Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CD34 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD34 Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Belongs to the CD34 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell surface
Cellular Component: intercellular bridge; cell surface; membrane; perinuclear region of cytoplasm; lysosome; apical plasma membrane; cytoplasm; plasma membrane; integral to membrane; basal plasma membrane; extracellular region; external side of plasma membrane
Molecular Function: sulfate binding; carbohydrate binding; transcription factor binding
Biological Process: positive regulation of odontogenesis; glutamate metabolic process; negative regulation of nitric oxide biosynthetic process; negative regulation of blood coagulation; negative regulation of tumor necrosis factor production; positive regulation of interleukin-10 production; cell-cell adhesion; positive regulation of angiogenesis; endothelial cell proliferation; regulation of blood pressure; tissue homeostasis; hemopoiesis; cell adhesion; leukocyte migration
Reference #:  Q64314 (UniProtKB)
Alt. Names/Synonyms: AU040960; Cd34; CD34 antigen; cluster designation 34; Hematopoietic progenitor cell antigen CD34
Gene Symbols: Cd34
Molecular weight: 40,983 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
Select Structure to View Below

CD34

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S175-p IKGEIKCsGIREVRL
0 1 S195 LELSEASSCEEFKKE
0 1 R265 EKHQSDLRKLGIQSF
0 1 S279 FNKQDIGSHQSYSRK
0 1 Y283 DIGSHQSYSRKTLIA
1 0 S313-p YFLMNRRsWSPTGER
0 34 Y326-p ERLGEDPyyTENGGG
0 19 Y327-p RLGEDPyyTENGGGQ
0 2 T328 LGEDPyyTENGGGQG
0 16 Y336-p ENGGGQGyssGPGAs
1 1 S337-p NGGGQGyssGPGAsP
1 3 S338-p GGGQGyssGPGAsPE
1 7 S343-p yssGPGAsPETQGkA
0 1 K349-ub AsPETQGkANVTRGA
1 0 S371-p ATSRNGHsARQHVVA
  human

 
S178 IKAEIKCSGIREVKL
S198-p LEQNKTSsCAEFKKD
K268-ac KKHQSDLkKLGILDF
S282-p FTEQDVAsHQSySQK
Y286-p DVAsHQSySQKTLIA
S316 YFLMNRRSWSPTGER
Y329-p ERLGEDPyytENGGG
Y330-p RLGEDPyytENGGGQ
T331-p LGEDPyytENGGGQG
Y339-p ENGGGQGySsGPGTS
S340 NGGGQGySsGPGTSP
S341-p GGGQGySsGPGTSPE
S346 ySsGPGTSPEAQGKA
K352 TSPEAQGKASVNRGA
S374 ATSRNGHSARQHVVA
  rat

 
S179 IKGDIKCSGIRGVPF
S199 LELSEASSCEEFKKE
R269 EKHQSDLRKLGIQSF
S283 FNKQDLGSHQSYSRK
Y287 DLGSHQSYSRKTLIA
S317 YFLMNRRSWSPTGER
Y330 ERLGEDPYYTENGGG
Y331 RLGEDPYYTENGGGQ
T332 LGEDPYYTENGGGQG
Y340 ENGGGQGYSSGPGTs
S341 NGGGQGYSSGPGTsP
S342 GGGQGYSSGPGTsPE
S347-p YSSGPGTsPETQGKA
K353 TsPETQGKANVTRGA
S375 ATSRNGHSARQHVVA
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.