a G-beta like protein containing 7 WD domains. A presumptive scaffold protein, linking protein kinase C to its substrates. Binds inositol 1,4,5-trisphosphate receptors and regulates Ca2+ release by enhancing inositol 1,4,5-trisphosphate receptor binding affinity for inositol 1,4,5-trisphosphate. An insulin-like growth factor 1 receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; G protein; G protein, heterotrimeric beta WD; Motility/polarity/chemotaxis; Adaptor/scaffold; G protein, heterotrimeric
Cellular Component: small ribosomal subunit; cytoskeleton; cell soma; mitochondrion; perinuclear region of cytoplasm; cytoplasm; dendrite; perikaryon; midbody; cytosol; nucleus; phagocytic cup
Molecular Function: protein tyrosine kinase inhibitor activity; protein binding; enzyme binding; protein kinase C binding; caspase activator activity; SH2 domain binding; protein complex scaffold; receptor tyrosine kinase binding; protein phosphatase binding; ion channel inhibitor activity; receptor binding
Biological Process: caspase activation; negative regulation of phagocytosis; negative regulation of protein kinase B signaling cascade; negative regulation of Wnt receptor signaling pathway; viral reproduction; regulation of cell cycle; positive regulation of protein homooligomerization; positive regulation of apoptosis; rhythmic process; gastrulation; cell cycle; regulation of protein localization; positive regulation of mitochondrial depolarization; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of translation; positive regulation of cAMP catabolic process; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of protein amino acid phosphorylation; negative regulation of cell growth; regulation of cell division; positive regulation of GTPase activity; positive regulation of cell migration
Alt. Names/Synonyms: Cell proliferation-inducing gene 21 protein; GBLP; Gnb2-rs1; GNB2L1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; Guanine nucleotide-binding protein subunit beta-2-like 1; Guanine nucleotide-binding protein subunit beta-like protein 12.3; H12.3; HLC-7; Human lung cancer oncogene 7 protein; lung cancer oncogene 7; PIG21; proliferation-inducing gene 21; protein homologous to chicken B complex protein, guanine nucleotide binding; RACK1; Receptor for activated C kinase; Receptor for Activated C Kinase 1; Receptor of activated protein kinase C 1
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.