Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Dicer1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Dicer1 a cytoplasmic type-III RNase that plays a central role in RNA interference (RNAi) pathways to produce the active small RNAs that represses gene expression. Possesses a DEAD box RNA helicase motif in its amino terminus and a dsRNA-binding motif in the carboxy terminus. Dicer, along with Ago2 andTRBP, are the main components of the RNA-induced silencing complex (RISC). Fragile X syndrome repeats form RNA hairpins that are cut by Dicer but do not activate the interferon-inducible protein kinase, PKR. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: RNA processing; EC 3.1.26.; EC 3.1.26.-; Ribonuclease; Helicase; Cell development/differentiation; RNA binding protein
Cellular Component: cytosol
Molecular Function: protein binding; miRNA binding; ribonuclease III activity; metal ion binding; double-stranded RNA binding; ATP-dependent helicase activity; ATP binding
Biological Process: zygote asymmetric cell division; apoptosis; regulation of cell cycle; regulation of neuron differentiation; regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; olfactory bulb interneuron differentiation; embryonic hindlimb morphogenesis; post-embryonic development; cardiac muscle cell development; pre-microRNA processing; angiogenesis; defense response to virus; regulation of viral genome replication; positive regulation of myelination; spleen development; positive regulation of Schwann cell differentiation; hair follicle morphogenesis; multicellular organism growth; RNA interference, targeting of mRNA for destruction; stem cell maintenance; spindle assembly; spinal cord motor neuron differentiation; miRNA-mediated gene silencing, production of miRNAs; myelin formation in the peripheral nervous system; branching morphogenesis of a tube; nerve development; positive regulation of transcription from RNA polymerase II promoter; gene expression; cerebral cortex development; RNA interference, production of siRNA; neurite morphogenesis; lung development; negative regulation of apoptosis
Reference #:  Q9UPY3 (UniProtKB)
Alt. Names/Synonyms: DCR1; DICER; dicer 1, double-stranded RNA-specific endoribonuclease; dicer 1, ribonuclease type III; DICER1; Dicer1, Dcr-1 homolog; Endoribonuclease Dicer; Helicase MOI; Helicase with RNase motif; helicase-moi; HERNA; K12H4.8-LIKE; KIAA0928
Gene Symbols: DICER1
Molecular weight: 218,682 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Dicer1
Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 S82-p VLLTKELsYQIRGDF
0 1 T238-p KSNAETAtDLVVLDR
0 11 S397-p YERQQFEsVEWYNNR
0 2 S413-p QDNYVSWsDsEDDDE
0 2 S415-p NYVSWsDsEDDDEDE
0 1 Y452-p IIFVERRyTAVVLNR
0 1 Y546-p LPTEYRSyVQSKGRA
0 1 K652 PFTHLAPKCRTRELP
0 5 Y664-p ELPDGTFySTLyLPI
0 2 Y668-p GTFySTLyLPINSPL
0 1 Y819-p QIPHFPVytRsGEVt
0 2 T820-p IPHFPVytRsGEVtI
0 1 S822-p HFPVytRsGEVtIsI
0 1 T826-p ytRsGEVtIsIELKK
0 1 S828-p RsGEVtIsIELKKSG
0 1 Y946 FDQPHRFYVADVYTD
0 1 Y951 RFYVADVYTDLTPLS
0 1 T974 TFAEYYKTKYNLDLT
0 1 Y976 AEYYKTKYNLDLTNL
0 1 T981 TKYNLDLTNLNQPLL
0 1 T993 PLLDVDHTSSRLNLL
0 1 S994 LLDVDHTSSRLNLLT
0 1 S995 LDVDHTSSRLNLLTP
0 1 S1016-p GKALPLSsAEKRKAK
0 1 Y1091-p SLPADFRyPNLDFGW
0 2 Y1121-p SSAENDNyCKHSTIV
0 1 S1142-p QGANRTSsLENHDQM
0 1 S1160-p CRTLLSEsPGKLHVE
0 8 Y1204-p CQGNQLNyYKQEIPV
0 5 Y1330-p LKHAITTyLFCTYPD
0 1 K1391-a GYVVNQDkSNTDKWE
0 199 Y1438-p APKEEADyEDDFLEy
0 136 Y1445-p yEDDFLEyDQEHIRF
0 1 K1466 GSGAFVKKIsLsPFS
0 2 S1468-p GAFVKKIsLsPFSTT
0 6 S1470-p FVKKIsLsPFSTTDS
0 8 Y1479-p FSTTDSAyEWKMPKK
0 1 S1814 AMGDIFESLAGAIYM
0 1 Y1820 ESLAGAIYMDSGMSL
0 1 S1823 AGAIYMDSGMSLETV
0 2 S1852-p FSANVPRsPVRELLE
  mouse

 
A82 VLLTKELAHQIRGDL
T238 RSDAETATDLVVLDR
S397 YERQQFESVEWYNNR
S413 QDNYVSWSDSEDDDD
S415 NYVSWSDSEDDDDDE
Y452 IIFVERRYTAVVLNR
Y546 LPTEYRSYVQSKGRA
K652-u PFTHLAPkCRTRELP
Y664 ELPDGTFYSTLYLPI
Y668 GTFYSTLYLPINSPL
Y819 QIPHFPVYTRSGEVT
T820 IPHFPVYTRSGEVTI
S822 HFPVYTRSGEVTISI
T826 YTRSGEVTISIELKK
S828 RSGEVTISIELKKSG
Y946 FDQPHRFYVADVYTD
Y951 RFYVADVYTDLTPLS
T974 TFAEYYKTKYNLDLT
Y976 AEYYKTKYNLDLTNL
T981 TKYNLDLTNLNQPLL
T993 PLLDVDHTSSRLNLL
S994 LLDVDHTSSRLNLLT
S995 LDVDHTSSRLNLLTP
S1016 GKALPLSSAEKRKAK
Y1091 SLPVDFRYPNLDFGW
Y1121 SLAESDNYCKHSTTV
S1142 HQGATRPSLENHDQM
S1160 CKRLPAESPAKLQSE
Y1204 CQGNQLNYFKQEIPV
Y1330 LKHAITTYLFCTYPD
K1391 GYVVNQDKSNSEKWE
D1434 APKEEAEDEDDFLEY
Y1441 DEDDFLEYDQEHIQF
K1462-u GSGAFVRkIsLsPFS
S1464-p GAFVRkIsLsPFSAS
S1466-p FVRkIsLsPFSASDS
Y1475 FSASDSAYEWKMPKK
S1808-p AMGDIFEsLAGAIyM
Y1814-p EsLAGAIyMDsGMSL
S1817-p AGAIyMDsGMSLEVV
S1846-p FSANVPRsPVRELLE
  rat

 
A82 VLLTKELAHQIRGDL
T238 KSGAETATDLVVLDR
S397 YERQQFESVEWYNNR
S413 QDNYVSWSDSEDDDD
S415 NYVSWSDSEDDDDDE
Y452 IIFVERRYTAVVLNR
Y546-p LPTEYRSyVQSKGRA
K652 PFTHLAPKCRTRELP
Y664 ELPDGTFYSTLYLPI
Y668 GTFYSTLYLPINSPL
Y819 QIPHFPVYTRSGEVT
T820 IPHFPVYTRSGEVTI
S822 HFPVYTRSGEVTISI
T826 YTRSGEVTISIELKK
S828 RSGEVTISIELKKSG
Y946-p FDQPHRFyVADVyTD
Y951-p RFyVADVyTDLTPLS
T974-p TFAEYYKtKyNLDLt
Y976-p AEYYKtKyNLDLtNL
T981-p tKyNLDLtNLNQPLL
T993-p PLLDVDHtssRLNLL
S994-p LLDVDHtssRLNLLT
S995-p LDVDHtssRLNLLTP
S1016 GKALPLSSAEKRKAK
Y1091 SLPADFRYPNLDFGW
Y1121 SLAESDNYCKHSTTV
S1142 HQGATRPSLENHDQM
S1160 CKRLPAESPAKLQSE
Y1204 CQGNQLTYFKQEIPV
Y1330 LKHAITTYLFCTYPD
K1391 GYVVNQDKSNSEKWE
Y1436 APKEEAEYEDDLLEY
Y1443 YEDDLLEYDQEHIQF
K1464 GSGAFVKKIPLSPFS
P1466 GAFVKKIPLSPFSTS
S1468 FVKKIPLSPFSTSDS
Y1477 FSTSDSAYEWKMPKK
S1810 AMGDIFESLAGAIYM
Y1816 ESLAGAIYMDSGMSL
S1819 AGAIYMDSGMSLEVV
S1848 FSANVPRSPVRELLE
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.