Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
PABP 1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PABP 1 poly(A) binding protein 1. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Shuttles between the cytoplasm and the nucleus. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. A potential substrate in MAPKAP kinase 2-induced mRNA stabilization. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Spliceosome; RNA binding protein; Translation; RNA splicing; Motility/polarity/chemotaxis
Cellular Component: membrane; stress granule; cytoplasm; ribonucleoprotein complex; nucleus; cytosol
Molecular Function: protein C-terminus binding; protein binding; translation activator activity; nucleotide binding; poly(U) binding; poly(A) binding
Biological Process: positive regulation of translation; translation; mRNA stabilization; mRNA polyadenylation; mRNA metabolic process; nuclear mRNA splicing, via spliceosome; poly(A) tail shortening; cellular protein metabolic process; RNA metabolic process; translational initiation; mRNA catabolic process, nonsense-mediated decay; gene expression; RNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay
Reference #:  P11940 (UniProtKB)
Alt. Names/Synonyms: PAB1; PABP; PABP-1; PABP1; PABPC1; PABPC2; PABPL1; poly(A) binding protein, cytoplasmic 1; poly(A) binding protein, cytoplasmic 2; Poly(A)-binding protein 1; Polyadenylate-binding protein 1
Gene Symbols: PABPC1
Molecular weight: 70,671 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF4E and p70S6K  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PABP 1

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 S51-p RDMITRRsLGyAyVN
0 64 Y54-p ITRRsLGyAyVNFQQ
0 25 Y56-p RRsLGyAyVNFQQPA
0 1 K78 TMNFDVIKGkPVRIM
0 69 K78-ub TMNFDVIkGkPVRIM
0 14 K80-ub NFDVIkGkPVRIMWS
0 41 K95-ub QRDPSLRksGVGNIF
0 6 S96-p RDPSLRksGVGNIFI
0 3 K104-ac GVGNIFIkNLDkSID
0 4 K104-ub GVGNIFIkNLDkSID
0 1 K108-ac IFIkNLDkSIDNkAL
0 36 K108-ub IFIkNLDkSIDNkAL
0 30 K113-ub LDkSIDNkALyDTFS
0 34 Y116-p SIDNkALyDTFSAFG
0 33 K129-ub FGNILSCkVVCDENG
0 21 K138-ub VCDENGSkGYGFVHF
0 20 K157-ub AAERAIEkMNGMLLN
0 18 K167-ub GMLLNDRkVFVGRFK
0 1 K188-ac AELGARAkEFTNVYI
0 63 K188-ub AELGARAkEFTNVYI
0 1 K196-ac EFTNVYIkNFGEDMD
0 5 K196-ub EFTNVYIkNFGEDMD
0 1 K208 DMDDERLKDLFGkFG
0 2 K213-ac RLKDLFGkFGPALSV
0 26 K213-ub RLKDLFGkFGPALSV
0 2 K221-ub FGPALSVkVMTDESG
0 1 K229 VMTDESGKSkGFGFV
0 5 K229-ub VMTDESGkSkGFGFV
0 9 K231-ub TDESGkSkGFGFVsF
0 3 S237-p SkGFGFVsFERHEDA
0 4 K246-ub ERHEDAQkAVDEMNG
0 3 K259-ac NGKELNGkQIYVGRA
0 39 K259-ub NGKELNGkQIYVGRA
0 9 K279-ub RQTELKRkFEQMkQD
0 55 K284-ub KRkFEQMkQDRITRY
0 45 Y297-p RYQGVNLyVkNLDDG
0 1 K299-ac QGVNLyVkNLDDGID
0 21 K299-ub QGVNLyVkNLDDGID
0 70 K312-ub IDDERLRkEFsPFGt
0 15 S315-p ERLRkEFsPFGtITs
0 3 T319-p kEFsPFGtITsAkVM
0 1 S322-p sPFGtITsAkVMMEG
0 1 K324-ub FGtITsAkVMMEGGR
0 45 K333-ub MMEGGRSkGFGFVCF
0 3 S341-p GFGFVCFssPEEATk
0 7 S342-p FGFVCFssPEEATkA
0 50 K348-ub ssPEEATkAVTEMNG
0 6 T360-p MNGRIVAtkPLyVAL
0 39 K361-ub NGRIVAtkPLyVALA
0 606 Y364-p IVAtkPLyVALAQRK
0 23 Y382-p QAHLTNQyMQrMASV
0 3 R385-m1 LTNQyMQrMASVRAV
0 11 Y400-p PNPVINPyQPAPPSG
0 14 R419-m1 AIPQTQNrAAyYPPS
0 1 R419-m2 AIPQTQNrAAyYPPS
0 22 Y422-p QTQNrAAyYPPSQIA
0 1 R432-m1 PSQIAQLrPsPrWTA
0 5 R432-m2 PSQIAQLrPsPrWTA
0 1 S434-p QIAQLrPsPrWTAQG
0 1 R436-m1 AQLrPsPrWTAQGAr
0 2 R443-m2 rWTAQGArPHPFQNM
1 0 R455-me QNMPGAIrPAAPrPP
0 2 R455-m2 QNMPGAIrPAAPrPP
1 0 R460-me AIrPAAPrPPFSTMr
0 1 R460-m2 AIrPAAPrPPFSTMr
0 1 R467-m2 rPPFSTMrPASSQVP
0 7 R475-m1 PASSQVPrVMsTQrV
0 3 R475-m2 PASSQVPrVMsTQrV
0 1 S478-p SQVPrVMsTQrVANT
0 2 R481-m1 PrVMsTQrVANTSTQ
0 1 R493-m1 STQTMGPrPAAAAAA
0 8 R493-m2 STQTMGPrPAAAAAA
0 3 T502-p AAAAAAAtPAVrTVP
0 1 R506-m1 AAAtPAVrTVPQykY
0 10 Y511-p AVrTVPQykYAAGVr
0 2 K512-ac VrTVPQykYAAGVrN
0 7 K512-ub VrTVPQykYAAGVrN
0 1 R518-m1 ykYAAGVrNPQQHLN
0 5 S599-p ELLHMLEsPESLRSK
0 3 K620-ub VLQAHQAkEAAQkAV
0 1 K620-sc VLQAHQAkEAAQkAV
0 22 K625-ub QAkEAAQkAVNsATG
0 1 S629-p AAQkAVNsATGVPtV
0 1 T635-p NsATGVPtV______
3505 : Asymmetric-Methyl-PABP1 (Arg455/Arg460) (C60A10) Rabbit mAb
3505 : Asymmetric-Methyl-PABP1 (Arg455/Arg460) (C60A10) Rabbit mAb
  mouse

 
S51-p RDMITRRsLGyAyVN
Y54-p ITRRsLGyAyVNFQQ
Y56-p RRsLGyAyVNFQQPA
K78-ac TMNFDVIkGkPVRIM
K78-ub TMNFDVIkGkPVRIM
K80-ub NFDVIkGkPVRIMWS
K95-ub QRDPSLRksGVGNIF
S96-p RDPSLRksGVGNIFI
K104-ac GVGNIFIkNLDkSID
K104-ub GVGNIFIkNLDkSID
K108 IFIkNLDKSIDNKAL
K108-ub IFIkNLDkSIDNKAL
K113 LDkSIDNKALyDTFS
Y116-p SIDNKALyDTFSAFG
K129-ub FGNILSCkVVCDENG
K138-ub VCDENGSkGYGFVHF
K157-ub AAERAIEkMNGMLLN
K167 GMLLNDRKVFVGRFK
K188 AELGARAKEFTNVYI
K188-ub AELGARAkEFTNVYI
K196 EFTNVYIKNFGEDMD
K196-ub EFTNVYIkNFGEDMD
K208-ac DMDDERLkELFGkFG
K213-ac RLkELFGkFGPALSV
K213-ub RLkELFGkFGPALSV
K221 FGPALSVKVMTDESG
K229-ac VMTDESGkSkGFGFV
K229-ub VMTDESGkSkGFGFV
K231-ub TDESGkSkGFGFVSF
S237 SkGFGFVSFERHEDA
K246-ub ERHEDAQkAVDEMNG
K259 NGKELNGKQIYVGRA
K259-ub NGKELNGkQIYVGRA
K279-ub RQTELKRkFEQMkQD
K284-ub KRkFEQMkQDRITRY
Y297-p RYQGVNLyVkNLDDG
K299-ac QGVNLyVkNLDDGID
K299-ub QGVNLyVkNLDDGID
K312-ub IDDERLRkEFsPFGT
S315-p ERLRkEFsPFGTITS
T319 kEFsPFGTITSAKVM
S322 sPFGTITSAKVMMEG
K324 FGTITSAKVMMEGGR
K333-ub MMEGGRSkGFGFVCF
S341 GFGFVCFSsPEEATk
S342-p FGFVCFSsPEEATkA
K348-ub SsPEEATkAVTEMNG
T360 MNGRIVATkPLyVAL
K361-ub NGRIVATkPLyVALA
Y364-p IVATkPLyVALAQRK
Y382 QAHLTNQYMQRMASV
R385 LTNQYMQRMASVRAV
Y400 PNPVINPYQPAPPSG
R419-m1 AIPQTQNrAAYYPPS
R419 AIPQTQNRAAYYPPS
Y422 QTQNrAAYYPPSQIA
R432-m1 PSQIAQLrPSPrWTA
R432-m2 PSQIAQLrPSPrWTA
S434 QIAQLrPSPrWTAQG
R436-m1 AQLrPSPrWTAQGAR
R443 rWTAQGARPHPFQNM
R455 QNMPGAIRPAAPRPP
R455-m2 QNMPGAIrPAAPRPP
R460 AIrPAAPRPPFSTMR
R460 AIrPAAPRPPFSTMR
R467 RPPFSTMRPASSQVP
R475-m1 PASSQVPrVMSTQRV
R475-m2 PASSQVPrVMSTQRV
S478 SQVPrVMSTQRVANT
R481 PrVMSTQRVANTSTQ
R493-m1 STQTMGPrPAAAAAA
R493-m2 STQTMGPrPAAAAAA
T502 AAAAAAATPAVrTVP
R506-m1 AAATPAVrTVPQYkY
Y511 AVrTVPQYkYAAGVR
K512-ac VrTVPQYkYAAGVRN
K512-ub VrTVPQYkYAAGVRN
R518 YkYAAGVRNPQQHLN
S599-p ELLHMLEsPESLRSK
K620-ub VLQAHQAkEAAQkAV
K620 VLQAHQAKEAAQkAV
K625-ub QAkEAAQkAVNSATG
S629 AAQkAVNSATGVPTV
T635 NSATGVPTV______
3505 : Asymmetric-Methyl-PABP1 (Arg455/Arg460) (C60A10) Rabbit mAb
3505 : Asymmetric-Methyl-PABP1 (Arg455/Arg460) (C60A10) Rabbit mAb
  rat

 
S51 RDMITRRSLGYAYVN
Y54 ITRRSLGYAYVNFQQ
Y56 RRSLGYAYVNFQQPA
K78-ac TMNFDVIkGKPVRIM
K78 TMNFDVIKGKPVRIM
K80 NFDVIkGKPVRIMWS
K95 QRDPSLRKSGVGNIF
S96 RDPSLRKSGVGNIFI
K104-ac GVGNIFIkNLDkSID
K104 GVGNIFIKNLDkSID
K108-ac IFIkNLDkSIDNKAL
K108 IFIkNLDKSIDNKAL
K113 LDkSIDNKALYDTFS
Y116 SIDNKALYDTFSAFG
K129 FGNILSCKVVCDENG
K138 VCDENGSKGYGFVHF
K157 AAERAIEKMNGMLLN
K167 GMLLNDRKVFVGRFK
K188-ac AELGARAkEFTNVYI
K188 AELGARAKEFTNVYI
K196 EFTNVYIKNFGEDMD
K196 EFTNVYIKNFGEDMD
K208 DMDDERLKELFGKFG
K213 RLKELFGKFGPALSV
K213 RLKELFGKFGPALSV
K221 FGPALSVKVMTDESG
K229 VMTDESGKSKGFGFV
K229 VMTDESGKSKGFGFV
K231 TDESGKSKGFGFVsF
S237-p SKGFGFVsFERHEDA
K246 ERHEDAQKAVDEMNG
K259-ac NGKELNGkQIYVGRA
K259 NGKELNGKQIYVGRA
K279 RQTELKRKFEQMkQD
K284-ub KRKFEQMkQDRITRY
Y297 RYQGVNLYVKNLDDG
K299 QGVNLYVKNLDDGID
K299 QGVNLYVKNLDDGID
K312 IDDERLRKEFSPFGT
S315 ERLRKEFSPFGTITS
T319 KEFSPFGTITSAKVM
S322 SPFGTITSAKVMMEG
K324 FGTITSAKVMMEGGR
K333 MMEGGRSKGFGFVCF
S341 GFGFVCFSSPEEATK
S342 FGFVCFSSPEEATKA
K348 SSPEEATKAVTEMNG
T360 MNGRIVATKPLyVAL
K361 NGRIVATKPLyVALA
Y364-p IVATKPLyVALAQRK
Y382 QAHLTNQYMQrMASV
R385-m1 LTNQYMQrMASVRAV
Y400 PNPVINPYQPAPPSG
R419-m1 AIPQTQNrAAYYPPS
R419 AIPQTQNRAAYYPPS
Y422 QTQNrAAYYPPSQIA
R432 PSQIAQLRPSPRWTA
R432 PSQIAQLRPSPRWTA
S434 QIAQLRPSPRWTAQG
R436 AQLRPSPRWTAQGAR
R443 RWTAQGARPHPFQNM
R455 QNMPGAIRPAAPRPP
R455 QNMPGAIRPAAPRPP
R460 AIRPAAPRPPFSTMR
R460 AIRPAAPRPPFSTMR
R467 RPPFSTMRPASSQVP
R475 PASSQVPRVMSTQRV
R475 PASSQVPRVMSTQRV
S478 SQVPRVMSTQRVANT
R481 PRVMSTQRVANTSTQ
R493 STQTMGPRPAAAATA
R493 STQTMGPRPAAAATA
T502 AAAATAATPAVRTVP
R506 TAATPAVRTVPQYKY
Y511 AVRTVPQYKYAAGVR
K512 VRTVPQYKYAAGVRN
K512 VRTVPQYKYAAGVRN
R518 YKYAAGVRNPQQHLN
S599-p ELLHMLEsPESLRSK
K620 VLQAHQAKEAAQKAV
K620 VLQAHQAKEAAQKAV
K625 QAKEAAQKAVNSATG
S629 AAQKAVNSATGVPTV
T635 NSATGVPTV______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.