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TGM2 (human)

Overview TGM2 an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: EC 2.3.2.13; Transferase Cellular Component: mitochondrion; plasma membrane Molecular Function: identical protein binding; protein domain specific binding; protein binding; GTP binding; protein-glutamine gamma-glutamyltransferase activity; metal ion binding Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of cell adhesion; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; positive regulation of smooth muscle cell proliferation; induction of apoptosis; blood vessel remodeling; apoptotic cell clearance; protein homooligomerization; positive regulation of inflammatory response Reference #:  P21980 (UniProtKB) Alt. Names/Synonyms: C polypeptide; G-ALPHA-h; GNAH; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; TG(C); TG2; TGase C; TGase H; TGase-2; TGase-H; TGC; TGM2; Tissue transglutaminase; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Transglutaminase C; Transglutaminase H; Transglutaminase-2 Gene Symbols: TGM2 Molecular weight: 77,329 Da Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TGM2 1FAU - A=1-687 (human) 1KV3 - A/B/C/D/E/F=1-687 (human) 2Q3Z - A=1-687 (human) 3LY6 - A/C/B=1-687 (human) 3S3J - A=2-687 (human) 3S3P - A=2-687 (human) 3S3S - A=2-687 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: S215‑p, S216‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		H44	QPFWLTLHFEGRNYE
0	1		T58	EASVDSLTFSVVTGP
0	1		S68	VVTGPAPSQEAGTKA
0	3		K202-a	ILLDVNPkFLKNAGR
1	0		S212-p	KNAGRDCsRRssPVy
1	0		S215-p	GRDCsRRssPVyVGR
3	3		S216-p	RDCsRRssPVyVGRV
0	7		Y219-p	sRRssPVyVGRVVSG
0	1		G325	NEFGEIQGDKSEMIW
0	8		T368-p	PQEKSEGtyCCGPVP
0	616		Y369-p	QEKSEGtyCCGPVPV
0	3		K425	RSLIVGLKIsTKSVG
0	1		S427-p	LIVGLKIsTKSVGRD
0	1		R458	EEREAFTRANHLNKL
0	1		K590	YLENPEIKIRILGEP
0	10		E618	NPLPVALEGCTFTVE
0	1		K649	VEAGEEVKVRMDLLP

	mouse
Y44	QRFRLTLYFEGRGYE
T58	EASVDSLTFGAVTGP
S68	AVTGPDPSEEAGTKA
K202	MLLDMNPKFLKNRSR
S212	KNRSRDCSRRSsPIy
S215	SRDCSRRSsPIyVGR
S216-p	RDCSRRSsPIyVGRV
Y219-p	SRRSsPIyVGRVVSA
S325-p	NEFGELEsNKSEMIW
T368	PQEKSEGTyCCGPVS
Y369-p	QEKSEGTyCCGPVSV
K425-u	RSLVVGQkISTKSVG
S427	LVVGQkISTKSVGRD
K458-u	EEREVFTkANHLNKL
K589-u	YLENPEIkIRVLGEP
Y617-p	NPLSDPLyDCIFTVE
K648-u	VPAGDLVkARVDLFP

	rat
Y44-p	QRFRLTLyFEGRGYE
T58-p	EASVDRLtFGAVTGP
S68-p	AVTGPDPsEEAGTKA
K202	MLLDVNPKFLKDRSR
S212	KDRSRDCSRRSSPIY
S215	SRDCSRRSSPIYVGR
S216	RDCSRRSSPIYVGRV
Y219	SRRSSPIYVGRVVSG
S325	NEYGELESNKSEMIW
T368	PQEKSEGTyCCGPVS
Y369-p	QEKSEGTyCCGPVSV
K425	NSLVVGQKISTKSVG
S427	LVVGQKISTKSVGRD
R458	EEREVFTRANHLNKL
K589	YLENPEIKIRILGEP
Y617	NPLSDSLYDCVFTVE
K648	VPAGDAVKVRVDLFP

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