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Protein Page:
TEAD1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TEAD1 Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. Interacts with YAP1 and WWTR1/TAZ. Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Chromosomal Location of Human Ortholog: 11p15.2
Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; gene expression
Reference #:  P28347 (UniProtKB)
Alt. Names/Synonyms: AA; atrophia areata, peripapillary chorioretinal degeneration; NTEF-1; Protein GT-IIC; REF1; SV40 transcriptional enhancer factor; TCF-13; TCF13; TEA domain family member 1; TEA domain family member 1 (SV40 transcriptional enhancer factor); TEAD-1; TEAD1; TEF-1; TEF1; Transcription factor 13; transcriptional enhancer factor 1; Transcriptional enhancer factor TEF-1
Gene Symbols: TEAD1
Molecular weight: 47,946 Da
Basal Isoelectric point: 8.33  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TEAD1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S7-p _MEPSSWsGSEsPAE
0 6 S11-p SSWsGSEsPAENMER
0 2 S20-p AENMERMsDSADKPI
0 1 S36-p NDAEGVWsPDIEQSF
0 3 S61-p GRRKIILsDEGKMYG
0 1 K101-m2 IQVLARRksRDFHSK
1 1 S102-p QVLARRksRDFHSKL
0 1 K270-ac YDKFPEKkGGLkELF
0 1 K274-ac PEKkGGLkELFGKGP
  mouse

 
S7 _MEPSSWSGSESPAE
S11 SSWSGSESPAENMER
S20 AENMERMSDSADKPI
S36 NDAEGVWSPDIEQSF
S61 GRRKIILSDEGKMYG
K101 IQVLARRKsRDFHSK
S102-p QVLARRKsRDFHSKL
K270 YDKFPEKKGGLKELF
K274 PEKKGGLKELFGKGP
  rat

 
- gap
- gap
S5 ___MERMSDSADKPI
S21 NDAEGVWSPDIEQSF
S46 GRRKIILSDEGKMYG
K86 IQVLARRKSRDFHSK
S87 QVLARRKSRDFHSKL
K259 YDKFPEKKGGLKELF
K263 PEKKGGLKELFGKGP
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