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HSC70 (human)

Overview HSC70 Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co- chaperones. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7. Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Constitutively synthesized. Ubiquitous. Belongs to the heat shock protein 70 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Chaperone Cellular Component: spliceosome; synaptic vesicle; neuron projection; cell surface; cell soma; nucleolus; plasma membrane; melanosome; intracellular; nucleus; ribonucleoprotein complex; cytosol Molecular Function: protein binding; unfolded protein binding; ATPase activity, coupled; ADP binding; ATP binding; receptor binding Biological Process: protein folding; chaperone cofactor-dependent protein folding; transcription, DNA-dependent; regulation of cell cycle; neurotransmitter secretion; RNA splicing; response to unfolded protein; membrane organization and biogenesis; mRNA metabolic process; synaptic transmission; RNA metabolic process; virus-host interaction; gene expression; post-Golgi vesicle-mediated transport; mRNA processing; negative regulation of transcription, DNA-dependent Reference #:  P11142 (UniProtKB) Alt. Names/Synonyms: constitutive heat shock protein 70; Heat shock 70 kDa protein 8; heat shock 70kd protein 10; heat shock 70kD protein 8; heat shock 70kDa protein 8; Heat shock cognate 71 kDa protein; heat shock cognate protein 54; heat shock cognate protein, 71-kDa; HSC54; HSC70; HSC71; HSP71; HSP73; HSP7C; HSPA10; HSPA8; LAP1; lipopolysaccharide-associated protein 1; LPS-associated protein 1; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; NIP71 Gene Symbols: HSPA8 Molecular weight: 70,898 Da Basal Isoelectric point: 5.37  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HSC70 3AGY - F/D/C=639-646 (human) 3AGZ - F/D/C/E=639-646 (human) 3ESK - B=635-646 (human) 3FZF - A=4-381 (human) 3FZH - A=4-381 (human) 3FZK - A=4-381 (human) 3FZL - A=4-381 (human) 3FZM - A=4-381 (human) 3LDQ - A=4-381 (human) 3M3Z - A=4-381 (human) 1CKR - A=385-543 (rat) 1Q2G - A=776-910 (rat) 1UD0 - A/B/C/D=542-646 (rat) 2V7Z - A/B=1-543 (rat) 7HSC - A=385-543 (rat)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	19		K3-a	_____MSkGPAVGID
0	2		K3-u	_____MSkGPAVGID
0	1		T13-p	AVGIDLGtTysCVGV
0	43		Y15-p	GIDLGtTysCVGVFQ
0	5		S16-p	IDLGtTysCVGVFQH
0	3		K25-u	VGVFQHGkVEIIAND
0	6		S40-p	QGNRTTPsyVAFTDT
0	415		Y41-p	GNRTTPsyVAFTDTE
0	1		K56	RLIGDAAKNQVAMNP
0	96		K56-u	RLIGDAAkNQVAMNP
0	1		T66-p	VAMNPTNtVFDAkRL
0	174		K71-a	TNtVFDAkRLIGRRF
0	83		K71-u	TNtVFDAkRLIGRRF
0	17		K88-a	AVVQSDMkHWPFMVV
0	1		K88-m3	AVVQSDMkHWPFMVV
0	5		K88-u	AVVQSDMkHWPFMVV
0	375		Y107-p	RPKVQVEykGEtkSF
0	17		K108-a	PKVQVEykGEtkSFY
0	114		K108-u	PKVQVEykGEtkSFY
0	3		T111-p	QVEykGEtkSFYPEE
0	14		K112-a	VEykGEtkSFYPEEV
0	15		K112-u	VEykGEtkSFYPEEV
0	8		K126-u	VSSMVLTkMkEIAEA
0	7		K128-u	SMVLTkMkEIAEAyL
0	23		Y134-p	MkEIAEAyLGktVtN
0	9		K137-u	IAEAyLGktVtNAVV
0	4		T138-p	AEAyLGktVtNAVVT
0	1		T140-p	AyLGktVtNAVVTVP
0	1		Y149-p	AVVTVPAyFNDsQRQ
0	2		S153-p	VPAyFNDsQRQAtkD
0	1		T158-p	NDsQRQAtkDAGtIA
0	28		K159-u	DsQRQAtkDAGtIAG
0	1		T163-p	QAtkDAGtIAGLNVL
0	1		T177-p	LRIINEPtAAAIAYG
0	11		K187-a	AIAYGLDkkVGAERN
0	38		K187-u	AIAYGLDkkVGAERN
0	1		K188	IAYGLDkKVGAERNV
0	27		K188-u	IAYGLDkkVGAERNV
0	1		K220-u	EDGIFEVksTAGDtH
0	2		S221-p	DGIFEVksTAGDtHL
0	5		T226-p	VksTAGDtHLGGEDF
0	189		K246-a	NHFIAEFkRKHKkDI
0	43		K246-u	NHFIAEFkRKHKkDI
0	1		K251-u	EFkRKHKkDIsENkR
0	3		S254-p	RKHKkDIsENkRAVR
0	2		K257-a	KkDIsENkRAVRRLR
0	49		K257-u	KkDIsENkRAVRRLR
0	103		T265-p	RAVRRLRtACERAKR
0	1		T273-p	ACERAKRtLSSsTQA
0	1		S277-p	AKRtLSSsTQASIEI
0	1		T313-p	NADLFRGtLDPVEkA
0	1		K319-a	GtLDPVEkALRDAkL
0	10		K319-u	GtLDPVEkALRDAkL
0	37		K325-u	EkALRDAkLDksQIH
0	21		K328-u	LRDAkLDksQIHDIV
0	21		S329-p	RDAkLDksQIHDIVL
0	1		T341-p	IVLVGGStRIPkIQk
0	10		K345-u	GGStRIPkIQkLLQD
0	3		K348-a	tRIPkIQkLLQDFFN
0	97		K348-u	tRIPkIQkLLQDFFN
0	26		K357-u	LQDFFNGkELNksIN
0	15		K361-u	FNGkELNksINPDEA
0	1		S362-p	NGkELNksINPDEAV
0	3		S400-p	LLDVTPLsLGIETAG
0	1		T405	PLsLGIETAGGVMtV
0	3		T411-p	ETAGGVMtVLIkRNT
0	1		K415-u	GVMtVLIkRNTTIPT
0	7		K423-u	RNTTIPTkQTQTFTT
0	1		Y431-p	QTQTFTTySDNQPGV
0	16		K451-u	EGERAMTkDNNLLGk
0	5		K458-u	kDNNLLGkFELTGIP
0	25		R469-m1	TGIPPAPrGVPQIEV
0	1		T477-p	GVPQIEVtFDIDANG
0	8		K500-u	KSTGKENkItITNDk
0	1		T502-p	TGKENkItITNDkGR
0	122		K507-u	kItITNDkGRLskED
0	1		S511-p	TNDkGRLskEDIERM
0	2		K512-a	NDkGRLskEDIERMV
0	101		K512-u	NDkGRLskEDIERMV
0	4		K524-a	RMVQEAEkykAEDEk
0	147		K524-u	RMVQEAEkykAEDEk
0	43		Y525-p	MVQEAEkykAEDEkQ
0	30		K526-u	VQEAEkykAEDEkQR
0	39		K531-u	kykAEDEkQRDkVSS
0	4		K535-u	EDEkQRDkVSSkNsL
0	1		K539-a	QRDkVSSkNsLEsYA
0	85		K539-u	QRDkVSSkNsLEsYA
0	2		S541-p	DkVSSkNsLEsYAFN
0	1		S544-p	SSkNsLEsYAFNMkA
0	2		K550-u	EsYAFNMkATVEDEk
0	3		K557-m2	kATVEDEkLQGkIND
0	2		K557-m3	kATVEDEkLQGkIND
0	7		K557-u	kATVEDEkLQGkIND
0	1		K561-a	EDEkLQGkINDEDkQ
0	7		K561-m1	EDEkLQGkINDEDkQ
1	6		K561-m3	EDEkLQGkINDEDkQ
0	2		K561-u	EDEkLQGkINDEDkQ
0	1		K567-m1	GkINDEDkQkILDkC
0	4		K567-m2	GkINDEDkQkILDkC
0	1		K567-m3	GkINDEDkQkILDkC
0	4		K569-m2	INDEDkQkILDkCNE
0	2		K573-u	DkQkILDkCNEIINW
0	1		N579	DkCNEIINWLDkNQT
0	110		K583-u	EIINWLDkNQTAEkE
0	1		K589-a	DkNQTAEkEEFEHQQ
0	39		K589-u	DkNQTAEkEEFEHQQ
0	7		K597-a	EEFEHQQkELEkVCN
0	41		K597-u	EEFEHQQkELEkVCN
0	7		K601-a	HQQkELEkVCNPIIT
0	99		K601-u	HQQkELEkVCNPIIT
0	2		K609	VCNPIITKLYQsAGG
0	1		S613-p	IITKLYQsAGGMPGG

	mouse
K3	_____MSKGPAVGID
K3-u	_____MSkGPAVGID
T13	AVGIDLGTTySCVGV
Y15-p	GIDLGTTySCVGVFQ
S16	IDLGTTySCVGVFQH
K25	VGVFQHGKVEIIAND
S40-p	QGNRTTPsyVAFTDT
Y41-p	GNRTTPsyVAFTDTE
K56-a	RLIGDAAkNQVAMNP
K56-u	RLIGDAAkNQVAMNP
T66	VAMNPTNTVFDAkRL
K71-a	TNTVFDAkRLIGRRF
K71-u	TNTVFDAkRLIGRRF
K88-a	AVVQSDMkHWPFMVV
K88	AVVQSDMKHWPFMVV
K88-u	AVVQSDMkHWPFMVV
Y107-p	RPKVQVEykGEtkSF
K108-a	PKVQVEykGEtkSFY
K108-u	PKVQVEykGEtkSFY
T111-p	QVEykGEtkSFYPEE
K112	VEykGEtKSFYPEEV
K112-u	VEykGEtkSFYPEEV
K126-u	VSSMVLTkMkEIAEA
K128-u	SMVLTkMkEIAEAYL
Y134	MkEIAEAYLGkTVTN
K137-u	IAEAYLGkTVTNAVV
T138	AEAYLGkTVTNAVVT
T140	AYLGkTVTNAVVTVP
Y149	AVVTVPAYFNDSQRQ
S153	VPAYFNDSQRQATkD
T158	NDSQRQATkDAGTIA
K159-u	DSQRQATkDAGTIAG
T163	QATkDAGTIAGLNVL
T177	LRIINEPTAAAIAYG
K187-a	AIAYGLDkkVGAERN
K187-u	AIAYGLDkkVGAERN
K188-a	IAYGLDkkVGAERNV
K188-u	IAYGLDkkVGAERNV
K220	EDGIFEVKsTAGDtH
S221-p	DGIFEVKsTAGDtHL
T226-p	VKsTAGDtHLGGEDF
K246-a	NHFIAEFkRKHKKDI
K246-u	NHFIAEFkRKHKKDI
K251	EFkRKHKKDISENkR
S254	RKHKKDISENkRAVR
K257-a	KKDISENkRAVRRLR
K257-u	KKDISENkRAVRRLR
T265-p	RAVRRLRtACERAKR
T273	ACERAKRTLSSSTQA
S277	AKRTLSSSTQASIEI
T313	NADLFRGTLDPVEkA
K319	GTLDPVEKALRDAkL
K319-u	GTLDPVEkALRDAkL
K325-u	EkALRDAkLDksQIH
K328-u	LRDAkLDksQIHDIV
S329-p	RDAkLDksQIHDIVL
T341	IVLVGGSTRIPkIQk
K345-u	GGSTRIPkIQkLLQD
K348-a	TRIPkIQkLLQDFFN
K348-u	TRIPkIQkLLQDFFN
K357-u	LQDFFNGkELNkSIN
K361-u	FNGkELNkSINPDEA
S362	NGkELNkSINPDEAV
S400	LLDVTPLSLGIETAG
T405	PLSLGIETAGGVMTV
T411	ETAGGVMTVLIKRNT
K415	GVMTVLIKRNTTIPT
K423-u	RNTTIPTkQTQTFTT
Y431	QTQTFTTYSDNQPGV
K451-u	EGERAMTkDNNLLGk
K458-u	kDNNLLGkFELTGIP
R469-m1	TGIPPAPrGVPQIEV
T477	GVPQIEVTFDIDANG
K500-u	KSTGKENkITITNDk
T502	TGKENkITITNDkGR
K507-u	kITITNDkGRLSkED
S511	TNDkGRLSkEDIERM
K512	NDkGRLSKEDIERMV
K512-u	NDkGRLSkEDIERMV
K524	RMVQEAEKykAEDEk
K524-u	RMVQEAEkykAEDEk
Y525-p	MVQEAEkykAEDEkQ
K526-u	VQEAEkykAEDEkQR
K531-u	kykAEDEkQRDKVSS
K535	EDEkQRDKVSSkNsL
K539	QRDKVSSKNsLESYA
K539-u	QRDKVSSkNsLESYA
S541-p	DKVSSkNsLESYAFN
S544	SSkNsLESYAFNMkA
K550-u	ESYAFNMkATVEDEk
K557	kATVEDEKLQGkIND
K557	kATVEDEKLQGkIND
K557-u	kATVEDEkLQGkIND
K561	EDEkLQGKINDEDKQ
K561-m1	EDEkLQGkINDEDKQ
K561	EDEkLQGKINDEDKQ
K561	EDEkLQGKINDEDKQ
K567	GkINDEDKQKILDkC
K567	GkINDEDKQKILDkC
K567	GkINDEDKQKILDkC
K569	INDEDKQKILDkCNE
K573-u	DKQKILDkCNEIIsW
S579-p	DkCNEIIsWLDkNQT
K583-u	EIIsWLDkNQTAEkE
K589	DkNQTAEKEEFEHQQ
K589-u	DkNQTAEkEEFEHQQ
K597-a	EEFEHQQkELEkVCN
K597-u	EEFEHQQkELEkVCN
K601-a	HQQkELEkVCNPIIT
K601-u	HQQkELEkVCNPIIT
K609-u	VCNPIITkLYQSAGG
S613	IITkLYQSAGGMPGG

	rat
K3	_____MSKGPAVGID
K3	_____MSKGPAVGID
T13	AVGIDLGTTYSCVGV
Y15	GIDLGTTYSCVGVFQ
S16	IDLGTTYSCVGVFQH
K25	VGVFQHGKVEIIAND
S40	QGNRTTPSyVAFTDT
Y41-p	GNRTTPSyVAFTDTE
K56	RLIGDAAKNQVAMNP
K56	RLIGDAAKNQVAMNP
T66	VAMNPTNTVFDAKRL
K71	TNTVFDAKRLIGRRF
K71	TNTVFDAKRLIGRRF
K88	AVVQSDMKHWPFMVV
K88	AVVQSDMKHWPFMVV
K88	AVVQSDMKHWPFMVV
Y107-p	RPKVQVEyKGETKSF
K108	PKVQVEyKGETKSFY
K108	PKVQVEyKGETKSFY
T111	QVEyKGETKSFYPEE
K112	VEyKGETKSFYPEEV
K112	VEyKGETKSFYPEEV
K126	VSSMVLTKMKEIAEA
K128	SMVLTKMKEIAEAyL
Y134-p	MKEIAEAyLGKTVTN
K137	IAEAyLGKTVTNAVV
T138	AEAyLGKTVTNAVVT
T140	AyLGKTVTNAVVTVP
Y149	AVVTVPAYFNDSQRQ
S153	VPAYFNDSQRQATKD
T158	NDSQRQATKDAGTIA
K159	DSQRQATKDAGTIAG
T163	QATKDAGTIAGLNVL
T177	LRIINEPTAAAIAYG
K187	AIAYGLDKKVGAERN
K187	AIAYGLDKKVGAERN
K188	IAYGLDKKVGAERNV
K188	IAYGLDKKVGAERNV
K220	EDGIFEVKSTAGDTH
S221	DGIFEVKSTAGDTHL
T226	VKSTAGDTHLGGEDF
K246-a	NHFIAEFkRKHKKDI
K246-u	NHFIAEFkRKHKKDI
K251	EFkRKHKKDISENKR
S254	RKHKKDISENKRAVR
K257	KKDISENKRAVRRLR
K257	KKDISENKRAVRRLR
T265	RAVRRLRTACERAKR
T273	ACERAKRTLSSSTQA
S277	AKRTLSSSTQASIEI
T313	NADLFRGTLDPVEKA
K319	GTLDPVEKALRDAkL
K319	GTLDPVEKALRDAkL
K325-u	EKALRDAkLDkSQIH
K328-u	LRDAkLDkSQIHDIV
S329	RDAkLDkSQIHDIVL
T341	IVLVGGSTRIPkIQk
K345-u	GGSTRIPkIQkLLQD
K348	TRIPkIQKLLQDFFN
K348-u	TRIPkIQkLLQDFFN
K357	LQDFFNGKELNKSIN
K361	FNGKELNKSINPDEA
S362	NGKELNKSINPDEAV
S400	LLDVTPLSLGIEtAG
T405-p	PLSLGIEtAGGVMtV
T411-p	EtAGGVMtVLIKRNT
K415	GVMtVLIKRNTTIPT
K423	RNTTIPTKQTQTFTT
Y431	QTQTFTTYSDNQPGV
K451	EGERAMTKDNNLLGK
K458	KDNNLLGKFELTGIP
R469-m1	TGIPPAPrGVPQIEV
T477	GVPQIEVTFDIDANG
K500	KSTGKENKITITNDk
T502	TGKENKITITNDkGR
K507-u	KITITNDkGRLSkED
S511	TNDkGRLSkEDIERM
K512	NDkGRLSKEDIERMV
K512-u	NDkGRLSkEDIERMV
K524	RMVQEAEKykAEDEk
K524-u	RMVQEAEkykAEDEk
Y525-p	MVQEAEkykAEDEkQ
K526-u	VQEAEkykAEDEkQR
K531-u	kykAEDEkQRDKVSS
K535	EDEkQRDKVSSkNSL
K539	QRDKVSSKNSLESYA
K539-u	QRDKVSSkNSLESYA
S541	DKVSSkNSLESYAFN
S544	SSkNSLESYAFNMKA
K550	ESYAFNMKATVEDEK
K557	KATVEDEKLQGKIND
K557	KATVEDEKLQGKIND
K557	KATVEDEKLQGKIND
K561	EDEKLQGKINDEDKQ
K561	EDEKLQGKINDEDKQ
K561	EDEKLQGKINDEDKQ
K561	EDEKLQGKINDEDKQ
K567	GKINDEDKQKILDKC
K567	GKINDEDKQKILDKC
K567	GKINDEDKQKILDKC
K569	INDEDKQKILDKCNE
K573	DKQKILDKCNEIISW
S579	DKCNEIISWLDKNQT
K583	EIISWLDKNQTAEkE
K589	DKNQTAEKEEFEHQQ
K589-u	DKNQTAEkEEFEHQQ
K597	EEFEHQQKELEKVCN
K597	EEFEHQQKELEKVCN
K601	HQQKELEKVCNPIIT
K601	HQQKELEKVCNPIIT
K609	VCNPIITKLYQSAGG
S613	IITKLYQSAGGMPGG

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