a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; TK group; Tec family
Cellular Component: extrinsic to internal side of plasma membrane; mast cell granule; intracellular membrane-bound organelle; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; intracellular; cytoplasmic vesicle; nucleus; cytosol; lipid raft
Molecular Function: identical protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein kinase activity; transferase activity; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; kinase activity; lipid binding; ATP binding
Biological Process: I-kappaB kinase/NF-kappaB cascade; adaptive immune response; peptidyl-tyrosine phosphorylation; transcription, DNA-dependent; immune system process; apoptosis; protein amino acid autophosphorylation; cell maturation; protein amino acid phosphorylation; regulation of cell proliferation; response to organic substance; B cell receptor signaling pathway; histamine secretion by mast cell; regulation of transcription, DNA-dependent; innate immune response; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.