Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
HSP70RY (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
HSP70RY Interacts with TJP1/ZO-1. Belongs to the heat shock protein 70 family. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein
Cellular Component: mitochondrion
Molecular Function: ATP binding
Biological Process: chaperone-mediated protein complex assembly; protein import into mitochondrial outer membrane; response to unfolded protein
Reference #:  P34932 (UniProtKB)
Alt. Names/Synonyms: APG-2; APG2; Heat shock 70 kDa protein 4; Heat shock 70-related protein APG-2; heat shock 70kD protein 4; heat shock 70kDa protein 4; heat shock protein, 110 kDa; HS24/P52; hsp70; HSP70RY; HSP74; HSPA4; MGC131852; RY
Gene Symbols: HSPA4
Molecular weight: 94,331 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HSP70RY

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K44 ACISFGPKNRSIGAA
0 2 K53-u RSIGAAAksQVISNA
0 2 S54-p SIGAAAksQVISNAK
0 1 K61 sQVISNAKNTVQGFK
0 23 S76-p RFHGRAFsDPFVEAE
0 14 Y89-p AEKSNLAyDIVQLPT
0 1 T113-p MEEERNFttEQVtAM
0 1 T114-p EEERNFttEQVtAML
0 1 T118-p NFttEQVtAMLLSkL
0 7 K124-u VtAMLLSkLkETAES
0 2 K126-u AMLLSkLkETAESVL
0 1 K135 TAESVLKKPVVDCVV
0 6 Y184-p VALAYGIyKQDLPAL
0 5 K194-u DLPALEEkPRNVVFV
0 1 K221-u AFNRGKLkVLATAFD
0 1 T230-p LATAFDTtLGGRkFD
0 5 K235-u DTtLGGRkFDEVLVN
0 4 K272-a RLSQECEkLKKLMSA
0 1 K305 SGTMNRGKFLEMCND
0 1 K329 RSVLEQTKLKKEDIy
0 649 Y336-p KLKKEDIyAVEIVGG
0 2 K360-u KISKFFGkELSTTLN
0 88 K388-u AILSPAFkVREFsIT
0 1 S393-p AFkVREFsITDVVPY
0 2 S408-p PISLRWNsPAEEGSs
0 3 S415-p sPAEEGSsDCEVFSK
0 9 K430-a NHAAPFSkVLtFyRk
0 2 K430-u NHAAPFSkVLtFyRk
0 1 T433-p APFSkVLtFyRkEPF
0 3 Y435-p FSkVLtFyRkEPFTL
0 1 K437-u kVLtFyRkEPFTLEA
0 1 K517-u METDQNAkEEEKMQV
0 14 T538-p VEEQQQQtPAENkAE
0 1 K543-u QQtPAENkAEsEEME
0 6 S546-p PAENkAEsEEMETsQ
0 8 S552-p EsEEMETsQAGSkDk
0 1 K557-m3 ETsQAGSkDkKMDQP
0 1 K557-u ETsQAGSkDkKMDQP
0 1 K559-m3 sQAGSkDkKMDQPPQ
0 1 K568-u MDQPPQAkKAKVkTS
0 2 K573-u QAkKAKVkTSTVDLP
0 2 K603-a LYIENEGkMIMQDKL
0 1 K603 LYIENEGKMIMQDKL
0 1 K618 EKERNDAKNAVEEyV
0 13 Y624-p AKNAVEEyVyEMRDK
0 18 Y626-p NAVEEyVyEMRDKLS
0 1 K631 yVyEMRDKLSGEyEk
0 9 Y636-p RDKLSGEyEkFVSED
0 3 K638-u KLSGEyEkFVSEDDR
0 3 S647-p VSEDDRNsFTLKLED
0 13 Y660-p EDTENWLyEDGEDQP
0 2 K674-u PKQVYVDkLAELkNL
0 1 K679-a VDkLAELkNLGQPIk
0 2 K679-u VDkLAELkNLGQPIk
0 4 K686-u kNLGQPIkIRFQESE
0 1 K697-u QESEERPkLFEELGk
0 2 K704-u kLFEELGkQIQQYMk
0 2 K711-u kQIQQYMkIISSFKN
0 2 K719-u IISSFKNkEDQyDHL
0 25 Y723-p FKNkEDQyDHLdAAD
0 1 D727-ca EDQyDHLdAADMTKV
0 1 K736-u ADMTKVEkSTNEAME
0 1 K748-u AMEWMNNkLNLQNkQ
0 8 K754-u NkLNLQNkQsLTMDP
0 1 S756-p LNLQNkQsLTMDPVV
0 1 K773-m1 KEIEAKIkELTSTCs
0 2 K773-u KEIEAKIkELTSTCs
0 1 S780-p kELTSTCsPIISKPK
0 1 K785 TCsPIISKPKPKVEP
0 1 K794-u KPKVEPPkEEQkNAE
0 1 K798-u EPPkEEQkNAEQNGP
0 10 P815 GQGDNPGPQAAEQGT
0 3 S828-p GTDTAVPsDSDKKLP
  mouse

► Hide Isoforms
 
K44-u ACVSFGPkNRSIGAA
K53 RSIGAAAKSQVISNA
S54 SIGAAAKSQVISNAk
K61-u SQVISNAkNTVQGFK
S76-p RFHGRAFsDPFVEAE
Y89 AEKSNLAYDIVQLPT
T113 MEEERNFTTEQVTAM
T114 EEERNFTTEQVTAML
T118 NFTTEQVTAMLLSkL
K124-u VTAMLLSkLkETAES
K126-u AMLLSkLkETAESVL
K135-u TAESVLKkPVVDCVV
Y184 VALAYGIYKQDLPAL
K194-u DLPALEEkPRNVVFV
K221 AFNKGKLKVLATAFD
T230 LATAFDTTLGGRkFD
K235-u DTTLGGRkFDEVLVN
K272 RLSQECEKLKKLMSA
K305-u SGTMNRGkFLEMCDD
K329-u RSVLEQSkLKKEDIy
Y336-p kLKKEDIyAVEIVGG
K360 KISKFFGKELSTTLN
K388-u AILSPAFkVREFSIT
S393 AFkVREFSITDVVPY
S408 PISLRWNSPAEEGLs
S415-p SPAEEGLsDCEVFPK
K430 NHAAPFSKVLTFYRK
K430-u NHAAPFSkVLTFYRK
T433 APFSkVLTFYRKEPF
Y435 FSkVLTFYRKEPFTL
K437 kVLTFYRKEPFTLEA
K517 METDQNAKEEEKMQV
T540-p EQQQQPQtPAENKAE
K545 PQtPAENKAEsEEME
S548-p PAENKAEsEEMETSQ
S554 EsEEMETSQAGSKDK
K559 ETSQAGSKDKKTDQP
K559 ETSQAGSKDKKTDQP
K561 SQAGSKDKKTDQPPQ
K570 TDQPPQAKKAKVKTS
K575 QAKKAKVKTSTVDLP
K604 LYTENEGKMIMQDKL
K604 LYTENEGKMIMQDKL
K619-u EKERNDAkNAVEEYV
Y625 AkNAVEEYVyEMRDk
Y627-p NAVEEYVyEMRDkLS
K632-u YVyEMRDkLSGEYEk
Y637 RDkLSGEYEkFVSED
K639-u kLSGEYEkFVSEDDR
T648 VSEDDRNTFTLKLED
Y661-p EDTENWLyEDGEDQP
K675-u PKQVYVDkLAELkSL
K680 VDkLAELKSLGQPIk
K680-u VDkLAELkSLGQPIk
K687-u kSLGQPIkTRFQESE
K698 QESEERPKLFEELGk
K705-u KLFEELGkQIQQYMk
K712-u kQIQQYMkVISSFKN
K720-u VISSFKNkEDQyEHL
Y724-p FKNkEDQyEHLDAAD
D728 EDQyEHLDAADVTKV
K737 ADVTKVEKSTNEAME
K749 AMEWMNSKLNLQNkQ
K755-u SKLNLQNkQSLTVDP
S757 LNLQNkQSLTVDPVV
K774 KEIEAKIKELTSICs
K774-u KEIEAKIkELTSICs
S781-p kELTSICsPIISkPK
K786-u ICsPIISkPKPKVEP
K795 KPKVEPPKEEPKHAE
K799 EPPKEEPKHAEQNGP
S816-p GQGDNPGsQAAEHGA
S829-p GADTAVPsDGDKKLP
  HSP70RY iso3  
K44 ACVSFGPKNRSIGAA
K53 RSIGAAAKSQVISNA
S54 SIGAAAKSQVISNAK
K61 SQVISNAKNTVQGFK
S76 RFHGRAFSDPFVEAE
Y89 AEKSNLAYDIVQLPT
T113 MEEERNFTTEQVTAM
T114 EEERNFTTEQVTAML
T118 NFTTEQVTAMLLSKL
K124 VTAMLLSKLKETAES
K126 AMLLSKLKETAESVL
K135 TAESVLKKPVVDCVV
Y184 VALAYGIYKQDLPAL
K194 DLPALEEKPRNVVFV
K221 AFNKGKLKVLATAFD
T230 LATAFDTTLGGRKFD
K235 DTTLGGRKFDEVLVN
K272 RLSQECEKLKKLMSA
K305 SGTMNRGKFLEMCDD
K329 RSVLEQSKLKKEDIY
Y336 KLKKEDIYAVEIVGG
K360 KISKFFGKELSTTLN
K388 AILSPAFKVREFSIT
S393 AFKVREFSITDVVPY
S408 PISLRWNSPAEEGLS
S415 SPAEEGLSDCEVFPK
K430 NHAAPFSKVLTFYRK
K430 NHAAPFSKVLTFYRK
T433 APFSKVLTFYRKEPF
Y435 FSKVLTFYRKEPFTL
K437 KVLTFYRKEPFTLEA
K517 METDQNAKEEEKMQV
T540 EQQQQPQTPAENKAE
K545 PQTPAENKAESEEME
S548 PAENKAESEEMETSQ
S554 ESEEMETSQAGSKDK
K559 ETSQAGSKDKKTDQP
K559 ETSQAGSKDKKTDQP
K561 SQAGSKDKKTDQPPQ
K570 TDQPPQAKKAKVkTS
K575-u QAKKAKVkTSTVDLP
K605 LYTENEGKMIMQDKL
K605-u LYTENEGkMIMQDKL
K620 EKERNDAKNAVEEYV
Y626 AKNAVEEYVYEMRDK
Y628 NAVEEYVYEMRDKLS
K633 YVYEMRDKLSGEYEK
Y638 RDKLSGEYEKFVSED
K640 KLSGEYEKFVSEDDR
T649 VSEDDRNTFTLKLED
Y662 EDTENWLYEDGEDQP
K676 PKQVYVDKLAELKSL
K681 VDKLAELKSLGQPIK
K681 VDKLAELKSLGQPIK
K688 KSLGQPIKTRFQESE
K699 QESEERPKLFEELGK
K706 KLFEELGKQIQQYMK
K713 KQIQQYMKVISSFKN
K721 VISSFKNKEDQYEHL
Y725 FKNKEDQYEHLDAAD
D729 EDQYEHLDAADVTKV
K738 ADVTKVEKSTNEAME
K750 AMEWMNSKLNLQNKQ
K756 SKLNLQNKQSLTVDP
S758 LNLQNKQSLTVDPVV
K775 KEIEAKIKELTSICS
K775 KEIEAKIKELTSICS
S782 KELTSICSPIISKPK
K787 ICSPIISKPKPKVEP
K796 KPKVEPPKEEPKHAE
K800 EPPKEEPKHAEQNGP
S817 GQGDNPGSQAAEHGA
S830 GADTAVPSDGDKKLP
  rat

 
K44 ACVSFGPKNRSVGAA
K53 RSVGAAAKSQVISNA
S54 SVGAAAKSQVISNAK
K61 SQVISNAKNTVQGFK
S76 RFHGRAFSDPFVEAE
Y89 AEKSNLAYDIVQLPT
T113 MEEERNFTTEQVTAM
T114 EEERNFTTEQVTAML
T118 NFTTEQVTAMLLSKL
K124 VTAMLLSKLKETAES
K126 AMLLSKLKETAESVL
K135 TAESVLKKPVVDCVV
Y184-p VALAYGIyKQDLPAL
K194 DLPALEEKPRNVVFV
K221 AFNRGKLKVLATAFD
T230 LATAFDTTLGGRKFD
K235 DTTLGGRKFDEVLVN
K272 RLSQECEKLKKLMSA
K305 SGTMNRGKFLEMCDD
K329 RSILDQSKLKKEDIy
Y336-p KLKKEDIyAVEIVGG
K360 KISKFFGKELSTTLN
K388-u AILSPAFkVREFSIT
S393 AFkVREFSITDVVPY
S408 PISLRWNSPAEEGSS
S415 SPAEEGSSDCEVFPK
K430 NHAAPFSKVLTFYRK
K430 NHAAPFSKVLTFYRK
T433 APFSKVLTFYRKEPF
Y435 FSKVLTFYRKEPFTL
K437 KVLTFYRKEPFTLEA
K517 METDQNAKEEEKMQV
T538 TEEQQPQTPAENKAE
K543 PQTPAENKAESEEME
S546 PAENKAESEEMETSQ
S552 ESEEMETSQAGSKDK
K557 ETSQAGSKDKKMDQP
K557 ETSQAGSKDKKMDQP
K559 SQAGSKDKKMDQPPQ
K568 MDQPPQAKKAKVKTS
K573 QAKKAKVKTSTVDLP
K603 LYTENEGKMIMQDKL
K603 LYTENEGKMIMQDKL
K618 EKERNDAKNAVEEYV
Y624 AKNAVEEYVYEMRDK
Y626 NAVEEYVYEMRDKLS
K631 YVYEMRDKLSGEYEK
Y636 RDKLSGEYEKFVSED
K638 KLSGEYEKFVSEDDR
N647 VSEDDRNNFTLKLED
Y660 EDTENWLYEDGEDQP
K674 PKQVYVDKLAELRTL
R679 VDKLAELRTLGQPIK
R679 VDKLAELRTLGQPIK
K686 RTLGQPIKTRFQESE
K697 QESEERPKLFEELGK
K704 KLFEELGKQIQQYMK
K711 KQIQQYMKVISSFKN
K719 VISSFKNKEDQYEHL
Y723 FKNKEDQYEHLDAAD
D727 EDQYEHLDAADMTKV
K736 ADMTKVEKSTNEAME
K748 AMEWMNSKLNLQNKQ
K754 SKLNLQNKQSLTADP
S756 LNLQNKQSLTADPVV
K773 KEIEAKIKELTNICS
K773 KEIEAKIKELTNICS
S780 KELTNICSPIISKPK
K785 ICSPIISKPKPKVEP
K794 KPKVEPPKEEPKHAE
K798 EPPKEEPKHAEQNGP
T815 GQGDNPGTQAAEHGA
S828 GADTAVPSDGDKKLP
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.