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PIP4K2A (human)

Overview PIP4K2A Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Kinase, lipid; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; EC 2.7.1.68 Cellular Component: plasma membrane; nucleus; cytosol Molecular Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding Biological Process: phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphorylation Reference #:  P48426 (UniProtKB) Alt. Names/Synonyms: 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-4-phosphate-5-kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha; Diphosphoinositide kinase 2-alpha; FLJ13267; phosphatidylinositol-4-phosphate 5-kinase, type II, alpha; Phosphatidylinositol-5-phosphate 4-kinase type II alpha; Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha; phosphatidylinositol-5-phosphate 4-kinase, type II, alpha; PI(5)P 4-kinase type II alpha; PI42A; PI5P4KA; PIP4K2A; PIP4KII-alpha; PIP5K2; PIP5K2A; PIP5KII-alpha; PIP5KIIA; PIP5KIIalpha; PIP5KIII; PIPK; PtdIns(4)P-5-kinase B isoform; PtdIns(4)P-5-kinase C isoform; PtdIns(5)P-4-kinase isoform 2-alpha; type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform Gene Symbols: PIP4K2A Molecular weight: 46,225 Da Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states CST Pathways:  PI3K/Akt Signaling  |  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PIP4K2A 2YBX - A/B=35-405 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME 2.7.1.149 2.7.1.68  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, inhibited: T376‑p intracellular localization: S304‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		T3-p	_____MAtPGNLGSs
0	2		S10-p	tPGNLGSsVLAsKTK
0	4		S14-p	LGSsVLAsKTKTKKK
0	1		K81	VDNHLFNKENMPSHF
0	1		K89-a	ENMPSHFkFKEyCPM
0	33		Y93-p	SHFkFKEyCPMVFRN
0	1		K145-a	YDKRYIIkTITSEDV
0	1		K160	AEMHNILKKYHQYIV
0	3		Y246-p	INEGQKIyIDDNNKK
1	0		S304-p	DGEEEGEsDGTHPVG
0	9		K367-a	ILTHYDAkKKAAHAA
1	0		T376-p	KAAHAAKtVKHGAGA

	mouse
T3	_____MATPGNLGSs
S10-p	TPGNLGSsVLAsKTK
S14-p	LGSsVLAsKTKTKKK
K81-u	VDNHLFNkENMPSHF
K89	ENMPSHFKFKEyCPM
Y93-p	SHFKFKEyCPMVFRN
K145	YDKRYVIKTITSEDV
K160-u	AEMHNILkKYHQYIV
Y246	INEGQKIYIDDNNKK
S304	DGEEEGESDSTHPIG
K367	ILTHYDAKKKAAHAA
T376	KAAHAAKTVKHGAGA

	rat
T3	_____MATPSNLGSS
S10	TPSNLGSSVLASKTK
S14	LGSSVLASKTKTKKK
K81	VDNHLFNKENMPSHF
K89	ENMPSHFKFKEYCPM
Y93	SHFKFKEYCPMVFRN
K145	YDKRYVIKTITSEDV
K160	AEMHNILKKYHQYIV
Y246	INEGQKIYIDDSNKK
S304	EGEEEGESDGAHPIG
K367	ILTHYDAKKKAAHAA
T376	KAAHAAKTVKHGAGA

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