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PhosphoSitePlus
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Protein Page:
eIF1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
eIF1 a translation initiation factor. Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Cellular Component: cytoplasm
Molecular Function: translation factor activity, nucleic acid binding; translation initiation factor activity
Biological Process: dosage compensation, by inactivation of X chromosome; response to stress; regulation of translational initiation
Reference #:  P41567 (UniProtKB)
Alt. Names/Synonyms: A121; EIF-1; EIF1; EIF1A; Eukaryotic translation initiation factor 1; ISO1; Protein translation factor SUI1 homolog; SUI1; Sui1iso1
Gene Symbols: EIF1
Molecular weight: 12,732 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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eIF1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S2-p ______MsAIQNLHs
0 4 S9-p sAIQNLHsFDPFADA
0 34 Y30-p LPAGTEDyIHIRIQQ
0 19 K42-u IQQRNGRkTLTTVQG
0 1 Y54 VQGIADDYDKKkLVK
0 2 K58-a ADDYDKKkLVKAFKK
0 65 Y79-p TVIEHPEyGEVIQLQ
0 64 K91-u QLQGDQRkNICQFLV
0 8 K109-u LAKDDQLkVHGF___
  mouse

 
S2 ______MSAIQNLHs
S9-p SAIQNLHsFDPFADA
Y30 LPAGTEDYIHIRIQQ
K42-u IQQRNGRkTLTTVQG
Y54 VQGIADDYDKKkLVK
K58-a ADDYDKKkLVKAFKK
Y79-p TVIEHPEyGEVIQLQ
K91-u QLQGDQRkNICQFLI
K109-u LAKDDQLkVHGF___
  rat

 
S7 _MRPSPMSAIQNLHS
S14 SAIQNLHSFDPFADA
Y35 LPAGTENYIRIRIQQ
K47 IQQRNSRKTLTTVQG
Y59-p VQGITDDyDKKKLVK
K63 TDDyDKKKLVKAFKK
Y84 AVIDPPDYIQLQGAQ
K93 QLQGAQRKNVCQLLI
K111 LAKDGQLKVHGF___
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