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Protein Page:
GCN5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GCN5 an ubiquitous histone acetyltransferase that promotes transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Interacts with P300, CBP, ADA2, and is a component of the TFTC-HAT complex. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.3.1.48; Acetyltransferase
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: nucleoplasm; extracellular space
Molecular Function: protein binding; histone acetyltransferase activity; histone deacetylase binding; transcription coactivator activity; chromatin binding; H3 histone acetyltransferase activity
Biological Process: transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; somitogenesis; viral reproduction; in utero embryonic development; multicellular organism growth; regulation of protein stability; metencephalon development; histone deubiquitination; regulation of transcription from RNA polymerase II promoter; chromatin remodeling; cell proliferation; telencephalon development; midbrain development; neural tube closure
Reference #:  Q92830 (UniProtKB)
Alt. Names/Synonyms: GCN5; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; GCN5L2; General control of amino acid synthesis protein 5-like 2; General control of amino acid synthesis, yeast, homolog-like 2; HGCN5; Histone acetyltransferase GCN5; Histone acetyltransferase KAT2A; HsGCN5; K(lysine) acetyltransferase 2A; KAT2A; Lysine acetyltransferase 2A; MGC102791; PCAF-b; STAF97
Gene Symbols: KAT2A
Molecular weight: 93,926 Da
Basal Isoelectric point: 9.18  Predict pI for various phosphorylation states
CST Pathways:  Crosstalk between PTMs  |  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GCN5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K289-ub AEDVATYkVNYTRWL
1 0 S307-p HVPQSCDsLPRYETT
0 1 T441 RTLPENLTLEDAKRL
1 0 K549-ac LVFDPKHkTLALIKD
0 8 K721-ac TGWKPLGkEKGKELK
0 34 Y734-p LKDPDQLyttLKNLL
1 0 T735-p KDPDQLyttLKNLLA
0 6 T736-p DPDQLyttLKNLLAQ
0 1 Y787-p ERLRSRYyVTRKLFV
  mouse

 
K284 SEDVATYKVNYTRWL
S302 HVPQSCDSLPRYETT
T434-p RKLPENLtLEDAKRL
K542 LVFDPKHKTLALIKD
K714-ac TGWKPLGkEKGKELK
Y727-p LKDPDQLyTtLKNLL
T728 KDPDQLyTtLKNLLA
T729-p DPDQLyTtLKNLLAQ
Y780 ERLRSRYYVTRKLFV
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