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Protein Page:
MIF (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MIF a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. Also acts as a phenylpyruvate tautomerase. Note: This description may include information from UniProtKB.
Protein type: Cytokine; EC 5.3.3.12; Amino Acid Metabolism - tyrosine; Cell development/differentiation; Apoptosis; Amino Acid Metabolism - phenylalanine; Isomerase; EC 5.3.2.1
Cellular Component: extracellular space; cell surface; cytoplasm; extracellular region
Molecular Function: phenylpyruvate tautomerase activity; protein binding; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine activity; dopachrome isomerase activity; chemoattractant activity; receptor binding
Biological Process: DNA damage response, signal transduction by p53 class mediator; regulation of macrophage activation; positive regulation of lipopolysaccharide-mediated signaling pathway; carboxylic acid metabolic process; cell aging; negative regulation of cellular protein metabolic process; prostaglandin biosynthetic process; positive regulation of peptidyl-serine phosphorylation; cell proliferation; positive regulation of MAP kinase activity; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of fibroblast proliferation; negative regulation of myeloid cell apoptosis; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mature B cell apoptosis; cell surface receptor linked signal transduction; positive chemotaxis; positive regulation of B cell proliferation; innate immune response; inflammatory response; positive regulation of phosphorylation; negative regulation of apoptosis; positive regulation of cytokine secretion
Reference #:  P14174 (UniProtKB)
Alt. Names/Synonyms: GIF; GLIF; Glycosylation-inhibiting factor; L-dopachrome isomerase; L-dopachrome tautomerase; Macrophage migration inhibitory factor; macrophage migration inhibitory factor (glycosylation-inhibiting factor); MIF; MMIF; Phenylpyruvate tautomerase
Gene Symbols: MIF
Molecular weight: 12,476 Da
Basal Isoelectric point: 7.73  Predict pI for various phosphorylation states
Select Structure to View Below

MIF

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T8-p MPMFIVNtNVPrAsV
0 1 R12-m1 IVNtNVPrAsVPDGF
0 1 S14-p NtNVPrAsVPDGFLs
0 1 S21-p sVPDGFLsELTQQLA
0 13 Y37-p ATGKPPQyIAVHVVP
0 12 K78-ac AQNRSYSkLLCGLLA
0 79 K78-ub AQNRSYSkLLCGLLA
1 1 S91-p LAERLRIsPDRVYIN
0 3 Y99-p PDRVYINyyDMNAAN
0 1 Y100-p DRVYINyyDMNAANV
  mouse

 
T8 MPMFIVNTNVPRASV
R12 IVNTNVPRASVPEGF
S14 NTNVPRASVPEGFLS
S21 SVPEGFLSELTQQLA
Y37-p ATGKPAQyIAVHVVP
K78-ac AQNRNYSkLLCGLLS
K78-ub AQNRNYSkLLCGLLS
S91-p LSDRLHIsPDRVYIN
Y99 PDRVYINYYDMNAAN
Y100 DRVYINYYDMNAANV
  rat

 
T8 MPMFIVNTNVPRASV
R12 IVNTNVPRASVPEGF
S14 NTNVPRASVPEGFLS
S21 SVPEGFLSELTQQLA
Y37 ATGKPAQYIAVHVVP
K78 AQNRNYSKLLCGLLS
K78-ub AQNRNYSkLLCGLLS
S91 LSDRLHISPDRVYIN
Y99 PDRVYINYYDMNAAN
Y100 DRVYINYYDMNAANV
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