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TIAL1
a member of a family of RNA-binding proteins that possesses nucleolytic activity. A cytotoxic T cell granule-associated protein that has been shown to bind specifically to poly(A) homopolymers and to fragment DNA in permeabilized target cells. Members of this protein family may be involved in the induction of apoptosis. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: RNA binding protein; Apoptosis |
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Cellular Component: lysosome; stress granule; cytoplasm; nucleus
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Molecular Function: RNA binding; nucleotide binding; AU-rich element binding
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Biological Process: regulation of transcription from RNA polymerase II promoter; apoptosis; stem cell division; positive regulation of cell proliferation; induction of apoptosis; defense response; germ cell development
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Reference #:
Q01085 (UniProtKB)
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| Alt. Names/Synonyms: aging-associated gene 7 protein; MGC33401; Nucleolysin TIAR; T-cluster binding protein; TCBP; TIA-1 related protein; TIA-1-related nucleolysin; TIA-1-related protein; TIA1 cytotoxic granule-associated RNA binding protein-like 1; TIA1 cytotoxic granule-associated RNA-binding protein-like 1; TIAL1; TIAR |
| Gene Symbols: TIAL1 |
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Molecular weight: 41,591 Da
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Basal Isoelectric point: 7.62
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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