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Protein Page:
TKT (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TKT Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Homodimer. Belongs to the transketolase family. Note: This description may include information from UniProtKB.
Protein type: Transferase; EC 2.2.1.1; Carbohydrate Metabolism - pentose phosphate pathway
Cellular Component: endoplasmic reticulum membrane; nucleolus; peroxisome; cytosol; nucleus
Molecular Function: monosaccharide binding; transketolase activity; protein homodimerization activity; magnesium ion binding; thiamin pyrophosphate binding; cofactor binding
Biological Process: pentose-phosphate shunt; ribose phosphate biosynthetic process; regulation of growth; carbohydrate metabolic process; glyceraldehyde-3-phosphate biosynthetic process; energy reserve metabolic process; pentose-phosphate shunt, non-oxidative branch; xylulose biosynthetic process
Reference #:  P29401 (UniProtKB)
Alt. Names/Synonyms: FLJ34765; TK; TKT; TKT1; Transketolase
Gene Symbols: TKT
Molecular weight: 67,878 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TKT
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 5 K6-a __MESYHkPDQQkLQ
0 1 K6 __MESYHKPDQQkLQ
0 2 K11-a YHkPDQQkLQALkDT
0 14 K16-u QQkLQALkDTANRLR
0 1 T39 AAGSGHPTSCCSAAE
0 1 S40 AGSGHPTSCCSAAEI
0 9 K102-u AELLNLRkISSDLDG
0 4 K114-u LDGHPVPkQAFTDVA
0 1 K140-a CGMAYTGkYFDkASY
0 1 K140-u CGMAYTGkYFDkASY
0 1 K144-a YTGkYFDkASYRVYC
0 3 K144-u YTGkYFDkASYRVYC
0 1 K174-u MAFASIYkLDNLVAI
0 1 Y202-p LQHQMDIyQkRCEAF
0 1 K204-a HQMDIyQkRCEAFGW
0 8 K204-u HQMDIyQkRCEAFGW
0 3 K232-a CKAFGQAkHQPTAII
0 4 K232-u CKAFGQAkHQPTAII
0 1 K241-a QPTAIIAkTFkGRGI
0 3 K241-u QPTAIIAkTFkGRGI
0 1 K244-u AIIAkTFkGRGITGV
0 29 K254-u GITGVEDkESWHGkP
0 7 K260-u DkESWHGkPLPkNMA
0 2 K260-a DkESWHGkPLPkNMA
0 1 K264-u WHGkPLPkNMAEQII
0 812 Y275-p EQIIQEIysQIQskk
0 10 S276-p QIIQEIysQIQskkk
0 1 S280-p EIysQIQskkkILAt
0 14 K281-a IysQIQskkkILAtP
0 32 K281-u IysQIQskkkILAtP
0 18 K282-u ysQIQskkkILAtPP
0 6 K283-u sQIQskkkILAtPPQ
0 13 T287-p skkkILAtPPQEDAP
0 3 S295-p PPQEDAPsVDIANIR
0 2 S305-p IANIRMPsLPsYkVG
0 1 S308-p IRMPsLPsYkVGDkI
0 5 K310-u MPsLPsYkVGDkIAT
0 1 K314-u PsYkVGDkIATRkAY
0 1 - gap
0 74 K319-u GDkIATRkAYGQALA
0 2 K327-u AYGQALAkLGHASDR
0 2 T342 IIALDGDTkNSTFSE
0 2 K343-u IALDGDTkNSTFSEI
0 1 S345 LDGDTkNSTFSEIFk
0 2 K352-a STFSEIFkKEHPDRF
0 3 K352-u STFSEIFkKEHPDRF
0 1 S387 NRTVPFCSTFAAFFT
0 1 T388 RTVPFCSTFAAFFTR
0 1 T444 FRSVPTSTVFYPSDG
0 1 Y447 VPTSTVFYPSDGVAT
0 1 K456-a SDGVATEkAVELAAN
0 4 K456-u SDGVATEkAVELAAN
0 2 K465-a VELAANTkGICFIRT
0 2 K465-u VELAANTkGICFIRT
0 1 K493 DFQVGQAKVVLKSkD
0 2 K499-u AKVVLKSkDDQVTVI
0 4 K523-a LAAAELLkKEKINIR
0 6 K538-u VLDPFTIkPLDRKLI
0 1 K543 TIkPLDRKLILDsAR
0 1 S548-p DRKLILDsARATKGR
0 2 Y563-p ILTVEDHyYEGGIGE
0 1 S595 AVNRVPRSGkPAELL
0 1 K597-a NRVPRSGkPAELLkM
0 1 K597 NRVPRSGKPAELLkM
0 2 K603-a GkPAELLkMFGIDRD
  TKT iso3  
- gap
- under review  
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- gap
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- gap
- gap
S21-p SRRSTARsRAFPLSS
K35 SSQIATRKAYGQALA
K43 AYGQALAKLGHASDR
T58 IIALDGDTKNSTFSE
K59 IALDGDTKNSTFSEI
S61 LDGDTKNSTFSEIFK
K68 STFSEIFKKEHPDRF
K68 STFSEIFKKEHPDRF
S103 NRTVPFCSTFAAFFT
T104 RTVPFCSTFAAFFTR
T160 FRSVPTSTVFYPSDG
Y163 VPTSTVFYPSDGVAT
K172 SDGVATEKAVELAAN
K172 SDGVATEKAVELAAN
K181 VELAANTKGICFIRT
K181 VELAANTKGICFIRT
K209 DFQVGQAKVVLKSKD
K215 AKVVLKSKDDQVTVI
K239 LAAAELLKKEKINIR
K254 VLDPFTIKPLDRKLI
K259 TIKPLDRKLILDSAR
S264 DRKLILDSARATKGR
Y279 ILTVEDHYYEGGIGE
S311 AVNRVPRSGKPAELL
K313 NRVPRSGKPAELLKM
K313 NRVPRSGKPAELLKM
K319 GKPAELLKMFGIDRD
  mouse

 
K6-a __MEGYHkPDQQKLQ
K6-u __MEGYHkPDQQKLQ
K11 YHkPDQQKLQALkDT
K16-u QQKLQALkDTANRLR
T39-p AAGSGHPtsCCSAAE
S40-p AGSGHPtsCCSAAEI
K102-u AELLNLRkISSDLDG
K114-u LDGHPVPkQAFTDVA
K140 CGMAYTGKYFDkASY
K140 CGMAYTGKYFDkASY
K144 YTGKYFDKASYRVYC
K144-u YTGKYFDkASYRVYC
K174 MAFAGIYKLDNLVAI
Y202 LQHQVDIYQKRCEAF
K204 HQVDIYQKRCEAFGW
K204 HQVDIYQKRCEAFGW
K232 CKAFGQAKHQPTAII
K232-u CKAFGQAkHQPTAII
K241 QPTAIIAKTFKGRGI
K241-u QPTAIIAkTFKGRGI
K244 AIIAkTFKGRGITGI
K254-u GITGIEDkEAWHGkP
K260-u DkEAWHGkPLPKNMA
K260 DkEAWHGKPLPKNMA
K264 WHGkPLPKNMAEQII
Y275-p EQIIQEIySQVQSkk
S276 QIIQEIySQVQSkkk
S280 EIySQVQSkkkILAt
K281-a IySQVQSkkkILAtP
K281-u IySQVQSkkkILAtP
K282-u ySQVQSkkkILAtPP
K283-u SQVQSkkkILAtPPQ
T287-p SkkkILAtPPQEDAP
S295 PPQEDAPSVDIANIR
T305-p IANIRMPtPPSYkVG
S308 IRMPtPPSYkVGDKI
K310-u MPtPPSYkVGDKIAT
K314 PSYkVGDKIATRkAY
- gap
K319-u GDKIATRkAYGLALA
K327-u AYGLALAkLGHASDR
T342-p IIALDGDtkNsTFSE
K343-u IALDGDtkNsTFSEL
S345-p LDGDtkNsTFSELFk
K352-a sTFSELFkKEHPDRF
K352 sTFSELFKKEHPDRF
S387-p DRTVPFCstFAAFFT
T388-p RTVPFCstFAAFFTR
T444-p FRSVPMStVFyPSDG
Y447-p VPMStVFyPSDGVAT
K456 SDGVATEKAVELAAN
K456-u SDGVATEkAVELAAN
K465 VELAANTKGICFIRT
K465 VELAANTKGICFIRT
K493-u DFQVGQAkVVLKSkD
K499-u AkVVLKSkDDQVTVI
K523-a LAAAESLkKDKISIR
K538-u VLDPFTIkPLDRkLI
K543-u TIkPLDRkLILDSAR
S548 DRkLILDSARATKGR
Y563 ILTVEDHYYEGGIGE
S595-p AVSQVPRsGkPAELL
K597 SQVPRsGKPAELLKM
K597-u SQVPRsGkPAELLKM
K603 GkPAELLKMFGIDKD
  rat

 
K6 __MEGYHKPDQQKLQ
K6 __MEGYHKPDQQKLQ
K11 YHKPDQQKLQALKDT
K16 QQKLQALKDTANRLR
T39 AAGSGHPTSCCSAAE
S40 AGSGHPTSCCSAAEI
K102 AELLNLRKISSDLDG
K114 LDGHPVPKQAFTDVA
K140 CGMAYTGKYFDKASY
K140 CGMAYTGKYFDKASY
K144 YTGKYFDKASYRVYC
K144 YTGKYFDKASYRVYC
K174 MAFAGIYKLDNLVAI
Y202 LQHQVDVYQKRCEAF
K204 HQVDVYQKRCEAFGW
K204 HQVDVYQKRCEAFGW
K232 CKAFGQAKHQPTAII
K232 CKAFGQAKHQPTAII
K241 QPTAIIAKTFKGRGI
K241 QPTAIIAKTFKGRGI
K244 AIIAKTFKGRGITGI
K254 GITGIEDKEAWHGKP
K260 DKEAWHGKPLPKNMA
K260 DKEAWHGKPLPKNMA
K264 WHGKPLPKNMAEQII
Y275 EQIIQEIYSQVQSKk
S276 QIIQEIYSQVQSKkK
S280 EIYSQVQSKkKILAt
K281 IYSQVQSKkKILAtP
K281 IYSQVQSKkKILAtP
K282-u YSQVQSKkKILAtPP
K283 SQVQSKkKILAtPPQ
T287-p SKkKILAtPPQEDAP
S295-p PPQEDAPsVDIANIR
T305-p IANIRMPtPPNYKVG
N308 IRMPtPPNYKVGDKI
K310 MPtPPNYKVGDKIAT
K314 PNYKVGDKIATRKAY
- gap
K319 GDKIATRKAYGLALA
K327 AYGLALAKLGHASDR
T342 IIALDGDTKNsTFSE
K343 IALDGDTKNsTFSEL
S345-p LDGDTKNsTFSELFK
K352 sTFSELFKKEHPDRF
K352 sTFSELFKKEHPDRF
S387 DRTVPFCSTFAAFFT
T388 RTVPFCSTFAAFFTR
T444 FRSVPMSTVFYPSDG
Y447 VPMSTVFYPSDGVAT
K456 SDGVATEKAVELAAN
K456 SDGVATEKAVELAAN
K465 VELAANTKGICFIRT
K465 VELAANTKGICFIRT
K493 DFQVGQAKVVLKSKD
K499 AKVVLKSKDDQVTVI
K523 LAAAEMLKKEKIGVR
K538 VLDPFTIKPLDKKLI
K543 TIKPLDKKLILDCAR
C548 DKKLILDCARATKGR
Y563 ILTVEDHYYEGGIGE
S595 AVSQVPRSGKPAELL
K597 SQVPRSGKPAELLKM
K597 SQVPRSGKPAELLKM
K603 GKPAELLKMFGIDKD
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