Home

TBC1D1 (human)

Overview TBC1D1 a putative GTPase activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Note: This description may include information from UniProtKB. Protein type: Ubiquitin-specific protease; GTPase activating protein, Rab Cellular Component: nucleus Molecular Function: Rab GTPase activator activity Biological Process: regulation of protein localization Reference #:  Q86TI0 (UniProtKB) Alt. Names/Synonyms: KIAA1108; TBC; TBC1; TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; TBC1 domain family member 1; TBC1D1; TBCD1 Gene Symbols: TBC1D1 Molecular weight: 133,084 Da Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states CST Pathways:  Insulin Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TBC1D1 3QYE - A/B=750-1076 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: S237‑p, T596‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y90-p	QQWDPLIySSIFECK
0	11		Y113-p	HNSHDPSyFACLIKE
0	1		S145	TKVPEIISSIRQAGK
0	1		S146	KVPEIISSIRQAGKI
0	1		S163	QEELHCPSEFDDTFS
0	1		S235	VRRPMRKSFsQPGLR
4	87		S237-p	RPMRKSFsQPGLRSL
1	5		F260	GGLRSSGFFSsFEES
0	2		S262	LRSSGFFSsFEESDI
0	11		S263-p	RSSGFFSsFEESDIE
0	1		S340	GFICRESSGGGGFHF
0	1		-	gap
0	1		S408-p	RIEGMNSsKtKLELQ
0	1		T410-p	EGMNSsKtKLELQKH
0	1		M495	ATRFRLDMLkNKAkR
0	1		K497-a	RFRLDMLkNKAkRsL
0	1		K501-a	DMLkNKAkRsLTEsL
0	9		S503-p	LkNKAkRsLTEsLES
2	4		T505	NKAkRsLTEsLESIL
1	6		S507-p	AkRsLTEsLESILsR
0	1		S510	sLTEsLESILsRGNK
0	1		S513-p	EsLESILsRGNKARG
0	1		S525	ARGLQEHSISVDLDS
0	1		S527	GLQEHSISVDLDSSL
0	1		S559-p	ALPISESsFKLLGss
2	22		S565-p	SsFKLLGssEDLssD
1	21		S566-p	sFKLLGssEDLssDs
0	15		S570-p	LGssEDLssDsEsHL
0	23		S571-p	GssEDLssDsEsHLP
0	15		S573-p	sEDLssDsEsHLPEE
0	6		S575-p	DLssDsEsHLPEEPA
0	1		P581	EsHLPEEPAPLsPQQ
0	33		S585-p	PEEPAPLsPQQAFRR
5	140		T596-p	AFRRRANtLsHFPIE
0	42		S598-p	RRRANtLsHFPIECQ
0	11		G613	EPPQPARGsPGVsQR
0	47		S614-p	PPQPARGsPGVsQRK
0	4		S618-p	ARGsPGVsQRKLMRY
1	43		S627-p	RKLMRYHsVSTETPH
0	1		S629	LMRYHsVSTETPHER
0	1		T630	MRYHsVSTETPHERK
1	4		-	gap
0	1		-	gap
0	1		-	gap
0	1		-	gap
0	1		-	gap
0	1		-	gap
1	4		-	gap
0	5		T652-p	HLGDSGGtPVKTRRH
0	5		S660-p	PVKTRRHsWRQQIFL
0	4		T671-p	QIFLRVAtPQKACDS
0	2		S695	LGELPPRSPLEPVCE
0	1		K826	LKHQFPSKQQPKDVP
0	1		K830	FPSKQQPKDVPYKEL
0	1		Y880-p	LYNILKAySLLDQEV
0	1		S941	QIQMYQLSRLLHDYH
0	1		Y952	HDYHRDLYNHLEEHE
0	1		K1092	KTNSSLRKQNLDLLE
0	1		T1131	KLKQAMLTLELERsA
0	1		S1137-p	LTLELERsALLQTVE
0	2		S1150	VEELRRRSAEPSDRE
0	2		S1154	RRRSAEPSDREPECT
0	5		D1155	RRSAEPSDREPECTQ

	mouse ► Hide Isoforms
C90	QPWDPLICSSIFECK
Y113-p	HNSHDPSyFACLIKE
S145-p	TKVPEIIssIRQAGK
S146-p	KVPEIIssIRQAGKI
S163-p	QEELRCPsEFDDTFA
S229-p	GPRPMRKsFsQPGLR
S231-p	RPMRKsFsQPGLRSL
T253-p	DASLRSStFssFDND
S255-p	SLRSStFssFDNDIE
S256-p	LRSStFssFDNDIEN
S332-p	GFICRECsGGGsGGF
S336-p	RECsGGGsGGFHFVC
S402	RIEGMNSSKTKLELQ
T404	EGMNSSKTKLELQKH
S489-p	ASRFRLDsLKNRAKR
K491	RFRLDsLKNRAKRsL
K495	DsLKNRAKRsLtEsL
S497-p	LKNRAKRsLtEsLEs
T499-p	NRAKRsLtEsLEsIL
S501-p	AKRsLtEsLEsILSR
S504-p	sLtEsLEsILSRGNK
S507	EsLEsILSRGNKARG
S519-p	ARGLQDHsAsVDLDS
S521-p	GLQDHsAsVDLDSST
S553	AFPVSETSFKLLGss
S559-p	TSFKLLGssDDLssD
S560-p	SFKLLGssDDLssDs
S564-p	LGssDDLssDsEGHI
S565-p	GssDDLssDsEGHIA
S567-p	sDDLssDsEGHIAEE
G569	DLssDsEGHIAEEsA
S575-p	EGHIAEEsALLsPQQ
S579-p	AEEsALLsPQQAFRR
T590-p	AFRRRANtLsHFPVE
S592-p	RRRANtLsHFPVECP
S607-p	APPEPAQssPGVSQR
S608-p	PPEPAQssPGVSQRK
S612	AQssPGVSQRKLMRY
S621-p	RKLMRYHsVstETPH
S623-p	LMRYHsVstETPHER
T624-p	MRYHsVstETPHERN
S660-p	PRLNPSAssPNFFKY
S661-p	RLNPSAssPNFFKYL
K669-m1	PNFFKYLkHNSSGEQ
S697-p	ALRKKLHssssVPNF
S698-p	LRKKLHssssVPNFL
S699-p	RKKLHssssVPNFLK
S700-p	KKLHssssVPNFLKF
T739-p	HLGDTDGtPVKTRRH
S747	PVKTRRHSWRQQIFL
T758	QIFLRVATPQKACDS
S782-p	LGELPPRsPLEPVCE
K913	LKHPFPSKQQPKDVP
K917	FPSKQQPKDVPYKEL
Y967	LYNILKAYSLLDQEV
S1028-p	QIQMYQLsRLLHDYH
Y1039-p	HDYHRDLyNHLEEHE
K1179-u	KTNSSLRkQNLDLLE
T1218-p	KLKQAALtLEVERSA
S1224	LtLEVERSALLQMVE
S1237-p	VEELRRQsARPstPE
S1241-p	RRQsARPstPEPDCT
T1242-p	RQsARPstPEPDCTQ

	TBC1D1 iso2
C90	QPWDPLICSSIFECK
Y113	HNSHDPSYFACLIKE
S145	TKVPEIISSIRQAGK
S146	KVPEIISSIRQAGKI
S163	QEELRCPSEFDDTFA
S229	GPRPMRKSFSQPGLR
S231	RPMRKSFSQPGLRSL
T253	DASLRSSTFSSFDND
S255	SLRSSTFSSFDNDIE
S256	LRSSTFSSFDNDIEN
S332	GFICRECSGGGSGGF
S336	RECSGGGSGGFHFVC
S402	RIEGMNSSKTKLELQ
T404	EGMNSSKTKLELQKH
S489	ASRFRLDSLKNRAKR
K491	RFRLDSLKNRAKRSL
K495	DSLKNRAKRSLTESL
S497	LKNRAKRSLTESLES
T499	NRAKRSLTESLESIL
S501	AKRSLTESLESILSR
S504	SLTESLESILSRGNK
S507	ESLESILSRGNKARG
S519	ARGLQDHSASVDLDS
S521	GLQDHSASVDLDSST
S553	AFPVSETSFKLLGSS
S559	TSFKLLGSSDDLSSD
S560	SFKLLGSSDDLSSDS
S564	LGSSDDLSSDSEGHI
S565	GSSDDLSSDSEGHIA
S567	SDDLSSDSEGHIAEE
G569	DLSSDSEGHIAEESA
S575	EGHIAEESALLSPQQ
S579	AEESALLSPQQAFRR
T590	AFRRRANTLSHFPVE
S592	RRRANTLSHFPVECP
S607	APPEPAQSSPGVSQR
S608	PPEPAQSSPGVSQRK
S612	AQSSPGVSQRKLMRY
S621	RKLMRYHSVSTETPH
S623	LMRYHSVSTETPHER
T624	MRYHSVSTETPHERK
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
T646	HLGDTDGTPVKTRRH
S654	PVKTRRHSWRQQIFL
T665	QIFLRVATPQKACDS
S689	LGELPPRSPLEPVCE
K820	LKHPFPSKQQPKDVP
K824	FPSKQQPKDVPYKEL
Y874	LYNILKAYSLLDQEV
S935	QIQMYQLSRLLHDYH
Y946	HDYHRDLYNHLEEHE
K1086	KTNSSLRKQNLDLLE
T1125	KLKQAALTLEVERSA
S1131	LTLEVERSALLQMVE
S1144	VEELRRQSARPSTPE
S1148	RRQSARPSTPEPDCT
T1149	RQSARPSTPEPDCTQ

	rat
C90	QPWDPLICSSIFECK
Y113	HNSQDPSYFACLIKE
S145	TKVPEIISSIRQAGK
S146	KVPEIISSIRQAGKI
S163	QEELRCPSEFDDTFA
S229	GARPMRKSFsQPGLR
S231-p	RPMRKSFsQPGLRSL
T253	DASLRSSTFSSFDND
S255	SLRSSTFSSFDNDIE
S256	LRSSTFSSFDNDIEN
S332	GFICRECSGGGGAGF
G336	RECSGGGGAGFHFVC
S402	RIEGMNSSKTKLELQ
T404	EGMNSSKTKLELQKH
S489	ASRFRLDSLKNRAKR
K491	RFRLDSLKNRAKRSL
K495	DSLKNRAKRSLTESL
S497	LKNRAKRSLTESLES
T499	NRAKRSLTESLESIL
S501	AKRSLTESLESILSR
S504	SLTESLESILSRGNK
S507	ESLESILSRGNKARG
S519	ARGLQDHSASVDLDS
S521	GLQDHSASVDLDSST
S553	ALPISESSFKLLGSS
S559	SSFKLLGSSDDLSSD
S560	SFKLLGSSDDLSSDS
S564	LGSSDDLSSDSESHI
S565	GSSDDLSSDSESHIA
S567	SDDLSSDSESHIAEE
S569	DLSSDSESHIAEESA
S575	ESHIAEESALLSPQQ
S579	AEESALLSPQQAFRR
T590	AFRRRANTLSHFPVE
S592	RRRANTLSHFPVECP
T607	APPEPAQTSPGVSQR
S608	PPEPAQTSPGVSQRK
S612	AQTSPGVSQRKLMRY
S621	RKLMRYHSVSTETPH
S623	LMRYHSVSTETPHER
T624	MRYHSVSTETPHERN
-	gap
S663	RLNPSASSPNFFKYL
-	gap
S699	ALRKKLHSSSSVPNF
S700	LRKKLHSSSSVPNFL
S701	RKKLHSSSSVPNFLK
-	gap
T741	HLGDTDGTPVKARRH
S749	PVKARRHSWRQQIFL
T760	QIFLRVATPQKACDS
S784	LGELPPRSPLEPVCE
K915-u	LKHPFPSkQQPkDVP
K919-u	FPSkQQPkDVPYKEL
Y969	LYNILKAYSLLDQEV
S1030	QIQMYQLSRLLHDYH
Y1041	HDYHRDLYNHLEEYE
K1181	KTNSSLRKQNLDLLE
T1220	KLKQAVLTLEMERSA
S1226	LTLEMERSALLQMVE
M1239	VEELRRQMAQPSTAE
S1243	RRQMAQPSTAEPDCT
T1244	RQMAQPSTAEPDCTR

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.