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Protein Page:
TBC1D1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TBC1D1 a putative GTPase activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Note: This description may include information from UniProtKB.
Protein type: GAPs, Rab; Ubiquitin-specific protease; GAPs
Cellular Component: nucleus; cytosol
Molecular Function: Rab GTPase activator activity
Biological Process: regulation of protein localization; positive regulation of Rab GTPase activity
Reference #:  Q86TI0 (UniProtKB)
Alt. Names/Synonyms: KIAA1108; TBC; TBC1; TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; TBC1 domain family member 1; TBC1D1; TBCD1
Gene Symbols: TBC1D1
Molecular weight: 133,084 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TBC1D1

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S237‑p, T596‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y90-p QQWDPLIySSIFECK
0 11 Y113-p HNSHDPSyFACLIKE
0 1 S145 TKVPEIISSIRQAGK
0 1 S146 KVPEIISSIRQAGKI
0 1 S163 QEELHCPSEFDDTFS
1 1 S235-p VRRPMRKsFsQPGLR
5 91 S237-p RPMRKsFsQPGLRSL
1 6 - gap
0 2 S262 LRSSGFFSsFEESDI
0 11 S263-p RSSGFFSsFEESDIE
0 1 S340 GFICRESSGGGGFHF
0 1 - gap
0 1 S408-p RIEGMNSsKtKLELQ
0 1 T410-p EGMNSsKtKLELQKH
0 2 - gap
0 1 K497-ac RFRLDMLkNKAkRsL
0 1 K501-ac DMLkNKAkRsLTEsL
0 10 S503-p LkNKAkRsLTEsLES
2 4 T505 NKAkRsLTEsLESIL
1 7 S507-p AkRsLTEsLESILsR
0 1 S510 sLTEsLESILsRGNK
0 1 S513-p EsLESILsRGNKARG
0 1 S525 ARGLQEHSISVDLDS
0 1 S527 GLQEHSISVDLDSSL
0 2 S559-p ALPISESsFKLLGss
2 22 S565-p SsFKLLGssEDLssD
1 21 S566-p sFKLLGssEDLssDs
0 15 S570-p LGssEDLssDsEsHL
0 23 S571-p GssEDLssDsEsHLP
0 15 S573-p sEDLssDsEsHLPEE
0 6 S575-p DLssDsEsHLPEEPA
0 1 - gap
0 33 S585-p PEEPAPLsPQQAFRR
7 140 T596-p AFRRRANtLsHFPIE
0 41 S598-p RRRANtLsHFPIECQ
0 11 G613 EPPQPARGsPGVsQR
0 48 S614-p PPQPARGsPGVsQRK
0 5 S618-p ARGsPGVsQRKLMRY
1 44 S627-p RKLMRYHsVSTETPH
0 1 S629 LMRYHsVSTETPHER
0 1 T630 MRYHsVSTETPHERK
2 4 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
2 4 - gap
0 1 S649-p KANHLGDsGGtPVKT
0 7 T652-p HLGDsGGtPVKTRRH
0 5 S660-p PVKTRRHsWRQQIFL
0 4 T671-p QIFLRVAtPQKACDS
0 2 S695 LGELPPRSPLEPVCE
0 1 K826 LKHQFPSKQQPKDVP
0 1 K830 FPSKQQPKDVPYKEL
0 1 Y880-p LYNILKAySLLDQEV
0 1 S941 QIQMYQLSRLLHDYH
0 1 Y952 HDYHRDLYNHLEEHE
0 1 K1092 KTNSSLRKQNLDLLE
0 1 T1131 KLKQAMLTLELERsA
0 1 S1137-p LTLELERsALLQTVE
0 3 S1150 VEELRRRSAEPSDRE
0 3 S1154 RRRSAEPSDREPECT
0 6 D1155 RRSAEPSDREPECTQ
  mouse

► Hide Isoforms
 
- gap
Y113-p HNSHDPSyFACLIKE
S145-p TKVPEIIssIRQAGK
S146-p KVPEIIssIRQAGKI
S163-p QEELRCPsEFDDTFA
S229-p GPRPMRKsFsQPGLR
S231-p RPMRKsFsQPGLRSL
T253-p DASLRSStFssFDND
S255-p SLRSStFssFDNDIE
S256-p LRSStFssFDNDIEN
S332-p GFICRECsGGGsGGF
S336-p RECsGGGsGGFHFVC
S402 RIEGMNSSKTKLELQ
T404 EGMNSSKTKLELQKH
S489-p ASRFRLDsLKNRAKR
K491 RFRLDsLKNRAKRsL
K495 DsLKNRAKRsLtEsL
S497-p LKNRAKRsLtEsLEs
T499-p NRAKRsLtEsLEsIL
S501-p AKRsLtEsLEsILSR
S504-p sLtEsLEsILSRGNK
S507 EsLEsILSRGNKARG
S519-p ARGLQDHsAsVDLDS
S521-p GLQDHsAsVDLDSST
S553 AFPVSETSFKLLGss
S559-p TSFKLLGssDDLssD
S560-p SFKLLGssDDLssDs
S564-p LGssDDLssDsEGHI
S565-p GssDDLssDsEGHIA
S567-p sDDLssDsEGHIAEE
- gap
S575-p EGHIAEEsALLsPQQ
S579-p AEEsALLsPQQAFRR
T590-p AFRRRANtLsHFPVE
S592-p RRRANtLsHFPVECP
S607-p APPEPAQssPGVsQR
S608-p PPEPAQssPGVsQRK
S612-p AQssPGVsQRKLMRY
S621-p RKLMRYHsVstETPH
S623-p LMRYHsVstETPHER
T624-p MRYHsVstETPHERN
S660-p PRLNPSAssPNFFKY
S661-p RLNPSAssPNFFKYL
K669-m1 PNFFKYLkHNSSGEQ
S697-p ALRKKLHssssVPNF
S698-p LRKKLHssssVPNFL
S699-p RKKLHssssVPNFLK
S700-p KKLHssssVPNFLKF
T736 KANHLGDTDGtPVKT
T739-p HLGDTDGtPVKTRRH
S747 PVKTRRHSWRQQIFL
T758 QIFLRVATPQKACDS
S782-p LGELPPRsPLEPVCE
K913 LKHPFPSKQQPKDVP
K917 FPSKQQPKDVPYKEL
Y967 LYNILKAYSLLDQEV
S1028-p QIQMYQLsRLLHDYH
Y1039-p HDYHRDLyNHLEEHE
K1179-ub KTNSSLRkQNLDLLE
T1218-p KLKQAALtLEVERSA
S1224 LtLEVERSALLQMVE
S1237-p VEELRRQsARPstPE
S1241-p RRQsARPstPEPDCT
T1242-p RQsARPstPEPDCTQ
6929 : Phospho-TBC1D1 (Ser700) Antibody
  TBC1D1 iso2  
- gap
Y113 HNSHDPSYFACLIKE
S145 TKVPEIISSIRQAGK
S146 KVPEIISSIRQAGKI
S163 QEELRCPSEFDDTFA
S229 GPRPMRKSFSQPGLR
S231 RPMRKSFSQPGLRSL
T253 DASLRSSTFSSFDND
S255 SLRSSTFSSFDNDIE
S256 LRSSTFSSFDNDIEN
S332 GFICRECSGGGSGGF
S336 RECSGGGSGGFHFVC
S402 RIEGMNSSKTKLELQ
T404 EGMNSSKTKLELQKH
S489 ASRFRLDSLKNRAKR
K491 RFRLDSLKNRAKRSL
K495 DSLKNRAKRSLTESL
S497 LKNRAKRSLTESLES
T499 NRAKRSLTESLESIL
S501 AKRSLTESLESILSR
S504 SLTESLESILSRGNK
S507 ESLESILSRGNKARG
S519 ARGLQDHSASVDLDS
S521 GLQDHSASVDLDSST
S553 AFPVSETSFKLLGSS
S559 TSFKLLGSSDDLSSD
S560 SFKLLGSSDDLSSDS
S564 LGSSDDLSSDSEGHI
S565 GSSDDLSSDSEGHIA
S567 SDDLSSDSEGHIAEE
- gap
S575 EGHIAEESALLSPQQ
S579 AEESALLSPQQAFRR
T590 AFRRRANTLSHFPVE
S592 RRRANTLSHFPVECP
S607 APPEPAQSSPGVSQR
S608 PPEPAQSSPGVSQRK
S612 AQSSPGVSQRKLMRY
S621 RKLMRYHSVSTETPH
S623 LMRYHSVSTETPHER
T624 MRYHSVSTETPHERK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T643 KANHLGDTDGTPVKT
T646 HLGDTDGTPVKTRRH
S654 PVKTRRHSWRQQIFL
T665 QIFLRVATPQKACDS
S689 LGELPPRSPLEPVCE
K820 LKHPFPSKQQPKDVP
K824 FPSKQQPKDVPYKEL
Y874 LYNILKAYSLLDQEV
S935 QIQMYQLSRLLHDYH
Y946 HDYHRDLYNHLEEHE
K1086 KTNSSLRKQNLDLLE
T1125 KLKQAALTLEVERSA
S1131 LTLEVERSALLQMVE
S1144 VEELRRQSARPSTPE
S1148 RRQSARPSTPEPDCT
T1149 RQSARPSTPEPDCTQ
  rat

 
- gap
Y113 HNSQDPSYFACLIKE
S145 TKVPEIISSIRQAGK
S146 KVPEIISSIRQAGKI
S163 QEELRCPSEFDDTFA
S229 GARPMRKSFsQPGLR
S231-p RPMRKSFsQPGLRSL
T253 DASLRSSTFSSFDND
S255 SLRSSTFSSFDNDIE
S256 LRSSTFSSFDNDIEN
S332 GFICRECSGGGGAGF
G336 RECSGGGGAGFHFVC
S402 RIEGMNSSKTKLELQ
T404 EGMNSSKTKLELQKH
S489 ASRFRLDSLKNRAKR
K491 RFRLDSLKNRAKRSL
K495 DSLKNRAKRSLTESL
S497 LKNRAKRSLTESLES
T499 NRAKRSLTESLESIL
S501 AKRSLTESLESILSR
S504 SLTESLESILSRGNK
S507 ESLESILSRGNKARG
S519 ARGLQDHSASVDLDS
S521 GLQDHSASVDLDSST
S553 ALPISESSFKLLGSS
S559 SSFKLLGSSDDLSSD
S560 SFKLLGSSDDLSSDS
S564 LGSSDDLSSDSESHI
S565 GSSDDLSSDSESHIA
S567 SDDLSSDSESHIAEE
S569 DLSSDSESHIAEESA
S575 ESHIAEESALLSPQQ
S579 AEESALLSPQQAFRR
T590 AFRRRANTLSHFPVE
S592 RRRANTLSHFPVECP
T607 APPEPAQTSPGVSQR
S608 PPEPAQTSPGVSQRK
S612 AQTSPGVSQRKLMRY
S621 RKLMRYHSVSTETPH
S623 LMRYHSVSTETPHER
T624 MRYHSVSTETPHERN
S662 PRLNPSASSPNFFKY
S663 RLNPSASSPNFFKYL
K671 PNFFKYLKHNSSGEQ
S699 ALRKKLHSSSSVPNF
S700 LRKKLHSSSSVPNFL
S701 RKKLHSSSSVPNFLK
S702 KKLHSSSSVPNFLKF
T738 KANHLGDTDGTPVKA
T741 HLGDTDGTPVKARRH
S749 PVKARRHSWRQQIFL
T760 QIFLRVATPQKACDS
S784 LGELPPRSPLEPVCE
K915-ub LKHPFPSkQQPkDVP
K919-ub FPSkQQPkDVPYKEL
Y969 LYNILKAYSLLDQEV
S1030 QIQMYQLSRLLHDYH
Y1041 HDYHRDLYNHLEEYE
K1181 KTNSSLRKQNLDLLE
T1220 KLKQAVLTLEMERSA
S1226 LTLEMERSALLQMVE
M1239 VEELRRQMAQPSTAE
S1243 RRQMAQPSTAEPDCT
T1244 RQMAQPSTAEPDCTR
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