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TBC1D1 (mouse)

Overview TBC1D1 a putative GTPase activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Note: This description may include information from UniProtKB. Protein type: Ubiquitin-specific protease; GTPase activating protein, Rab Cellular Component: intracellular; nucleus Molecular Function: Rab GTPase activator activity; GTPase activator activity Biological Process: regulation of protein localization; regulation of Rab GTPase activity Reference #:  Q60949 (UniProtKB) Alt. Names/Synonyms: 1110062G02Rik; AI385682; AW555803; Kiaa1108; MGC106104; MGC144097; mKIAA1108; Tbc1; TBC1 domain family member 1; TBC1 domain family, member 1; Tbc1d1; TBCD1; tre-2/USP6, BUB2, cdc16) domain family, member 1 Gene Symbols: Tbc1d1 Molecular weight: 142,026 Da Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states CST Pathways:  Insulin Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TBC1D1 3QYE - A/B=750-1076 (human)

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	Sites Implicated In
inhibition: T499‑p, S501‑p, T590‑p phosphorylation: T590‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse ► Hide Isoforms
0	1		C90	QPWDPLICSSIFECK
0	11		Y113-p	HNSHDPSyFACLIKE
0	1		S145-p	TKVPEIIssIRQAGK
0	1		S146-p	KVPEIIssIRQAGKI
0	1		S163-p	QEELRCPsEFDDTFA
0	1		S229-p	GPRPMRKsFsQPGLR
4	87		S231-p	RPMRKsFsQPGLRSL
1	5		T253-p	DASLRSStFssFDND
0	2		S255-p	SLRSStFssFDNDIE
0	11		S256-p	LRSStFssFDNDIEN
0	1		S332-p	GFICRECsGGGsGGF
0	1		S336-p	RECsGGGsGGFHFVC
0	1		S402	RIEGMNSSKTKLELQ
0	1		T404	EGMNSSKTKLELQKH
0	1		S489-p	ASRFRLDsLKNRAKR
0	1		K491	RFRLDsLKNRAKRsL
0	1		K495	DsLKNRAKRsLtEsL
0	9		S497-p	LKNRAKRsLtEsLEs
2	4		T499-p	NRAKRsLtEsLEsIL
1	6		S501-p	AKRsLtEsLEsILSR
0	1		S504-p	sLtEsLEsILSRGNK
0	1		S507	EsLEsILSRGNKARG
0	1		S519-p	ARGLQDHsAsVDLDS
0	1		S521-p	GLQDHsAsVDLDSST
0	1		S553	AFPVSETSFKLLGss
2	22		S559-p	TSFKLLGssDDLssD
1	21		S560-p	SFKLLGssDDLssDs
0	15		S564-p	LGssDDLssDsEGHI
0	23		S565-p	GssDDLssDsEGHIA
0	15		S567-p	sDDLssDsEGHIAEE
0	6		G569	DLssDsEGHIAEEsA
0	1		S575-p	EGHIAEEsALLsPQQ
0	33		S579-p	AEEsALLsPQQAFRR
5	140		T590-p	AFRRRANtLsHFPVE
0	42		S592-p	RRRANtLsHFPVECP
0	11		S607-p	APPEPAQssPGVSQR
0	47		S608-p	PPEPAQssPGVSQRK
0	4		S612	AQssPGVSQRKLMRY
1	43		S621-p	RKLMRYHsVstETPH
0	1		S623-p	LMRYHsVstETPHER
0	1		T624-p	MRYHsVstETPHERN
1	4		S660-p	PRLNPSAssPNFFKY
0	1		S661-p	RLNPSAssPNFFKYL
0	1		K669-m1	PNFFKYLkHNSSGEQ
0	1		S697-p	ALRKKLHssssVPNF
0	1		S698-p	LRKKLHssssVPNFL
0	1		S699-p	RKKLHssssVPNFLK
1	4		S700-p	KKLHssssVPNFLKF
0	5		T739-p	HLGDTDGtPVKTRRH
0	5		S747	PVKTRRHSWRQQIFL
0	4		T758	QIFLRVATPQKACDS
0	2		S782-p	LGELPPRsPLEPVCE
0	1		K913	LKHPFPSKQQPKDVP
0	1		K917	FPSKQQPKDVPYKEL
0	1		Y967	LYNILKAYSLLDQEV
0	1		S1028-p	QIQMYQLsRLLHDYH
0	1		Y1039-p	HDYHRDLyNHLEEHE
0	1		K1179-u	KTNSSLRkQNLDLLE
0	1		T1218-p	KLKQAALtLEVERSA
0	1		S1224	LtLEVERSALLQMVE
0	2		S1237-p	VEELRRQsARPstPE
0	2		S1241-p	RRQsARPstPEPDCT
0	5		T1242-p	RQsARPstPEPDCTQ

	TBC1D1 iso2
C90	QPWDPLICSSIFECK
Y113	HNSHDPSYFACLIKE
S145	TKVPEIISSIRQAGK
S146	KVPEIISSIRQAGKI
S163	QEELRCPSEFDDTFA
S229	GPRPMRKSFSQPGLR
S231	RPMRKSFSQPGLRSL
T253	DASLRSSTFSSFDND
S255	SLRSSTFSSFDNDIE
S256	LRSSTFSSFDNDIEN
S332	GFICRECSGGGSGGF
S336	RECSGGGSGGFHFVC
S402	RIEGMNSSKTKLELQ
T404	EGMNSSKTKLELQKH
S489	ASRFRLDSLKNRAKR
K491	RFRLDSLKNRAKRSL
K495	DSLKNRAKRSLTESL
S497	LKNRAKRSLTESLES
T499	NRAKRSLTESLESIL
S501	AKRSLTESLESILSR
S504	SLTESLESILSRGNK
S507	ESLESILSRGNKARG
S519	ARGLQDHSASVDLDS
S521	GLQDHSASVDLDSST
S553	AFPVSETSFKLLGSS
S559	TSFKLLGSSDDLSSD
S560	SFKLLGSSDDLSSDS
S564	LGSSDDLSSDSEGHI
S565	GSSDDLSSDSEGHIA
S567	SDDLSSDSEGHIAEE
G569	DLSSDSEGHIAEESA
S575	EGHIAEESALLSPQQ
S579	AEESALLSPQQAFRR
T590	AFRRRANTLSHFPVE
S592	RRRANTLSHFPVECP
S607	APPEPAQSSPGVSQR
S608	PPEPAQSSPGVSQRK
S612	AQSSPGVSQRKLMRY
S621	RKLMRYHSVSTETPH
S623	LMRYHSVSTETPHER
T624	MRYHSVSTETPHERK
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
T646	HLGDTDGTPVKTRRH
S654	PVKTRRHSWRQQIFL
T665	QIFLRVATPQKACDS
S689	LGELPPRSPLEPVCE
K820	LKHPFPSKQQPKDVP
K824	FPSKQQPKDVPYKEL
Y874	LYNILKAYSLLDQEV
S935	QIQMYQLSRLLHDYH
Y946	HDYHRDLYNHLEEHE
K1086	KTNSSLRKQNLDLLE
T1125	KLKQAALTLEVERSA
S1131	LTLEVERSALLQMVE
S1144	VEELRRQSARPSTPE
S1148	RRQSARPSTPEPDCT
T1149	RQSARPSTPEPDCTQ

	human
Y90-p	QQWDPLIySSIFECK
Y113-p	HNSHDPSyFACLIKE
S145	TKVPEIISSIRQAGK
S146	KVPEIISSIRQAGKI
S163	QEELHCPSEFDDTFS
S235	VRRPMRKSFsQPGLR
S237-p	RPMRKSFsQPGLRSL
F260	GGLRSSGFFSsFEES
S262	LRSSGFFSsFEESDI
S263-p	RSSGFFSsFEESDIE
S340	GFICRESSGGGGFHF
-	gap
S408-p	RIEGMNSsKtKLELQ
T410-p	EGMNSsKtKLELQKH
M495	ATRFRLDMLkNKAkR
K497-a	RFRLDMLkNKAkRsL
K501-a	DMLkNKAkRsLTEsL
S503-p	LkNKAkRsLTEsLES
T505	NKAkRsLTEsLESIL
S507-p	AkRsLTEsLESILsR
S510	sLTEsLESILsRGNK
S513-p	EsLESILsRGNKARG
S525	ARGLQEHSISVDLDS
S527	GLQEHSISVDLDSSL
S559-p	ALPISESsFKLLGss
S565-p	SsFKLLGssEDLssD
S566-p	sFKLLGssEDLssDs
S570-p	LGssEDLssDsEsHL
S571-p	GssEDLssDsEsHLP
S573-p	sEDLssDsEsHLPEE
S575-p	DLssDsEsHLPEEPA
P581	EsHLPEEPAPLsPQQ
S585-p	PEEPAPLsPQQAFRR
T596-p	AFRRRANtLsHFPIE
S598-p	RRRANtLsHFPIECQ
G613	EPPQPARGsPGVsQR
S614-p	PPQPARGsPGVsQRK
S618-p	ARGsPGVsQRKLMRY
S627-p	RKLMRYHsVSTETPH
S629	LMRYHsVSTETPHER
T630	MRYHsVSTETPHERK
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
T652-p	HLGDSGGtPVKTRRH
S660-p	PVKTRRHsWRQQIFL
T671-p	QIFLRVAtPQKACDS
S695	LGELPPRSPLEPVCE
K826	LKHQFPSKQQPKDVP
K830	FPSKQQPKDVPYKEL
Y880-p	LYNILKAySLLDQEV
S941	QIQMYQLSRLLHDYH
Y952	HDYHRDLYNHLEEHE
K1092	KTNSSLRKQNLDLLE
T1131	KLKQAMLTLELERsA
S1137-p	LTLELERsALLQTVE
S1150	VEELRRRSAEPSDRE
S1154	RRRSAEPSDREPECT
D1155	RRSAEPSDREPECTQ

	rat
C90	QPWDPLICSSIFECK
Y113	HNSQDPSYFACLIKE
S145	TKVPEIISSIRQAGK
S146	KVPEIISSIRQAGKI
S163	QEELRCPSEFDDTFA
S229	GARPMRKSFsQPGLR
S231-p	RPMRKSFsQPGLRSL
T253	DASLRSSTFSSFDND
S255	SLRSSTFSSFDNDIE
S256	LRSSTFSSFDNDIEN
S332	GFICRECSGGGGAGF
G336	RECSGGGGAGFHFVC
S402	RIEGMNSSKTKLELQ
T404	EGMNSSKTKLELQKH
S489	ASRFRLDSLKNRAKR
K491	RFRLDSLKNRAKRSL
K495	DSLKNRAKRSLTESL
S497	LKNRAKRSLTESLES
T499	NRAKRSLTESLESIL
S501	AKRSLTESLESILSR
S504	SLTESLESILSRGNK
S507	ESLESILSRGNKARG
S519	ARGLQDHSASVDLDS
S521	GLQDHSASVDLDSST
S553	ALPISESSFKLLGSS
S559	SSFKLLGSSDDLSSD
S560	SFKLLGSSDDLSSDS
S564	LGSSDDLSSDSESHI
S565	GSSDDLSSDSESHIA
S567	SDDLSSDSESHIAEE
S569	DLSSDSESHIAEESA
S575	ESHIAEESALLSPQQ
S579	AEESALLSPQQAFRR
T590	AFRRRANTLSHFPVE
S592	RRRANTLSHFPVECP
T607	APPEPAQTSPGVSQR
S608	PPEPAQTSPGVSQRK
S612	AQTSPGVSQRKLMRY
S621	RKLMRYHSVSTETPH
S623	LMRYHSVSTETPHER
T624	MRYHSVSTETPHERN
-	gap
S663	RLNPSASSPNFFKYL
-	gap
S699	ALRKKLHSSSSVPNF
S700	LRKKLHSSSSVPNFL
S701	RKKLHSSSSVPNFLK
-	gap
T741	HLGDTDGTPVKARRH
S749	PVKARRHSWRQQIFL
T760	QIFLRVATPQKACDS
S784	LGELPPRSPLEPVCE
K915-u	LKHPFPSkQQPkDVP
K919-u	FPSkQQPkDVPYKEL
Y969	LYNILKAYSLLDQEV
S1030	QIQMYQLSRLLHDYH
Y1041	HDYHRDLYNHLEEYE
K1181	KTNSSLRKQNLDLLE
T1220	KLKQAVLTLEMERSA
S1226	LTLEMERSALLQMVE
M1239	VEELRRQMAQPSTAE
S1243	RRQMAQPSTAEPDCT
T1244	RQMAQPSTAEPDCTR

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