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Protein Page:
PSMA3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSMA3 a proteasomal protein of the T1A peptidase family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. Two alternatively spliced isoforms have been identified. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.25.1; Proteasome complex; Protease
Cellular Component: nucleoplasm; proteasome complex; proteasome core complex; cytoplasm; cytosol; nucleus
Molecular Function: threonine endopeptidase activity; protein binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mRNA metabolic process; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; RNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
Reference #:  P25788 (UniProtKB)
Alt. Names/Synonyms: HC8; Macropain subunit C8; MGC12306; MGC32631; Multicatalytic endopeptidase complex subunit C8; proteasome (prosome, macropain) subunit, alpha type, 3; Proteasome component C8; Proteasome subunit alpha type-3; proteasome subunit C8; PSA3; PSC3; PSC8; PSMA3
Gene Symbols: PSMA3
Molecular weight: 28,433 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSMA3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y8-p MSSIGTGyDLSASTF
0 1 S16-p DLSASTFsPDGRVFQ
0 8 K29-ub FQVEYAMkAVENSSt
0 1 T36-p kAVENSStAIGIRCk
0 16 K43-ub tAIGIRCkDGVVFGV
0 8 K57-ac VEKLVLSkLYEEGSN
0 44 K57-ub VEKLVLSkLYEEGSN
0 1 K57-sc VEKLVLSkLYEEGSN
0 1 K65-ac LYEEGSNkRLFNVDR
0 5 K65-ub LYEEGSNkRLFNVDR
0 1 K65 LYEEGSNKRLFNVDR
0 1 S97-p DIAREEAsNFRsNFG
0 1 S101-p EEAsNFRsNFGyNIP
0 3 Y105-p NFRsNFGyNIPLkHL
0 1 K110-ac FGyNIPLkHLADRVA
0 5 K110-ub FGyNIPLkHLADRVA
0 1 S155 QLYMIDPSGVSYGyW
0 1 S158 MIDPSGVSYGyWGCA
0 1 Y159 IDPSGVSYGyWGCAI
0 2 Y161-p PSGVSYGyWGCAIGK
0 1 K179 AAKTEIEKLQMkEMt
0 2 K179-ub AAKTEIEkLQMkEMt
0 17 K183-ub EIEkLQMkEMtCRDI
0 1 T186-p kLQMkEMtCRDIVkE
0 2 K192-ub MtCRDIVkEVAKIIY
0 2 K206-ac YIVHDEVkDKAFELE
0 18 K206-ub YIVHDEVkDKAFELE
0 4 N222 SWVGELTNGRHEIVP
0 1 K230-ac GRHEIVPkDIREEAE
0 10 K230-ub GRHEIVPkDIREEAE
0 2 K238-ac DIREEAEkYAKEsLk
0 2 K238-ub DIREEAEkYAKEsLk
0 1 Y239 IREEAEkYAKEsLkE
2 10 S243-p AEkYAKEsLkEEDEs
0 1 K245-ub kYAKEsLkEEDEsDD
2 871 S250-p sLkEEDEsDDDNM__
  mouse

 
Y8 MSSIGTGYDLSASTF
S16 DLSASTFSPDGRVFQ
K29 FQVEYAMKAVENSST
T36 KAVENSSTAIGIRCK
K43 TAIGIRCKDGVVFGV
K57-ac VEKLVLSkLYEEGSN
K57-ub VEKLVLSkLYEEGSN
K57-sc VEKLVLSkLYEEGSN
K65 LYEEGSNKRLFNVDR
K65 LYEEGSNKRLFNVDR
K65-sc LYEEGSNkRLFNVDR
S97 DIAREEASNFRSNFG
S101 EEASNFRSNFGYNIP
Y105 NFRSNFGYNIPLkHL
K110 FGYNIPLKHLADRVA
K110-ub FGYNIPLkHLADRVA
S155-p QLYMIDPsGVsyGYW
S158-p MIDPsGVsyGYWGCA
Y159-p IDPsGVsyGYWGCAI
Y161 PsGVsyGYWGCAIGK
K179-ac AAKTEIEkLQMkEMT
K179-ub AAKTEIEkLQMkEMT
K183-ub EIEkLQMkEMTCRDV
T186 kLQMkEMTCRDVVKE
K192 MTCRDVVKEVAKIIY
K206-ac YIVHDEVkDKAFELE
K206-ub YIVHDEVkDKAFELE
K222-ub SWVGELTkGRHEIVP
K230 GRHEIVPKDIREEAE
K230-ub GRHEIVPkDIREEAE
K238-ac DIREEAEkYAKEsLK
K238 DIREEAEKYAKEsLK
Y239 IREEAEkYAKEsLKE
S243-p AEkYAKEsLKEEDEs
K245 kYAKEsLKEEDEsDD
S250-p sLKEEDEsDDDNM__
  rat

 
Y8 MSSIGTGYDLSASTF
S16 DLSASTFSPDGRVFQ
K29 FQVEYAMKAVENSST
T36 KAVENSSTAIGIRCK
K43 TAIGIRCKDGVVFGV
K57 VEKLVLSKLYEEGSN
K57 VEKLVLSKLYEEGSN
K57 VEKLVLSKLYEEGSN
K65 LYEEGSNKRLFNVDR
K65 LYEEGSNKRLFNVDR
K65 LYEEGSNKRLFNVDR
S97 DIAREEASNFRSNFG
S101 EEASNFRSNFGYNIP
Y105 NFRSNFGYNIPLKHL
K110 FGYNIPLKHLADRVA
K110 FGYNIPLKHLADRVA
S155 QLYMIDPSGVSYGYW
S158 MIDPSGVSYGYWGCA
Y159 IDPSGVSYGYWGCAI
Y161 PSGVSYGYWGCAIGK
K179 AAKTEIEKLQMKEMT
K179 AAKTEIEKLQMKEMT
K183 EIEKLQMKEMTCRDV
T186 KLQMKEMTCRDVVKE
K192 MTCRDVVKEVAKIIY
K206 YIVHDEVKDKAFELE
K206 YIVHDEVKDKAFELE
K222 SWVGELTKGRHEIVP
K230 GRHEIVPKDVREEAE
K230 GRHEIVPKDVREEAE
K238 DVREEAEKyAKEsLK
K238 DVREEAEKyAKEsLK
Y239-p VREEAEKyAKEsLKE
S243-p AEKyAKEsLKEEDEs
K245 KyAKEsLKEEDEsDD
S250-p sLKEEDEsDDDNM__
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