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Protein Page:
GABBR2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GABBR2 Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region. Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: Receptor, GPCR; GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: postsynaptic membrane; neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; cell junction
Molecular Function: protein binding; GABA-B receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; synaptic transmission; negative regulation of adenylate cyclase activity; gamma-aminobutyric acid signaling pathway
Reference #:  O75899 (UniProtKB)
Alt. Names/Synonyms: FLJ36928; G protein-coupled receptor 51; G-protein coupled receptor 51; GABA-B receptor 2; GABA-B receptor, R2 subunit; GABA-B-R2; GABA-BR2; GABABR2; GABBR2; GABR2; gamma-aminobutyric acid (GABA) B receptor, 2; Gamma-aminobutyric acid type B receptor subunit 2; Gb2; GPR51; GPRC3B; HG20; HRIHFB2099
Gene Symbols: GABBR2
Molecular weight: 105,821 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GABBR2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 6 T763 QNRRFQFTQNQKKED
0 1 K767 FQFTQNQKKEDSKTS
0 2 S771 QNQKKEDSKTSTSVT
0 1 T773 QKKEDSKTSTSVTSV
0 2 S776 EDSKTSTSVTSVNQA
0 2 T778 SKTSTSVTSVNQAST
0 3 S779 KTSTSVTSVNQASTS
3 0 S784 VTSVNQASTSRLEGL
0 1 K801 ENHRLRMKITELDKD
0 8 T819-p VTMQLQDtPEKTTYI
0 11 S884-p DPIEDINsPEHIQRR
2 1 S893 EHIQRRLSLQLPILH
0 1 S913 SIGGVDASCVSPCVS
0 2 S916 GVDASCVSPCVSPTA
0 1 S920 SCVSPCVSPTAsPRH
0 2 S924-p PCVSPTAsPRHRHVP
  mouse

 
T762-p QNRRFQFtQNQkKED
K766-u FQFtQNQkKEDsKtS
S770-p QNQkKEDsKtSTsVt
T772-p QkKEDsKtSTsVtsV
S775-p EDsKtSTsVtsVNQA
T777-p sKtSTsVtsVNQAsT
S778-p KtSTsVtsVNQAsTS
S783-p VtsVNQAsTSRLEGL
K800-u ENHRLRMkITELDKD
T818-p VTMQLQDtPEKTTYI
S883-p DPIEDINsPEHIQRR
S892-p EHIQRRLsLQLPILH
S912-p SIGGVDAsCVsPCVs
S915-p GVDAsCVsPCVsPTA
S919-p sCVsPCVsPTAsPRH
S923-p PCVsPTAsPRHRHVP
  rat

 
T762 QNRRFQFTQNQKKED
K766 FQFTQNQKKEDSKTS
S770 QNQKKEDSKTSTSVT
T772 QKKEDSKTSTSVTSV
S775 EDSKTSTSVTSVNQA
T777 SKTSTSVTSVNQAsT
S778 KTSTSVTSVNQAsTS
S783-p VTSVNQAsTSRLEGL
K800 ENHRLRMKITELDKD
T818 VTMQLQDTPEKTTYI
S883 DPIEDINSPEHIQRR
S892-p EHIQRRLsLQLPILH
S912 SIGGVDASCVSPCVS
S915 GVDASCVSPCVSPTA
S919 SCVSPCVSPTASPRH
S923 PCVSPTASPRHRHVP
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