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Protein Page:
LSM2 (human)

Overview
LSM2 Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing. Identified in the spliceosome C complex. LSm subunits form a heteromer with a doughnut shape. Belongs to the snRNP Sm proteins family. Note: This description may include information from UniProtKB.
Protein type: Spliceosome; RNA binding protein; RNA splicing
Cellular Component: nucleoplasm; cytosol
Molecular Function: protein binding; protein kinase binding; U6 snRNA binding
Biological Process: nuclear mRNA splicing, via spliceosome; RNA metabolic process; RNA splicing; gene expression; mRNA metabolic process; mRNA catabolic process, deadenylation-dependent decay
Reference #:  Q9Y333 (UniProtKB)
Alt. Names/Synonyms: C6orf28; G7B; LSM2; LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae); Protein G7b; Small nuclear ribonuclear protein D homolog; snRNP; snRNP core Sm-like protein Sm-x5; U6 snRNA-associated Sm-like protein LSm2; YBL026W
Gene Symbols: LSM2
Molecular weight: 10,835 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LSM2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 8 Y4-p ____MLFysFFKSLV
0 2 S5-p ___MLFysFFKSLVG
0 6 Y35-p TLHSVDQyLNIKLTD
0 1 S44-p NIKLTDIsVTDPEKy
0 3 Y51-p sVTDPEKyPHMLSVK
0 2 S65-p KNCFIRGsVVRYVQL
0 1 T79-p LPADEVDtQLLQDAA
  mouse

 
Y4 ____MLFYSFFKSLV
S5 ___MLFYSFFKSLVG
Y35-p TLHSVDQyLNIKLTD
S44 NIKLTDISVTDPEKY
Y51 SVTDPEKYPHMLSVK
S65-p KNCFIRGsVVRYVQL
T79 LPADEVDTQLLQDAA
  rat

 
Y40 QDFVRLFYSFFKSLV
S41 DFVRLFYSFFKSLVG
Y71 TLHSVDQYLNIKLTD
S80 NIKLTDISVTDPEKY
Y87 SVTDPEKYPHMLSVK
S101 KNCFIRGSVVRYVQL
T115 LPADEVDTQLLQDAA
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