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Protein Page:
TRIM25 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TRIM25 a ubiquitous protein that mediates estrogen action in various target organs. Contains one RING-type zinc finger and one SPRY domain.. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; EC 6.3.2.-; Ligase; EC 6.3.2.n3; Transcription factor; Ubiquitin conjugating system; Ubiquitin ligase
Cellular Component: cytoplasm; nucleolus; cytosol; nucleus
Molecular Function: protein binding; acid-amino acid ligase activity; zinc ion binding; transcription factor activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; response to vitamin D; viral reproduction; response to estrogen stimulus; protein ubiquitination; innate immune response; positive regulation of transcription factor activity; regulation of virion penetration into host cell; defense response to virus; negative regulation of interferon type I production; activation of NF-kappaB transcription factor
Reference #:  Q14258 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin/ISG15 ligase TRIM25; EFP; Estrogen-responsive finger protein; RING finger protein 147; RNF147; TRI25; TRIM25; tripartite motif protein TRIM25; tripartite motif-containing 25; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Z147; Zinc finger protein 147; zinc finger protein 147 (estrogen-responsive finger protein); zinc finger protein-147; ZNF147
Gene Symbols: TRIM25
Molecular weight: 70,973 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TRIM25

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S46-p ETWAVQGsPyLCPQC
0 2 Y48-p WAVQGsPyLCPQCRA
0 2 Y57-p CPQCRAVyQARPQLH
0 2 E84 LQADLAREPPADVWt
0 33 T91-p EPPADVWtPPARAsA
0 3 S97-p WtPPARAsAPsPNAQ
0 10 S100-p PARAsAPsPNAQVAC
0 26 K117-ub CLKEAAVkTCLVCMA
0 1 S190-p HKTCSPAsLSQASAD
0 1 T201 ASADLEATLRHkLTV
0 1 K205-ub LEATLRHkLTVMYSQ
0 1 R226 ALDDVRNRQQDVRMT
0 1 N235 QDVRMTANRkVEQLQ
0 1 K237-ub VRMTANRkVEQLQQE
0 14 Y245-p VEQLQQEytEMkALL
0 1 T246-p EQLQQEytEMkALLD
0 1 K249-ub QQEytEMkALLDASE
0 1 T258-p LLDASETtSTRKIKE
0 7 K273-ac EEKRVNSkFDtIyQI
0 3 K273-ub EEKRVNSkFDtIyQI
0 20 T276-p RVNSkFDtIyQILLk
0 286 Y278-p NSkFDtIyQILLkkK
0 6 K283-ub tIyQILLkkKSEIQt
0 3 K284-ub IyQILLkkKSEIQtL
0 1 T290-p kkKSEIQtLkEEIEQ
0 1 K292-ub KSEIQtLkEEIEQSL
0 1 K301-ub EIEQSLTkRDEFEFL
0 2 K310-ub DEFEFLEkAsKLRGI
0 1 S312-p FEFLEkAsKLRGISt
0 1 K313 EFLEkAsKLRGIStk
0 1 T319-p sKLRGIStkPVyIPE
0 1 K320-ac KLRGIStkPVyIPEV
0 5 K320-ub KLRGIStkPVyIPEV
0 4 Y323-p GIStkPVyIPEVELN
0 1 K335-ub ELNHKLIkGIHQSTI
0 3 K345-ub HQSTIDLkNELKQCI
0 1 K375 HDPASTHKSTRPVKK
0 1 V380 THKSTRPVKKVSKEE
0 1 K381 HKSTRPVKKVSKEEK
0 2 K392-ub KEEKKSKkPPPVPAL
0 1 L399 kPPPVPALPSkLPTF
0 1 K402-ac PVPALPSkLPTFGAP
0 5 K402-ub PVPALPSkLPTFGAP
0 12 K416-ub PEQLVDLkQAGLEAA
0 1 G419 LVDLkQAGLEAAAkA
0 7 K425-ub AGLEAAAkATSsHPN
0 1 S429-p AAAkATSsHPNstsL
0 1 S433-p ATSsHPNstsLkAkV
0 1 T434-p TSsHPNstsLkAkVL
0 9 S435-p SsHPNstsLkAkVLE
0 18 K437-ub HPNstsLkAkVLETF
0 20 K439-ub NstsLkAkVLETFLA
0 4 K447-ub VLETFLAkSRPELLE
0 1 C475 NKVALSECYTVASVA
0 1 K509-ub LGLHCYKkGIHYWEV
0 2 K567-ac AWHNNVEkTLPSTkA
0 2 K567-ub AWHNNVEkTLPSTkA
0 2 K573-ub EkTLPSTkATRVGVL
  mouse

 
P46 ETWVVQGPPYRCPQC
Y48 WVVQGPPYRCPQCRK
Y57 CPQCRKVYQVRPQLQ
T84-p LQAEQARtPVDDWtP
T90-p RtPVDDWtPPARFSA
S96 WtPPARFSASSAATQ
S99 PARFSASSAATQVAC
K116-ub CLTEIAVkTCLVCMA
T189 HKTCSPTTLSQASAD
K200-ub ASADLEYkLRNKLTI
K204 LEYkLRNKLTIMHSH
K225-ub ALEDVRSkQQCVQDS
K234-ub QCVQDSMkRKMEQLR
K236 VQDSMkRKMEQLRQE
Y244 MEQLRQEYMEMKAVI
M245 EQLRQEYMEMKAVID
K248 RQEYMEMKAVIDAAE
S257 VIDAAETSSLRKLKE
K272 EEKRVYGKFDTIyQV
K272 EEKRVYGKFDTIyQV
T275 RVYGKFDTIyQVLVk
Y277-p YGKFDTIyQVLVkKK
K282-ub TIyQVLVkKKSEMQK
K283 IyQVLVkKKSEMQKL
K289 kKKSEMQKLKAEVEL
K291 KSEMQKLKAEVELIM
K300 EVELIMDKGDEFEFL
K309-ub DEFEFLEkAAkLQGE
A311 FEFLEkAAkLQGEST
K312-ub EFLEkAAkLQGESTk
T318 AkLQGESTkPVYIPK
K319 kLQGESTKPVYIPKI
K319-ub kLQGESTkPVYIPKI
Y322 GESTkPVYIPKIDLD
M334 DLDHDLIMGIYQGAA
K344-ub YQGAADLkSELKHSI
K376-ub DQTQSTFkPVQPskK
S381-p TFkPVQPskKTIQEK
K382-ub FkPVQPskKTIQEKK
T393 QEKKTKKTPVAPGPP
S404-p PGPPSHFsPNkLPTF
K407 PSHFsPNKLPTFGAP
K407-ub PSHFsPNkLPTFGAP
K421-ub PGQSLDSkATsPDAA
S424-p SLDSkATsPDAAPkA
K430-ub TsPDAAPkASAAQPD
A434 AAPkASAAQPDSVGV
S438 ASAAQPDSVGVkAkV
V439 SAAQPDSVGVkAkVL
G440 AAQPDSVGVkAkVLE
K442-ub QPDSVGVkAkVLENF
K444-ub DSVGVkAkVLENFLT
K452 VLENFLTKSRTELLE
K480-ub NKVSLSNkYTTASVS
N514 LGLHCYKNGIHYWEV
K572 AWHNNVEKTLPSTKA
K572 AWHNNVEKTLPSTKA
K578 EKTLPSTKATRVGVL
  rat

 
P46 ETWVVQGPPYRCPQC
Y48 WVVQGPPYRCPQCRT
Y57 CPQCRTVYQVRPQLH
T84 LQAEQARTPVDDWIP
I90 RTPVDDWIPPTRSAA
A96 WIPPTRSAASSSDTQ
S99 PTRSAASSSDTQVSC
K116 CLKEVAVKTCLVCMA
I189 HKTCSPTILSQASAD
K200 ASADLENKLRQKLTI
K204 LENKLRQKLTIMYSH
K225 ALEDVKSKQQNVQES
K234 QNVQESMKRKMLQLR
K236 VQESMKRKMLQLRQE
Y244 MLQLRQEYLEMKAVI
L245 LQLRQEYLEMKAVID
K248 RQEYLEMKAVIDAAE
S257 VIDAAETSSTHKLKE
K272 EEKRVYGKLDTIYQV
K272 EEKRVYGKLDTIYQV
T275 RVYGKLDTIYQVLLK
Y277 YGKLDTIYQVLLKKK
K282 TIYQVLLKKKNEMQN
K283 IYQVLLKKKNEMQNL
N289 KKKNEMQNLKAEVEL
K291 KNEMQNLKAEVELIL
K300 EVELILAKGDEFEFL
K309 DEFEFLEKAAKLQEV
A311 FEFLEKAAKLQEVST
K312 EFLEKAAKLQEVSTK
T318 AKLQEVSTKPVYIPK
K319 KLQEVSTKPVYIPKI
K319 KLQEVSTKPVYIPKI
Y322 EVSTKPVYIPKIDLD
K334 DLDHDLIKGVYQGAL
K344 YQGALDLKSELKLSL
K377 DHAQSTSKPTRPAKK
A382 TSKPTRPAKKTAPDK
K383 SKPTRPAKKTAPDKK
T394 PDKKTKKTPGAAGAA
S417 AGPTSYSSSSNKLPT
K421 SYSSSSNKLPTFGAP
K421 SYSSSSNKLPTFGAP
Q430 PTFGAPGQATIPDAT
I433 GAPGQATIPDATLKP
K439 TIPDATLKPNAPQPN
P443 ATLKPNAPQPNSAAV
S447 PNAPQPNSAAVKAKV
A448 NAPQPNSAAVKAKVL
A449 APQPNSAAVKAKVLE
K451 QPNSAAVKAKVLENF
K453 NSAAVKAKVLENFLT
M461 VLENFLTMSRTELLE
N489 NKVALADNYTTASVA
K523 LGLHCYKKGIHYWEV
K581 AWHNNMEKTLPSTKA
K581 AWHNNMEKTLPSTKA
K587 EKTLPSTKATRVGVL
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