a cytoplasmic type-III RNase that plays a central role in RNA interference (RNAi) pathways to produce the active small RNAs that represses gene expression. Possesses a DEAD box RNA helicase motif in its amino terminus and a dsRNA-binding motif in the carboxy terminus. Dicer, along with Ago2 andTRBP, are the main components of the RNA-induced silencing complex (RISC). Fragile X syndrome repeats form RNA hairpins that are cut by Dicer but do not activate the interferon-inducible protein kinase, PKR. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: RNA processing; EC 3.1.26.; EC 3.1.26.-; Ribonuclease; Helicase; Cell development/differentiation; RNA binding protein
Cellular Component: cytosol
Molecular Function: protein binding; miRNA binding; ribonuclease III activity; metal ion binding; double-stranded RNA binding; ATP-dependent helicase activity; ATP binding
Biological Process: zygote asymmetric cell division; apoptosis; regulation of cell cycle; regulation of neuron differentiation; regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; olfactory bulb interneuron differentiation; embryonic hindlimb morphogenesis; post-embryonic development; cardiac muscle cell development; pre-microRNA processing; angiogenesis; defense response to virus; regulation of viral genome replication; positive regulation of myelination; spleen development; positive regulation of Schwann cell differentiation; hair follicle morphogenesis; multicellular organism growth; RNA interference, targeting of mRNA for destruction; stem cell maintenance; spindle assembly; spinal cord motor neuron differentiation; miRNA-mediated gene silencing, production of miRNAs; myelin formation in the peripheral nervous system; branching morphogenesis of a tube; nerve development; positive regulation of transcription from RNA polymerase II promoter; gene expression; cerebral cortex development; RNA interference, production of siRNA; neurite morphogenesis; lung development; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.