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Protein Page:
TBC1D1 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TBC1D1 a putative GTPase activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin-specific protease; GAPs; GAPs, Rab
Cellular Component: nucleus
Molecular Function: Rab GTPase activator activity; GTPase activator activity
Biological Process: regulation of protein localization; regulation of Rab GTPase activity
Reference #:  Q60949 (UniProtKB)
Alt. Names/Synonyms: 1110062G02Rik; AI385682; AW555803; Kiaa1108; MGC106104; MGC144097; mKIAA1108; Tbc1; TBC1 domain family member 1; TBC1 domain family, member 1; Tbc1d1; TBCD1; tre-2/USP6, BUB2, cdc16) domain family, member 1
Gene Symbols: Tbc1d1
Molecular weight: 142,026 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TBC1D1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
activity, inhibited: T499‑p, S501‑p, T590‑p
phosphorylation: T590‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 11 Y113-p HNSHDPSyFACLIKE
0 1 S145-p TKVPEIIssIRQAGK
0 1 S146-p KVPEIIssIRQAGKI
0 1 S229-p GPRPMRKsFsQPGLR
5 90 S231-p RPMRKsFsQPGLRSL
1 5 T253-p DASLRSStFssFDND
0 2 S255-p SLRSStFssFDNDIE
0 11 S256-p LRSStFssFDNDIEN
0 1 S332-p GFICRECsGGGsGGF
0 1 S336-p RECsGGGsGGFHFVC
0 1 S489-p ASRFRLDsLKNRAKR
0 9 S497-p LKNRAKRsLtEsLEs
2 4 T499-p NRAKRsLtEsLEsIL
1 6 S501-p AKRsLtEsLEsILSR
0 1 S504-p sLtEsLEsILSRGNK
0 1 S519-p ARGLQDHsAsVDLDS
0 1 S521-p GLQDHsAsVDLDSST
0 1 S553 AFPVSETSFKLLGss
2 22 S559-p TSFKLLGssDDLssD
1 21 S560-p SFKLLGssDDLssDs
0 15 S564-p LGssDDLssDsEGHI
0 23 S565-p GssDDLssDsEGHIA
0 15 S567-p sDDLssDsEGHIAEE
0 6 - gap
0 1 S575-p EGHIAEEsALLsPQQ
0 33 S579-p AEEsALLsPQQAFRR
6 140 T590-p AFRRRANtLsHFPVE
0 42 S592-p RRRANtLsHFPVECP
0 11 S607-p APPEPAQssPGVsQR
0 47 S608-p PPEPAQssPGVsQRK
0 4 S612-p AQssPGVsQRKLMRY
1 43 S621-p RKLMRYHsVstETPH
0 1 S623-p LMRYHsVstETPHER
0 1 T624-p MRYHsVstETPHERN
2 4 S660-p PRLNPSAssPNFFKY
0 1 S661-p RLNPSAssPNFFKYL
0 1 S697-p ALRKKLHssssVPNF
0 1 S698-p LRKKLHssssVPNFL
0 1 S699-p RKKLHssssVPNFLK
2 4 S700-p KKLHssssVPNFLKF
0 5 T739-p HLGDTDGtPVKTRRH
0 5 S747 PVKTRRHSWRQQIFL
0 4 T758 QIFLRVATPQKACDS
0 2 S782-p LGELPPRsPLEPVCE
0 1 S1028-p QIQMYQLsRLLHDYH
0 1 Y1039-p HDYHRDLyNHLEEHE
0 1 K1179-u KTNSSLRkQNLDLLE
0 1 T1218-p KLKQAALtLEVERSA
0 2 S1237-p VEELRRQsARPstPE
0 2 S1241-p RRQsARPstPEPDCT
0 5 T1242-p RQsARPstPEPDCTQ
6929 : Phospho-TBC1D1 (Ser700) Antibody
  TBC1D1 iso2  
Y113 HNSHDPSYFACLIKE
S145 TKVPEIISSIRQAGK
S146 KVPEIISSIRQAGKI
S229 GPRPMRKSFSQPGLR
S231 RPMRKSFSQPGLRSL
T253 DASLRSSTFSSFDND
S255 SLRSSTFSSFDNDIE
S256 LRSSTFSSFDNDIEN
S332 GFICRECSGGGSGGF
S336 RECSGGGSGGFHFVC
S489 ASRFRLDSLKNRAKR
S497 LKNRAKRSLTESLES
T499 NRAKRSLTESLESIL
S501 AKRSLTESLESILSR
S504 SLTESLESILSRGNK
S519 ARGLQDHSASVDLDS
S521 GLQDHSASVDLDSST
S553 AFPVSETSFKLLGSS
S559 TSFKLLGSSDDLSSD
S560 SFKLLGSSDDLSSDS
S564 LGSSDDLSSDSEGHI
S565 GSSDDLSSDSEGHIA
S567 SDDLSSDSEGHIAEE
- gap
S575 EGHIAEESALLSPQQ
S579 AEESALLSPQQAFRR
T590 AFRRRANTLSHFPVE
S592 RRRANTLSHFPVECP
S607 APPEPAQSSPGVSQR
S608 PPEPAQSSPGVSQRK
S612 AQSSPGVSQRKLMRY
S621 RKLMRYHSVSTETPH
S623 LMRYHSVSTETPHER
T624 MRYHSVSTETPHERK
- gap
- gap
- gap
- gap
- gap
- gap
T646 HLGDTDGTPVKTRRH
S654 PVKTRRHSWRQQIFL
T665 QIFLRVATPQKACDS
S689 LGELPPRSPLEPVCE
S935 QIQMYQLSRLLHDYH
Y946 HDYHRDLYNHLEEHE
K1086 KTNSSLRKQNLDLLE
T1125 KLKQAALTLEVERSA
S1144 VEELRRQSARPSTPE
S1148 RRQSARPSTPEPDCT
T1149 RQSARPSTPEPDCTQ
  human

 
Y113-p HNSHDPSyFACLIKE
S145 TKVPEIISSIRQAGK
S146 KVPEIISSIRQAGKI
S235 VRRPMRKSFsQPGLR
S237-p RPMRKSFsQPGLRSL
- gap
S262 LRSSGFFSsFEESDI
S263-p RSSGFFSsFEESDIE
S340 GFICRESSGGGGFHF
- gap
- gap
S503-p LKNKAKRsLTEsLES
T505 NKAKRsLTEsLESIL
S507-p AKRsLTEsLESILSR
S510 sLTEsLESILSRGNK
S525 ARGLQEHSISVDLDS
S527 GLQEHSISVDLDSSL
S559-p ALPISESsFKLLGss
S565-p SsFKLLGssEDLssD
S566-p sFKLLGssEDLssDs
S570-p LGssEDLssDsEsHL
S571-p GssEDLssDsEsHLP
S573-p sEDLssDsEsHLPEE
S575-p DLssDsEsHLPEEPA
- gap
S585-p PEEPAPLsPQQAFRR
T596-p AFRRRANtLsHFPIE
S598-p RRRANtLsHFPIECQ
G613 EPPQPARGsPGVsQR
S614-p PPQPARGsPGVsQRK
S618-p ARGsPGVsQRKLMRY
S627-p RKLMRYHsVSTETPH
S629 LMRYHsVSTETPHER
T630 MRYHsVSTETPHERK
- gap
- gap
- gap
- gap
- gap
- gap
T652-p HLGDSGGtPVKTRRH
S660-p PVKTRRHsWRQQIFL
T671-p QIFLRVAtPQKACDS
S695 LGELPPRSPLEPVCE
S941 QIQMYQLSRLLHDYH
Y952 HDYHRDLYNHLEEHE
K1092 KTNSSLRKQNLDLLE
T1131 KLKQAMLTLELERSA
S1150 VEELRRRSAEPSDRE
S1154 RRRSAEPSDREPECT
D1155 RRSAEPSDREPECTQ
  rat

 
Y113 HNSQDPSYFACLIKE
S145 TKVPEIISSIRQAGK
S146 KVPEIISSIRQAGKI
S229 GARPMRKSFsQPGLR
S231-p RPMRKSFsQPGLRSL
T253 DASLRSSTFSSFDND
S255 SLRSSTFSSFDNDIE
S256 LRSSTFSSFDNDIEN
S332 GFICRECSGGGGAGF
G336 RECSGGGGAGFHFVC
S489 ASRFRLDSLKNRAKR
S497 LKNRAKRSLTESLES
T499 NRAKRSLTESLESIL
S501 AKRSLTESLESILSR
S504 SLTESLESILSRGNK
S519 ARGLQDHSASVDLDS
S521 GLQDHSASVDLDSST
S553 ALPISESSFKLLGSS
S559 SSFKLLGSSDDLSSD
S560 SFKLLGSSDDLSSDS
S564 LGSSDDLSSDSESHI
S565 GSSDDLSSDSESHIA
S567 SDDLSSDSESHIAEE
S569 DLSSDSESHIAEESA
S575 ESHIAEESALLSPQQ
S579 AEESALLSPQQAFRR
T590 AFRRRANTLSHFPVE
S592 RRRANTLSHFPVECP
T607 APPEPAQTSPGVSQR
S608 PPEPAQTSPGVSQRK
S612 AQTSPGVSQRKLMRY
S621 RKLMRYHSVSTETPH
S623 LMRYHSVSTETPHER
T624 MRYHSVSTETPHERN
S662 PRLNPSASSPNFFKY
S663 RLNPSASSPNFFKYL
S699 ALRKKLHSSSSVPNF
S700 LRKKLHSSSSVPNFL
S701 RKKLHSSSSVPNFLK
S702 KKLHSSSSVPNFLKF
T741 HLGDTDGTPVKARRH
S749 PVKARRHSWRQQIFL
T760 QIFLRVATPQKACDS
S784 LGELPPRSPLEPVCE
S1030 QIQMYQLSRLLHDYH
Y1041 HDYHRDLYNHLEEYE
K1181 KTNSSLRKQNLDLLE
T1220 KLKQAVLTLEMERSA
M1239 VEELRRQMAQPSTAE
S1243 RRQMAQPSTAEPDCT
T1244 RQMAQPSTAEPDCTR
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