Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
TRXR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TRXR1 a cytoplasmic pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.8.1.9; Nucleotide Metabolism - pyrimidine; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 12q23-q24.1
Cellular Component: mitochondrion; nucleolus; nucleus; cytosol
Molecular Function: protein binding; thioredoxin-disulfide reductase activity; electron carrier activity; FAD binding; protein disulfide oxidoreductase activity; NADP binding
Biological Process: cell proliferation; mesoderm formation; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; cell redox homeostasis; cellular lipid metabolic process; signal transduction
Reference #:  Q16881 (UniProtKB)
Alt. Names/Synonyms: Gene associated with retinoic and IFN-induced mortality 12 protein; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; GRIM12; KDRF; KM-102-derived reductase-like factor; MGC9145; oxidoreductase; thioredoxin reductase 1; Thioredoxin reductase 1, cytoplasmic; thioredoxin reductase GRIM-12; Thioredoxin reductase TR1; TR1; TRXR1; TXNR; TXNRD1
Gene Symbols: TXNRD1
Molecular weight: 70,906 Da
Basal Isoelectric point: 7.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TRXR1

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 - gap
0 1 - gap
0 35 Y161-p PEDLPKSyDyDLIII
0 47 Y163-p DLPKSyDyDLIIIGG
0 1 Y184-p AAKEAAQyGKKVMVL
0 1 K217-ub VNVGCIPkkLMHQAA
0 2 K218-ub NVGCIPkkLMHQAAL
0 1 Q231 ALLGQALQDSRNYGW
0 2 K239-ub DSRNYGWkVEETVkH
0 2 K239-ac DSRNYGWkVEETVkH
0 1 K245-sc WkVEETVkHDWDRMI
0 2 K245-ub WkVEETVkHDWDRMI
0 1 K274 RVALREKKVVyENAy
0 23 Y277-p LREKKVVyENAyGQF
0 558 Y281-p KVVyENAyGQFIGPH
0 1 K296 RIKATNNKGkEKIyS
0 2 K296 RIKATNNKGkEKIyS
0 1 K298-ac KATNNKGkEKIySAE
0 1 K300 TNNKGkEKIySAERF
0 4 Y302-p NKGkEKIySAERFLI
0 2 K385-ub FDQDMANkIGEHMEE
0 1 K396-ub HMEEHGIkFIRQFVP
0 1 K405-ac IRQFVPIkVEQIEAG
0 1 K405-sc IRQFVPIkVEQIEAG
0 4 K405-ub IRQFVPIkVEQIEAG
0 2 T413-p VEQIEAGtPGRLRVV
0 1 Y434-p EEIIEGEyNTVMLAI
0 1 K449-ub GRDACTRkIGLETVG
0 1 K458 GLETVGVKINEKTGk
0 2 K458-ub GLETVGVkINEKTGk
0 1 K465-ub kINEKTGkIPVTDEE
0 1 Y555-p NIEVYHSyFWPLEWT
0 1 Y572-p SRDNNKCyAKIICNT
0 12 K580-ub AKIICNTkDNERVVG
0 2 K607-ub QGFAAALkCGLTKKQ
  TRXR1 iso3  
S30-p RKPRPRRssRLLAGE
S31-p KPRPRRssRLLAGEK
- gap
Y110 PEDLPKSYDYDLIII
Y112 DLPKSYDYDLIIIGG
Y133 AAKEAAQYGKKVMVL
K166 VNVGCIPKKLMHQAA
K167 NVGCIPKKLMHQAAL
Q180 ALLGQALQDSRNYGW
K188 DSRNYGWKVEETVKH
K188 DSRNYGWKVEETVKH
K194 WKVEETVKHDWDRMI
K194 WKVEETVKHDWDRMI
K223 RVALREKKVVYENAY
Y226 LREKKVVYENAYGQF
Y230 KVVYENAYGQFIGPH
K245 RIKATNNKGKEKIyS
K245 RIKATNNKGKEKIyS
K247 KATNNKGKEKIySAE
K249 TNNKGKEKIySAERF
Y251-p NKGKEKIySAERFLI
K334 FDQDMANKIGEHMEE
K345 HMEEHGIKFIRQFVP
K354 IRQFVPIKVEQIEAG
K354 IRQFVPIKVEQIEAG
K354 IRQFVPIKVEQIEAG
T362 VEQIEAGTPGRLRVV
Y383 EEIIEGEYNTVMLAI
K398 GRDACTRKIGLETVG
K407 GLETVGVKINEKTGK
K407 GLETVGVKINEKTGK
K414 KINEKTGKIPVTDEE
Y504 NIEVYHSYFWPLEWT
Y521 SRDNNKCYAKIICNT
K529 AKIICNTKDNERVVG
K556 QGFAAALKCGLTKKQ
  TRXR1 iso4  
- gap
- gap
S2-p ______MsCEDGRAL
Y63 PEDLPKSYDYDLIII
Y65 DLPKSYDYDLIIIGG
Y86 AAKEAAQYGKKVMVL
K119 VNVGCIPKKLMHQAA
K120 NVGCIPKKLMHQAAL
Q133 ALLGQALQDSRNYGW
K141 DSRNYGWKVEETVKH
K141 DSRNYGWKVEETVKH
K147 WKVEETVKHDWDRMI
K147 WKVEETVKHDWDRMI
K176 RVALREKKVVYENAY
Y179 LREKKVVYENAYGQF
Y183 KVVYENAYGQFIGPH
K198 RIKATNNKGKEKIYS
K198 RIKATNNKGKEKIYS
K200 KATNNKGKEKIYSAE
K202 TNNKGKEKIYSAERF
Y204 NKGKEKIYSAERFLI
K287 FDQDMANKIGEHMEE
K298 HMEEHGIKFIRQFVP
K307 IRQFVPIKVEQIEAG
K307 IRQFVPIKVEQIEAG
K307 IRQFVPIKVEQIEAG
T315 VEQIEAGTPGRLRVV
Y336 EEIIEGEYNTVMLAI
K351 GRDACTRKIGLETVG
K360 GLETVGVKINEKTGK
K360 GLETVGVKINEKTGK
K367 KINEKTGKIPVTDEE
Y457 NIEVYHSYFWPLEWT
Y474 SRDNNKCYAKIICNT
K482 AKIICNTKDNERVVG
K509 QGFAAALKCGLTKKQ
  mouse

 
- gap
- gap
T27 QTVWVAPTCPNCCWF
Y125 SKDPPGSYDFDLIII
F127 DPPGSYDFDLIIIGG
F148 AAKEAAKFDKKVLVL
K181 VNVGCIPKKLMHQAA
K182 NVGCIPKKLMHQAAL
K195-ub ALLGQALkDSRNYGW
K203-ub DSRNYGWkVEDTVkH
K203-ac DSRNYGWkVEDTVkH
K209 WkVEDTVKHDWEKMT
K209-ub WkVEDTVkHDWEKMT
K238-ub RVALREKkVVYENAy
Y241 LREKkVVYENAyGRF
Y245-p kVVYENAyGRFIGPH
K260-ac RIVATNNkGKEkIYS
K260-ub RIVATNNkGKEkIYS
K262 VATNNkGKEkIYSAE
K264-ac TNNkGKEkIYSAERF
Y266 NkGKEkIYSAERFLI
K349-ub FDQDMANkIGEHMEE
K360 HMEEHGIKFIRQFVP
K369 IRQFVPTKIEQIEAG
K369 IRQFVPTKIEQIEAG
K369-ub IRQFVPTkIEQIEAG
T377 IEQIEAGTPGRLRVT
F398 EETIEGEFNTVLLAV
T413 GRDSCTRTIGLETVG
K422-ac GLETVGVkINEKTGK
K422-ub GLETVGVkINEKTGK
K429 kINEKTGKIPVTDEE
F519 NIEVYHSFFWPLEWT
Y536 SRDNNKCYAKIICNL
K544-ub AKIICNLkDDERVVG
K571 QGFAAALKCGLTKQQ
  rat

 
- gap
- gap
- gap
Y11 SKDAPKSYDFDLIII
F13 DAPKSYDFDLIIIGG
F34 AAKEAAKFDKKVMVL
K67 VNVGCIPKKLMHQAA
K68 NVGCIPKKLMHQAAL
K81 ALLGQALKDSRNYGW
K89 DSRNYGWKLEDTVKH
K89 DSRNYGWKLEDTVKH
K95 WKLEDTVKHDWEKMT
K95 WKLEDTVKHDWEKMT
K124 RVALREKKVVYENAY
Y127 LREKKVVYENAYGKF
Y131 KVVYENAYGKFIGPH
K146 KIMATNNKGKEkVYS
K146 KIMATNNKGKEkVYS
K148 MATNNKGKEkVYSAE
K150-ac TNNKGKEkVYSAERF
Y152 NKGKEkVYSAERFLI
K235 FDQDMANKIGEHMEE
K246 HMEEHGIKFIRQFVP
K255 IRQFVPTKIEQIEAG
K255 IRQFVPTKIEQIEAG
K255 IRQFVPTKIEQIEAG
T263 IEQIEAGTPGRLKVT
F284 EETIEDEFNTVLLAV
T299 GRDSCTRTIGLETVG
K308-ac GLETVGVkINEKTGK
K308 GLETVGVKINEKTGK
K315 kINEKTGKIPVTDEE
F405 NIEVYHSFFWPLEWT
Y422 SRDNNKCYAKVICNL
K430 AKVICNLKDNERVVG
K457 QGFAAALKCGLTKQQ
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.