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p57Kip2
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life. Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver. Belongs to the CDI family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor protein; Nuclear receptor co-regulator |
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Cellular Component: cytoplasm; nucleolus; nucleus
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Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding
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Biological Process: negative regulation of cell proliferation; negative regulation of kinase activity; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of phosphorylation; regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; cell cycle arrest; negative regulation of transcription, DNA-dependent; G1 phase of mitotic cell cycle; neuron maturation; negative regulation of epithelial cell proliferation
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Reference #:
P49918 (UniProtKB)
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| Alt. Names/Synonyms: BWCR; BWS; CDKN1C; CDN1C; Cyclin-dependent kinase inhibitor 1C; cyclin-dependent kinase inhibitor 1C (p57, Kip2); Cyclin-dependent kinase inhibitor p57; KIP2; p57; p57Kip2; WBS |
| Gene Symbols: CDKN1C |
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Molecular weight: 32,177 Da
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Basal Isoelectric point: 5.39
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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