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Protein Page:
TKT (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TKT Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Homodimer. Belongs to the transketolase family. Note: This description may include information from UniProtKB.
Protein type: Transferase; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.1
Cellular Component: nucleolus; peroxisome; nucleus; cytosol
Molecular Function: transketolase activity; protein homodimerization activity; metal ion binding; cofactor binding
Biological Process: pentose-phosphate shunt; regulation of growth; carbohydrate metabolic process; glyceraldehyde-3-phosphate biosynthetic process; energy reserve metabolic process; pentose-phosphate shunt, non-oxidative branch; xylulose biosynthetic process
Reference #:  P29401 (UniProtKB)
Alt. Names/Synonyms: FLJ34765; TK; TKT; TKT1; Transketolase
Gene Symbols: TKT
Molecular weight: 67,878 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TKT

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3-p _____MEsYHkPDQQ
0 6 K6-ac __MEsYHkPDQQkLQ
0 1 K6 __MEsYHKPDQQkLQ
0 3 K11-ac YHkPDQQkLQALkDT
0 1 K16 QQkLQALKDTANRLR
0 14 K16-ub QQkLQALkDTANRLR
0 1 K16-sc QQkLQALkDTANRLR
0 1 T39 AAGSGHPTSCCSAAE
0 1 S40 AGSGHPTSCCSAAEI
0 9 K102-ub AELLNLRkIsSDLDG
0 1 S104-p LLNLRkIsSDLDGHP
0 4 K114-ub LDGHPVPkQAFTDVA
0 1 K140-ac CGMAYTGkYFDkASY
0 1 K140-ub CGMAYTGkYFDkASY
0 2 K144-ac YTGkYFDkASYRVYC
0 3 K144-ub YTGkYFDkASYRVYC
0 1 K174-ub MAFASIYkLDNLVAI
0 1 S190-p DINRLGQsDPAPLQH
0 1 Y202-p LQHQMDIyQkRCEAF
0 2 K204-ac HQMDIyQkRCEAFGW
0 8 K204-ub HQMDIyQkRCEAFGW
0 1 K204-sc HQMDIyQkRCEAFGW
0 4 K232-ac CKAFGQAkHQPTAII
0 4 K232-ub CKAFGQAkHQPTAII
0 2 K241-ac QPTAIIAkTFkGRGI
0 3 K241-ub QPTAIIAkTFkGRGI
0 1 K241 QPTAIIAKTFkGRGI
0 1 K244-ub AIIAkTFkGRGITGV
0 1 K254-ac GITGVEDkESWHGkP
0 29 K254-ub GITGVEDkESWHGkP
0 3 K260-ac DkESWHGkPLPkNMA
0 7 K260-ub DkESWHGkPLPkNMA
0 1 K260-sc DkESWHGkPLPkNMA
0 1 K264 WHGkPLPKNMAEQII
0 1 K264-ub WHGkPLPkNMAEQII
0 768 Y275-p EQIIQEIysQIQskk
0 10 S276-p QIIQEIysQIQskkk
0 2 S280-p EIysQIQskkkILAt
0 15 K281-ac IysQIQskkkILAtP
0 32 K281-ub IysQIQskkkILAtP
0 18 K282-ub ysQIQskkkILAtPP
0 6 K283-ub sQIQskkkILAtPPQ
0 17 T287-p skkkILAtPPQEDAP
0 5 S295-p PPQEDAPsVDIANIR
0 5 S305-p IANIRMPsLPsYkVG
0 1 S308-p IRMPsLPsYkVGDkI
0 1 K310-ac MPsLPsYkVGDkIAT
0 5 K310-ub MPsLPsYkVGDkIAT
0 1 K310-sc MPsLPsYkVGDkIAT
0 1 K314-ub PsYkVGDkIATRkAY
0 74 K319-ub GDkIATRkAYGQALA
0 1 K327-ac AYGQALAkLGHASDR
0 2 K327-ub AYGQALAkLGHASDR
0 3 T342-p IIALDGDtkNSTFSE
0 1 K343-ac IALDGDtkNSTFSEI
0 2 K343-ub IALDGDtkNSTFSEI
0 1 S345 LDGDtkNSTFSEIFk
0 3 K352-ac STFSEIFkKEHPDRF
0 3 K352-ub STFSEIFkKEHPDRF
0 1 K352-sc STFSEIFkKEHPDRF
0 1 S387 NRTVPFCSTFAAFFT
0 1 T388 RTVPFCSTFAAFFTR
0 1 S439-p EDLAMFRsVPtSTVF
0 1 T442-p AMFRsVPtSTVFYPs
0 1 T444 FRsVPtSTVFYPsDG
0 1 Y447 VPtSTVFYPsDGVAT
0 1 S449-p tSTVFYPsDGVATEk
0 1 K456-ac sDGVATEkAVELAAN
0 4 K456-ub sDGVATEkAVELAAN
0 2 K465-ac VELAANTkGICFIRt
0 2 K465-ub VELAANTkGICFIRt
0 1 K465-sc VELAANTkGICFIRt
0 1 T472-p kGICFIRtSRPENAI
0 1 K493 DFQVGQAKVVLKSkD
0 1 K499-ac AKVVLKSkDDQVTVI
0 2 K499-ub AKVVLKSkDDQVTVI
0 5 K523-ac LAAAELLkKEKINIR
0 6 K538-ub VLDPFTIkPLDRKLI
0 1 K538-sc VLDPFTIkPLDRKLI
0 1 K543 TIkPLDRKLILDsAR
0 1 S548-p DRKLILDsARATKGR
0 2 Y563-p ILTVEDHyYEGGIGE
0 1 S595 AVNRVPRSGkPAELL
0 1 K597-ac NRVPRSGkPAELLkM
0 1 K597 NRVPRSGKPAELLkM
0 3 K603-ac GkPAELLkMFGIDRD
0 1 K603-sc GkPAELLkMFGIDRD
0 1 R609 LkMFGIDRDAIAQAV
  mouse

 
G3 _____MEGYHkPDQQ
K6-ac __MEGYHkPDQQkLQ
K6-ub __MEGYHkPDQQkLQ
K11-ac YHkPDQQkLQALkDT
K16-ac QQkLQALkDTANRLR
K16-ub QQkLQALkDTANRLR
K16-sc QQkLQALkDTANRLR
T39-p AAGSGHPtsCCSAAE
S40-p AGSGHPtsCCSAAEI
K102-ub AELLNLRkISSDLDG
S104 LLNLRkISSDLDGHP
K114-ub LDGHPVPkQAFTDVA
K140 CGMAYTGKYFDkASY
K140 CGMAYTGKYFDkASY
K144-ac YTGKYFDkASYRVYC
K144-ub YTGKYFDkASYRVYC
K174 MAFAGIYKLDNLVAI
S190 DINRLGQSDPAPLQH
Y202 LQHQVDIYQkRCEAF
K204-ac HQVDIYQkRCEAFGW
K204 HQVDIYQKRCEAFGW
K204 HQVDIYQKRCEAFGW
K232 CKAFGQAKHQPTAII
K232-ub CKAFGQAkHQPTAII
K241-ac QPTAIIAkTFKGRGI
K241-ub QPTAIIAkTFKGRGI
K241-sc QPTAIIAkTFKGRGI
K244 AIIAkTFKGRGITGI
K254-ac GITGIEDkEAWHGkP
K254-ub GITGIEDkEAWHGkP
K260-ac DkEAWHGkPLPkNMA
K260-ub DkEAWHGkPLPkNMA
K260-sc DkEAWHGkPLPkNMA
K264-ac WHGkPLPkNMAEQII
K264 WHGkPLPKNMAEQII
Y275-p EQIIQEIySQVQSkk
S276 QIIQEIySQVQSkkk
S280 EIySQVQSkkkILAt
K281-ac IySQVQSkkkILAtP
K281-ub IySQVQSkkkILAtP
K282-ub ySQVQSkkkILAtPP
K283-ub SQVQSkkkILAtPPQ
T287-p SkkkILAtPPQEDAP
S295 PPQEDAPSVDIANIR
T305-p IANIRMPtPPSYkVG
S308 IRMPtPPSYkVGDKI
K310-ac MPtPPSYkVGDKIAT
K310-ub MPtPPSYkVGDKIAT
K310 MPtPPSYKVGDKIAT
K314 PSYkVGDKIATRkAY
K319-ub GDKIATRkAYGLALA
K327 AYGLALAKLGHASDR
K327-ub AYGLALAkLGHASDR
T342-p IIALDGDtkNsTFSE
K343 IALDGDtKNsTFSEL
K343-ub IALDGDtkNsTFSEL
S345-p LDGDtkNsTFSELFk
K352-ac sTFSELFkKEHPDRF
K352 sTFSELFKKEHPDRF
K352-sc sTFSELFkKEHPDRF
S387-p DRTVPFCstFAAFFT
T388-p RTVPFCstFAAFFTR
S439 EDLAMFRSVPMStVF
M442 AMFRSVPMStVFyPS
T444-p FRSVPMStVFyPSDG
Y447-p VPMStVFyPSDGVAT
S449 MStVFyPSDGVATEk
K456 SDGVATEKAVELAAN
K456-ub SDGVATEkAVELAAN
K465 VELAANTKGICFIRT
K465 VELAANTKGICFIRT
K465 VELAANTKGICFIRT
T472 KGICFIRTSRPENAI
K493-ub DFQVGQAkVVLKSkD
K499-ac AkVVLKSkDDQVTVI
K499-ub AkVVLKSkDDQVTVI
K523-ac LAAAESLkKDKISIR
K538-ub VLDPFTIkPLDRkLI
K538 VLDPFTIKPLDRkLI
K543-ub TIkPLDRkLILDSAR
S548 DRkLILDSARATKGR
Y563 ILTVEDHYYEGGIGE
S595-p AVSQVPRsGkPAELL
K597 SQVPRsGKPAELLkM
K597-ub SQVPRsGkPAELLkM
K603-ac GkPAELLkMFGIDkD
K603 GkPAELLKMFGIDkD
K609-ac LkMFGIDkDAIVQAV
  rat

 
G3 _____MEGYHKPDQQ
K6 __MEGYHKPDQQKLQ
K6 __MEGYHKPDQQKLQ
K11 YHKPDQQKLQALKDT
K16 QQKLQALKDTANRLR
K16 QQKLQALKDTANRLR
K16 QQKLQALKDTANRLR
T39 AAGSGHPTSCCSAAE
S40 AGSGHPTSCCSAAEI
K102 AELLNLRKISSDLDG
S104 LLNLRKISSDLDGHP
K114 LDGHPVPKQAFTDVA
K140 CGMAYTGKYFDKASY
K140 CGMAYTGKYFDKASY
K144 YTGKYFDKASYRVYC
K144 YTGKYFDKASYRVYC
K174 MAFAGIYKLDNLVAI
S190 DINRLGQSDPAPLQH
Y202 LQHQVDVYQKRCEAF
K204 HQVDVYQKRCEAFGW
K204 HQVDVYQKRCEAFGW
K204 HQVDVYQKRCEAFGW
K232 CKAFGQAKHQPTAII
K232 CKAFGQAKHQPTAII
K241 QPTAIIAKTFKGRGI
K241 QPTAIIAKTFKGRGI
K241 QPTAIIAKTFKGRGI
K244 AIIAKTFKGRGITGI
K254 GITGIEDKEAWHGKP
K254 GITGIEDKEAWHGKP
K260 DKEAWHGKPLPKNMA
K260 DKEAWHGKPLPKNMA
K260 DKEAWHGKPLPKNMA
K264 WHGKPLPKNMAEQII
K264 WHGKPLPKNMAEQII
Y275 EQIIQEIYSQVQSKk
S276 QIIQEIYSQVQSKkK
S280 EIYSQVQSKkKILAt
K281 IYSQVQSKkKILAtP
K281 IYSQVQSKkKILAtP
K282-ub YSQVQSKkKILAtPP
K283 SQVQSKkKILAtPPQ
T287-p SKkKILAtPPQEDAP
S295-p PPQEDAPsVDIANIR
T305-p IANIRMPtPPNYKVG
N308 IRMPtPPNYKVGDKI
K310 MPtPPNYKVGDKIAT
K310 MPtPPNYKVGDKIAT
K310 MPtPPNYKVGDKIAT
K314 PNYKVGDKIATRKAY
K319 GDKIATRKAYGLALA
K327 AYGLALAKLGHASDR
K327 AYGLALAKLGHASDR
T342 IIALDGDTKNsTFSE
K343 IALDGDTKNsTFSEL
K343 IALDGDTKNsTFSEL
S345-p LDGDTKNsTFSELFK
K352 sTFSELFKKEHPDRF
K352 sTFSELFKKEHPDRF
K352 sTFSELFKKEHPDRF
S387 DRTVPFCSTFAAFFT
T388 RTVPFCSTFAAFFTR
S439 EDLAMFRSVPMSTVF
M442 AMFRSVPMSTVFYPS
T444 FRSVPMSTVFYPSDG
Y447 VPMSTVFYPSDGVAT
S449 MSTVFYPSDGVATEK
K456 SDGVATEKAVELAAN
K456 SDGVATEKAVELAAN
K465 VELAANTKGICFIRT
K465 VELAANTKGICFIRT
K465 VELAANTKGICFIRT
T472 KGICFIRTSRPENAI
K493 DFQVGQAKVVLKSKD
K499 AKVVLKSKDDQVTVI
K499 AKVVLKSKDDQVTVI
K523 LAAAEMLKKEKIGVR
K538 VLDPFTIKPLDKKLI
K538 VLDPFTIKPLDKKLI
K543 TIKPLDKKLILDCAR
C548 DKKLILDCARATKGR
Y563 ILTVEDHYYEGGIGE
S595 AVSQVPRSGKPAELL
K597 SQVPRSGKPAELLKM
K597 SQVPRSGKPAELLKM
K603 GKPAELLKMFGIDKD
K603 GKPAELLKMFGIDKD
K609 LKMFGIDKDAIVQAV
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