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Protein Page:
eIF3-eta (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
eIF3-eta eukaryotic translation initiation factor 3 subunit 9. Binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA. eIF-3 is composed of at least 12 different subunits. Note: This description may include information from UniProtKB.
Protein type: Translation initiation; Translation
Cellular Component: eukaryotic translation initiation factor 3 complex; cytosol
Molecular Function: protein binding; translation initiation factor binding; translation initiation factor activity; nucleotide binding; protein complex scaffold
Biological Process: cellular protein metabolic process; translation; translational initiation; gene expression; formation of translation preinitiation complex; regulation of translational initiation
Reference #:  P55884 (UniProtKB)
Alt. Names/Synonyms: eIF-3-eta; eIF3 p110; eIF3 p116; EIF3-ETA; EIF3-P110; EIF3-P116; EIF3B; EIF3S9; Eukaryotic translation initiation factor 3 subunit 9; Eukaryotic translation initiation factor 3 subunit B; eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD); eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa; eukaryotic translation initiation factor 3, subunit B; hPrt1; MGC104664; MGC131875; PRT1; Prt1 homolog
Gene Symbols: EIF3B
Molecular weight: 92,482 Da
Basal Isoelectric point: 4.89  Predict pI for various phosphorylation states
Select Structure to View Below

eIF3-eta

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 P28 QQQPAAEPPPAEGLL
0 5 A31 PAAEPPPAEGLLRPA
0 6 P40 GLLRPAGPGAPEAAG
0 7 P43 RPAGPGAPEAAGTEA
0 1 T48 GAPEAAGTEASSEEV
0 2 T68-p GPESEVRtEPAAEAE
0 12 A74 RtEPAAEAEAAsGPs
0 10 S78-p AAEAEAAsGPsEsPs
0 8 P80 EAEAAsGPsEsPsPP
0 28 S81-p AEAAsGPsEsPsPPA
0 11 S83-p AAsGPsEsPsPPAAE
0 32 S85-p sGPsEsPsPPAAEEL
0 8 P87 PsEsPsPPAAEELPG
0 4 E90 sPsPPAAEELPGsHA
0 7 G94 PAAEELPGsHAEPPV
0 11 S95-p AAEELPGsHAEPPVP
0 1 P100 PGsHAEPPVPAQGEA
0 3 Q104 AEPPVPAQGEAPGEQ
0 12 S117-p EQARDERsDsRAQAV
0 5 S119-p ARDERsDsRAQAVsE
0 6 S125-p DsRAQAVsEDAGGNE
0 39 N131 VsEDAGGNEGRAAEA
0 38 R134 DAGGNEGRAAEAEPR
0 23 S152-p NGDADEPsFsDPEDF
0 32 S154-p DADEPsFsDPEDFVD
0 37 S164-p EDFVDDVsEEELLGD
0 9 K202-u VGPDRLEkLkNVIHk
0 3 K204-u PDRLEkLkNVIHkIF
0 2 K209-a kLkNVIHkIFSkFGk
0 5 K209-u kLkNVIHkIFSkFGk
0 19 K213-u VIHkIFSkFGkITND
0 2 K216-u kIFSkFGkITNDFYP
0 8 K228-u FYPEEDGkTkGYIFL
0 7 K230-u PEEDGkTkGYIFLEY
0 30 S239-p YIFLEYAsPAHAVDA
0 2 K248-u AHAVDAVkNADGYkL
0 1 K254-u VkNADGYkLDkQHTF
0 9 K257-u ADGYkLDkQHTFRVN
0 6 Y272-p LFTDFDKyMTISDEW
0 2 K284-u DEWDIPEkQPFkDLG
0 1 K288-a IPEkQPFkDLGNLRY
0 3 K288-u IPEkQPFkDLGNLRY
0 18 K324-u SIFWNDVkDPVSIEE
0 9 Y339-p RARWTETyVRWSPkG
0 1 K345-u TyVRWSPkGTYLATF
0 1 K364-a IALWGGEkFKQIQRF
0 10 K364-u IALWGGEkFKQIQRF
0 1 K436-a FKWSHDGkFFARMTL
0 3 S447-p RMTLDTLsIyEtPSM
0 58 Y449-p TLDTLsIyEtPSMGL
0 2 T451-p DTLsIyEtPSMGLLD
0 7 K459-u PSMGLLDkKSLkISG
0 3 K463-u LLDkKSLkISGIKDF
0 2 K487-u AFWVPEDkDIPARVT
0 2 T500-p VTLMQLPtRQEIRVR
0 5 K516-u LFNVVDCkLHWQkNG
0 2 K521-u DCkLHWQkNGDyLCV
0 63 Y525-p HWQkNGDyLCVkVDR
0 2 K529-u NGDyLCVkVDRTPkG
0 30 K535-u VkVDRTPkGtQGVVT
0 2 T537-p VDRTPkGtQGVVTNF
0 14 K552-u EIFRMREkQVPVDVV
0 1 K599-u YHVKNNGkIELIkMF
0 2 K604-u NGkIELIkMFDkQQA
0 7 K608-u ELIkMFDkQQANTIF
0 2 Y652 VMNIAEHYMASDVEW
0 1 S713-p PRPPTLLsQEQIkQI
0 1 K718-u LLsQEQIkQIKKDLK
0 1 S728-p KKDLKKYskIFEQKD
0 2 K729-u KDLKKYskIFEQKDR
0 1 S738-p FEQKDRLsQSKASkE
0 1 K744-a LsQSKASkELVERRR
0 1 K744-u LsQSKASkELVERRR
0 2 K762-u EDFRKYRkMAQELYM
0 1 E770 MAQELYMEQkNERLE
0 1 K772-u QELYMEQkNERLELR
  mouse

 
S28-p RQQPASEsPPtDEAA
T31-p PASEsPPtDEAAGsG
S37-p PtDEAAGsGGsEVGQ
S40-p EAAGsGGsEVGQtED
T45-p GGsEVGQtEDAEEDA
A62 GPEPEVRAKPAAQsE
S68-p RAKPAAQsEEEtAts
T72-p AAQsEEEtAtsPAAs
T74-p QsEEEtAtsPAAsPt
S75-p sEEEtAtsPAAsPtP
A77 EEtAtsPAAsPtPQs
S79-p tAtsPAAsPtPQsAE
T81-p tsPAAsPtPQsAERs
S84-p AAsPtPQsAERsPsQ
S88-p tPQsAERsPsQEPsA
S90-p QsAERsPsQEPsAPG
S94-p RsPsQEPsAPGkAEA
K98-u QEPsAPGkAEAVGEQ
S111-p EQARGHPsAGAEEEG
- gap
- gap
S120-p GAEEEGGsDGsAAEA
S123-p EEGGsDGsAAEAEPR
S141-p NGEADEPsFsDPEDF
S143-p EADEPsFsDPEDFVD
S153-p EDFVDDVsEEELLGD
K191-u VGPDRLEkLKNVIHk
K193 PDRLEkLKNVIHkIF
K198 kLKNVIHKIFSkFGk
K198-u kLKNVIHkIFSkFGk
K202-u VIHkIFSkFGkIIND
K205-u kIFSkFGkIINDYYP
K217 YYPEEDGKTKGYIFL
K219 PEEDGKTKGYIFLEY
S228-p YIFLEYAsPAHAVDA
K237-u AHAVDAVkNADGYKL
K243 VkNADGYKLDkQHTF
K246-u ADGYKLDkQHTFRVN
Y261 LFTDFDKYMTISDEW
K273-u DEWDIPEkQPFkDLG
K277 IPEkQPFKDLGNLRY
K277-u IPEkQPFkDLGNLRY
K313-u SIFWNDVkDPVSIEE
Y328-p RARWTETyVRWSPKG
K334 TyVRWSPKGTYLATF
K353 IALWGGDKFKQIQRF
K353-u IALWGGDkFKQIQRF
K425 FKWSHDGKFFARMTL
S436 RMTLDTLSIyEtPSM
Y438-p TLDTLSIyEtPSMGL
T440-p DTLSIyEtPSMGLLD
K448-u PSMGLLDkKSLKISG
K452 LLDkKSLKISGIKDF
K476 AFWVPEDKDIPARVT
T489-p VTLMQLPtRQEIRVR
K505-u LFNVVDCkLHWQKNG
K510 DCkLHWQKNGDyLCV
Y514-p HWQKNGDyLCVKVDR
K518 NGDyLCVKVDRTPkG
K524-u VKVDRTPkGTQGVVT
T526 VDRTPkGTQGVVTNF
K541-u EIFRMREkQVPVDVV
K588 YHVKSNGKIELIKMF
K593 NGKIELIKMFDKQQA
K597 ELIKMFDKQQANTIF
Y641-p VMNIAEHyMASDVEW
S702-p PRPPTLLsQDQIKQI
K707 LLsQDQIKQIKKDLK
S717 KKDLKKYSkIFEQKD
K718-u KDLKKYSkIFEQKDR
S727 FEQKDRLSQSKASKE
K733 LSQSKASKELVERRR
K733 LSQSKASKELVERRR
K751 EDFRQYRKMAQELYM
K759-u MAQELYMkQKNERLE
K761 QELYMkQKNERLELR
  rat

 
S28-p RQQPVSEsPPTDEAA
T31 PVSEsPPTDEAAGSG
S37 PTDEAAGSGGSEVGR
S40 EAAGSGGSEVGRTED
T45 GGSEVGRTEDAEEDA
A62 RPEPEVRAKPAAQsE
S68-p RAKPAAQsEEEtAAs
T72-p AAQsEEEtAAsPAAs
A74 QsEEEtAAsPAAsPt
S75-p sEEEtAAsPAAsPtP
A77 EEtAAsPAAsPtPQS
S79-p tAAsPAAsPtPQSAQ
T81-p AsPAAsPtPQSAQEP
S84 AAsPtPQSAQEPSAP
- gap
- gap
S89 PQSAQEPSAPGKAEA
K93 QEPSAPGKAEAGGEQ
S105 GEQARHPSARAEEEG
- gap
- gap
S114-p RAEEEGGsDGsAAEA
S117-p EEGGsDGsAAEAEPR
S135-p NGEADEPsFsDPEDF
S137-p EADEPsFsDPEDFVD
S147-p EDFVDDVsEEELLGD
K185 VGPDRLEKLKNVIHK
K187 PDRLEKLKNVIHKIF
K192 KLKNVIHKIFSKFGK
K192 KLKNVIHKIFSKFGK
K196 VIHKIFSKFGKIIND
K199 KIFSKFGKIINDYYP
K211 YYPEEDGKTKGYIFL
K213 PEEDGKTKGYIFLEY
S222 YIFLEYASPAHAVDA
K231 AHAVDAVKNADGYKL
K237 VKNADGYKLDKQHTF
K240 ADGYKLDKQHTFRVN
Y255 LFTDFDKYMTISDEW
K267 DEWDIPEKQPFKDLG
K271 IPEKQPFKDLGNLRY
K271 IPEKQPFKDLGNLRY
K307 SIFWNDVKDPVSIEE
Y322 RARWTETYVRWSPKG
K328 TYVRWSPKGTYLATF
K347 IALWGGDKFKQIQRF
K347 IALWGGDKFKQIQRF
K419 FKWSHDGKFFARMTL
S430 RMTLDTLSIYETPSM
Y432 TLDTLSIYETPSMGL
T434 DTLSIYETPSMGLLD
K442 PSMGLLDKKSLKISG
K446 LLDKKSLKISGIKDF
K470 AFWVPEDKDIPARVT
T483 VTLMQLPTRQEIRVR
K499 LFNVVDCKLHWQKNG
K504 DCKLHWQKNGDYLCV
Y508 HWQKNGDYLCVKVDR
K512 NGDYLCVKVDRTPKG
K518 VKVDRTPKGTQGVVT
T520 VDRTPKGTQGVVTNF
K535 EIFRMREKQVPVDVV
K582 YHVKSNGKIELIKMF
K587 NGKIELIKMFDKQQA
K591 ELIKMFDKQQANTIF
Y635 VMNIAEHYMASDVEW
S696 PRPPTLLSQDQIKQI
K701 LLSQDQIKQIKKDLK
S711 KKDLKKYSKIFEQKD
K712 KDLKKYSKIFEQKDR
S721 FEQKDRLSQSKASKE
K727 LSQSKASKELVERRR
K727 LSQSKASKELVERRR
K745 EDFRQYRKMAQELYM
K753 MAQELYMKQKNERLE
K755 QELYMKQKNERLELR
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