a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Tec family
Cellular Component: extrinsic to internal side of plasma membrane; mast cell granule; membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasm; plasma membrane; intracellular; cytoplasmic vesicle; cytosol; nucleus; lipid raft
Molecular Function: transferase activity; identical protein binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; metal ion binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; kinase activity; lipid binding; ATP binding; protein kinase activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; adaptive immune response; peptidyl-tyrosine phosphorylation; transcription, DNA-dependent; immune system process; apoptosis; protein amino acid autophosphorylation; cell maturation; protein amino acid phosphorylation; regulation of cell proliferation; response to organic substance; B cell receptor signaling pathway; histamine secretion by mast cell; regulation of transcription, DNA-dependent; innate immune response; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.