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Protein Page:
TRXR1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TRXR1 a cytoplasmic pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.8.1.9; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine
Cellular Component: mitochondrion; cytosol
Molecular Function: protein binding; thioredoxin-disulfide reductase activity; electron carrier activity; FAD binding; protein disulfide oxidoreductase activity; NADP binding
Biological Process: cell proliferation; mesoderm formation; nucleobase, nucleoside and nucleotide interconversion; cell redox homeostasis; nucleobase, nucleoside and nucleotide metabolic process; cellular lipid metabolic process; signal transduction
Reference #:  Q16881 (UniProtKB)
Alt. Names/Synonyms: Gene associated with retinoic and IFN-induced mortality 12 protein; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; GRIM12; KDRF; KM-102-derived reductase-like factor; MGC9145; oxidoreductase; thioredoxin reductase 1; Thioredoxin reductase 1, cytoplasmic; thioredoxin reductase GRIM-12; Thioredoxin reductase TR1; TR1; TRXR1; TXNR; TXNRD1
Gene Symbols: TXNRD1
Molecular weight: 70,906 Da
Basal Isoelectric point: 7.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TRXR1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 - gap
0 36 Y161-p PEDLPKSyDyDLIII
0 48 Y163-p DLPKSyDyDLIIIGG
0 2 K218-u NVGCIPKkLMHQAAL
0 1 Q231 ALLGQALQDSRNYGW
0 1 K239-a DSRNYGWkVEETVkH
0 2 K239-u DSRNYGWkVEETVkH
0 2 K245-u WkVEETVkHDWDRMI
0 1 K274 RVALREKKVVyENAy
0 20 Y277-p LREKKVVyENAyGQF
0 541 Y281-p KVVyENAyGQFIGPH
0 2 K296 RIKATNNKGKEKIYS
0 4 Y302 NKGKEKIYSAERFLI
0 2 K385-u FDQDMANkIGEHMEE
0 1 K396-u HMEEHGIkFIRQFVP
0 1 K405-a IRQFVPIkVEQIEAG
0 4 K405-u IRQFVPIkVEQIEAG
0 1 T413-p VEQIEAGtPGRLRVV
0 1 K449-u GRDACTRkIGLETVG
0 2 K458-u GLETVGVkINEKTGk
0 1 K465-u kINEKTGkIPVTDEE
0 1 Y572-p SRDNNKCyAKIICNT
0 12 K580-u AKIICNTkDNERVVG
0 2 K607-u QGFAAALkCGLTKKQ
  TRXR1 iso3  
S30-p RKPRPRRssRLLAGE
S31-p KPRPRRssRLLAGEK
Y110 PEDLPKSYDYDLIII
Y112 DLPKSYDYDLIIIGG
K167 NVGCIPKKLMHQAAL
Q180 ALLGQALQDSRNYGW
K188 DSRNYGWKVEETVKH
K188 DSRNYGWKVEETVKH
K194 WKVEETVKHDWDRMI
K223 RVALREKKVVYENAY
Y226 LREKKVVYENAYGQF
Y230 KVVYENAYGQFIGPH
K245 RIKATNNKGKEKIyS
Y251-p NKGKEKIySAERFLI
K334 FDQDMANKIGEHMEE
K345 HMEEHGIKFIRQFVP
K354 IRQFVPIKVEQIEAG
K354 IRQFVPIKVEQIEAG
T362 VEQIEAGTPGRLRVV
K398 GRDACTRKIGLETVG
K407 GLETVGVKINEKTGK
K414 KINEKTGKIPVTDEE
Y521 SRDNNKCYAKIICNT
K529 AKIICNTKDNERVVG
K556 QGFAAALKCGLTKKQ
  mouse

 
- gap
- gap
Y125 SKDPPGSYDFDLIII
F127 DPPGSYDFDLIIIGG
K182 NVGCIPKKLMHQAAL
K195-u ALLGQALkDSRNYGW
K203 DSRNYGWKVEDTVkH
K203-u DSRNYGWkVEDTVkH
K209-u WkVEDTVkHDWEKMT
K238-u RVALREKkVVYENAy
Y241 LREKkVVYENAyGRF
Y245-p kVVYENAyGRFIGPH
K260-u RIVATNNkGKEKIYS
Y266 NkGKEKIYSAERFLI
K349-u FDQDMANkIGEHMEE
K360 HMEEHGIKFIRQFVP
K369 IRQFVPTKIEQIEAG
K369-u IRQFVPTkIEQIEAG
T377 IEQIEAGTPGRLRVT
T413 GRDSCTRTIGLETVG
K422-u GLETVGVkINEKTGK
K429 kINEKTGKIPVTDEE
Y536 SRDNNKCYAKIICNL
K544-u AKIICNLkDDERVVG
K571 QGFAAALKCGLTKQQ
  rat

 
- gap
- gap
Y11 SKDAPKSYDFDLIII
F13 DAPKSYDFDLIIIGG
K68 NVGCIPKKLMHQAAL
K81 ALLGQALKDSRNYGW
K89 DSRNYGWKLEDTVKH
K89 DSRNYGWKLEDTVKH
K95 WKLEDTVKHDWEKMT
K124 RVALREKKVVYENAY
Y127 LREKKVVYENAYGKF
Y131 KVVYENAYGKFIGPH
K146 KIMATNNKGKEKVYS
Y152 NKGKEKVYSAERFLI
K235 FDQDMANKIGEHMEE
K246 HMEEHGIKFIRQFVP
K255 IRQFVPTKIEQIEAG
K255 IRQFVPTKIEQIEAG
T263 IEQIEAGTPGRLKVT
T299 GRDSCTRTIGLETVG
K308 GLETVGVKINEKTGK
K315 KINEKTGKIPVTDEE
Y422 SRDNNKCYAKVICNL
K430 AKVICNLKDNERVVG
K457 QGFAAALKCGLTKQQ
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