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ELP3 (human)

Overview ELP3 a histone acetyltransferase. A subunit of the Elongator complex, which associates with the elongating, hyperphosphorylated form of RNA polymerase II. Note: This description may include information from UniProtKB. Protein type: Acetyltransferase; EC 2.3.1.48 Cellular Component: transcription elongation factor complex; Elongator holoenzyme complex; cytoplasm; nucleolus; DNA-directed RNA polymerase II, holoenzyme Molecular Function: protein binding; histone acetyltransferase activity; DNA binding; metal ion binding; iron-sulfur cluster binding; phosphorylase kinase regulator activity Biological Process: regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter; positive regulation of cell migration Reference #:  Q9H9T3 (UniProtKB) Alt. Names/Synonyms: elongation protein 3 homolog (S. cerevisiae); Elongator complex protein 3; ELP3; FLJ10422; hELP3; KAT9 Gene Symbols: ELP3 Molecular weight: 62,259 Da Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ELP3

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	32		K77-u	KVLMPKLkAKPIRTA
0	5		K34-u	IEAHEQGkDIDLNkV
0	2		K40-u	GkDIDLNkVKTKTAA
0	3		K48-u	VKTKTAAkYGLSAQP
0	1		K156-u	RHRIEQLkQLGHsVD
0	2		S161-p	QLkQLGHsVDKVEFI
0	1		T197-p	HDALSGHtSNNIyEA
0	341		Y202-p	GHtSNNIyEAVkySE
0	2		K206-u	NNIyEAVkySERSLT
0	1		Y207-p	NIyEAVkySERSLTK
0	2		Y251-p	EIGVQSVyEDVARDT
0	1		K316-u	AFRPDGLkLyPTLVI
0	3		Y318-p	RPDGLkLyPTLVIRG
0	109		Y329-p	VIRGTGLyELWkSGR
0	3		K333-u	TGLyELWkSGRYkSY
0	2		K338-u	LWkSGRYkSYSPSDL
0	1		T360-p	LALVPPWtRVYRVQR
0	2		K392-u	ELALARMkDLGIQCR
0	1		Y427-p	VELVRRDyVANGGWE
0	1		S470	FELGGGVSIVRELHV
0	1		K491-u	VSSRDPTkFQHQGFG
0	1		K517-u	REEHGSGkIAVISGV

	mouse
K77	KILIPKLKAKPVRTA
K34-u	VEAHEQGkDVDLNkM
K40-u	GkDVDLNkMKTKTAA
K48-u	MKTKTAAkYGLASQP
K156	RHRIEQLKQLGHsVD
S161-p	QLKQLGHsVDKVEFI
T197	HDALSGHTSNNIHEA
H202	GHTSNNIHEAIKYSE
K206	NNIHEAIKYSERSFT
Y207	NIHEAIKYSERSFTK
Y251	EIGVQSVYEDVARDT
K316	AFRPDGLKLYPTLVI
Y318	RPDGLKLYPTLVIRG
Y329-p	VIRGTGLyELWkSGR
K333-u	TGLyELWkSGRYRSY
R338	LWkSGRYRSYSPSDL
T360	LALVPPWTRVYRVQR
K392-u	ELAFARMkDLGIQCR
Y427	VELVRRDYVANGGWE
S470-p	FELGGGVsIVRELHV
K491	VSSRDPTKFQHQGFG
K517	REEHGSGKMAVISGV

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