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Protein Page:
EML4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EML4 a microtubule-associated protein. A WD-repeat protein associated with the mitotic spindle apparatus. May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. Strongly overexpressed during mitosis. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: microtubule; cytoplasm
Biological Process: mitosis; negative regulation of microtubule depolymerization; microtubule-based process
Reference #:  Q9HC35 (UniProtKB)
Alt. Names/Synonyms: C2orf2; DKFZp686P18118; echinoderm microtubule associated protein like 4; Echinoderm microtubule-associated protein-like 4; ELP120; EMAL4; EMAP-4; EMAPL4; EML4; FLJ10942; FLJ32318; Restrictedly overexpressed proliferation-associated protein; Ropp 120; ROPP120
Gene Symbols: EML4
Molecular weight: 108,916 Da
Basal Isoelectric point: 5.96  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EML4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S7-p _MDGFAGsLDDsIsA
0 3 S11-p FAGsLDDsIsAAsTs
0 1 S13-p GsLDDsIsAAsTsDV
0 1 S16-p DDsIsAAsTsDVQDR
0 1 S18-p sIsAAsTsDVQDRLs
0 1 S25-p sDVQDRLsALEsRVQ
0 1 S29-p DRLsALEsRVQQQED
0 1 K42-ub EDEITVLkAALADVL
0 4 S61-p ISEDHVAsVKKsVSs
0 1 S65-p HVAsVKKsVSsKGQP
0 1 S68-p sVKKsVSsKGQPsPR
0 1 S73-p VSsKGQPsPRAVIPM
0 2 P79 PsPRAVIPMSCITNG
0 19 S94-p SGANRKPsHtSAVSI
0 7 T96-p ANRKPsHtSAVSIAG
0 2 S134-p EKKEESHsNDQsPQI
0 5 S138-p ESHsNDQsPQIRAsP
0 25 S144-p QsPQIRAsPsPQPSS
0 29 S146-p PQIRAsPsPQPSSQP
0 1 S150 AsPsPQPSSQPLQIH
0 11 T160-p PLQIHRQtPEsKNAT
0 4 S163-p IHRQtPEsKNATPTk
0 10 K170-ac sKNATPTksIkRPsP
0 2 S171-p KNATPTksIkRPsPA
0 10 K173-ac ATPTksIkRPsPAEK
0 3 S176-p TksIkRPsPAEKSHN
0 1 S184-p PAEKSHNsWENSDDs
0 1 S191-p sWENSDDsRNKLSKI
0 6 S200-p NKLSKIPstPKLIPK
0 3 T201-p KLSKIPstPKLIPKV
0 2 T209-p PKLIPKVtKtADKHK
0 1 T211-p LIPKVtKtADKHKDV
0 365 Y226-p IINQEGEyIKMFMRG
0 1 T237-p FMRGRPItMFIPSDV
0 7 Y247-p IPSDVDNyDDIRTEL
0 9 Y265-p KLKLEWAyGyRGKDC
0 4 Y267-p KLEWAyGyRGKDCRA
0 3 Y297-p SVVVLFNyEERTQRH
0 5 Y305-p EERTQRHyLGHTDCV
0 1 T437-p KSHIFFWtWSGNSLT
0 1 Y453-p KQGIFGKyEKPKFVQ
0 1 Y499-p GKGPKGVyQIsKQIK
0 1 S502-p PKGVyQIsKQIKAHD
0 3 Y743-p IMSNSGDyEILYWDI
0 1 T875-p LSLPQNEtVADTtLT
0 1 T880-p NEtVADTtLTKAPVS
0 1 S887 tLTKAPVSstEsVIQ
0 1 S888-p LTKAPVSstEsVIQs
0 1 T889-p TKAPVSstEsVIQsN
0 1 S891-p APVSstEsVIQsNtP
0 3 S895-p stEsVIQsNtPtPPP
0 9 T897-p EsVIQsNtPtPPPsQ
0 14 T899-p VIQsNtPtPPPsQPL
0 2 S903-p NtPtPPPsQPLNEtA
0 1 T909-p PsQPLNEtAEEESRI
0 1 S919-p EESRISSsPtLLENS
0 1 T921-p SRISSsPtLLENSLE
0 1 S934-p LEQTVEPsEDHsEEE
0 2 S938-p VEPsEDHsEEESEEG
0 1 S946-p EEESEEGsGDLGEPL
0 3 Y954-p GDLGEPLyEEPCNEI
0 6 S978-p LEDQQDPsPss____
0 1 S980-p DQQDPsPss______
0 3 S981-p QQDPsPss_______
  mouse

► Hide Isoforms
 
S7 _MDGFAGSLDDSISA
S11 FAGSLDDSISAASTS
S13 GSLDDSISAASTSDV
S16 DDSISAASTSDVQDR
S18 SISAASTSDVQDRLS
S25 SDVQDRLSALESRVQ
S29 DRLSALESRVQQQED
K42 EDEITVLKAALADVL
S61 ISEDHVASVKKSMPS
S65 HVASVKKSMPSKGQP
S68 SVKKSMPSKGQPSLR
S73 MPSKGQPSLREAIsM
S79-p PSLREAIsMSCITNG
N94 SGISRKQNHTSSVSI
T96 ISRKQNHTSSVSIAR
S134-p EKKEDSHsNDQsPQI
S138-p DSHsNDQsPQIRAsP
S144-p QsPQIRAsPsPQPsS
S146-p PQIRAsPsPQPsSQP
S150-p AsPsPQPsSQPLQIN
T160 PLQINRQTPESKSSA
S163 INRQTPESKSSAPIK
K170 SKSSAPIKsIKRPPT
S171-p KSSAPIKsIKRPPTA
K173 SAPIKsIKRPPTAEK
P176 IKsIKRPPTAEKSHN
S184 TAEKSHNSWENSDDS
S191 SWENSDDSRNKLMKT
S200-p NKLMKTVsTSKLISK
T201 KLMKTVsTSKLISKV
I209 SKLISKVIKNADKHK
N211 LISKVIKNADKHKDV
Y237-p KNSQEGEyIKMFMRG
T248 FMRGRPITMFIPSDV
Y258 IPSDVDNYDDIRTEL
Y276 KLKLEWVYGYRGKDC
Y278 KLEWVYGYRGKDCRA
Y308 SVVVLFNYEERTQRH
Y316 EERTQRHYLGHTDCV
T448 KSHIFFWTWSGNSLT
Y464 KQGIFGKYEKPKFVQ
Y510 GKGPKGVYQINRQIK
N513 PKGVYQINRQIKAHD
Y754 IMSNSGDYEILYWDI
V886 LPVPQNEVITDASVT
S891 NEVITDASVTKTPAs
S898-p SVTKTPAssSETARP
S899-p VTKTPAssSETARPs
S900 TKTPAssSETARPsN
T902 TPAssSETARPsNsP
S906-p sSETARPsNsPPLPP
S908-p ETARPsNsPPLPPSL
P910 ARPsNsPPLPPSLPL
S914 NsPPLPPSLPLTGTA
T920 PSLPLTGTAEEESRM
S930 EESRMGSSPTLVENS
T932 SRMGSSPTLVENSLE
S945 LEQIAEPSEEQSEWG
S949 AEPSEEQSEWGSEDL
S953 EEQSEWGSEDLGVVI
D961 EDLGVVIDEEPASEL
T985 PEEERGITPLC____
L987 EERGITPLC______
C988 ERGITPLC_______
  EML4 iso3  
- gap
S15 PVAIPDDSISAASTS
S17 AIPDDSISAASTSDV
S20 DDSISAASTSDVQDR
S22 SISAASTSDVQDRLS
S29 SDVQDRLSALESRVQ
S33 DRLSALESRVQQQED
K46 EDEITVLKAALADVL
S65 ISEDHVASVKKSMPS
S69 HVASVKKSMPSKGQP
S72 SVKKSMPSKGQPSLR
S77 MPSKGQPSLREAISM
S83 PSLREAISMSCITNG
N98 SGISRKQNHTSSVSI
T100 ISRKQNHTSSVSIAR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K116 ETLSSAAKSIKRPPT
S117 TLSSAAKSIKRPPTA
K119 SSAAKSIKRPPTAEK
P122 AKSIKRPPTAEKSHN
S130 TAEKSHNSWENSDDS
S137 SWENSDDSRNKLMKT
S146 NKLMKTVSTSKLISK
T147 KLMKTVSTSKLISKV
I155 SKLISKVIKNADKHK
N157 LISKVIKNADKHKDV
Y183 KNSQEGEYIKMFMRG
T194 FMRGRPITMFIPSDV
Y204 IPSDVDNYDDIRTEL
Y222 KLKLEWVYGYRGKDC
Y224 KLEWVYGYRGKDCRA
Y254 SVVVLFNYEERTQRH
Y262 EERTQRHYLGHTDCV
T394 KSHIFFWTWSGNSLT
Y410 KQGIFGKYEKPKFVQ
Y456 GKGPKGVYQINRQIK
N459 PKGVYQINRQIKAHD
Y700 IMSNSGDYEILYWDI
V832 LPVPQNEVITDASVT
S837 NEVITDASVTKTPAS
S844 SVTKTPASSSETARP
S845 VTKTPASSSETARPS
S846 TKTPASSSETARPSN
T848 TPASSSETARPSNSP
S852 SSETARPSNSPPLPP
S854 ETARPSNSPPLPPSL
P856 ARPSNSPPLPPSLPL
S860 NSPPLPPSLPLTGTA
T866 PSLPLTGTAEEESRM
S876 EESRMGSSPTLVENS
T878 SRMGSSPTLVENSLE
S891 LEQIAEPSEEQSEWG
S895 AEPSEEQSEWGSEDL
S899 EEQSEWGSEDLGVVI
D907 EDLGVVIDEEPASEL
T931 PEEERGITPLC____
L933 EERGITPLC______
C934 ERGITPLC_______
  rat

► Hide Isoforms
 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S3 _____MPSKGQPSLR
S8 MPSKGQPSLREAISM
S14 PSLREAISMSCITNG
N29 SGINRKQNHTSSISI
T31 INRKQNHTSSISIAR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K47 ETLSSAAKSIKRPPT
S48 TLSSAAKSIKRPPTA
K50 SSAAKSIKRPPTAEK
P53 AKSIKRPPTAEKSHN
S61 TAEKSHNSWENSDDS
S68 SWENSDDSRNKLLKT
S77 NKLLKTVSTSKLISK
T78 KLLKTVSTSKLISKV
I86 SKLISKVIKNTDKHK
N88 LISKVIKNTDKHKDV
Y114 KSSQEGEYIKMFMRG
T125 FMRGRPITMFIPSDV
Y135 IPSDVDNYDDIRTEL
Y151 PEKLKLEYGYRGKDC
Y153 KLKLEYGYRGKDCRA
Y183 SVVVLFNYEERTQRH
Y191 EERTQRHYLGHTDCV
T323 KSHIFFWTWSGNSLT
Y339 KQGIFGKYEKPKFVQ
Y385 GKGPKGVYQISRQIK
S388 PKGVYQISRQIKAHD
Y629 IMSNSGDYEILYWDI
V761 LPLPQNEVIADTSST
S766 NEVIADTSSTKAPAS
S773 SSTKAPASATENARL
A774 STKAPASATENARLC
T775 TKAPASATENARLCN
N777 APASATENARLCNAP
C781 ATENARLCNAPQPPS
A783 ENARLCNAPQPPSQP
- gap
S788 CNAPQPPSQPLPGTA
T794 PSQPLPGTAEEESRV
S804 EESRVSSSPTLVENS
T806 SRVSSSPTLVENSLE
- gap
S815 VENSLEQSEWGSEDL
S819 LEQSEWGSEDLGVVI
D827 EDLGVVIDEEPASER
A851 SEEEQGAAPLC____
L853 EEQGAAPLC______
C854 EQGAAPLC_______
  EML4 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S3 _____MPSKGQPSLR
S8 MPSKGQPSLREAISM
S14 PSLREAISMSCITNG
N29 SGINRKQNHTSSISI
T31 INRKQNHTSSISIAR
S69 EKKEESHSNDQSPQI
S73 ESHSNDQSPQIRAsP
S79-p QSPQIRAsPsPQPSS
S81-p PQIRAsPsPQPSSQP
S85 AsPsPQPSSQPLQIN
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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