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GCN5 (human)

Overview GCN5 an ubiquitous histone acetyltransferase that promotes transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Interacts with P300, CBP, ADA2, and is a component of the TFTC-HAT complex. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: EC 2.3.1.48; Acetyltransferase Molecular Function: protein binding; histone acetyltransferase activity; histone deacetylase binding; transcription coactivator activity; chromatin binding; H3 histone acetyltransferase activity Biological Process: transcription from RNA polymerase II promoter; somitogenesis; in utero embryonic development; multicellular organism growth; regulation of protein stability; metencephalon development; histone deubiquitination; chromatin remodeling; regulation of apoptosis; regulation of transcription from RNA polymerase II promoter; cell proliferation; telencephalon development; virus-host interaction; neural tube closure; midbrain development Reference #:  Q92830 (UniProtKB) Alt. Names/Synonyms: GCN5; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; GCN5L2; General control of amino acid synthesis protein 5-like 2; General control of amino acid synthesis, yeast, homolog-like 2; HGCN5; Histone acetyltransferase GCN5; Histone acetyltransferase KAT2A; HsGCN5; K(lysine) acetyltransferase 2A; KAT2A; Lysine acetyltransferase 2A; MGC102791; PCAF-b; STAF97 Gene Symbols: KAT2A Molecular weight: 93,926 Da Basal Isoelectric point: 9.18  Predict pI for various phosphorylation states CST Pathways:  Protein Acetylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GCN5 1F68 - A=731-832 (human) 1Z4R - A=497-662 (human) 3D7C - A/B=729-837 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1F68 1Z4R 3D7C  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K289-u	AEDVATYkVNYTRWL
1	0		S307-p	HVPQSCDsLPRYETT
0	1		T441	RTLPENLTLEDAKRL
1	0		K549-a	LVFDPKHkTLALIKD
0	8		K721-a	TGWKPLGkEKGKELK
0	33		Y734-p	LKDPDQLyttLKNLL
1	0		T735-p	KDPDQLyttLKNLLA
0	6		T736-p	DPDQLyttLKNLLAQ
0	1		Y787-p	ERLRSRYyVTRKLFV

	mouse
K284	SEDVATYKVNYTRWL
S302	HVPQSCDSLPRYETT
T434-p	RKLPENLtLEDAKRL
K542	LVFDPKHKTLALIKD
K714-a	TGWKPLGkEKGKELK
Y727-p	LKDPDQLyTtLKNLL
T728	KDPDQLyTtLKNLLA
T729-p	DPDQLyTtLKNLLAQ
Y780	ERLRSRYYVTRKLFV

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