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Protein Page:
BAP37 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
BAP37 a protein of the band 7 family. This family includes the prohibitins, cytoplasmic anti-proliferative proteins and stomatin, an erythrocyte membrane protein. A repressor of estrogen receptor (ER) activity. Reverses steroid receptor coactivator 1 enhancement of ER activity. May play a role in determining the sensitivity of estrogen target cells to antiestrogen and estrogen therapy. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Cellular Component: mitochondrion; mitochondrial inner membrane; nucleus
Molecular Function: protein binding; estrogen receptor binding
Biological Process: transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; negative regulation of mammary gland epithelial cell proliferation; negative regulation of estrogen receptor signaling pathway
Reference #:  Q99623 (UniProtKB)
Alt. Names/Synonyms: B-cell associated protein; B-cell receptor-associated protein BAP37; BAP; Bap37; BCAP37; D-prohibitin; MGC117268; p22; PHB2; PNAS-141; prohibitin 2; Prohibitin-2; REA; Repressor of estrogen receptor activity
Gene Symbols: PHB2
Molecular weight: 33,296 Da
Basal Isoelectric point: 9.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BAP37
Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S91‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 3 K6-u __MAQNLkDLAGRLP
0 1 T21-p AGPRGMGtALKLLLG
0 2 Y34-p LGAGAVAyGVRESVF
0 45 Y77-p FRIPWFQyPIIyDIR
0 7 Y81-p WFQyPIIyDIRARPR
0 3 K89-u DIRARPRkIsSPTGS
1 1 S91-p RARPRkIsSPTGSkD
0 2 K97-u IsSPTGSkDLQMVNI
0 2 S119-p PNAQELPsMyQRLGL
0 131 Y121-p AQELPsMyQRLGLDy
0 16 Y128-p yQRLGLDyEERVLPs
0 2 S135-p yEERVLPsIVNEVLK
0 1 K147-u VLKSVVAkFNAsQLI
0 6 S151-p VVAkFNAsQLItQRA
0 6 T155-p FNAsQLItQRAQVsL
0 1 S161-p ItQRAQVsLLIRREL
0 3 K200-u YTAAVEAkQVAQQEA
0 1 K200 YTAAVEAKQVAQQEA
0 2 K216-a RAQFLVEkAKQEQRQ
0 1 K216-u RAQFLVEkAKQEQRQ
0 2 K224-u AKQEQRQkIVQAEGE
0 1 K236-u EGEAEAAkMLGEALs
1 0 S243-p kMLGEALskNPGyIk
0 2 K244-u MLGEALskNPGyIkL
1 227 Y248-p ALskNPGyIkLRKIR
0 1 K250-a skNPGyIkLRKIRAA
0 1 K250-u skNPGyIkLRKIRAA
0 2 K262-u RAAQNISktIATSQN
0 1 T263-p AAQNISktIATSQNR
0 2 S293-p SFTRGSDsLIkGKK_
0 1 K296-u RGSDsLIkGKK____
  mouse

 
K6-u __MAQNLkDLAGRLP
T21 AGPRGMGTALKLLLG
Y34 LGAGAVAYGVRESVF
Y77-p FRIPWFQyPIIYDIR
Y81 WFQyPIIYDIRARPR
K89 DIRARPRKISSPTGS
S91 RARPRKISSPTGSKD
K97 ISSPTGSKDLQMVNI
S119 PNAQELPSMyQRLGL
Y121-p AQELPSMyQRLGLDY
Y128 yQRLGLDYEERVLPS
S135 YEERVLPSIVNEVLK
K147 VLKSVVAKFNAsQLI
S151-p VVAKFNAsQLItQRA
T155-p FNAsQLItQRAQVsL
S161-p ItQRAQVsLLIRREL
K200 YTAAVEAKQVAQQEA
K200-a YTAAVEAkQVAQQEA
K216 RAQFLVEKAKQEQRQ
K216 RAQFLVEKAKQEQRQ
K224-u AKQEQRQkIVQAEGE
K236 EGEAEAAKMLGEALS
S243 KMLGEALSKNPGyIK
K244 MLGEALSKNPGyIKL
Y248-p ALSKNPGyIKLRKIR
K250 SKNPGyIKLRKIRAA
K250 SKNPGyIKLRKIRAA
K262-u RAAQNISkTIATSQN
T263 AAQNISkTIATSQNR
S293-p SFTRGSDsLIKGKK_
K296 RGSDsLIKGKK____
  rat

 
K6 __MAQNLKDLAGRLP
T21 SGPRGMGTALKLLLG
Y34 LGAGAVAYGVRESVF
Y77-p FRIPWFQyPIIYDIR
Y81 WFQyPIIYDIRARPR
K89 DIRARPRKISSPTGS
S91 RARPRKISSPTGSKD
K97 ISSPTGSKDLQMVNI
S119 PNAQELPSMyQRLGL
Y121-p AQELPSMyQRLGLDY
Y128 yQRLGLDYEERVLPS
S135 YEERVLPSIVNEVLK
K147 VLKSVVAKFNASQLI
S151 VVAKFNASQLItQRA
T155-p FNASQLItQRAQVSL
S161 ItQRAQVSLLIRREL
K200 YTAAVEAKQVAQQEA
K200 YTAAVEAKQVAQQEA
K216-a RAQFLVEkAKQEQRQ
K216 RAQFLVEKAKQEQRQ
K224 AKQEQRQKIVQAEGE
K236 EGEAEAAKMLGEALS
S243 KMLGEALSKNPGyIK
K244 MLGEALSKNPGyIKL
Y248-p ALSKNPGyIKLRKIR
K250 SKNPGyIKLRKIRAA
K250 SKNPGyIKLRKIRAA
K262 RAAQNISKTIATSQN
T263 AAQNISKTIATSQNR
S293 SFTRGSDSLIKGKK_
K296 RGSDSLIKGKK____
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