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Protein Page:
PIP4K2A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PIP4K2A Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis
Cellular Component: plasma membrane; cytosol; nucleus
Molecular Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding
Biological Process: phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process
Reference #:  P48426 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-4-phosphate-5-kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha; Diphosphoinositide kinase 2-alpha; FLJ13267; phosphatidylinositol-4-phosphate 5-kinase, type II, alpha; Phosphatidylinositol-5-phosphate 4-kinase type II alpha; Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha; phosphatidylinositol-5-phosphate 4-kinase, type II, alpha; PI(5)P 4-kinase type II alpha; PI42A; PI5P4KA; PIP4K2A; PIP4KII-alpha; PIP5K2; PIP5K2A; PIP5KII-alpha; PIP5KIIA; PIP5KIIalpha; PIP5KIII; PIPK; PtdIns(4)P-5-kinase B isoform; PtdIns(4)P-5-kinase C isoform; PtdIns(5)P-4-kinase isoform 2-alpha; type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform
Gene Symbols: PIP4K2A
Molecular weight: 46,225 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PIP4K2A

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, inhibited: T376‑p
intracellular localization: S304‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 T3-p _____MAtPGNLGSs
0 3 S10-p tPGNLGSsVLAsKTK
0 5 S14-p LGSsVLAsKTKTKKK
0 1 K89-a ENMPSHFkFKEyCPM
0 33 Y93-p SHFkFKEyCPMVFRN
0 1 K145-a YDKRYIIkTITSEDV
0 1 K160 AEMHNILKKYHQYIV
0 3 Y246-p INEGQKIyIDDNNKK
1 0 S304-p DGEEEGEsDGTHPVG
0 9 K367-a ILTHYDAkKKAAHAA
1 0 T376-p KAAHAAKtVKHGAGA
  mouse

 
T3 _____MATPGNLGSs
S10-p TPGNLGSsVLAsKTK
S14-p LGSsVLAsKTKTKKK
K89 ENMPSHFKFKEyCPM
Y93-p SHFKFKEyCPMVFRN
K145 YDKRYVIKTITSEDV
K160-u AEMHNILkKYHQYIV
Y246 INEGQKIYIDDNNKK
S304 DGEEEGESDSTHPIG
K367 ILTHYDAKKKAAHAA
T376 KAAHAAKTVKHGAGA
  rat

 
T3 _____MATPSNLGSS
S10 TPSNLGSSVLASKTK
S14 LGSSVLASKTKTKKK
K89 ENMPSHFKFKEYCPM
Y93 SHFKFKEYCPMVFRN
K145 YDKRYVIKTITSEDV
K160 AEMHNILKKYHQYIV
Y246 INEGQKIYIDDSNKK
S304 EGEEEGESDGAHPIG
K367 ILTHYDAKKKAAHAA
T376 KAAHAAKTVKHGAGA
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