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Protein Page:
GEM (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GEM Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Belongs to the small GTPase superfamily. RGK family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein; G protein, monomeric, RGK
Cellular Component: internal side of plasma membrane; midbody; spindle midzone; nucleus
Molecular Function: GTPase activity; calmodulin binding; protein binding; GDP binding; GTP binding; magnesium ion binding
Biological Process: mitosis; cell surface receptor linked signal transduction; small GTPase mediated signal transduction; metaphase plate congression; immune response; signal transduction; chromosome organization and biogenesis
Reference #:  P55040 (UniProtKB)
Alt. Names/Synonyms: GEM; GTP binding protein overexpressed in skeletal muscle; GTP-binding mitogen-induced T-cell protein; GTP-binding protein GEM; GTP-binding protein overexpressed in skeletal muscle; kinase-inducible Ras-like protein; KIR; MGC26294; RAS-like protein KIR
Gene Symbols: GEM
Molecular weight: 33,949 Da
Basal Isoelectric point: 8.77  Predict pI for various phosphorylation states
Select Structure to View Below

GEM

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: S23‑p
cytoskeletal reorganization: S23‑p, S261‑p, S289‑p
intracellular localization: S261‑p
molecular association, regulation: S23‑p, S261‑p, S287‑p, S289‑p
protein stabilization: S23‑p, S289‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 6 S23-p QPQQQRWsIPADGRH
2 0 S261-p AYQKRKEsMPRKARR
0 1 K276-a FWGKIVAkNNkNMAF
0 1 K279-a KIVAkNNkNMAFKLK
2 1 S287-p NMAFKLKsKsCHDLS
2 5 S289-p AFKLKsKsCHDLSVL
  mouse

 
S22-p MQPQQRWsIPADARH
S260 AYQKRRESIPRKARR
K275 FWGKIVAKNNKNMAF
K278 KIVAKNNKNMAFKLK
S286-p NMAFKLKsKsCHDLS
S288-p AFKLKsKsCHDLSVL
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