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PSMB7
a proteasomal protein of the T1B peptidase family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. Not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit). Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.25.1; Protease; Proteasome complex |
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Cellular Component: nucleoplasm; proteasome complex; proteasome core complex; cytosol
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Molecular Function: threonine endopeptidase activity; protein binding
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Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; M/G1 transition of mitotic cell cycle; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mRNA metabolic process; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; virus-host interaction; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; S phase of mitotic cell cycle; cell cycle checkpoint; G1/S transition of mitotic cell cycle
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Reference #:
Q99436 (UniProtKB)
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| Alt. Names/Synonyms: Macropain chain Z; Multicatalytic endopeptidase complex chain Z; proteasome (prosome, macropain) subunit, beta type, 7; proteasome catalytic subunit 2; proteasome subunit alpha; proteasome subunit beta 7; Proteasome subunit beta type-7; Proteasome subunit Z; PSB7; PSMB7; Z |
| Gene Symbols: PSMB7 |
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Molecular weight: 29,965 Da
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Basal Isoelectric point: 7.58
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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