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LSm2 (human)

Overview LSm2 Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing. Identified in the spliceosome C complex. LSm subunits form a heteromer with a doughnut shape. Belongs to the snRNP Sm proteins family. Note: This description may include information from UniProtKB. Protein type: RNA binding protein; RNA splicing Cellular Component: nucleoplasm; nucleus; cytosol Molecular Function: protein binding; protein kinase binding; U6 snRNA binding Biological Process: nuclear mRNA splicing, via spliceosome; RNA metabolic process; RNA splicing; gene expression; mRNA catabolic process, deadenylation-dependent decay; mRNA metabolic process Reference #:  Q9Y333 (UniProtKB) Alt. Names/Synonyms: C6orf28; G7B; LSM2; LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae); Protein G7b; Small nuclear ribonuclear protein D homolog; snRNP; snRNP core Sm-like protein Sm-x5; U6 snRNA-associated Sm-like protein LSm2; YBL026W Gene Symbols: LSM2 Molecular weight: 10,835 Da Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below LSm2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	8		Y4-p	____MLFysFFkSLV
0	2		S5-p	___MLFysFFkSLVG
0	1		K8-u	MLFysFFkSLVGKDV
0	6		Y35-p	TLHSVDQyLNIKLTD
0	1		S44-p	NIKLTDIsVTDPEKy
0	3		Y51-p	sVTDPEKyPHMLSVK
0	1		S65-p	KNCFIRGsVVRYVQL
0	1		T79-p	LPADEVDtQLLQDAA
0	1		K88-u	LLQDAARkEALQQkQ
0	1		K94-u	RkEALQQkQ______

	mouse
Y4	____MLFYSFFKSLV
S5	___MLFYSFFKSLVG
K8	MLFYSFFKSLVGKDV
Y35-p	TLHSVDQyLNIKLTD
S44	NIKLTDISVTDPEKY
Y51	SVTDPEKYPHMLSVK
S65-p	KNCFIRGsVVRYVQL
T79	LPADEVDTQLLQDAA
K88	LLQDAARKEALQQKQ
K94	RKEALQQKQ______

	rat
Y40	QDFVRLFYSFFKSLV
S41	DFVRLFYSFFKSLVG
K44	RLFYSFFKSLVGKDV
Y71	TLHSVDQYLNIKLTD
S80	NIKLTDISVTDPEKY
Y87	SVTDPEKYPHMLSVK
S101	KNCFIRGSVVRYVQL
T115	LPADEVDTQLLQDAA
K124	LLQDAARKEALQQKQ
K130	RKEALQQKQ______

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