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Protein Page:
PSMB7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSMB7 a proteasomal protein of the T1B peptidase family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. Not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit). Note: This description may include information from UniProtKB.
Protein type: EC 3.4.25.1; Proteasome complex; Protease
Cellular Component: proteasome complex; microtubule cytoskeleton; nucleoplasm; proteasome core complex; nucleolus; nucleus; cytosol
Molecular Function: threonine endopeptidase activity; protein binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mRNA metabolic process; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Reference #:  Q99436 (UniProtKB)
Alt. Names/Synonyms: Macropain chain Z; Multicatalytic endopeptidase complex chain Z; proteasome (prosome, macropain) subunit, beta type, 7; proteasome catalytic subunit 2; proteasome subunit alpha; proteasome subunit beta 7; Proteasome subunit beta type-7; Proteasome subunit Z; PSB7; PSMB7; Z
Gene Symbols: PSMB7
Molecular weight: 29,965 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSMB7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S5-p ___MAAVsVyAPPVG
0 1 Y7-p _MAAVsVyAPPVGGF
0 19 K31-ub VLEADFAkRGYKLPK
0 1 T44-p PKVRKTGtTIAGVVy
0 1 Y51-p tTIAGVVykDGIVLG
0 2 K52-ub TIAGVVykDGIVLGA
0 12 K72-ub EGMVVADkNCSKIHF
0 1 T121 GRLPRVVTANRMLkQ
0 7 K127-ub VTANRMLkQMLFRYQ
0 3 Y154-p DVTGPHLySIYPHGS
0 1 K195 DMEEEEAKNLVSEAI
0 2 K195 DMEEEEAKNLVSEAI
0 1 N196 MEEEEAKNLVSEAIA
0 3 K225-ub LCVISKNkLDFLRPY
0 2 K237 RPYTVPNKKGTRLGR
0 2 K237-ub RPYTVPNkKGTRLGR
0 6 K249-ub LGRYRCEkGTTAVLT
  mouse

 
S5 ___MAAVSVFQPPVG
F7 _MAAVSVFQPPVGGF
K31 VLEADFAKKGFKLPK
T44 PKARKTGTTIAGVVY
Y51 TTIAGVVYkDGIVLG
K52-ub TIAGVVYkDGIVLGA
K72-ub EGMVVADkNCSKIHF
T121-p GRLPRVVtANRMLKQ
K127 VtANRMLKQMLFRYQ
Y154-p DVTGPHLySIYPHGS
K195-ac DMEEEEAkkLVSEAI
K195-ub DMEEEEAkkLVSEAI
K196-ub MEEEEAkkLVSEAIA
K225-ub LCVISKSkLDFLRPF
K237-ac RPFSVPNkKGTRLGR
K237-ub RPFSVPNkKGTRLGR
K249 LGRYRCEKGTTAVLT
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