an ubiquitous histone acetyltransferase that promotes transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Interacts with P300, CBP, ADA2, and is a component of the TFTC-HAT complex. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Biological Process: transcription from RNA polymerase II promoter; somitogenesis; in utero embryonic development; multicellular organism growth; regulation of protein stability; metencephalon development; histone deubiquitination; chromatin remodeling; regulation of apoptosis; regulation of transcription from RNA polymerase II promoter; cell proliferation; telencephalon development; virus-host interaction; neural tube closure; midbrain development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.