a ubiquitous protein that mediates estrogen action in various target organs. Contains one RING-type zinc finger and one SPRY domain.. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.n3; EC 6.3.2.-; Transcription factor; Ligase; Ubiquitin ligase; EC 220.127.116.11; Ubiquitin conjugating system
Molecular Function: protein binding; acid-amino acid ligase activity; zinc ion binding; transcription factor activity
Biological Process: response to vitamin D; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; response to estrogen stimulus; protein ubiquitination; innate immune response; positive regulation of transcription factor activity; regulation of virion penetration into host cell; defense response to virus; negative regulation of interferon type I production; activation of NF-kappaB transcription factor
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.