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Protein Page:
PDCD4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PDCD4 protein localized to the nucleus in proliferating cells that seems to possess a tumor suppressor activity. Directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Suppresses carbonic anhydrase type II protein expression in carcinoid cell lines. Since tumor cells require a high bicarbonate flux for their growth, carbonic anhydrase suppression results in growth inhibition. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two differentially spliced isoforms have been identified. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Apoptosis
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; RNA binding
Biological Process: negative regulation of JNK activity; apoptosis; cell aging; negative regulation of transcription, DNA-dependent; negative regulation of cell cycle
Reference #:  Q53EL6 (UniProtKB)
Alt. Names/Synonyms: H731; MGC33046; MGC33047; Neoplastic transformation inhibitor protein; nuclear antigen H731; Nuclear antigen H731-like; PDCD4; programmed cell death 4; programmed cell death 4 (neoplastic transformation inhibitor); Programmed cell death protein 4; Protein 197/15a
Gene Symbols: PDCD4
Molecular weight: 51,735 Da
Basal Isoelectric point: 5.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PDCD4

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S67‑p, S71‑p
cell growth, altered: S67‑p, S71‑p
translation, altered: S67‑p, S71‑p
intracellular localization: S457‑p
molecular association, regulation: S67‑p, S71‑p, S76‑p
protein degradation: S67‑p, S71‑p, S76‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S20-p PADPDNLsDsLFsGD
0 1 S22-p DPDNLsDsLFsGDEE
0 4 S25-p NLsDsLFsGDEENAG
0 1 S46-p EINGNWIsASSINEA
0 2 K58-ub NEARINAkAkRRLRK
0 2 K60-ub ARINAkAkRRLRKNs
4 49 S67-p kRRLRKNssRDsGRG
0 22 S68-p RRLRKNssRDsGRGD
1 30 S71-p RKNssRDsGRGDsVs
3 111 S76-p RDsGRGDsVsDsGsD
0 24 S78-p sGRGDsVsDsGsDAL
0 2 S80-p RGDsVsDsGsDALRs
1 4 S82-p DsVsDsGsDALRsGL
0 2 S87-p sGsDALRsGLtVPts
0 1 T90-p DALRsGLtVPtsPKG
0 25 T93-p RsGLtVPtsPKGRLL
1 79 S94-p sGLtVPtsPKGRLLD
0 2 T126-p GGKGVWGtPGQVyDV
0 2 Y131-p WGtPGQVyDVEEVDV
0 1 Y143-p VDVKDPNyDDDQENC
0 15 Y152-p DDQENCVyETVVLPL
0 3 K166-ub LDERAFEkTLTPIIQ
0 2 K212-ub VSLALEGkASHREMT
0 2 K242-ub DVEKSFDkLLkDLPE
0 5 K245-ub KSFDkLLkDLPELAL
0 8 K283-ub NTYIDSYkGTVDCVQ
0 1 K297 QARAALDKAtVLLsM
0 1 T299-p RAALDKAtVLLsMSK
0 1 S303-p DKAtVLLsMSKGGKR
0 1 K306 tVLLsMSKGGKRKDs
0 10 S313-p KGGKRKDsVWGsGGG
0 7 S317-p RKDsVWGsGGGQQsV
0 2 S323-p GsGGGQQsVNHLVKE
0 1 S345-p YLLSGDIsEAEHCLK
0 1 Y405-p VDQMKRGyERIYNEI
0 1 S440-p CFQAGIIsKQLRDLC
6 83 S457-p RGRKRFVsEGDGGRL
0 2 S468-p GGRLKPEsY______
  PDCD4 iso2  
S9 TKYPDNLSDSLFSGD
S11 YPDNLSDSLFSGDEE
S14 NLSDSLFSGDEENAG
S35 EINGNWISASSINEA
K47 NEARINAKAKRRLRK
K49 ARINAKAKRRLRKNS
S56 KRRLRKNSSRDSGRG
S57 RRLRKNSSRDSGRGD
S60 RKNSSRDSGRGDSVS
S65 RDSGRGDSVSDSGSD
S67 SGRGDSVSDSGSDAL
S69 RGDSVSDSGSDALRS
S71 DSVSDSGSDALRSGL
S76 SGSDALRSGLTVPTS
T79 DALRSGLTVPTSPKG
T82 RSGLTVPTSPKGRLL
S83 SGLTVPTSPKGRLLD
T115 GGKGVWGTPGQVYDV
Y120 WGTPGQVYDVEEVDV
Y132 VDVKDPNYDDDQENC
Y141 DDQENCVYETVVLPL
K155 LDERAFEKTLTPIIQ
K201 VSLALEGKASHREMT
K231 DVEKSFDKLLKDLPE
K234 KSFDKLLKDLPELAL
K272 NTYIDSYKGTVDCVQ
K286 QARAALDKATVLLSM
T288 RAALDKATVLLSMSK
S292 DKATVLLSMSKGGKR
K295 TVLLSMSKGGKRKDS
S302 KGGKRKDSVWGSGGG
S306 RKDSVWGSGGGQQSV
S312 GSGGGQQSVNHLVKE
S334 YLLSGDISEAEHCLK
Y394 VDQMKRGYERIYNEI
S429 CFQAGIISKQLRDLC
S446 RGRKRFVSEGDGGRL
S457 GGRLKPESY______
  mouse

 
S20 PTDPDNLSDSLFsGD
S22 DPDNLSDSLFsGDEE
S25-p NLSDSLFsGDEENAG
S46 EINGNWISASTINEA
K58 NEARINAKAKRRLRK
K60 ARINAKAKRRLRKNs
S67-p KRRLRKNssRDsGRG
S68-p RRLRKNssRDsGRGD
S71-p RKNssRDsGRGDsVs
S76-p RDsGRGDsVsDNGsE
S78-p sGRGDsVsDNGsEAV
N80 RGDsVsDNGsEAVRS
S82-p DsVsDNGsEAVRSGV
S87 NGsEAVRSGVAVPts
A90 EAVRSGVAVPtsPKG
T93-p RSGVAVPtsPKGRLL
S94-p SGVAVPtsPKGRLLD
T126 GGKGVWGTPGQVYDV
Y131 WGTPGQVYDVEEVDV
Y143 VDVKDPNYDDDQENC
Y152-p DDQENCVyETVVLPL
K166 LDETAFEKTLTPIIQ
K212 VSLALEGKASHREMT
K242-ub DVEKSFDkLLkDLPE
K245-ub KSFDkLLkDLPELAL
K283 NTYIDSYKGTVDCVQ
K297-ub QARAALDkATVLLSM
T299 RAALDkATVLLSMSk
S303 DkATVLLSMSkGGKR
K306-ub TVLLSMSkGGKRKDs
S313-p kGGKRKDsVWGsGGG
S317-p RKDsVWGsGGGQQPV
P323 GsGGGQQPVNHLVKE
S345 YLLSGDISEAEHCLK
Y405 IDQMKRGYERIYNEI
S440 CFQAGIISKQLRDLC
S457-p RGRKRFVsEGDGGRL
S468 GGRLKPESY______
  rat

 
S20 PTDPDNLSDSLFsGD
S22 DPDNLSDSLFsGDEE
S25-p NLSDSLFsGDEENAG
S46 EINGNWISASTINEA
K58 NEARINAKAKRRLRK
K60 ARINAKAKRRLRKNs
S67-p KRRLRKNsSRDSGRG
S68 RRLRKNsSRDSGRGD
S71 RKNsSRDSGRGDsVS
S76-p RDSGRGDsVSDNGSE
S78 SGRGDsVSDNGSEAV
N80 RGDsVSDNGSEAVRS
S82 DsVSDNGSEAVRSGV
S87 NGSEAVRSGVAVPts
A90 EAVRSGVAVPtsPKG
T93-p RSGVAVPtsPKGRLL
S94-p SGVAVPtsPKGRLLD
T126 GGKGVWGTPGQVYDV
Y131 WGTPGQVYDVEEVDV
Y143 VDVKDPNYDDDQENC
Y152 DDQENCVYETVVLPL
K166 LDETAFEKTLTPIIQ
K212 VSLALEGKASHREMT
K242 DVEKSFDKLLKDLPE
K245 KSFDKLLKDLPELAL
K283 NTYIDSYKGTVDCVQ
K297 QARAALDKATVLLSM
T299 RAALDKATVLLSMSK
S303 DKATVLLSMSKGGKR
K306 TVLLSMSKGGKRKDS
S313 KGGKRKDSVWGSGGG
S317 RKDSVWGSGGGQQPV
P323 GSGGGQQPVNHLVKE
S345 YLLSGDMSEAEHCLK
Y405 IDQMKRGYERIYNEI
S440 CFQAGIISKQLRDLC
S457-p RGRKRFVsEGDGGRL
S468 GGRLKPESY______
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