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Btk (mouse)

Overview Btk a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis. Note: This description may include information from UniProtKB. Protein type: EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; Tec family Cellular Component: membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cytoplasmic vesicle; nucleus; cytosol; lipid raft Molecular Function: identical protein binding; metal ion binding; nucleotide binding; non-membrane spanning protein tyrosine kinase activity; protein kinase activity; transferase activity; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; phospholipid binding; kinase activity; lipid binding; ATP binding Biological Process: I-kappaB kinase/NF-kappaB cascade; peptidyl-tyrosine phosphorylation; transcription, DNA-dependent; apoptosis; protein amino acid autophosphorylation; cell maturation; protein amino acid phosphorylation; response to organic substance; response to reactive oxygen species; histamine secretion by mast cell; regulation of transcription, DNA-dependent; response to biotic stimulus; innate immune response; phosphorylation Reference #:  P35991 (UniProtKB) Alt. Names/Synonyms: Agammaglobulinaemia tyrosine kinase; AI528679; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton's tyrosine kinase; Btk; Kinase EMB; OTTMUSP00000020834; Tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); X-linked immune deficiency; xid Gene Symbols: Btk Molecular weight: 76,437 Da Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Btk 1AWW - A=212-275 (human) 1AWX - A=212-275 (human) 1B55 - A/B=1-170 (human) 1BTK - A/B=1-170 (human) 1BWN - A/B=1-170 (human) 1K2P - A/B=397-659 (human) 1QLY - A=216-273 (human) 2GE9 - A=269-387 (human) 2Z0P - A/D/C/B=2-170 (human) 3GEN - A=382-659 (human) 3K54 - A=382-659 (human) 3OCS - A=393-656 (human) 3OCT - A=393-656 (human) 3P08 - A/B=393-659 (human) 3PIX - A=387-659 (human) 3PIY - A=387-659 (human) 3PIZ - A=387-659 (human) 3PJ1 - A=387-659 (human) 3PJ2 - A=387-659 (human) 3PJ3 - A=387-659 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell growth, altered: Y223‑p, Y551‑p enzymatic activity, induced: Y223‑p, Y551‑p inhibition: S180‑p intracellular localization: S180‑p molecular association, regulation: S21‑p, S115‑p, Y223‑p not reported: Y375‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
1	3		S21-p	SQQKKKTsPLNFKKR
0	26		Y40-p	TVHKLSYyEYDFERG
0	1		S55	RRGSKKGSIDVEKIT
1	0		S115-p	EGPLYVFsPTEELRK
0	1		S179	NGSLKPGSsHRKTKK
1	2		S180-p	GSLKPGSsHRKTKKP
0	1		K183	KPGSsHRKTKKPLPP
0	1		T191	TKKPLPPTPEEDQIL
15	259		Y223-p	LKKVVALyDyMPMNA
0	93		Y225-p	KVVALyDyMPMNAND
0	1		Y263	DKNGQEGYIPSNYIT
0	1		Y279	AEDSIEMYEWYSKHM
0	1		K300	QLLKQEGKEGGFIVR
0	6		K322	YTVSVFAKSTGEPQG
0	7		Y334-p	PQGVIRHyVVCSTPQ
0	1		S342	VVCSTPQSQyyLAEK
0	190		Y344-p	CSTPQSQyyLAEKHL
0	6		Y345-p	STPQSQyyLAEKHLF
0	106		Y361-p	TIPELINyHQHNSAG
0	3		S366	INyHQHNSAGLISRL
0	1		S371	HNSAGLISRLKyPVS
1	22		Y375-p	GLISRLKyPVSKQNK
0	13		K406	PKDLTFLKELGTGQF
0	1		Y425-p	YGKWRGQyDVAIKMI
0	1		S436-p	IKMIREGsMSEDEFI
0	15		Y461-p	HEKLVQLyGVCTKQR
0	3		K466	QLyGVCTKQRPIFII
0	1		Y511	DVCEAMEYLESKQFL
0	5		K536	VNDQGVVKVSDFGLs
0	2		S543-p	KVSDFGLsRYVLDDE
21	143		Y551-p	RYVLDDEyTsSVGSK
0	7		T552	YVLDDEyTsSVGSKF
0	5		S553-p	VLDDEyTsSVGSKFP
0	12		K558	yTsSVGSKFPVRWSP
0	1		S564	SKFPVRWSPPEVLMY
0	1		T602	KMPYERFTNSETAEH
0	1		S604	PYERFTNSETAEHIA
1	1		Y617-p	IAQGLRLyRPHLAsE
0	1		S623-p	LyRPHLAsERVYTIM
0	1		S659	LDVMDEES_______

	human
S21-p	SQQKKKTsPLNFKKR
Y40-p	TVHKLSYyEYDFERG
S55-p	RRGSKKGsIDVEKIT
S115	EGPLYVFSPTEELRK
S179-p	NGSLKPGssHRkTKK
S180-p	GSLKPGssHRkTKKP
K183-a	KPGssHRkTKKPLPP
T191-p	TKKPLPPtPEEDQIL
Y223-p	LKKVVALyDyMPMNA
Y225-p	KVVALyDyMPMNAND
Y263-p	DKNGQEGyIPSNYVT
Y279-p	AEDSIEMyEWYSKHM
K300-u	QLLKQEGkEGGFIVR
K322-u	YTVSVFAkSTGDPQG
Y334-p	PQGVIRHyVVCSTPQ
S342-p	VVCSTPQsQyyLAEK
Y344-p	CSTPQsQyyLAEKHL
Y345-p	STPQsQyyLAEKHLF
Y361-p	TIPELINyHQHNsAG
S366-p	INyHQHNsAGLIsRL
S371-p	HNsAGLIsRLKyPVS
Y375-p	GLIsRLKyPVSQQNK
K406-u	PKDLTFLkELGTGQF
Y425	YGKWRGQYDVAIKMI
S436	IKMIKEGSMSEDEFI
Y461-p	HEKLVQLyGVCTkQR
K466-u	QLyGVCTkQRPIFII
Y511-p	DVCEAMEyLESKQFL
K536-u	VNDQGVVkVSDFGLs
S543-p	kVSDFGLsRYVLDDE
Y551-p	RYVLDDEytsSVGSk
T552-p	YVLDDEytsSVGSkF
S553-p	VLDDEytsSVGSkFP
K558-u	ytsSVGSkFPVRWsP
S564-p	SkFPVRWsPPEVLMY
T602-p	KMPYERFtNsETAEH
S604-p	PYERFtNsETAEHIA
Y617	IAQGLRLYRPHLASE
S623	LYRPHLASEKVYTIM
S659-p	LDVMDEEs_______

	rat
S21	SQQKKKTSPLNFKKR
Y40	TVHKLSYYEYDFERG
S55	RRGSKKGSIDVEKIT
S116	EGPLYVFSPTEELRK
S180	NGSLKPGSSHRKTKK
S181	GSLKPGSSHRKTKKP
K184	KPGSSHRKTKKPLPP
T192	TKKPLPPTPEEDQIL
Y224	LKKVVALYDYMPMNA
Y226	KVVALYDYMPMNAND
Y264	DKNGQEGYIPSNYVT
Y280	AEDSIEMYEWYSKHM
K301	QLLKQEGKEGGFIVR
K323	YTVSVFAKSTGEPQG
Y335	PQGVIRHYVVCSTPQ
S343	VVCSTPQSQYYLAEK
Y345	CSTPQSQYYLAEKHL
Y346	STPQSQYYLAEKHLF
Y362	TIPELINYHQHNSAG
S367	INYHQHNSAGLISRL
S372	HNSAGLISRLKYPVS
Y376	GLISRLKYPVSKQNK
K407	PKDLTFLKELGTGQF
Y426	YGKWRGQYDVAIKMI
S437	IKMIREGSMSEDEFI
Y462-p	HEKLVQLyGVCTKQR
K467	QLyGVCTKQRPIFII
Y512	DVCEAMEYLESKQFL
K537	VNDQGVVKVSDFGLS
S544	KVSDFGLSRYVLDDE
Y552	RYVLDDEYTSSVGSK
T553	YVLDDEYTSSVGSKF
S554	VLDDEYTSSVGSKFP
K559	YTSSVGSKFPVRWSP
S565	SKFPVRWSPPEVLMY
T603	KIPYERFTNSETAEH
S605	PYERFTNSETAEHIA
Y618	IAQGLRLYRPHLASD
S624	LYRPHLASDRVYTIM
S660	LDVMDEES_______

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