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Protein Page:
PKM2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PKM2 one of three rate-limiting enzymes in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule ATP and a pyruvate molecule, which is a central metabolic intermediate that can be used as a building block or oxidized further. Overexpressed in a variety of cancers. Interacts with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. Binds Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogens is. There are several mammalian isozymes of pyruvate kinase encoded by different genes. The L type predominates in liver, and the M type in muscle and brain. Two alternatively spliced human isoforms of PKM2 have been reported. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Protein kinase, tyrosine (non-receptor); EC 2.7.1.40; Kinase, protein; Nucleotide Metabolism - purine; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Kinase, other
Cellular Component: mitochondrion; flagellum; cytoplasm; plasma membrane; cytosol; nucleus
Molecular Function: potassium ion binding; protein binding; magnesium ion binding; ADP binding; pyruvate kinase activity; ATP binding
Biological Process: pyruvate biosynthetic process; response to gravity; organ regeneration; glycolysis; programmed cell death; skeletal muscle regeneration; glucose metabolic process; liver development; response to insulin stimulus; ATP biosynthetic process; carbohydrate metabolic process; response to hypoxia; response to nutrient; response to muscle inactivity
Reference #:  P14618 (UniProtKB)
Alt. Names/Synonyms: CTHBP; Cytosolic thyroid hormone-binding protein; KPYM; MGC3932; OIP-3; OIP3; Opa-interacting protein 3; p58; PK, muscle type; PK2; PK3; PKM; PKM2; Pyruvate kinase 2/3; Pyruvate kinase isozymes M1/M2; Pyruvate kinase muscle isozyme; pyruvate kinase, muscle; TCB; THBP1; Thyroid hormone-binding protein 1; thyroid hormone-binding protein, cytosolic; Tumor M2-PK
Gene Symbols: PKM
Molecular weight: 57,937 Da
Basal Isoelectric point: 7.96  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PKM2
Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 - gap
0 1 - gap
0 1 - gap
0 39 K3-a _____MSkPHSEAGT
0 3 K3-u _____MSkPHSEAGT
1 30 S37-p MCRLDIDsPPItARN
0 4 T41-p DIDsPPItARNtGII
0 2 T45-p PPItARNtGIICtIG
0 3 T50-p RNtGIICtIGPASRs
0 2 S57-p tIGPASRsVEtLkEM
0 1 T60-p PASRsVEtLkEMIkS
0 2 K62-a SRsVEtLkEMIkSGM
0 13 K62-u SRsVEtLkEMIkSGM
0 10 K66-u EtLkEMIkSGMNVAR
0 16 S77-p NVARLNFsHGtHEyH
0 1 T80-p RLNFsHGtHEyHAEt
1 230 Y83-p FsHGtHEyHAEtIkN
0 1 T87-p tHEyHAEtIkNVRtA
0 1 K89-a EyHAEtIkNVRtAtE
0 15 K89-u EyHAEtIkNVRtAtE
0 1 T93-p EtIkNVRtAtEsFAs
0 3 T95-p IkNVRtAtEsFAsDP
0 1 S97-p NVRtAtEsFAsDPIL
0 28 S100-p tAtEsFAsDPILyRP
1 418 Y105-p FAsDPILyRPVAVAL
0 37 K115-u VAVALDTkGPEIRTG
0 3 K125-u EIRTGLIkGsGtAEV
0 1 S127-p RTGLIkGsGtAEVEL
0 1 T129-p GLIkGsGtAEVELkk
0 38 K135-a GtAEVELkkGATLkI
0 20 K135-u GtAEVELkkGATLkI
0 2 K136-u tAEVELkkGATLkIT
0 2 K141-u LkkGATLkITLDNAy
1 305 Y148-p kITLDNAyMEkCDEN
0 1 K151-a LDNAyMEkCDENILW
0 32 K151-u LDNAyMEkCDENILW
0 1 Y161-p ENILWLDykNICkVV
0 4 K162-a NILWLDykNICkVVE
0 26 K162-u NILWLDykNICkVVE
0 1 K166-a LDykNICkVVEVGsK
0 99 K166-u LDykNICkVVEVGsK
0 2 S172-p CkVVEVGsKIyVDDG
1 16 Y175-p VEVGsKIyVDDGLIS
0 1 K186-a GLISLQVkQkGADFL
0 4 K186-u GLISLQVkQkGADFL
0 3 K188-u ISLQVkQkGADFLVt
0 2 T195-p kGADFLVtEVENGGS
0 1 S202 tEVENGGSLGSkkGV
0 162 K206-a NGGSLGSkkGVNLPG
0 12 K206-u NGGSLGSkkGVNLPG
0 6 K207-a GGSLGSkkGVNLPGA
0 32 K207-u GGSLGSkkGVNLPGA
0 1 S222-p AVDLPAVsEkDIQDL
0 1 K224-u DLPAVsEkDIQDLkF
0 3 K230-a EkDIQDLkFGVEQDV
0 1 K230-u EkDIQDLkFGVEQDV
0 6 S243-p DVDMVFAsFIRkAsD
0 1 K247-u VFAsFIRkAsDVHEV
0 16 S249-p AsFIRkAsDVHEVRK
0 7 K261-u VRKVLGEkGKNIkII
0 1 K261-a VRKVLGEkGKNIkII
0 1 K266-a GEkGKNIkIIskIEN
0 31 K266-u GEkGKNIkIIskIEN
0 1 S269-p GKNIkIIskIENHEG
0 61 K270-u KNIkIIskIENHEGV
0 1 S287-p FDEILEAsDGIMVAR
1 32 K305-a GIEIPAEkVFLAQkM
0 22 K305-u GIEIPAEkVFLAQkM
0 19 K311-u EkVFLAQkMMIGRCN
0 16 K322-u GRCNRAGkPVICAtQ
0 2 T328-p GkPVICAtQMLESMI
0 6 K336-u QMLESMIkkPRPTRA
0 4 K337-u MLESMIkkPRPTRAE
0 1 D354 DVANAVLDGADCIML
0 1 S362-p GADCIMLsGETAkGD
0 2 K367-u MLsGETAkGDyPLEA
1 221 Y370-p GETAkGDyPLEAVRM
1 103 Y390-p REAEAAIyHLQLFEE
0 1 - gap
0 1 - gap
0 4 K422-a GAVEASFkCCSGAII
0 2 K433-a GAIIVLTkSGRSAHQ
0 4 K433-u GAIIVLTkSGRSAHQ
0 2 S437 VLTkSGRSAHQVARY
0 1 T454-p RAPIIAVtRNPQTAR
0 3 Y466-p TARQAHLyRGIFPVL
0 16 K475-u GIFPVLCkDPVQEAW
0 3 K498-a NFAMNVGkARGFFKk
0 3 K498-u NFAMNVGkARGFFKk
0 1 K505-u kARGFFKkGDVVIVL
3827
  PKM2 iso2  
- gap
- gap
- gap
K3-a _____MSkPHSEAGT
K3 _____MSKPHSEAGT
S37 MCRLDIDSPPITARN
T41 DIDSPPITARNTGII
T45 PPITARNTGIICTIG
T50 RNTGIICTIGPASRS
S57 TIGPASRSVETLKEM
T60 PASRSVETLKEMIKS
K62 SRSVETLKEMIKSGM
K62 SRSVETLKEMIKSGM
K66 ETLKEMIKSGMNVAR
S77 NVARLNFSHGTHEyH
T80 RLNFSHGTHEyHAET
Y83-p FSHGTHEyHAETIKN
T87 THEyHAETIKNVRTA
K89 EyHAETIKNVRTATE
K89 EyHAETIKNVRTATE
T93 ETIKNVRTATESFAS
T95 IKNVRTATESFASDP
S97 NVRTATESFASDPIL
S100 TATESFASDPILyRP
Y105-p FASDPILyRPVAVAL
K115 VAVALDTKGPEIRTG
K125 EIRTGLIKGSGTAEV
S127 RTGLIKGSGTAEVEL
T129 GLIKGSGTAEVELkK
K135-a GTAEVELkKGATLKI
K135 GTAEVELKKGATLKI
K136 TAEVELkKGATLKIT
K141 LkKGATLKITLDNAy
Y148-p KITLDNAyMEKCDEN
K151 LDNAyMEKCDENILW
K151 LDNAyMEKCDENILW
Y161 ENILWLDYKNICKVV
K162 NILWLDYKNICKVVE
K162 NILWLDYKNICKVVE
K166 LDYKNICKVVEVGSK
K166 LDYKNICKVVEVGSK
S172 CKVVEVGSKIYVDDG
Y175 VEVGSKIYVDDGLIS
K186 GLISLQVKQKGADFL
K186 GLISLQVKQKGADFL
K188 ISLQVKQKGADFLVT
T195 KGADFLVTEVENGGS
S202 TEVENGGSLGSkkGV
K206-a NGGSLGSkkGVNLPG
K206 NGGSLGSKkGVNLPG
K207-a GGSLGSkkGVNLPGA
K207 GGSLGSkKGVNLPGA
S222 AVDLPAVSEKDIQDL
K224 DLPAVSEKDIQDLKF
K230 EKDIQDLKFGVEQDV
K230 EKDIQDLKFGVEQDV
S243 DVDMVFASFIRKAsD
K247 VFASFIRKAsDVHEV
S249-p ASFIRKAsDVHEVRK
K261 VRKVLGEKGKNIKII
K261 VRKVLGEKGKNIKII
K266 GEKGKNIKIISKIEN
K266 GEKGKNIKIISKIEN
S269 GKNIKIISKIENHEG
K270 KNIKIISKIENHEGV
S287 FDEILEASDGIMVAR
K305-a GIEIPAEkVFLAQKM
K305 GIEIPAEKVFLAQKM
K311 EkVFLAQKMMIGRCN
K322 GRCNRAGKPVICATQ
T328 GKPVICATQMLESMI
K336 QMLESMIKKPRPTRA
K337 MLESMIKKPRPTRAE
D354 DVANAVLDGADCIML
S362 GADCIMLSGETAKGD
K367 MLSGETAKGDyPLEA
Y370-p GETAKGDyPLEAVRM
- gap
S405-p LVRASSHsTDLMEAM
Y421-p MGSVEASyKCLAAAL
- gap
- gap
- gap
S437 VLTESGRSAHQVARY
T454 RAPIIAVTRNPQTAR
Y466 TARQAHLYRGIFPVL
K475 GIFPVLCKDPVQEAW
K498 NFAMNVGKARGFFKK
K498 NFAMNVGKARGFFKK
K505 KARGFFKKGDVVIVL
3827
  PKM2 iso3  
T13-p ERGERLLtPGACSSE
S32-p VPSRSGGsPGHtVFS
T36-p SGGsPGHtVFSSERS
K77 RTSAAMSKPHSEAGT
K77 RTSAAMSKPHSEAGT
S111 MCRLDIDSPPITARN
T115 DIDSPPITARNTGII
T119 PPITARNTGIICTIG
T124 RNTGIICTIGPASRS
S131 TIGPASRSVETLKEM
T134 PASRSVETLKEMIKS
K136 SRSVETLKEMIKSGM
K136 SRSVETLKEMIKSGM
K140 ETLKEMIKSGMNVAR
S151 NVARLNFSHGTHEYH
T154 RLNFSHGTHEYHAET
Y157 FSHGTHEYHAETIKN
T161 THEYHAETIKNVRTA
K163 EYHAETIKNVRTATE
K163 EYHAETIKNVRTATE
T167 ETIKNVRTATESFAS
T169 IKNVRTATESFASDP
S171 NVRTATESFASDPIL
S174 TATESFASDPILYRP
Y179 FASDPILYRPVAVAL
K189 VAVALDTKGPEIRTG
K199 EIRTGLIKGSGTAEV
S201 RTGLIKGSGTAEVEL
T203 GLIKGSGTAEVELKK
K209 GTAEVELKKGATLKI
K209 GTAEVELKKGATLKI
K210 TAEVELKKGATLKIT
K215 LKKGATLKITLDNAY
Y222 KITLDNAYMEKCDEN
K225 LDNAYMEKCDENILW
K225 LDNAYMEKCDENILW
Y235 ENILWLDYKNICKVV
K236 NILWLDYKNICKVVE
K236 NILWLDYKNICKVVE
K240 LDYKNICKVVEVGSK
K240 LDYKNICKVVEVGSK
S246 CKVVEVGSKIYVDDG
Y249 VEVGSKIYVDDGLIS
K260 GLISLQVKQKGADFL
K260 GLISLQVKQKGADFL
K262 ISLQVKQKGADFLVT
T269 KGADFLVTEVENGGS
S276 TEVENGGSLGSKKGV
K280 NGGSLGSKKGVNLPG
K280 NGGSLGSKKGVNLPG
K281 GGSLGSKKGVNLPGA
K281 GGSLGSKKGVNLPGA
S296 AVDLPAVSEKDIQDL
K298 DLPAVSEKDIQDLKF
K304 EKDIQDLKFGVEQDV
K304 EKDIQDLKFGVEQDV
S317 DVDMVFASFIRKASD
K321 VFASFIRKASDVHEV
S323 ASFIRKASDVHEVRK
K335 VRKVLGEKGKNIKII
K335 VRKVLGEKGKNIKII
K340 GEKGKNIKIISKIEN
K340 GEKGKNIKIISKIEN
S343 GKNIKIISKIENHEG
K344 KNIKIISKIENHEGV
S361 FDEILEASDGIMVAR
K379 GIEIPAEKVFLAQKM
K379 GIEIPAEKVFLAQKM
K385 EKVFLAQKMMIGRCN
K396 GRCNRAGKPVICATQ
T402 GKPVICATQMLESMI
K410 QMLESMIKKPRPTRA
K411 MLESMIKKPRPTRAE
D428 DVANAVLDGADCIML
S436 GADCIMLSGETAKGD
K441 MLSGETAKGDYPLEA
Y444 GETAKGDYPLEAVRM
- gap
S479 LVRASSHSTDLMEAM
Y495-p MGSVEASyKCLAAAL
- gap
- gap
- gap
S511 VLTESGRSAHQVARY
T528 RAPIIAVTRNPQTAR
Y540 TARQAHLYRGIFPVL
K549 GIFPVLCKDPVQEAW
K572 NFAMNVGKARGFFKK
K572 NFAMNVGKARGFFKK
K579 KARGFFKKGDVVIVL
  mouse

 
- gap
- gap
- gap
K3 _____MPKPHSEAGT
K3-u _____MPkPHSEAGT
S37-p MCRLDIDsAPItARN
T41-p DIDsAPItARNTGII
T45 APItARNTGIICTIG
T50 RNTGIICTIGPASRS
S57 TIGPASRSVEMLkEM
M60 PASRSVEMLkEMIkS
K62 SRSVEMLKEMIkSGM
K62-u SRSVEMLkEMIkSGM
K66-u EMLkEMIkSGMNVAR
S77-p NVARLNFsHGTHEyH
T80 RLNFsHGTHEyHAET
Y83-p FsHGTHEyHAETIkN
T87 THEyHAETIkNVREA
K89 EyHAETIKNVREAtE
K89-u EyHAETIkNVREAtE
E93 ETIkNVREAtESFAs
T95-p IkNVREAtESFAsDP
S97 NVREAtESFAsDPIL
S100-p EAtESFAsDPILyRP
Y105-p FAsDPILyRPVAVAL
K115-u VAVALDTkGPEIRTG
K125-u EIRTGLIkGSGTAEV
S127 RTGLIkGSGTAEVEL
T129 GLIkGSGTAEVELkK
K135-a GTAEVELkKGATLkI
K135-u GTAEVELkKGATLkI
K136 TAEVELkKGATLkIT
K141-u LkKGATLkITLDNAy
Y148-p kITLDNAyMEkCDEN
K151 LDNAyMEKCDENILW
K151-u LDNAyMEkCDENILW
Y161 ENILWLDYkNICkVV
K162 NILWLDYKNICkVVE
K162-u NILWLDYkNICkVVE
K166 LDYkNICKVVEVGSK
K166-u LDYkNICkVVEVGSK
S172 CkVVEVGSKIyVDDG
Y175-p VEVGSKIyVDDGLIS
K186 GLISLQVKEkGADFL
K186-u GLISLQVkEkGADFL
K188-u ISLQVkEkGADFLVT
T195 kGADFLVTEVENGGs
S202-p TEVENGGsLGSkkGV
K206-a NGGsLGSkkGVNLPG
K206-u NGGsLGSkkGVNLPG
K207 GGsLGSkKGVNLPGA
K207-u GGsLGSkkGVNLPGA
S222 AVDLPAVSEKDIQDL
K224 DLPAVSEKDIQDLKF
K230 EKDIQDLKFGVEQDV
K230 EKDIQDLKFGVEQDV
S243 DVDMVFASFIRKAAD
K247 VFASFIRKAADVHEV
A249 ASFIRKAADVHEVRK
K261 VRKVLGEKGKNIKII
K261 VRKVLGEKGKNIKII
K266 GEKGKNIKIISkIEN
K266 GEKGKNIKIISkIEN
S269 GKNIKIISkIENHEG
K270-u KNIKIISkIENHEGV
S287 FDEILEASDGIMVAR
K305-a GIEIPAEkVFLAQkM
K305-u GIEIPAEkVFLAQkM
K311-u EkVFLAQkMMIGRCN
K322 GRCNRAGKPVICAtQ
T328-p GKPVICAtQMLESMI
K336 QMLESMIKKPRPTRA
K337 MLESMIKKPRPTRAE
D354-ca DVANAVLdGADCIML
S362 GADCIMLSGETAKGD
K367 MLSGETAKGDyPLEA
Y370-p GETAKGDyPLEAVRM
Y390-p REAEAAIyHLQLFEE
- gap
- gap
K422 GAVEASFKCCSGAII
K433 GAIIVLTKSGRsAHQ
K433 GAIIVLTKSGRsAHQ
S437-p VLTKSGRsAHQVARY
T454 RAPIIAVTRNPQTAR
Y466 TARQAHLYRGIFPVL
K475-u GIFPVLCkDAVLNAW
K498 NLAMDVGKARGFFKK
K498 NLAMDVGKARGFFKK
K505 KARGFFKKGDVVIVL
3827
  rat

► Hide Isoforms 		 
- gap
- gap
- gap
K3 _____MPKPDSEAGT
K3 _____MPKPDSEAGT
S37 MCRLDIDSAPITARN
T41 DIDSAPITARNTGII
T45 APITARNTGIICTIG
T50 RNTGIICTIGPASRS
S57 TIGPASRSVEMLKEM
M60 PASRSVEMLKEMIKS
K62 SRSVEMLKEMIKSGM
K62 SRSVEMLKEMIKSGM
K66 EMLKEMIKSGMNVAR
S77 NVARLNFSHGTHEyH
T80 RLNFSHGTHEyHAET
Y83-p FSHGTHEyHAETIKN
T87 THEyHAETIKNVRAA
K89 EyHAETIKNVRAATE
K89 EyHAETIKNVRAATE
A93 ETIKNVRAATESFAS
T95 IKNVRAATESFASDP
S97 NVRAATESFASDPIL
S100 AATESFASDPILyRP
Y105-p FASDPILyRPVAVAL
K115 VAVALDTKGPEIRTG
K125 EIRTGLIKGSGTAEV
S127 RTGLIKGSGTAEVEL
T129 GLIKGSGTAEVELkK
K135 GTAEVELKKGATLKI
K135-u GTAEVELkKGATLKI
K136 TAEVELkKGATLKIT
K141 LkKGATLKITLDNAy
Y148-p KITLDNAyMEKCDEN
K151 LDNAyMEKCDENILW
K151 LDNAyMEKCDENILW
Y161 ENILWLDYKNICkVV
K162 NILWLDYKNICkVVE
K162 NILWLDYKNICkVVE
K166 LDYKNICKVVEVGSK
K166-u LDYKNICkVVEVGSK
S172 CkVVEVGSKIyVDDG
Y175-p VEVGSKIyVDDGLIS
K186 GLISLQVKEKGADYL
K186 GLISLQVKEKGADYL
K188 ISLQVKEKGADYLVT
T195 KGADYLVTEVENGGS
S202 TEVENGGSLGSKKGV
K206 NGGSLGSKKGVNLPG
K206 NGGSLGSKKGVNLPG
K207 GGSLGSKKGVNLPGA
K207 GGSLGSKKGVNLPGA
S222 AVDLPAVSEKDIQDL
K224 DLPAVSEKDIQDLKF
K230 EKDIQDLKFGVEQDV
K230 EKDIQDLKFGVEQDV
S243 DVDMVFASFIRKAAD
K247 VFASFIRKAADVHEV
A249 ASFIRKAADVHEVRK
K261 VRKVLGEKGKNIkII
K261 VRKVLGEKGKNIkII
K266 GEKGKNIKIISKIEN
K266-u GEKGKNIkIISKIEN
S269 GKNIkIISKIENHEG
K270 KNIkIISKIENHEGV
S287 FDEILEASDGIMVAR
K305-a GIEIPAEkVFLAQKM
K305 GIEIPAEKVFLAQKM
K311 EkVFLAQKMMIGRCN
K322 GRCNRAGKPVICATQ
T328 GKPVICATQMLESMI
K336 QMLESMIKKPRPTRA
K337 MLESMIKKPRPTRAE
D354 DVANAVLDGADCIML
S362 GADCIMLSGETAKGD
K367 MLSGETAKGDYPLEA
Y370 GETAKGDYPLEAVRM
- gap
S405 LARASSQSTDPLEAM
Y421 MGSVEASYKCLAAAL
- gap
- gap
- gap
S437 VLTESGRSAHQVARY
T454 RAPIIAVTRNPQTAR
Y466 TARQAHLYRGIFPVL
K475 GIFPVLCKDAVLDAW
K498 NLAMNVGKARGFFKK
K498 NLAMNVGKARGFFKK
K505 KARGFFKKGDVVIVL
3827
  PKM2 iso2  
- gap
- gap
- gap
K3 _____MPKPDSEAGT
K3 _____MPKPDSEAGT
S37 MCRLDIDSAPITARN
T41 DIDSAPITARNTGII
T45 APITARNTGIICTIG
T50 RNTGIICTIGPASRS
S57 TIGPASRSVEMLKEM
M60 PASRSVEMLKEMIKS
K62 SRSVEMLKEMIKSGM
K62 SRSVEMLKEMIKSGM
K66 EMLKEMIKSGMNVAR
S77 NVARLNFSHGTHEYH
T80 RLNFSHGTHEYHAET
Y83 FSHGTHEYHAETIKN
T87 THEYHAETIKNVRAA
K89 EYHAETIKNVRAATE
K89 EYHAETIKNVRAATE
A93 ETIKNVRAATESFAS
T95 IKNVRAATESFASDP
S97 NVRAATESFASDPIL
S100 AATESFASDPILYRP
Y105 FASDPILYRPVAVAL
K115 VAVALDTKGPEIRTG
K125 EIRTGLIKGSGTAEV
S127 RTGLIKGSGTAEVEL
T129 GLIKGSGTAEVELKK
K135 GTAEVELKKGATLKI
K135 GTAEVELKKGATLKI
K136 TAEVELKKGATLKIT
K141 LKKGATLKITLDNAY
Y148 KITLDNAYMEKCDEN
K151 LDNAYMEKCDENILW
K151 LDNAYMEKCDENILW
Y161 ENILWLDYKNICKVV
K162 NILWLDYKNICKVVE
K162 NILWLDYKNICKVVE
K166 LDYKNICKVVEVGSK
K166 LDYKNICKVVEVGSK
S172 CKVVEVGSKIYVDDG
Y175 VEVGSKIYVDDGLIS
K186 GLISLQVKEKGADYL
K186 GLISLQVKEKGADYL
K188 ISLQVKEKGADYLVT
T195 KGADYLVTEVENGGS
S202 TEVENGGSLGSKKGV
K206 NGGSLGSKKGVNLPG
K206 NGGSLGSKKGVNLPG
K207 GGSLGSKKGVNLPGA
K207 GGSLGSKKGVNLPGA
S222 AVDLPAVSEKDIQDL
K224 DLPAVSEKDIQDLKF
K230 EKDIQDLKFGVEQDV
K230 EKDIQDLKFGVEQDV
S243 DVDMVFASFIRKAAD
K247 VFASFIRKAADVHEV
A249 ASFIRKAADVHEVRK
K261 VRKVLGEKGKNIKII
K261 VRKVLGEKGKNIKII
K266 GEKGKNIKIISKIEN
K266 GEKGKNIKIISKIEN
S269 GKNIKIISKIENHEG
K270 KNIKIISKIENHEGV
S287 FDEILEASDGIMVAR
K305 GIEIPAEKVFLAQKM
K305 GIEIPAEKVFLAQKM
K311 EKVFLAQKMMIGRCN
K322 GRCNRAGKPVICATQ
T328 GKPVICATQMLESMI
K336 QMLESMIKKPRPTRA
K337 MLESMIKKPRPTRAE
D354 DVANAVLDGADCIML
S362 GADCIMLSGETAKGD
K367 MLSGETAKGDYPLEA
Y370 GETAKGDYPLEAVRM
Y390-p REAEAAIyHLQLFEE
- gap
- gap
K422 GAVEASFKCCSGAII
K433 GAIIVLTKSGRSAHQ
K433 GAIIVLTKSGRSAHQ
S437 VLTKSGRSAHQVARY
T454 RAPIIAVTRNPQTAR
Y466 TARQAHLYRGIFPVL
K475 GIFPVLCKDAVLDAW
K498 NLAMNVGKARGFFKK
K498 NLAMNVGKARGFFKK
K505 KARGFFKKGDVVIVL
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