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PABP 1 (human)

Overview PABP 1 poly(A) binding protein 1. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Shuttles between the cytoplasm and the nucleus. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. A potential substrate in MAPKAP kinase 2-induced mRNA stabilization. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Translation; RNA splicing; RNA binding protein; Motility/polarity/chemotaxis Cellular Component: stress granule; cytoplasm; cytosol; ribonucleoprotein complex; nucleus Molecular Function: protein C-terminus binding; protein binding; translation activator activity; nucleotide binding; poly(A) binding Biological Process: positive regulation of translation; translation; mRNA stabilization; mRNA polyadenylation; mRNA metabolic process; nuclear mRNA splicing, via spliceosome; poly(A) tail shortening; cellular protein metabolic process; RNA metabolic process; mRNA catabolic process, nonsense-mediated decay; translational initiation; gene expression; mRNA catabolic process, deadenylation-dependent decay Reference #:  P11940 (UniProtKB) Alt. Names/Synonyms: PAB1; PABP; PABP-1; PABP1; PABPC1; PABPC2; PABPL1; poly(A) binding protein, cytoplasmic 1; poly(A) binding protein, cytoplasmic 2; Poly(A)-binding protein 1; Polyadenylate-binding protein 1 Gene Symbols: PABPC1 Molecular weight: 70,671 Da Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states CST Pathways:  Translation: eIF4E and p70S6K  |  Translational Control Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PABP 1 1CVJ - A/B/C/D/E/F/G/H=1-190 (human) 1G9L - A=498-636 (human) 1JGN - A=544-636 (human) 1JH4 - A=544-636 (human) 2K8G - A=90-182 (human) 2RQG - B=541-623 (human) 2RQH - B=541-623 (human) 2X04 - A/B=456-530 (human) 3KTP - A=544-626 (human) 3KTR - A=544-626 (human) 3KUI - A=544-626 (human) 3KUJ - A=544-626 (human) 3KUR - F/A/E/B/H/C/D/G=544-617 (human) 3KUS - A/B=544-626 (human) 3KUT - A/B=544-626 (human) 3PKN - A=544-626 (human) 3PTH - A=543-621 (human) 4F02 - A/D=1-190 (human) 4F25 - A=99-199 (human) 4F26 - A=99-199 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S51-p	RDMITRRsLGyAyVN
0	63		Y54-p	ITRRsLGyAyVNFQQ
0	24		Y56-p	RRsLGyAyVNFQQPA
0	69		K78-u	TMNFDVIkGkPVRIM
0	14		K80-u	NFDVIkGkPVRIMWS
0	41		K95-u	QRDPSLRksGVGNIF
0	3		S96-p	RDPSLRksGVGNIFI
0	2		K104-a	GVGNIFIkNLDkSID
0	4		K104-u	GVGNIFIkNLDkSID
0	36		K108-u	IFIkNLDkSIDNkAL
0	30		K113-u	LDkSIDNkALyDTFS
0	35		Y116-p	SIDNkALyDTFSAFG
0	33		K129-u	FGNILSCkVVCDENG
0	21		K138-u	VCDENGSkGYGFVHF
0	20		K157-u	AAERAIEkMNGMLLN
0	18		K167-u	GMLLNDRkVFVGRFK
0	1		K188-a	AELGARAkEFTNVYI
0	63		K188-u	AELGARAkEFTNVYI
0	1		K196-a	EFTNVYIkNFGEDMD
0	5		K196-u	EFTNVYIkNFGEDMD
0	26		K213-u	RLKDLFGkFGPALSV
0	2		K221-u	FGPALSVkVMTDESG
0	1		K229	VMTDESGKSkGFGFV
0	5		K229-u	VMTDESGkSkGFGFV
0	9		K231-u	TDESGkSkGFGFVSF
0	4		K246-u	ERHEDAQkAVDEMNG
0	3		K259-a	NGKELNGkQIYVGRA
0	39		K259-u	NGKELNGkQIYVGRA
0	9		K279-u	RQTELKRkFEQMkQD
0	55		K284-u	KRkFEQMkQDRITRY
0	39		Y297-p	RYQGVNLyVkNLDDG
0	21		K299-u	QGVNLyVkNLDDGID
0	70		K312-u	IDDERLRkEFsPFGT
0	11		S315-p	ERLRkEFsPFGTITS
0	1		K324-u	FGTITSAkVMMEGGR
0	45		K333-u	MMEGGRSkGFGFVCF
0	3		S342-p	FGFVCFSsPEEATkA
0	50		K348-u	SsPEEATkAVTEMNG
0	6		T360-p	MNGRIVAtkPLyVAL
0	39		K361-u	NGRIVAtkPLyVALA
0	557		Y364-p	IVAtkPLyVALAQRK
0	23		Y382-p	QAHLTNQyMQrMASV
0	2		R385-m1	LTNQyMQrMASVRAV
0	7		Y400-p	PNPVINPyQPAPPSG
0	13		R419-m1	AIPQTQNrAAyyPPS
0	1		R419-m2	AIPQTQNrAAyyPPS
0	21		Y422-p	QTQNrAAyyPPSQIA
0	1		Y423-p	TQNrAAyyPPSQIAQ
0	4		R432-m2	PSQIAQLrPSPRWTA
0	1		R443-m2	RWTAQGArPHPFQNM
1	0		R455-m	QNMPGAIrPAAPrPP
0	2		R455-m2	QNMPGAIrPAAPrPP
1	0		R460-m	AIrPAAPrPPFSTMr
0	1		R460-m2	AIrPAAPrPPFSTMr
0	1		R467-m2	rPPFSTMrPASSQVP
0	6		R475-m1	PASSQVPrVMsTQrV
0	3		R475-m2	PASSQVPrVMsTQrV
0	1		S478-p	SQVPrVMsTQrVANT
0	1		R481-m1	PrVMsTQrVANTSTQ
0	7		R493-m2	STQTMGPrPAAAAAA
0	3		T502-p	AAAAAAAtPAVRTVP
0	10		Y511-p	AVRTVPQykYAAGVR
0	1		K512-a	VRTVPQykYAAGVRN
0	7		K512-u	VRTVPQykYAAGVRN
0	3		S599-p	ELLHMLEsPESLRSK
0	3		K620-u	VLQAHQAkEAAQkAV
0	22		K625-u	QAkEAAQkAVNSATG

	mouse
S51-p	RDMITRRsLGyAyVN
Y54-p	ITRRsLGyAyVNFQQ
Y56-p	RRsLGyAyVNFQQPA
K78-u	TMNFDVIkGkPVRIM
K80-u	NFDVIkGkPVRIMWS
K95-u	QRDPSLRksGVGNIF
S96-p	RDPSLRksGVGNIFI
K104	GVGNIFIKNLDkSID
K104-u	GVGNIFIkNLDkSID
K108-u	IFIkNLDkSIDNKAL
K113	LDkSIDNKALyDTFS
Y116-p	SIDNKALyDTFSAFG
K129-u	FGNILSCkVVCDENG
K138-u	VCDENGSkGYGFVHF
K157-u	AAERAIEkMNGMLLN
K167	GMLLNDRKVFVGRFK
K188	AELGARAKEFTNVYI
K188-u	AELGARAkEFTNVYI
K196	EFTNVYIKNFGEDMD
K196-u	EFTNVYIkNFGEDMD
K213-u	RLKELFGkFGPALSV
K221	FGPALSVKVMTDESG
K229-a	VMTDESGkSkGFGFV
K229-u	VMTDESGkSkGFGFV
K231-u	TDESGkSkGFGFVSF
K246-u	ERHEDAQkAVDEMNG
K259	NGKELNGKQIYVGRA
K259-u	NGKELNGkQIYVGRA
K279-u	RQTELKRkFEQMkQD
K284-u	KRkFEQMkQDRITRY
Y297-p	RYQGVNLyVkNLDDG
K299-u	QGVNLyVkNLDDGID
K312-u	IDDERLRkEFsPFGT
S315-p	ERLRkEFsPFGTITS
K324	FGTITSAKVMMEGGR
K333-u	MMEGGRSkGFGFVCF
S342-p	FGFVCFSsPEEATkA
K348-u	SsPEEATkAVTEMNG
T360	MNGRIVATkPLyVAL
K361-u	NGRIVATkPLyVALA
Y364-p	IVATkPLyVALAQRK
Y382	QAHLTNQYMQRMASV
R385	LTNQYMQRMASVRAV
Y400	PNPVINPYQPAPPSG
R419-m1	AIPQTQNrAAYYPPS
R419	AIPQTQNRAAYYPPS
Y422	QTQNrAAYYPPSQIA
Y423	TQNrAAYYPPSQIAQ
R432-m2	PSQIAQLrPSPRWTA
R443	RWTAQGARPHPFQNM
R455	QNMPGAIRPAAPRPP
R455-m2	QNMPGAIrPAAPRPP
R460	AIrPAAPRPPFSTMR
R460	AIrPAAPRPPFSTMR
R467	RPPFSTMRPASSQVP
R475-m1	PASSQVPrVMSTQRV
R475-m2	PASSQVPrVMSTQRV
S478	SQVPrVMSTQRVANT
R481	PrVMSTQRVANTSTQ
R493-m2	STQTMGPrPAAAAAA
T502	AAAAAAATPAVRTVP
Y511	AVRTVPQYkYAAGVR
K512	VRTVPQYKYAAGVRN
K512-u	VRTVPQYkYAAGVRN
S599-p	ELLHMLEsPESLRSK
K620-u	VLQAHQAkEAAQkAV
K625-u	QAkEAAQkAVNSATG

	rat
S51	RDMITRRSLGYAYVN
Y54	ITRRSLGYAYVNFQQ
Y56	RRSLGYAYVNFQQPA
K78	TMNFDVIKGKPVRIM
K80	NFDVIKGKPVRIMWS
K95	QRDPSLRKSGVGNIF
S96	RDPSLRKSGVGNIFI
K104	GVGNIFIKNLDKSID
K104	GVGNIFIKNLDKSID
K108	IFIKNLDKSIDNKAL
K113	LDKSIDNKALYDTFS
Y116	SIDNKALYDTFSAFG
K129	FGNILSCKVVCDENG
K138	VCDENGSKGYGFVHF
K157	AAERAIEKMNGMLLN
K167	GMLLNDRKVFVGRFK
K188	AELGARAKEFTNVYI
K188	AELGARAKEFTNVYI
K196	EFTNVYIKNFGEDMD
K196	EFTNVYIKNFGEDMD
K213	RLKELFGKFGPALSV
K221	FGPALSVKVMTDESG
K229	VMTDESGKSKGFGFV
K229	VMTDESGKSKGFGFV
K231	TDESGKSKGFGFVSF
K246	ERHEDAQKAVDEMNG
K259	NGKELNGKQIYVGRA
K259	NGKELNGKQIYVGRA
K279	RQTELKRKFEQMkQD
K284-u	KRKFEQMkQDRITRY
Y297	RYQGVNLYVKNLDDG
K299	QGVNLYVKNLDDGID
K312	IDDERLRKEFSPFGT
S315	ERLRKEFSPFGTITS
K324	FGTITSAKVMMEGGR
K333	MMEGGRSKGFGFVCF
S342	FGFVCFSSPEEATKA
K348	SSPEEATKAVTEMNG
T360	MNGRIVATKPLyVAL
K361	NGRIVATKPLyVALA
Y364-p	IVATKPLyVALAQRK
Y382	QAHLTNQYMQrMASV
R385-m1	LTNQYMQrMASVRAV
Y400	PNPVINPYQPAPPSG
R419-m1	AIPQTQNrAAYYPPS
R419	AIPQTQNRAAYYPPS
Y422	QTQNrAAYYPPSQIA
Y423	TQNrAAYYPPSQIAQ
R432	PSQIAQLRPSPRWTA
R443	RWTAQGARPHPFQNM
R455	QNMPGAIRPAAPRPP
R455	QNMPGAIRPAAPRPP
R460	AIRPAAPRPPFSTMR
R460	AIRPAAPRPPFSTMR
R467	RPPFSTMRPASSQVP
R475	PASSQVPRVMSTQRV
R475	PASSQVPRVMSTQRV
S478	SQVPRVMSTQRVANT
R481	PRVMSTQRVANTSTQ
R493	STQTMGPRPAAAATA
T502	AAAATAATPAVRTVP
Y511	AVRTVPQYKYAAGVR
K512	VRTVPQYKYAAGVRN
K512	VRTVPQYKYAAGVRN
S599	ELLHMLESPESLRSK
K620	VLQAHQAKEAAQKAV
K625	QAKEAAQKAVNSATG

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