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Protein Page:
MDH2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MDH2 mitochondrial malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. May play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Carbohydrate Metabolism - pyruvate; EC 1.1.1.37; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Mitochondrial; Carbohydrate Metabolism - citrate (TCA) cycle
Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane; plasma membrane; nucleolus; nucleus
Molecular Function: protein self-association; L-malate dehydrogenase activity; malate dehydrogenase (NADP+) activity
Biological Process: cellular metabolic process; malate metabolic process; oxaloacetate metabolic process; NADH metabolic process; tricarboxylic acid cycle; carbohydrate metabolic process; glucose metabolic process; cellular carbohydrate metabolic process; internal protein amino acid acetylation; gluconeogenesis
Reference #:  P40926 (UniProtKB)
Alt. Names/Synonyms: M-MDH; malate dehydrogenase 2, NAD (mitochondrial); Malate dehydrogenase, mitochondrial; MDH; MDH2; MDHM; MGC:3559; MOR1
Gene Symbols: MDH2
Molecular weight: 35,503 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MDH2

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: K314‑ac

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K26 TSAQNNAKVAVLGAS
0 1 K26 TSAQNNAKVAVLGAS
0 1 S41-p GGIGQPLsLLLKNSP
0 1 S51-p LKNSPLVsRLTLyDI
0 77 Y56-p LVsRLTLyDIAHTPG
0 1 S69 PGVAADLSHIETkAA
0 3 K74-ac DLSHIETkAAVkGyL
0 1 K74-ub DLSHIETkAAVkGyL
0 17 K78-ac IETkAAVkGyLGPEQ
0 2 K78-ub IETkAAVkGyLGPEQ
0 1 K78 IETkAAVKGyLGPEQ
0 22 Y80-p TkAAVkGyLGPEQLP
0 6 K91-ac EQLPDCLkGCDVVVI
0 2 K91-sc EQLPDCLkGCDVVVI
0 51 K156-ac PITAEVFkkHGVyNP
0 16 K157-ac ITAEVFkkHGVyNPN
0 23 Y161-p VFkkHGVyNPNkIFG
0 48 K165-ac HGVyNPNkIFGVttL
0 1 K165 HGVyNPNKIFGVttL
0 1 T170-p PNkIFGVttLDIVRA
0 2 T171-p NkIFGVttLDIVRAN
0 10 K185-ac NTFVAELkGLDPARV
0 2 K185-ub NTFVAELkGLDPARV
0 2 K185-sc NTFVAELkGLDPARV
1 7 K203-ac VIGGHAGktIIPLIS
0 1 T204-p IGGHAGktIIPLISQ
0 23 K215-ac LISQCTPkVDFPQDQ
0 2 K215-sc LISQCTPkVDFPQDQ
0 6 T235-p GRIQEAGtEVVkAkA
0 5 K239 EAGtEVVKAkAGAGs
0 2 K239-ub EAGtEVVkAkAGAGs
0 2 K239-sc EAGtEVVkAkAGAGs
0 3 K241-ub GtEVVkAkAGAGsAt
0 7 S246-p kAkAGAGsAtLSMAy
0 1 T248-p kAGAGsAtLSMAyAG
0 34 Y253-p sAtLSMAyAGARFVF
0 2 S261-p AGARFVFsLVDAMNG
0 1 S276 KEGVVECSFVKsQEt
0 1 S280-p VECSFVKsQEtECTy
0 2 T283-p SFVKsQEtECTyFST
0 2 Y287-p sQEtECTyFSTPLLL
0 145 K296-ac STPLLLGkkGIEkNL
0 1 K296 STPLLLGKkGIEkNL
0 2 K296-sc STPLLLGkkGIEkNL
0 57 K297-ac TPLLLGkkGIEkNLG
0 44 K301-ac LGkkGIEkNLGIGkV
0 2 K301-ub LGkkGIEkNLGIGkV
0 2 K301-sc LGkkGIEkNLGIGkV
0 7 K307-ac EkNLGIGkVSsFEEk
0 2 K307-ub EkNLGIGkVSsFEEk
0 2 K307-sc EkNLGIGkVSsFEEk
0 1 S309 NLGIGkVSsFEEkMI
0 1 S310-p LGIGkVSsFEEkMIs
0 14 K314-ac kVSsFEEkMIsDAIP
0 2 K314-ub kVSsFEEkMIsDAIP
0 2 K314-sc kVSsFEEkMIsDAIP
0 1 S317-p sFEEkMIsDAIPELk
0 10 K324-ac sDAIPELkAsIkkGE
0 1 K324 sDAIPELKAsIkkGE
0 2 K324-sc sDAIPELkAsIkkGE
0 2 S326-p AIPELkAsIkkGEDF
0 7 K328-ac PELkAsIkkGEDFVk
0 1 K328 PELkAsIKkGEDFVk
0 18 K329-ac ELkAsIkkGEDFVkt
0 2 K329-sc ELkAsIkkGEDFVkt
0 27 K335-ac kkGEDFVktLK____
0 2 K335-sc kkGEDFVktLK____
0 3 T336-p kGEDFVktLK_____
0 3 K338 EDFVktLK_______
  mouse

 
K26-ac TSAQNNAkVAVLGAS
K26-sc TSAQNNAkVAVLGAS
S41 GGIGQPLSLLLKNSP
S51-p LKNSPLVsRLTLyDI
Y56-p LVsRLTLyDIAHTPG
S69-p PGVAADLsHIETRAN
R74 DLsHIETRANVkGyL
R74 DLsHIETRANVkGyL
K78-ac IETRANVkGyLGPEQ
K78-ub IETRANVkGyLGPEQ
K78-sc IETRANVkGyLGPEQ
Y80-p TRANVkGyLGPEQLP
K91-ac EQLPDCLkGCDVVVI
K91-sc EQLPDCLkGCDVVVI
K156 PITAEVFKkHGVYNP
K157-ac ITAEVFKkHGVYNPN
Y161 VFKkHGVYNPNkIFG
K165-ac HGVYNPNkIFGVTtL
K165-sc HGVYNPNkIFGVTtL
T170 PNkIFGVTtLDIVRA
T171-p NkIFGVTtLDIVRAN
K185-ac NTFVAELkGLDPARV
K185-ub NTFVAELkGLDPARV
K185-sc NTFVAELkGLDPARV
K203-ac VIGGHAGkTIIPLIS
T204 IGGHAGkTIIPLISQ
K215-ac LISQCTPkVDFPQDQ
K215-sc LISQCTPkVDFPQDQ
T235-p GRIQEAGtEVVkAKA
K239-ac EAGtEVVkAKAGAGs
K239-ub EAGtEVVkAKAGAGs
K239-sc EAGtEVVkAKAGAGs
K241 GtEVVkAKAGAGsAT
S246-p kAKAGAGsATLSMAy
T248 KAGAGsATLSMAyAG
Y253-p sATLSMAyAGARFVF
S261-p AGARFVFsLVDAMNG
S276-gl KEGVVECsFVQSKET
S280 VECsFVQSKETECTY
T283 sFVQSKETECTYFST
Y287 SKETECTYFSTPLLL
K296-ac STPLLLGkkGLEkNL
K296-ub STPLLLGkkGLEkNL
K296-sc STPLLLGkkGLEkNL
K297-ac TPLLLGkkGLEkNLG
K301-ac LGkkGLEkNLGIGkI
K301-ub LGkkGLEkNLGIGkI
K301-sc LGkkGLEkNLGIGkI
K307-ac EkNLGIGkItPFEEk
K307-ub EkNLGIGkItPFEEk
K307-sc EkNLGIGkItPFEEk
T309-p NLGIGkItPFEEkMI
P310 LGIGkItPFEEkMIA
K314-ac kItPFEEkMIAEAIP
K314-ub kItPFEEkMIAEAIP
K314-sc kItPFEEkMIAEAIP
A317 PFEEkMIAEAIPELk
K324-ac AEAIPELkAsIkkGE
K324-ub AEAIPELkAsIkkGE
K324-sc AEAIPELkAsIkkGE
S326-p AIPELkAsIkkGEDF
K328-ac PELkAsIkkGEDFVk
K328-sc PELkAsIkkGEDFVk
K329-ac ELkAsIkkGEDFVkN
K329-sc ELkAsIkkGEDFVkN
K335-ac kkGEDFVkNMk____
K335-sc kkGEDFVkNMk____
N336 kGEDFVkNMk_____
K338-ac EDFVkNMk_______
  rat

 
K26 TSAQNNAKVAVLGAS
K26 TSAQNNAKVAVLGAS
S41 GGIGQPLSLLLKNSP
S51-p LKNSPLVsRLTLyDI
Y56-p LVsRLTLyDIAHTPG
S69 PGVAADLSHIETRAN
R74 DLSHIETRANVkGyL
R74 DLSHIETRANVkGyL
K78-ac IETRANVkGyLGPEQ
K78 IETRANVKGyLGPEQ
K78 IETRANVKGyLGPEQ
Y80-p TRANVkGyLGPEQLP
K91-ac EQLPDCLkGCDVVVI
K91 EQLPDCLKGCDVVVI
K156 PITAEVFKkHGVYNP
K157-ac ITAEVFKkHGVYNPN
Y161 VFKkHGVYNPNkIFG
K165-ac HGVYNPNkIFGVTTL
K165 HGVYNPNKIFGVTTL
T170 PNkIFGVTTLDIVRA
T171 NkIFGVTTLDIVRAN
K185-ac NTFVAELkGLDPARV
K185 NTFVAELKGLDPARV
K185 NTFVAELKGLDPARV
K203-ac VIGGHAGkTIIPLIS
T204 IGGHAGkTIIPLISQ
K215-ac LISQCTPkVDFPQDQ
K215 LISQCTPKVDFPQDQ
T235-p GRIQEAGtEVVkAKA
K239-ac EAGtEVVkAKAGAGs
K239 EAGtEVVKAKAGAGs
K239 EAGtEVVKAKAGAGs
K241 GtEVVkAKAGAGsAT
S246-p kAKAGAGsATLSMAy
T248 KAGAGsATLSMAyAG
Y253-p sATLSMAyAGARFVF
S261 AGARFVFSLVDAMNG
S276 KEGVIECSFVQSKET
S280 IECSFVQSKETECTY
T283 SFVQSKETECTYFST
Y287 SKETECTYFSTPLLL
K296-ac STPLLLGkkGLEkNL
K296 STPLLLGKkGLEkNL
K296 STPLLLGKkGLEkNL
K297-ac TPLLLGkkGLEkNLG
K301-ac LGkkGLEkNLGIGkI
K301 LGkkGLEKNLGIGkI
K301 LGkkGLEKNLGIGkI
K307-ac EkNLGIGkITPFEEk
K307 EkNLGIGKITPFEEk
K307 EkNLGIGKITPFEEk
T309 NLGIGkITPFEEkMI
P310 LGIGkITPFEEkMIA
K314-ac kITPFEEkMIAEAIP
K314 kITPFEEKMIAEAIP
K314 kITPFEEKMIAEAIP
A317 PFEEkMIAEAIPELk
K324-ac AEAIPELkASIkkGE
K324 AEAIPELKASIkkGE
K324 AEAIPELKASIkkGE
S326 AIPELkASIkkGEDF
K328-ac PELkASIkkGEDFVk
K328 PELkASIKkGEDFVk
K329-ac ELkASIkkGEDFVkN
K329 ELkASIkKGEDFVkN
K335-ac kkGEDFVkNMK____
K335 kkGEDFVKNMK____
N336 kGEDFVkNMK_____
K338 EDFVkNMK_______
  pig

 
K26 TSXQNNAKVAVLGAS
K26 TSXQNNAKVAVLGAS
S41 GGIGQPLSLLLKNSP
S51 LKNSPLVSRLTLYDI
Y56 LVSRLTLYDIAHTPG
S69 PGVAADLSHIETRAT
R74 DLSHIETRATVKGYL
R74 DLSHIETRATVKGYL
K78 IETRATVKGYLGPEQ
K78 IETRATVKGYLGPEQ
K78 IETRATVKGYLGPEQ
Y80 TRATVKGYLGPEQLP
K91 EQLPDCLKGCDVVVI
K91 EQLPDCLKGCDVVVI
K156 PITAEVFKKHGVYNP
K157 ITAEVFKKHGVYNPN
Y161 VFKKHGVYNPNKIFG
K165 HGVYNPNKIFGVTTL
K165 HGVYNPNKIFGVTTL
T170 PNKIFGVTTLDIVRA
T171 NKIFGVTTLDIVRAN
K185 NAFVAELKGLDPARV
K185 NAFVAELKGLDPARV
K185 NAFVAELKGLDPARV
K203 VIGGHAGKTIIPLIS
T204 IGGHAGKTIIPLISQ
K215 LISQCTPKVDFPQDQ
K215 LISQCTPKVDFPQDQ
T235-p GRIQEAGtEVVKAKA
K239 EAGtEVVKAKAGAGs
K239 EAGtEVVKAKAGAGs
K239 EAGtEVVKAKAGAGs
K241 GtEVVKAKAGAGsAT
S246-p KAKAGAGsATLSMAY
T248 KAGAGsATLSMAYAG
Y253 sATLSMAYAGARFVF
S261 AGARFVFSLVDAMNG
S276 KEGVVECSFVKSQET
S280 VECSFVKSQETDCPY
T283 SFVKSQETDCPYFST
Y287 SQETDCPYFSTPLLL
K296 STPLLLGKKGIEKNL
K296 STPLLLGKKGIEKNL
K296 STPLLLGKKGIEKNL
K297 TPLLLGKKGIEKNLG
K301 LGKKGIEKNLGIGKI
K301 LGKKGIEKNLGIGKI
K301 LGKKGIEKNLGIGKI
K307 EKNLGIGKISPFEEK
K307 EKNLGIGKISPFEEK
K307 EKNLGIGKISPFEEK
S309 NLGIGKISPFEEKMI
P310 LGIGKISPFEEKMIA
K314 KISPFEEKMIAEAIP
K314 KISPFEEKMIAEAIP
K314 KISPFEEKMIAEAIP
A317 PFEEKMIAEAIPELK
K324 AEAIPELKASIKKGE
K324 AEAIPELKASIKKGE
K324 AEAIPELKASIKKGE
S326 AIPELKASIKKGEEF
K328 PELKASIKKGEEFVK
K328 PELKASIKKGEEFVK
K329 ELKASIKKGEEFVKN
K329 ELKASIKKGEEFVKN
K335 KKGEEFVKNMK____
K335 KKGEEFVKNMK____
N336 KGEEFVKNMK_____
K338 EEFVKNMK_______
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