; negative regulation of phosphorylation; regulation of cyclin-dependent protein kinase activity; G1 phase of mitotic cell cycle; cell cycle arrest; negative regulation of transcription, DNA-dependent; negative regulation of epithelial cell proliferation; placenta development
Reference #:  P49918 (UniProtKB)
Alt. Names/Synonyms: BWCR; BWS; CDKN1C; CDN1C; Cyclin-dependent kinase inhibitor 1C; cyclin-dependent kinase inhibitor 1C (p57, Kip2); Cyclin-dependent kinase inhibitor p57; KIP2; p57; p57Kip2; WBS
Gene Symbols: CDKN1C
Molecular weight: 32,177 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

p57Kip2

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: T310‑p
protein degradation: S282‑p, T310‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 A17 STMERLVARGTFPVL
0 1 R18 TMERLVARGTFPVLV
0 1 R107 CRLLLAPRPVAVAVA
1 0 - gap
0 1 K266-ac ANGAAIKkLsGPLIS
0 2 S268-p GAAIKkLsGPLISDF
0 4 K278-ac LISDFFAkRKRsAPE
1 0 S282-p FFAkRKRsAPEKSSG
0 1 S297-p DVPAPCPsPsAAPGV
0 1 S299-p PAPCPsPsAAPGVGs
0 1 S306-p sAAPGVGsVEQtPRK
3 3 T310-p GVGsVEQtPRKRLR_
2558 : Phospho-p57 Kip2 (Thr310) Antibody
  mouse

► Hide Isoforms
 
S19-p TAMERLAssDTFPVI
S20-p AMERLAssDTFPVIA
R109-m1 CRLQLGPrPPPVAVA
T156 AEPTPPATPAPASDL
- gap
- gap
K309 NANDFFAKRKRTAQE
T313 FFAKRKRTAQENKAS
S329 DVPPGCPSPNVAPGV
N331 PPGCPSPNVAPGVGA
A338 NVAPGVGAVEQtPRK
T342-p GVGAVEQtPRKRLR_
  p57Kip2 iso2  
S6 __MERLASSDTFPVI
S7 _MERLASSDTFPVIA
R96 CRLQLGPRPPPVAVA
T143-p AEPTPPAtPAPASDL
- gap
- gap
K296 NANDFFAKRKRTAQE
T300 FFAKRKRTAQENKAS
S316 DVPPGCPSPNVAPGV
N318 PPGCPSPNVAPGVGA
A325 NVAPGVGAVEQTPRK
T329 GVGAVEQTPRKRLR_
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