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eIF3-eta (human)

Overview eIF3-eta eukaryotic translation initiation factor 3 subunit 9. Binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA. eIF-3 is composed of at least 12 different subunits. Note: This description may include information from UniProtKB. Protein type: Translation; Translation initiation Cellular Component: eukaryotic translation initiation factor 3 complex; cytosol Molecular Function: protein binding; translation initiation factor activity; nucleotide binding; protein complex scaffold Biological Process: cellular protein metabolic process; translation; translational initiation; gene expression; regulation of translational initiation Reference #:  P55884 (UniProtKB) Alt. Names/Synonyms: eIF-3-eta; eIF3 p110; eIF3 p116; EIF3-ETA; EIF3-P110; EIF3-P116; EIF3B; EIF3S9; Eukaryotic translation initiation factor 3 subunit 9; Eukaryotic translation initiation factor 3 subunit B; eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD); eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa; eukaryotic translation initiation factor 3, subunit B; hPrt1; MGC104664; MGC131875; PRT1; Prt1 homolog Gene Symbols: EIF3B Molecular weight: 92,482 Da Basal Isoelectric point: 4.89  Predict pI for various phosphorylation states CST Pathways:  Translational Control

Select Structure to View Below eIF3-eta 2KRB - A=184-264 (human) 2NLW - A=170-274 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		P28	QQQPAAEPPPAEGLL
0	4		A31	PAAEPPPAEGLLRPA
0	5		P40	GLLRPAGPGAPEAAG
0	6		P43	RPAGPGAPEAAGTEA
0	1		T48	GAPEAAGTEASSEEV
0	2		T68-p	GPESEVRtEPAAEAE
0	11		A74	RtEPAAEAEAAsGPs
0	8		S78-p	AAEAEAAsGPsEsPs
0	6		P80	EAEAAsGPsEsPsPP
0	24		S81-p	AEAAsGPsEsPsPPA
0	11		S83-p	AAsGPsEsPsPPAAE
0	29		S85-p	sGPsEsPsPPAAEEL
0	6		P87	PsEsPsPPAAEELPG
0	3		E90	sPsPPAAEELPGSHA
0	7		G94	PAAEELPGSHAEPPV
0	10		S95	AAEELPGSHAEPPVP
0	1		P100	PGSHAEPPVPAQGEA
0	3		Q104	AEPPVPAQGEAPGEQ
0	10		S117-p	EQARDERsDsRAQAV
0	5		S119-p	ARDERsDsRAQAVsE
0	6		S125-p	DsRAQAVsEDAGGNE
0	35		N131	VsEDAGGNEGRAAEA
0	34		R134	DAGGNEGRAAEAEPR
0	20		S152-p	NGDADEPsFsDPEDF
0	30		S154-p	DADEPsFsDPEDFVD
0	34		S164-p	EDFVDDVsEEELLGD
0	9		K202-u	VGPDRLEkLkNVIHk
0	3		K204-u	PDRLEkLkNVIHkIF
0	2		K209-a	kLkNVIHkIFSkFGk
0	5		K209-u	kLkNVIHkIFSkFGk
0	19		K213-u	VIHkIFSkFGkITND
0	2		K216-u	kIFSkFGkITNDFYP
0	8		K228-u	FYPEEDGkTkGyIFL
0	7		K230-u	PEEDGkTkGyIFLEy
0	1		Y232-p	EDGkTkGyIFLEyAs
0	1		Y237-p	kGyIFLEyAsPAHAV
0	28		S239-p	yIFLEyAsPAHAVDA
0	2		K248-u	AHAVDAVkNADGykL
0	1		Y253-p	AVkNADGykLDkQHT
0	1		K254-u	VkNADGykLDkQHTF
0	9		K257-u	ADGykLDkQHTFRVN
0	6		Y272-p	LFTDFDKyMTISDEW
0	2		K284-u	DEWDIPEkQPFkDLG
0	1		K288-a	IPEkQPFkDLGNLRY
0	3		K288-u	IPEkQPFkDLGNLRY
0	18		K324-u	SIFWNDVkDPVSIEE
0	9		Y339-p	RARWTETyVRWSPkG
0	1		K345-u	TyVRWSPkGTYLATF
0	1		K364-a	IALWGGEkFKQIQRF
0	10		K364-u	IALWGGEkFKQIQRF
0	1		K436-a	FKWSHDGkFFARMTL
0	3		S447-p	RMTLDTLsIyEtPSM
0	58		Y449-p	TLDTLsIyEtPSMGL
0	2		T451-p	DTLsIyEtPSMGLLD
0	7		K459-u	PSMGLLDkksLkIsG
0	1		K460-u	SMGLLDkksLkIsGI
0	1		S461-p	MGLLDkksLkIsGIK
0	3		K463-u	LLDkksLkIsGIKDF
0	1		S465-p	DkksLkIsGIKDFSW
0	2		K487-u	AFWVPEDkDIPARVT
0	1		T494	kDIPARVTLMQLPtR
0	2		T500-p	VTLMQLPtRQEIRVR
0	5		K516-u	LFNVVDCkLHWQkNG
0	2		K521-u	DCkLHWQkNGDyLCV
0	63		Y525-p	HWQkNGDyLCVkVDR
0	2		K529-u	NGDyLCVkVDRTPkG
0	30		K535-u	VkVDRTPkGtQGVVT
0	2		T537-p	VDRTPkGtQGVVTNF
0	1		K552	EIFRMREKQVPVDVV
0	14		K552-u	EIFRMREkQVPVDVV
0	1		K599-u	YHVKNNGkIELIkMF
0	2		K604-u	NGkIELIkMFDkQQA
0	7		K608-u	ELIkMFDkQQANTIF
0	1		T644	FVDTSDCTVMNIAEH
0	2		Y652	VMNIAEHYMASDVEW
0	1		S713-p	PRPPTLLsQEQIkQI
0	1		K718-u	LLsQEQIkQIKKDLK
0	1		S728-p	KKDLKKYskIFEQKD
0	1		K729-a	KDLKKYskIFEQKDR
0	2		K729-u	KDLKKYskIFEQKDR
0	1		S738-p	FEQKDRLsQSKASkE
0	1		K744-a	LsQSKASkELVERRR
0	1		K744-u	LsQSKASkELVERRR
0	1		T752-p	ELVERRRtMMEDFRK
0	2		K762-u	EDFRKYRkMAQELyM
0	1		Y768-p	RkMAQELyMEQkNER
0	1		E770	MAQELyMEQkNERLE
0	1		K772-u	QELyMEQkNERLELR

	mouse
S28-p	RQQPASEsPPtDEAA
T31-p	PASEsPPtDEAAGsG
S37-p	PtDEAAGsGGsEVGQ
S40-p	EAAGsGGsEVGQtED
T45-p	GGsEVGQtEDAEEDA
A62	GPEPEVRAKPAAQsE
S68-p	RAKPAAQsEEEtAts
T72-p	AAQsEEEtAtsPAAs
T74-p	QsEEEtAtsPAAsPt
S75-p	sEEEtAtsPAAsPtP
A77	EEtAtsPAAsPtPQs
S79-p	tAtsPAAsPtPQsAE
T81-p	tsPAAsPtPQsAERs
S84-p	AAsPtPQsAERsPsQ
S88-p	tPQsAERsPsQEPsA
S90-p	QsAERsPsQEPsAPG
S94-p	RsPsQEPsAPGkAEA
K98-u	QEPsAPGkAEAVGEQ
S111-p	EQARGHPsAGAEEEG
-	gap
-	gap
S120-p	GAEEEGGsDGsAAEA
S123-p	EEGGsDGsAAEAEPR
S141-p	NGEADEPsFsDPEDF
S143-p	EADEPsFsDPEDFVD
S153-p	EDFVDDVsEEELLGD
K191-u	VGPDRLEkLKNVIHk
K193	PDRLEkLKNVIHkIF
K198	kLKNVIHKIFSkFGk
K198-u	kLKNVIHkIFSkFGk
K202-u	VIHkIFSkFGkIIND
K205-u	kIFSkFGkIINDYYP
K217	YYPEEDGKTKGYIFL
K219	PEEDGKTKGYIFLEY
Y221	EDGKTKGYIFLEYAs
Y226	KGYIFLEYAsPAHAV
S228-p	YIFLEYAsPAHAVDA
K237-u	AHAVDAVkNADGYKL
Y242	AVkNADGYKLDkQHT
K243	VkNADGYKLDkQHTF
K246-u	ADGYKLDkQHTFRVN
Y261	LFTDFDKYMTISDEW
K273-u	DEWDIPEkQPFkDLG
K277	IPEkQPFKDLGNLRY
K277-u	IPEkQPFkDLGNLRY
K313-u	SIFWNDVkDPVSIEE
Y328-p	RARWTETyVRWSPKG
K334	TyVRWSPKGTYLATF
K353	IALWGGDKFKQIQRF
K353-u	IALWGGDkFKQIQRF
K425	FKWSHDGKFFARMTL
S436	RMTLDTLSIyEtPSM
Y438-p	TLDTLSIyEtPSMGL
T440-p	DTLSIyEtPSMGLLD
K448-u	PSMGLLDkKSLKISG
K449	SMGLLDkKSLKISGI
S450	MGLLDkKSLKISGIK
K452	LLDkKSLKISGIKDF
S454	DkKSLKISGIKDFSW
K476	AFWVPEDKDIPARVt
T483-p	KDIPARVtLMQLPtR
T489-p	VtLMQLPtRQEIRVR
K505-u	LFNVVDCkLHWQKNG
K510	DCkLHWQKNGDyLCV
Y514-p	HWQKNGDyLCVKVDR
K518	NGDyLCVKVDRTPkG
K524-u	VKVDRTPkGTQGVVT
T526	VDRTPkGTQGVVTNF
K541-a	EIFRMREkQVPVDVV
K541-u	EIFRMREkQVPVDVV
K588	YHVKSNGKIELIKMF
K593	NGKIELIKMFDKQQA
K597	ELIKMFDKQQANTIF
T633-p	FVDTSDCtVMNIAEH
Y641-p	VMNIAEHyMASDVEW
S702-p	PRPPTLLsQDQIKQI
K707	LLsQDQIKQIKKDLK
S717	KKDLKKYSkIFEQKD
K718	KDLKKYSKIFEQKDR
K718-u	KDLKKYSkIFEQKDR
S727	FEQKDRLSQSKASKE
K733	LSQSKASKELVERRR
K733	LSQSKASKELVERRR
T741	ELVERRRTMMEDFRQ
K751	EDFRQYRKMAQELYM
Y757	RKMAQELYMkQKNER
K759-u	MAQELYMkQKNERLE
K761	QELYMkQKNERLELR

	rat
S28-p	RQQPVSEsPPTDEAA
T31	PVSEsPPTDEAAGSG
S37	PTDEAAGSGGSEVGR
S40	EAAGSGGSEVGRTED
T45	GGSEVGRTEDAEEDA
A62	RPEPEVRAKPAAQsE
S68-p	RAKPAAQsEEEtAAs
T72-p	AAQsEEEtAAsPAAs
A74	QsEEEtAAsPAAsPt
S75-p	sEEEtAAsPAAsPtP
A77	EEtAAsPAAsPtPQS
S79-p	tAAsPAAsPtPQSAQ
T81-p	AsPAAsPtPQSAQEP
S84	AAsPtPQSAQEPSAP
-	gap
-	gap
S89	PQSAQEPSAPGKAEA
K93	QEPSAPGKAEAGGEQ
S105	GEQARHPSARAEEEG
-	gap
-	gap
S114-p	RAEEEGGsDGsAAEA
S117-p	EEGGsDGsAAEAEPR
S135	NGEADEPSFsDPEDF
S137-p	EADEPSFsDPEDFVD
S147	EDFVDDVSEEELLGD
K185	VGPDRLEKLKNVIHK
K187	PDRLEKLKNVIHKIF
K192	KLKNVIHKIFSKFGK
K192	KLKNVIHKIFSKFGK
K196	VIHKIFSKFGKIIND
K199	KIFSKFGKIINDYYP
K211	YYPEEDGKTKGYIFL
K213	PEEDGKTKGYIFLEY
Y215	EDGKTKGYIFLEYAS
Y220	KGYIFLEYASPAHAV
S222	YIFLEYASPAHAVDA
K231	AHAVDAVKNADGYKL
Y236	AVKNADGYKLDKQHT
K237	VKNADGYKLDKQHTF
K240	ADGYKLDKQHTFRVN
Y255	LFTDFDKYMTISDEW
K267	DEWDIPEKQPFKDLG
K271	IPEKQPFKDLGNLRY
K271	IPEKQPFKDLGNLRY
K307	SIFWNDVKDPVSIEE
Y322	RARWTETYVRWSPKG
K328	TYVRWSPKGTYLATF
K347	IALWGGDKFKQIQRF
K347	IALWGGDKFKQIQRF
K419	FKWSHDGKFFARMTL
S430	RMTLDTLSIYETPSM
Y432	TLDTLSIYETPSMGL
T434	DTLSIYETPSMGLLD
K442	PSMGLLDKKSLKISG
K443	SMGLLDKKSLKISGI
S444	MGLLDKKSLKISGIK
K446	LLDKKSLKISGIKDF
S448	DKKSLKISGIKDFSW
K470	AFWVPEDKDIPARVT
T477	KDIPARVTLMQLPTR
T483	VTLMQLPTRQEIRVR
K499	LFNVVDCKLHWQKNG
K504	DCKLHWQKNGDYLCV
Y508	HWQKNGDYLCVKVDR
K512	NGDYLCVKVDRTPKG
K518	VKVDRTPKGTQGVVT
T520	VDRTPKGTQGVVTNF
K535	EIFRMREKQVPVDVV
K535	EIFRMREKQVPVDVV
K582	YHVKSNGKIELIKMF
K587	NGKIELIKMFDKQQA
K591	ELIKMFDKQQANTIF
T627	FVDTSDCTVMNIAEH
Y635	VMNIAEHYMASDVEW
S696	PRPPTLLSQDQIKQI
K701	LLSQDQIKQIKKDLK
S711	KKDLKKYSKIFEQKD
K712	KDLKKYSKIFEQKDR
K712	KDLKKYSKIFEQKDR
S721	FEQKDRLSQSKASKE
K727	LSQSKASKELVERRR
K727	LSQSKASKELVERRR
T735	ELVERRRTMMEDFRQ
K745	EDFRQYRKMAQELYM
Y751	RKMAQELYMKQKNER
K753	MAQELYMKQKNERLE
K755	QELYMKQKNERLELR

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