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RAN
a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. It is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Involved in chromatin condensation and control of cell cycle Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Nuclear export; G protein, monomeric (Ran); G protein; Motility/polarity/chemotaxis |
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Cellular Component: nucleoplasm; cytoplasm; melanosome; nuclear pore; cytosol; chromatin
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Molecular Function: GTPase activity; protein binding; GTP binding; androgen receptor binding; transcription coactivator activity; chromatin binding
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Biological Process: mitosis; viral reproduction; positive regulation of protein binding; RNA export from nucleus; positive regulation of transcription, DNA-dependent; viral infectious cycle; signal transduction; mitotic spindle organization and biogenesis; cell division; small GTPase mediated signal transduction; virus-host interaction; androgen receptor signaling pathway; gene expression; protein export from nucleus; DNA metabolic process
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Reference #:
P62826 (UniProtKB)
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| Alt. Names/Synonyms: Androgen receptor-associated protein 24; ARA24; Gsp1; GTP-binding nuclear protein Ran; GTPase Ran; guanosine triphosphatase Ran; member RAS oncogene family; OK/SW-cl.81; RAN; RAN, member RAS oncogene family; RanGTPase; Ras-like protein TC4; Ras-related nuclear protein; TC4 |
| Gene Symbols: RAN |
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Molecular weight: 24,423 Da
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Basal Isoelectric point: 7.01
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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