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Protein Page:
TIAL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TIAL1 a member of a family of RNA-binding proteins that possesses nucleolytic activity. A cytotoxic T cell granule-associated protein that has been shown to bind specifically to poly(A) homopolymers and to fragment DNA in permeabilized target cells. Members of this protein family may be involved in the induction of apoptosis. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; RNA binding protein
Cellular Component: stress granule; lysosome; cytoplasm; nucleus
Molecular Function: RNA binding; nucleotide binding; AU-rich element binding
Biological Process: regulation of transcription from RNA polymerase II promoter; apoptosis; stem cell division; positive regulation of cell proliferation; defense response; germ cell development
Reference #:  Q01085 (UniProtKB)
Alt. Names/Synonyms: aging-associated gene 7 protein; MGC33401; Nucleolysin TIAR; T-cluster binding protein; TCBP; TIA-1 related protein; TIA-1-related nucleolysin; TIA-1-related protein; TIA1 cytotoxic granule-associated RNA binding protein-like 1; TIA1 cytotoxic granule-associated RNA-binding protein-like 1; TIAL1; TIAR
Gene Symbols: TIAL1
Molecular weight: 41,591 Da
Basal Isoelectric point: 7.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TIAL1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 16 - gap
0 1 - gap
0 7 - gap
0 20 Y50-p EHTSNDPyCFVEFYE
0 1 S105-p HVFVGDLsPEITTED
0 1 K122-ac SAFAPFGkISDARVV
0 4 K122-ub SAFAPFGkISDARVV
0 2 K130 ISDARVVKDMATGKS
0 7 Y140-p ATGKSKGyGFVSFyN
0 3 Y146-p GyGFVSFyNKLDAEN
0 4 S201-p EDVVNQSsPKNCTVY
0 1 S278-p KCYWGKEsPDMtKNF
0 1 T282-p GKEsPDMtKNFQQVD
  TIAL1 iso2  
S52-p PDSRRVNssVGFsVL
S53-p DSRRVNssVGFsVLQ
S57-p VNssVGFsVLQHTSN
Y67-p QHTSNDPyCFVEFYE
S122 HVFVGDLSPEITTED
K139 SAFAPFGKISDARVV
K139 SAFAPFGKISDARVV
K147 ISDARVVKDMATGKS
Y157 ATGKSKGYGFVSFYN
Y163 GYGFVSFYNKLDAEN
S218 EDVVNQSSPKNCTVY
S295 KCYWGKESPDMTKNF
T299 GKESPDMTKNFQQVD
  mouse

 
S52 PDSRRVNSSVGFSVL
S53 DSRRVNSSVGFSVLQ
S57 VNSSVGFSVLQHTSN
Y67 QHTSNDPYCFVEFYE
S122 HVFVGDLSPEITTED
K139 SAFAPFGKISDARVV
K139-ub SAFAPFGkISDARVV
K147-ac ISDARVVkDMATGKS
Y157 ATGKSKGYGFVSFYN
Y163 GYGFVSFYNKLDAEN
S218 EDVVNQSSPKNCTVY
S295 KCYWGKESPDMTKNF
T299 GKESPDMTKNFQQVD
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