Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Belongs to the small GTPase superfamily. RGK family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric, RGK; G protein; G protein, monomeric
Chromosomal Location of Human Ortholog: 8q13-q21
Cellular Component: internal side of plasma membrane; spindle midzone; midbody; nucleus
Molecular Function: calmodulin binding; GTPase activity; protein binding; GDP binding; GTP binding; magnesium ion binding
Biological Process: mitosis; cell surface receptor linked signal transduction; GTP catabolic process; small GTPase mediated signal transduction; metaphase plate congression; immune response; signal transduction; chromosome organization and biogenesis
Alt. Names/Synonyms: GEM; GTP binding protein overexpressed in skeletal muscle; GTP-binding mitogen-induced T-cell protein; GTP-binding protein GEM; GTP-binding protein overexpressed in skeletal muscle; kinase-inducible Ras-like protein; KIR; MGC26294; RAS-like protein KIR
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.