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Protein Page:
L-plastin (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
L-plastin Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Monomer. Interacts with AIF1. Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T- lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells. Note: This description may include information from UniProtKB.
Protein type: Actin binding protein; Motility/polarity/chemotaxis
Cellular Component: ruffle; extracellular space; focal adhesion; cytoplasm; stress fiber; actin filament bundle; plasma membrane; actin filament; cytosol; actin cytoskeleton; filopodium; phagocytic cup
Molecular Function: actin filament binding; identical protein binding; calcium ion binding; actin binding
Biological Process: actin filament bundle formation; cell migration; organ regeneration; regulation of intracellular protein transport; T cell activation during immune response
Reference #:  P13796 (UniProtKB)
Alt. Names/Synonyms: bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)); CP64; DKFZp781A23186; FLJ25423; FLJ26114; FLJ39956; L-plastin; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P); LC64P; LCP-1; LCP1; LPL; Lymphocyte cytosolic protein 1; lymphocyte cytosolic protein 1 (L-plastin); Lymphocyte cytosolic protein-1 (plasmin); plastin 2; Plastin-2; PLS2; PLSL
Gene Symbols: LCP1
Molecular weight: 70,288 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

L-plastin

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: S5‑p
cytoskeletal reorganization: S5‑p
intracellular localization: S5‑p
molecular association, regulation: S5‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
8 27 S5-p ___MARGsVsDEEMM
0 15 S7-p _MARGsVsDEEMMEL
0 3 K20-u ELREAFAkVDTDGNG
0 315 Y28-p VDTDGNGyIsFNELN
0 7 S30-p TDGNGyIsFNELNDL
0 6 K39-u NELNDLFkAACLPLP
0 68 Y48-p ACLPLPGyRVREITE
0 1 K76-a ISFDEFIkIFHGLkS
0 6 K76-u ISFDEFIkIFHGLkS
0 2 K82-u IkIFHGLkSTDVAkt
0 6 K88-a LkSTDVAktFRKAIN
0 2 K88-u LkSTDVAktFRKAIN
0 8 T89-p kSTDVAktFRKAINK
0 1 K97-u FRKAINKkEGICAIG
0 1 S110-p IGGTSEQsSVGtQHs
0 5 T114-p SEQsSVGtQHsysEE
0 7 S117-p sSVGtQHsysEEEKy
0 13 Y118-p SVGtQHsysEEEKyA
0 6 S119-p VGtQHsysEEEKyAF
0 128 Y124-p sysEEEKyAFVNWIN
0 2 K165-u GDGIVLCkMINLSVP
0 20 S257-p ALLREGEsLEDLMkL
0 7 K263-u EsLEDLMkLSPEELL
0 253 Y276-p LLLRWANyHLENAGC
0 1 K285-u LENAGCNkIGNFstD
0 2 S290-p CNkIGNFstDIkDSk
0 6 T291-p NkIGNFstDIkDSkA
0 1 K294-a GNFstDIkDSkAyyH
0 1 K297-a stDIkDSkAyyHLLE
0 2 K297-u stDIkDSkAyyHLLE
0 27 Y299-p DIkDSkAyyHLLEQV
0 122 Y300-p IkDSkAyyHLLEQVA
0 2 S323-p PAVVIDMsGLREKDD
0 3 T351-p LGCRQFVtAtDVVRG
0 3 T353-p CRQFVtAtDVVRGNP
0 1 K361-a DVVRGNPkLNLAFIA
0 4 K361-u DVVRGNPkLNLAFIA
1 110 Y374-p IANLFNRyPALHKPE
0 12 S406-p TFRNWMNsLGVNPRV
0 4 Y417-p NPRVNHLySDLSDAL
0 2 Y430-p ALVIFQLyEKIKVPV
0 2 K472-a ELGKNQAkFsLVGIG
0 11 S474-p GKNQAkFsLVGIGGQ
0 1 R530 NWVNETLREAKKSSS
0 1 S537 REAKKSSSISSFkDP
0 4 K542-a SSSISSFkDPKISTS
0 22 K542-u SSSISSFkDPKISTS
0 1 K579-a ENLNDDEkLNNAkYA
0 2 K584-u DEkLNNAkYAISMAR
0 88 Y598-p RKIGARVyALPEDLV
0 12 K610-u DLVEVNPkMVMTVFA
5277 : Phospho-LCP1 (Tyr28) Antibody
  mouse

 
S5-p ___MARGsVsDEEMM
S7-p _MARGsVsDEEMMEL
K20 ELREAFAKVDTDGNG
Y28-p VDTDGNGyIsCNELN
S30-p TDGNGyIsCNELNDL
K39-u NELNDLFkAACLPLP
Y48 ACLPLPGYRVREITE
K76 ISFDEFIKVFHGLKS
K76-u ISFDEFIkVFHGLKS
K82 IkVFHGLKSTEVAKT
K88 LKSTEVAKTFRKAIN
K88 LKSTEVAKTFRKAIN
T89 KSTEVAKTFRKAINK
K97 FRKAINKKEGICAIG
S110 IGGTSEQSSVGTQHs
T114 SEQSSVGTQHsYSEE
S117-p SSVGTQHsYSEEEKy
Y118 SVGTQHsYSEEEKyA
S119 VGTQHsYSEEEKyAF
Y124-p sYSEEEKyAFVNWIN
K165 GDGIVLCKMINLSVP
S257-p ALLREGEsLEDLMkL
K263-u EsLEDLMkLSPEELL
Y276-p LLLRWANyHLENAGC
K285 LENAGCTKITNFstD
S290-p CTKITNFstDIKDSk
T291-p TKITNFstDIKDSkA
K294 TNFstDIKDSkAYyH
K297 stDIKDSKAYyHLLE
K297-u stDIKDSkAYyHLLE
Y299 DIKDSkAYyHLLEQV
Y300-p IKDSkAYyHLLEQVA
S323-p PAVVIDMsGLREKDD
T351 LGCRQFVTATDVVRG
T353 CRQFVTATDVVRGNP
K361 DVVRGNPKLNLAFIA
K361 DVVRGNPKLNLAFIA
Y374 IANLFNKYPALHKPE
S406-p TFRNWMNsLGVNPRV
Y417 NPRVNHLYSDLSDAL
Y430 ALVIFQLYEKIKVPV
K472 DLGKNQAKFSLVGIA
S474 GKNQAKFSLVGIAGQ
K530-u NWVNTTLkEAQKSSs
S537-p kEAQKSSsIASFKDP
K542 SSsIASFKDPKISTS
K542 SSsIASFKDPKISTS
K579 ENLDDEEKLNNAkYA
K584-u EEKLNNAkYAISMAR
Y598-p RKIGARVyALPEDLV
K610 DLVEVNPKMVMTVFA
  rat

 
S5-p ___MARGsVSDEEMM
S7 _MARGsVSDEEMMEL
K20 ELREAFAKVDTDGNG
Y28 VDTDGNGYISCNELN
S30 TDGNGYISCNELNDL
K39 NELNDLFKAACLPLP
Y48 ACLPLPGYRVREITE
K76 ISFDEFIKVFHGLKS
K76 ISFDEFIKVFHGLKS
K82 IKVFHGLKSTEVAKT
K88 LKSTEVAKTFRKAIN
K88 LKSTEVAKTFRKAIN
T89 KSTEVAKTFRKAINK
K97 FRKAINKKEGICAIG
S110 IGGTSEQSSVGTQHS
T114 SEQSSVGTQHSYSEE
S117 SSVGTQHSYSEEEKY
Y118 SVGTQHSYSEEEKYA
S119 VGTQHSYSEEEKYAF
Y124 SYSEEEKYAFVNWIN
K165 GDGIVLCKMVNLSVP
S257-p ALLREGEsLEDLMKL
K263 EsLEDLMKLSPEELL
Y276 LLLRWANYHLENAGC
K285 LENAGCTKITNFSTD
S290 CTKITNFSTDIKDSK
T291 TKITNFSTDIKDSKA
K294 TNFSTDIKDSKAYYH
K297 STDIKDSKAYYHLLE
K297 STDIKDSKAYYHLLE
Y299 DIKDSKAYYHLLEQV
Y300 IKDSKAYYHLLEQVA
S323 PAVVIDMSGLREKDD
T351 LGCRQFVTATDVVRG
T353 CRQFVTATDVVRGNP
K361 DVVRGNPKLNLAFIA
K361 DVVRGNPKLNLAFIA
Y374 IANLFNKYPALHKPE
S406 TFRNWMNSLGVNPGV
Y417 NPGVNHLYSDLSDAL
Y430 ALVIFQLYEKIKVPV
K472 DLGKNQAKFSLVGIA
S474 GKNQAKFSLVGIAGQ
K530 NWVNTTLKEAQKSSS
S537 KEAQKSSSITSFKDP
K542 SSSITSFKDPKISTS
K542 SSSITSFKDPKISTS
K579 ENLDDEEKLNNAKYA
K584 EEKLNNAKYAISMAR
Y598 RKIGARVYALPEDLV
K610 DLVEVNPKMVMTVFA
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