a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. It is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Involved in chromatin condensation and control of cell cycle Note: This description may include information from UniProtKB.
Protein type: Nuclear export; G protein, monomeric; Motility/polarity/chemotaxis; G protein, monomeric, Ran; Nuclear receptor co-regulator; G protein
Biological Process: mitosis; mitotic spindle organization and biogenesis; viral reproduction; positive regulation of protein binding; small GTPase mediated signal transduction; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; gene expression; viral infectious cycle; protein export from nucleus; signal transduction; DNA metabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.