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Protein Page:
G6PD (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
G6PD glucose-6-phosphate dehydrogenase. A cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two splice variant isoforms have been described. The long isoform is found in lymphoblasts, granulocytes and sperm. Note: This description may include information from UniProtKB.
Protein type: EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Cell development/differentiation; Carbohydrate Metabolism - pentose phosphate pathway; Oxidoreductase
Cellular Component: internal side of plasma membrane; membrane; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; glucose-6-phosphate dehydrogenase activity; protein homodimerization activity; NADP binding; glucose binding
Biological Process: NADPH regeneration; response to food; pentose-phosphate shunt; ribose phosphate biosynthetic process; erythrocyte maturation; pentose-phosphate shunt, oxidative branch; glucose 6-phosphate metabolic process; cytokine production; NADP metabolic process; cholesterol biosynthetic process; response to organic cyclic substance; response to ethanol; glutathione metabolic process; substantia nigra development; regulation of neuron apoptosis; carbohydrate metabolic process; lipid metabolic process; pentose biosynthetic process
Reference #:  P11413 (UniProtKB)
Alt. Names/Synonyms: G6PD; G6PD1; Glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate dehydrogenase; glucose-6-phosphate dehydrogenase, G6PD
Gene Symbols: G6PD
Molecular weight: 59,257 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

G6PD

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: Y428‑p, Y507‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 - gap
0 1 S8-p MAEQVALsRtQVCGI
0 2 T10-p EQVALsRtQVCGILR
0 2 K89-ac KQSEPFFkATPEEKL
0 1 K89-ub KQSEPFFkATPEEKL
0 2 K97-ub ATPEEKLkLEDFFAR
0 2 S106-p EDFFARNsyVAGQyD
0 1 Y107-p DFFARNsyVAGQyDD
0 348 Y112-p NsyVAGQyDDAASYQ
0 2 S132-p MNALHLGsQANRLFY
0 5 K171-ac WNRIIVEkPFGRDLQ
0 4 K171-ub WNRIIVEkPFGRDLQ
1 0 S180 FGRDLQSSDRLSNHI
0 36 Y202-p QIYRIDHyLGKEMVQ
1 0 T236 NIACVILTFKEPFGT
0 6 Y249-p GTEGRGGyFDEFGII
0 1 S296-p VKVLKCIsEVQANNV
0 1 Y322-p EGEATKGyLDDPTVP
0 1 K386-ac DIFHQQCkRNELVIR
0 1 K386-sc DIFHQQCkRNELVIR
0 562 Y401-p VQPNEAVytkMMTKk
0 23 T402-p QPNEAVytkMMTKkP
0 1 K403-ac PNEAVytkMMTKkPG
0 1 K403-ub PNEAVytkMMTKkPG
0 1 K408-ac ytkMMTKkPGMFFNP
0 1 K408-ub ytkMMTKkPGMFFNP
0 3 T423-p EESELDLtyGNRyKN
0 27 Y424-p ESELDLtyGNRyKNV
1 0 Y428-p DLtyGNRyKNVkLPD
0 3 K432-ac GNRyKNVkLPDAYER
0 2 S448-p ILDVFCGsQMHFVRS
0 3 K497-ac TEADELMkRVGFQyE
0 1 K497-ub TEADELMkRVGFQyE
0 1 K497-sc TEADELMkRVGFQyE
0 950 Y503-p MkRVGFQyEGtyKWV
0 22 T506-p VGFQyEGtyKWVNPH
1 762 Y507-p GFQyEGtyKWVNPHk
0 2 K514-ac yKWVNPHkL______
  G6PD iso3  
S26-p RGGRRRRsADSVMAE
S38 MAEQVALSRTQVCGI
T40 EQVALSRTQVCGILR
K119 KQSEPFFKATPEEKL
K119 KQSEPFFKATPEEKL
K127 ATPEEKLKLEDFFAR
S136 EDFFARNSYVAGQyD
Y137 DFFARNSYVAGQyDD
Y142-p NSYVAGQyDDAASYQ
S162 MNALHLGSQANRLFY
K201 WNRIIVEKPFGRDLQ
K201 WNRIIVEKPFGRDLQ
S210-p FGRDLQSsDRLSNHI
Y232 QIYRIDHYLGKEMVQ
T266-p NIACVILtFKEPFGT
Y279 GTEGRGGYFDEFGII
S326 VKVLKCISEVQANNV
Y352 EGEATKGYLDDPTVP
K416 DIFHQQCKRNELVIR
K416 DIFHQQCKRNELVIR
Y431-p VQPNEAVyTKMMTKK
T432 QPNEAVyTKMMTKKP
K433 PNEAVyTKMMTKKPG
K433 PNEAVyTKMMTKKPG
K438 yTKMMTKKPGMFFNP
K438 yTKMMTKKPGMFFNP
T453 EESELDLTyGNRYKN
Y454-p ESELDLTyGNRYKNV
Y458 DLTyGNRYKNVKLPD
K462 GNRYKNVKLPDAYER
S478 ILDVFCGSQMHFVRS
K527 TEADELMKRVGFQyE
K527 TEADELMKRVGFQyE
K527 TEADELMKRVGFQyE
Y533-p MKRVGFQyEGTyKWV
T536 VGFQyEGTyKWVNPH
Y537-p GFQyEGTyKWVNPHK
K544 yKWVNPHKL______
  mouse

 
- gap
S8 MAEQVALSRTQVCGI
T10 EQVALSRTQVCGILR
K89 KQSEPFFKATPEERP
K89 KQSEPFFKATPEERP
K97 ATPEERPKLEEFFAR
S106 EEFFARNSYVAGQyD
Y107 EFFARNSYVAGQyDD
Y112-p NSYVAGQyDDAASYK
M132 MNALHQGMQANRLFY
K171 WNRIIVEKPFGRDLQ
K171 WNRIIVEKPFGRDLQ
S180 FGRDLQSSNQLSNHI
Y202-p QIYRIDHyLGKEMVQ
T236 NIACVILTFKEPFGT
Y249 GTEGRGGYFDEFGII
S296 VKVLKCISEVETDNV
Y322 EGEAANGYLDDPTVP
K386 DIFHQQCKRNELVIR
K386 DIFHQQCKRNELVIR
Y401-p VQPNEAVytKMMTKK
T402-p QPNEAVytKMMTKKP
K403 PNEAVytKMMTKKPG
K403 PNEAVytKMMTKKPG
K408 ytKMMTKKPGMFFNP
K408 ytKMMTKKPGMFFNP
T423 EESELDLTyGNRYKN
Y424-p ESELDLTyGNRYKNV
Y428 DLTyGNRYKNVKLPD
K432 GNRYKNVKLPDAYER
S448 ILDVFCGSQMHFVRS
K497 TEADELMKRVGFQyE
K497 TEADELMKRVGFQyE
K497 TEADELMKRVGFQyE
Y503-p MKRVGFQyEGTyKWV
T506 VGFQyEGTyKWVNPH
Y507-p GFQyEGTyKWVNPHK
K514 yKWVNPHKL______
  rat

 
- gap
S8 MAEQVALSRTQVCGI
T10 EQVALSRTQVCGILR
K89 KQSEPFFKVTPEERP
K89 KQSEPFFKVTPEERP
K97 VTPEERPKLEEFFAR
S106 EEFFARNSYVAGQYD
Y107 EFFARNSYVAGQYDD
Y112 NSYVAGQYDDPASYK
M132 MNALHQGMQANRLFY
K171 WNRIIVEKPFGRDLQ
K171 WNRIIVEKPFGRDLQ
S180 FGRDLQSSNQLSNHI
Y202 QIYRIDHYLGKEMVQ
T236 NIACVILTFKEPFGT
Y249 GTEGRGGYFDEFGII
S296 VKVLKCISEVETDNV
Y322 EGEATNGYLDDPTVP
K386 DIFHQQCKRNELVIR
K386 DIFHQQCKRNELVIR
Y401-p VQPNEAVyTKMMTKK
T402 QPNEAVyTKMMTKKP
K403 PNEAVyTKMMTKKPG
K403 PNEAVyTKMMTKKPG
K408 yTKMMTKKPGMFFNP
K408 yTKMMTKKPGMFFNP
T423 EESELDLTYGNRYKN
Y424 ESELDLTYGNRYKNV
Y428 DLTYGNRYKNVKLPD
K432 GNRYKNVKLPDAYER
S448 ILDVFCGSQMHFVRS
K497 TEADELMKRVGFQyE
K497 TEADELMKRVGFQyE
K497 TEADELMKRVGFQyE
Y503-p MKRVGFQyEGTyKWV
T506 VGFQyEGTyKWVNPH
Y507-p GFQyEGTyKWVNPHK
K514 yKWVNPHKL______
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