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RACK1
a G-beta like protein containing 7 WD domains. A presumptive scaffold protein, linking protein kinase C to its substrates. Binds inositol 1,4,5-trisphosphate receptors and regulates Ca2+ release by enhancing inositol 1,4,5-trisphosphate receptor binding affinity for inositol 1,4,5-trisphosphate. An insulin-like growth factor 1 receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death. Note: This description may include information from UniProtKB.
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| Protein type: G protein, heterotrimeric beta WD; Nuclear receptor co-regulator; Motility/polarity/chemotaxis; G protein; Adaptor/scaffold; G protein, heterotrimeric |
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Cellular Component: small ribosomal subunit; cytoskeleton; cell soma; perinuclear region of cytoplasm; cytoplasm; dendrite; perikaryon; midbody; nucleus; phagocytic cup
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Molecular Function: protein tyrosine kinase inhibitor activity; protein binding; protein kinase C binding; SH2 domain binding; caspase activator activity; receptor tyrosine kinase binding; protein phosphatase binding; ion channel inhibitor activity; receptor binding
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Biological Process: caspase activation; negative regulation of phagocytosis; negative regulation of protein kinase B signaling cascade; negative regulation of Wnt receptor signaling pathway; positive regulation of protein homooligomerization; regulation of cell cycle; positive regulation of apoptosis; rhythmic process; gastrulation; cell cycle; regulation of protein localization; virus-host interaction; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of translation; positive regulation of protein amino acid phosphorylation; negative regulation of cell growth; regulation of cell division; positive regulation of GTPase activity; positive regulation of cell migration
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Reference #:
P63244 (UniProtKB)
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| Alt. Names/Synonyms: Cell proliferation-inducing gene 21 protein; GBLP; Gnb2-rs1; GNB2L1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; Guanine nucleotide-binding protein subunit beta-2-like 1; Guanine nucleotide-binding protein subunit beta-like protein 12.3; H12.3; HLC-7; Human lung cancer oncogene 7 protein; lung cancer oncogene 7; PIG21; proliferation-inducing gene 21; protein homologous to chicken B complex protein, guanine nucleotide binding; RACK1; Receptor for activated C kinase; Receptor for Activated C Kinase 1; Receptor of activated protein kinase C 1 |
| Gene Symbols: GNB2L1 |
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Molecular weight: 35,077 Da
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Basal Isoelectric point: 7.6
Predict pI for various phosphorylation states
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CST Pathways:
GPCRs Signaling to MAPK/Erk
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MAPK/Erk in Growth and Differentiation
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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