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Protein Page:
TGM2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TGM2 an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.3.2.13; Transferase
Cellular Component: mitochondrion; plasma membrane; cytosol
Molecular Function: protein domain specific binding; protein binding; GTP binding; protein-glutamine gamma-glutamyltransferase activity; metal ion binding
Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of cell adhesion; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; positive regulation of apoptosis; positive regulation of smooth muscle cell proliferation; reduction of endoplasmic reticulum calcium ion concentration; blood vessel remodeling; protein homooligomerization; apoptotic cell clearance; positive regulation of inflammatory response; elevation of mitochondrial calcium ion concentration
Reference #:  P21980 (UniProtKB)
Alt. Names/Synonyms: C polypeptide; G-ALPHA-h; GNAH; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; TG(C); TG2; TGase C; TGase H; TGase-2; TGase-H; TGC; TGM2; Tissue transglutaminase; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Transglutaminase C; Transglutaminase H; Transglutaminase-2
Gene Symbols: TGM2
Molecular weight: 77,329 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TGM2

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S215‑p, S216‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 H44 QPFWLTLHFEGRNYE
0 1 T58 EASVDSLTFSVVTGP
0 1 S68 VVTGPAPSQEAGTKA
0 3 K202-ac ILLDVNPkFLKNAGR
1 0 S212-p KNAGRDCsRRssPVy
1 0 S215-p GRDCsRRssPVyVGR
3 3 S216-p RDCsRRssPVyVGRV
0 7 Y219-p sRRssPVyVGRVVSG
0 1 G325 NEFGEIQGDKSEMIW
0 8 T368-p PQEKSEGtyCCGPVP
0 606 Y369-p QEKSEGtyCCGPVPV
0 1 K414 QDDGSVHKSINRsLI
0 1 S419-p VHKSINRsLIVGLKI
0 3 K425 RsLIVGLKIsTKSVG
0 1 S427-p LIVGLKIsTKSVGRD
0 1 R458 EEREAFTRANHLNKL
0 1 S538-p NLNLEPFsEKsVPLC
0 1 S541-p LEPFsEKsVPLCILY
0 1 K590 YLENPEIKIRILGEP
0 1 K590 YLENPEIKIRILGEP
0 10 E618 NPLPVALEGCTFTVE
0 1 K649 VEAGEEVKVRMDLLP
0 1 K649 VEAGEEVKVRMDLLP
  mouse

 
Y44 QRFRLTLYFEGRGYE
T58 EASVDSLTFGAVTGP
S68 AVTGPDPSEEAGTKA
K202 MLLDMNPKFLKNRSR
S212 KNRSRDCSRRSsPIy
S215 SRDCSRRSsPIyVGR
S216-p RDCSRRSsPIyVGRV
Y219-p SRRSsPIyVGRVVSA
S325-p NEFGELEsNKSEMIW
T368 PQEKSEGTyCCGPVS
Y369-p QEKSEGTyCCGPVSV
K414-ac QEDGSVLkSINRSLV
S419 VLkSINRSLVVGQkI
K425-ub RSLVVGQkISTKSVG
S427 LVVGQkISTKSVGRD
K458-ub EEREVFTkANHLNKL
S537 NLTLDPYSENSIPLR
S540 LDPYSENSIPLRILY
K589-ac YLENPEIkIRVLGEP
K589-ub YLENPEIkIRVLGEP
Y617-p NPLSDPLyDCIFTVE
K648-ac VPAGDLVkARVDLFP
K648-ub VPAGDLVkARVDLFP
  rat

 
Y44-p QRFRLTLyFEGRGYE
T58-p EASVDRLtFGAVTGP
S68-p AVTGPDPsEEAGTKA
K202 MLLDVNPKFLKDRSR
S212 KDRSRDCSRRSSPIY
S215 SRDCSRRSSPIYVGR
S216 RDCSRRSSPIYVGRV
Y219 SRRSSPIYVGRVVSG
S325 NEYGELESNKSEMIW
T368 PQEKSEGTyCCGPVS
Y369-p QEKSEGTyCCGPVSV
K414 QSDGSVLKSINNSLV
S419 VLKSINNSLVVGQKI
K425 NSLVVGQKISTKSVG
S427 LVVGQKISTKSVGRD
R458 EEREVFTRANHLNKL
S537 NLTLDPYSENSIPLR
S540 LDPYSENSIPLRILY
K589 YLENPEIKIRILGEP
K589 YLENPEIKIRILGEP
Y617 NPLSDSLYDCVFTVE
K648 VPAGDAVKVRVDLFP
K648 VPAGDAVKVRVDLFP
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