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Protein Page:
HSP70RY (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
HSP70RY Interacts with TJP1/ZO-1. Belongs to the heat shock protein 70 family. Note: This description may include information from UniProtKB.
Protein type: Chaperone
Cellular Component: cytoplasm; nucleolus; lipid particle; nucleus; cytosol
Molecular Function: ATP binding
Biological Process: positive regulation of protein binding; response to heat; chaperone-mediated protein complex assembly; protein import into mitochondrial outer membrane; response to unfolded protein
Reference #:  P34932 (UniProtKB)
Alt. Names/Synonyms: APG-2; APG2; Heat shock 70 kDa protein 4; Heat shock 70-related protein APG-2; heat shock 70kD protein 4; heat shock 70kDa protein 4; heat shock protein, 110 kDa; HS24/P52; hsp70; HSP70RY; HSP74; HSPA4; MGC131852; RY
Gene Symbols: HSPA4
Molecular weight: 94,331 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HSP70RY
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 K44 ACISFGPKNRSIGAA
0 2 K53-u RSIGAAAksQVISNA
0 2 S54-p SIGAAAksQVISNAK
0 1 K61 sQVISNAKNTVQGFk
0 1 K68 KNTVQGFKRFHGRAF
0 1 K68-u KNTVQGFkRFHGRAF
0 20 S76-p RFHGRAFsDPFVEAE
0 1 K84-u DPFVEAEkSNLAyDI
0 14 Y89-p AEkSNLAyDIVQLPT
0 1 K102-u PTGLTGIkVTYMEEE
0 1 T113-p MEEERNFttEQVtAM
0 1 T114-p EEERNFttEQVtAML
0 1 T118-p NFttEQVtAMLLSkL
0 7 K124-u VtAMLLSkLkETAES
0 2 K126-u AMLLSkLkETAESVL
0 1 K135 TAESVLKKPVVDCVV
0 6 Y184-p VALAYGIykQDLPAL
0 1 K185-u ALAYGIykQDLPALE
0 5 K194-u DLPALEEkPRNVVFV
0 1 K221-u AFNRGKLkVLATAFD
0 5 K235-u DTTLGGRkFDEVLVN
0 4 K272-a RLSQECEkLKKLMSA
0 1 K305 SGTMNRGKFLEMCND
0 1 K329 RSVLEQTKLKKEDIy
0 647 Y336-p KLKKEDIyAVEIVGG
0 1 K351 ATRIPAVKEKISKFF
0 2 K360-u KISKFFGkELSTTLN
0 88 K388-u AILSPAFkVREFSIT
0 2 S408-p PISLRWNsPAEEGSS
0 1 S415 sPAEEGSSDCEVFSk
0 1 K422-a SDCEVFSkNHAAPFS
0 9 K430-a NHAAPFSkVLtFyRk
0 2 K430-u NHAAPFSkVLtFyRk
0 1 T433-p APFSkVLtFyRkEPF
0 3 Y435-p FSkVLtFyRkEPFTL
0 1 K437-u kVLtFyRkEPFTLEA
0 1 S475-p TPQSDGSssKVKVKV
0 1 S476-p PQSDGSssKVKVKVR
0 1 K517-u METDQNAkEEEKMQV
0 11 T538-p VEEQQQQtPAENkAE
0 1 K543-u QQtPAENkAEsEEME
0 5 S546-p PAENkAEsEEMETsQ
0 7 S552-p EsEEMETsQAGskDK
0 1 S556-p METsQAGskDKKMDQ
0 1 K557-u ETsQAGskDKKMDQP
0 1 M561 AGskDKKMDQPPQAk
0 1 K568-u MDQPPQAkKAKVkTS
0 2 K573-u QAkKAKVkTSTVDLP
0 2 K603-a LYIENEGkMIMQDKL
0 1 K603 LYIENEGKMIMQDKL
0 1 K618 EKERNDAKNAVEEyV
0 13 Y624-p AKNAVEEyVyEMRDK
0 18 Y626-p NAVEEyVyEMRDKLS
0 1 K631 yVyEMRDKLSGEyEk
0 9 Y636-p RDKLSGEyEkFVSED
0 3 K638-u KLSGEyEkFVSEDDR
0 2 S647-p VSEDDRNsFTLKLED
0 13 Y660-p EDTENWLyEDGEDQP
0 1 Y671-p EDQPKQVyVDkLAEL
0 2 K674-u PKQVyVDkLAELkNL
0 1 K679-a VDkLAELkNLGQPIk
0 2 K679-u VDkLAELkNLGQPIk
0 4 K686-u kNLGQPIkIRFQESE
0 1 K697-u QESEERPkLFEELGk
0 2 K704-u kLFEELGkQIQQYMk
0 2 K711-u kQIQQYMkIISSFKN
0 2 K719-u IISSFKNkEDQyDHL
0 25 Y723-p FKNkEDQyDHLdAAD
0 1 D727-ca EDQyDHLdAADMTKV
0 1 K736-u ADMTKVEkSTNEAME
0 1 K748-u AMEWMNNkLNLQNkQ
0 8 K754-u NkLNLQNkQSLTMDP
0 2 K773-u KEIEAKIkELTSTCS
0 1 S784-p STCSPIIsKPKPKVE
0 1 K785 TCSPIIsKPKPKVEP
0 1 K794-u KPKVEPPkEEQkNAE
0 1 K798-u EPPkEEQkNAEQNGP
0 9 P815 GQGDNPGPQAAEQGT
0 2 S828-p GTDTAVPsDSDKKLP
  mouse

 
K44-u ACVSFGPkNRSIGAA
K53 RSIGAAAKSQVISNA
S54 SIGAAAKSQVISNAk
K61-u SQVISNAkNTVQGFk
K68-a kNTVQGFkRFHGRAF
K68 kNTVQGFKRFHGRAF
S76-p RFHGRAFsDPFVEAE
K84 DPFVEAEKSNLAYDI
Y89 AEKSNLAYDIVQLPT
K102 PTGLTGIKVTYMEEE
T113 MEEERNFTTEQVTAM
T114 EEERNFTTEQVTAML
T118 NFTTEQVTAMLLSkL
K124-u VTAMLLSkLkETAES
K126-u AMLLSkLkETAESVL
K135-u TAESVLKkPVVDCVV
Y184 VALAYGIYKQDLPAL
K185 ALAYGIYKQDLPALE
K194-u DLPALEEkPRNVVFV
K221 AFNKGKLKVLATAFD
K235-u DTTLGGRkFDEVLVN
K272 RLSQECEKLKKLMSA
K305-u SGTMNRGkFLEMCDD
K329-u RSVLEQSkLKKEDIy
Y336-p kLKKEDIyAVEIVGG
K351-u ATRIPAVkEKISKFF
K360 KISKFFGKELSTTLN
K388-u AILSPAFkVREFSIT
S408 PISLRWNSPAEEGLs
S415-p SPAEEGLsDCEVFPK
K422 sDCEVFPKNHAAPFS
K430 NHAAPFSKVLTFYRK
K430-u NHAAPFSkVLTFYRK
T433 APFSkVLTFYRKEPF
Y435 FSkVLTFYRKEPFTL
K437 kVLTFYRKEPFTLEA
S475 TPQSDGSSSKVKVKV
S476 PQSDGSSSKVKVKVR
K517 METDQNAKEEEKMQV
T540-p EQQQQPQtPAENKAE
K545 PQtPAENKAEsEEME
S548-p PAENKAEsEEMETSQ
S554 EsEEMETSQAGSKDK
S558 METSQAGSKDKKtDQ
K559 ETSQAGSKDKKtDQP
T563-p AGSKDKKtDQPPQAK
K570 tDQPPQAKKAKVkTS
K575-u QAKKAKVkTSTVDLP
K605 LYTENEGKMIMQDKL
K605-u LYTENEGkMIMQDKL
K620-u EKERNDAkNAVEEYV
Y626 AkNAVEEYVyEMRDk
Y628-p NAVEEYVyEMRDkLS
K633-u YVyEMRDkLSGEYEk
Y638 RDkLSGEYEkFVSED
K640-u kLSGEYEkFVSEDDR
T649 VSEDDRNTFTLKLED
Y662-p EDTENWLyEDGEDQP
Y673 EDQPKQVYVDkLAEL
K676-u PKQVYVDkLAELkSL
K681 VDkLAELKSLGQPIk
K681-u VDkLAELkSLGQPIk
K688-u kSLGQPIkTRFQESE
K699 QESEERPKLFEELGk
K706-u KLFEELGkQIQQYMk
K713-u kQIQQYMkVISSFKN
K721-u VISSFKNkEDQyEHL
Y725-p FKNkEDQyEHLDAAD
D729 EDQyEHLDAADVTKV
K738 ADVTKVEKSTNEAME
K750 AMEWMNSKLNLQNkQ
K756-u SKLNLQNkQSLTVDP
K775-u KEIEAKIkELTSICS
S786 SICSPIISkPKPKVE
K787-u ICSPIISkPKPKVEP
K796 KPKVEPPKEEPKHAE
K800 EPPKEEPKHAEQNGP
S817-p GQGDNPGsQAAEHGA
S830-p GADTAVPsDGDKKLP
  rat

 
K44 ACVSFGPKNRSVGAA
K53 RSVGAAAKSQVISNA
S54 SVGAAAKSQVISNAK
K61 SQVISNAKNTVQGFK
K68 KNTVQGFKRFHGRAF
K68 KNTVQGFKRFHGRAF
S76 RFHGRAFSDPFVEAE
K84 DPFVEAEKSNLAYDI
Y89 AEKSNLAYDIVQLPT
K102 PTGLTGIKVTYMEEE
T113 MEEERNFTTEQVTAM
T114 EEERNFTTEQVTAML
T118 NFTTEQVTAMLLSKL
K124 VTAMLLSKLKETAES
K126 AMLLSKLKETAESVL
K135 TAESVLKKPVVDCVV
Y184-p VALAYGIyKQDLPAL
K185 ALAYGIyKQDLPALE
K194 DLPALEEKPRNVVFV
K221 AFNRGKLKVLATAFD
K235 DTTLGGRKFDEVLVN
K272 RLSQECEKLKKLMSA
K305 SGTMNRGKFLEMCDD
K329 RSILDQSKLKKEDIy
Y336-p KLKKEDIyAVEIVGG
K351 ATRIPAVKEKISKFF
K360 KISKFFGKELSTTLN
K388-u AILSPAFkVREFSIT
S408 PISLRWNSPAEEGSS
S415 SPAEEGSSDCEVFPK
K422 SDCEVFPKNHAAPFS
K430 NHAAPFSKVLTFYRK
K430 NHAAPFSKVLTFYRK
T433 APFSKVLTFYRKEPF
Y435 FSKVLTFYRKEPFTL
K437 KVLTFYRKEPFTLEA
S475 TPQSDGSSSKVKVKV
S476 PQSDGSSSKVKVKVR
K517 METDQNAKEEEKMQV
T538 TEEQQPQTPAENKAE
K543 PQTPAENKAESEEME
S546 PAENKAESEEMETSQ
S552 ESEEMETSQAGSKDK
S556 METSQAGSKDKKMDQ
K557 ETSQAGSKDKKMDQP
M561 AGSKDKKMDQPPQAK
K568 MDQPPQAKKAKVKTS
K573 QAKKAKVKTSTVDLP
K603 LYTENEGKMIMQDKL
K603 LYTENEGKMIMQDKL
K618 EKERNDAKNAVEEYV
Y624 AKNAVEEYVYEMRDK
Y626 NAVEEYVYEMRDKLS
K631 YVYEMRDKLSGEYEK
Y636 RDKLSGEYEKFVSED
K638 KLSGEYEKFVSEDDR
N647 VSEDDRNNFTLKLED
Y660 EDTENWLYEDGEDQP
Y671 EDQPKQVYVDKLAEL
K674 PKQVYVDKLAELRTL
R679 VDKLAELRTLGQPIK
R679 VDKLAELRTLGQPIK
K686 RTLGQPIKTRFQESE
K697 QESEERPKLFEELGK
K704 KLFEELGKQIQQYMK
K711 KQIQQYMKVISSFKN
K719 VISSFKNKEDQYEHL
Y723 FKNKEDQYEHLDAAD
D727 EDQYEHLDAADMTKV
K736 ADMTKVEKSTNEAME
K748 AMEWMNSKLNLQNKQ
K754 SKLNLQNKQSLTADP
K773 KEIEAKIKELTNICS
S784 NICSPIISKPKPKVE
K785 ICSPIISKPKPKVEP
K794 KPKVEPPKEEPKHAE
K798 EPPKEEPKHAEQNGP
T815 GQGDNPGTQAAEHGA
S828 GADTAVPSDGDKKLP
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