a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. It is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Involved in chromatin condensation and control of cell cycle Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; G protein, monomeric (Ran); Nuclear export; Nuclear receptor co-regulator; G protein
Biological Process: mitosis; positive regulation of protein binding; viral reproduction; RNA export from nucleus; positive regulation of transcription, DNA-dependent; viral infectious cycle; signal transduction; mitotic spindle organization and biogenesis; protein import into nucleus; cell division; virus-host interaction; small GTPase mediated signal transduction; androgen receptor signaling pathway; gene expression; protein export from nucleus; actin cytoskeleton organization and biogenesis; DNA metabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.