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Protein Page:
HSC70 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
HSC70 Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co- chaperones. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7. Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Constitutively synthesized. Ubiquitous. Belongs to the heat shock protein 70 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein
Cellular Component: spliceosome; nucleolus; plasma membrane; melanosome; intracellular; nucleus; ribonucleoprotein complex; cytosol
Molecular Function: protein binding; unfolded protein binding; ATPase activity, coupled; ATP binding
Biological Process: ATP catabolic process; axon guidance; chaperone cofactor-dependent protein folding; transcription, DNA-dependent; protein folding; viral reproduction; regulation of cell cycle; RNA splicing; neurotransmitter secretion; response to unfolded protein; mRNA metabolic process; synaptic transmission; RNA metabolic process; gene expression; post-Golgi vesicle-mediated transport; mRNA processing; negative regulation of transcription, DNA-dependent
Reference #:  P11142 (UniProtKB)
Alt. Names/Synonyms: constitutive heat shock protein 70; Heat shock 70 kDa protein 8; heat shock 70kd protein 10; heat shock 70kD protein 8; heat shock 70kDa protein 8; Heat shock cognate 71 kDa protein; heat shock cognate protein 54; heat shock cognate protein, 71-kDa; HSC54; HSC70; HSC71; HSP71; HSP73; HSP7C; HSPA10; HSPA8; LAP1; lipopolysaccharide-associated protein 1; LPS-associated protein 1; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; NIP71
Gene Symbols: HSPA8
Molecular weight: 70,898 Da
Basal Isoelectric point: 5.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HSC70

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 19 K3-a _____MSkGPAVGID
0 2 K3-u _____MSkGPAVGID
0 43 Y15-p GIDLGTTysCVGVFQ
0 5 S16-p IDLGTTysCVGVFQH
0 3 K25-u VGVFQHGkVEIIAND
0 6 S40-p QGNRTTPsyVAFTDT
0 417 Y41-p GNRTTPsyVAFTDTE
0 1 K56 RLIGDAAKNQVAMNP
0 96 K56-u RLIGDAAkNQVAMNP
0 1 T66-p VAMNPTNtVFDAkRL
0 174 K71-a TNtVFDAkRLIGRRF
0 83 K71-u TNtVFDAkRLIGRRF
0 17 K88-a AVVQSDMkHWPFMVV
0 5 K88-u AVVQSDMkHWPFMVV
0 375 Y107-p RPKVQVEykGEtkSF
0 17 K108-a PKVQVEykGEtkSFY
0 114 K108-u PKVQVEykGEtkSFY
0 3 T111-p QVEykGEtkSFYPEE
0 14 K112-a VEykGEtkSFYPEEV
0 15 K112-u VEykGEtkSFYPEEV
0 8 K126-u VSSMVLTkMkEIAEA
0 7 K128-u SMVLTkMkEIAEAyL
0 23 Y134-p MkEIAEAyLGktVTN
0 9 K137-u IAEAyLGktVTNAVV
0 4 T138-p AEAyLGktVTNAVVT
0 2 S153-p VPAYFNDsQRQAtkD
0 1 T158-p NDsQRQAtkDAGtIA
0 28 K159-u DsQRQAtkDAGtIAG
0 1 T163-p QAtkDAGtIAGLNVL
0 1 T177-p LRIINEPtAAAIAYG
0 11 K187-a AIAYGLDkkVGAERN
0 38 K187-u AIAYGLDkkVGAERN
0 27 K188-u IAYGLDkkVGAERNV
0 2 S221-p DGIFEVKsTAGDtHL
0 6 T226-p VKsTAGDtHLGGEDF
0 189 K246-a NHFIAEFkRKHKkDI
0 43 K246-u NHFIAEFkRKHKkDI
0 1 K251-u EFkRKHKkDIsENkR
0 4 S254-p RKHKkDIsENkRAVR
0 2 K257-a KkDIsENkRAVRRLR
0 49 K257-u KkDIsENkRAVRRLR
1 103 T265-p RAVRRLRtACERAKR
0 1 S277-p AKRTLSSsTQASIEI
0 1 T313-p NADLFRGtLDPVEkA
0 1 K319-a GtLDPVEkALRDAkL
0 10 K319-u GtLDPVEkALRDAkL
0 37 K325-u EkALRDAkLDksQIH
0 21 K328-u LRDAkLDksQIHDIV
0 22 S329-p RDAkLDksQIHDIVL
0 1 T341-p IVLVGGStRIPkIQk
0 10 K345-u GGStRIPkIQkLLQD
0 3 K348-a tRIPkIQkLLQDFFN
0 97 K348-u tRIPkIQkLLQDFFN
0 26 K357-u LQDFFNGkELNksIN
0 15 K361-u FNGkELNksINPDEA
0 1 S362-p NGkELNksINPDEAV
0 3 S400-p LLDVTPLsLGIETAG
0 1 T405 PLsLGIETAGGVMtV
0 3 T411-p ETAGGVMtVLIKRNT
0 7 K423-u RNTTIPTkQTQTFTT
0 16 K451-u EGERAMTkDNNLLGk
0 5 K458-u kDNNLLGkFELTGIP
0 26 R469-m1 TGIPPAPrGVPQIEV
0 1 T477-p GVPQIEVtFDIDANG
0 8 K500-u KSTGKENkItITNDk
0 1 T502-p TGKENkItITNDkGR
0 122 K507-u kItITNDkGRLskED
0 1 S511-p TNDkGRLskEDIERM
0 2 K512-a NDkGRLskEDIERMV
0 101 K512-u NDkGRLskEDIERMV
0 4 K524-a RMVQEAEkykAEDEk
0 147 K524-u RMVQEAEkykAEDEk
0 43 Y525-p MVQEAEkykAEDEkQ
0 30 K526-u VQEAEkykAEDEkQR
0 39 K531-u kykAEDEkQRDkVSS
0 4 K535-u EDEkQRDkVSSkNsL
0 85 K539-u QRDkVSSkNsLEsYA
0 3 S541-p DkVSSkNsLEsYAFN
0 2 S544-p SSkNsLEsYAFNMkA
0 2 K550-u EsYAFNMkATVEDEk
0 3 K557-m2 kATVEDEkLQGkIND
0 2 K557-m3 kATVEDEkLQGkIND
0 7 K557-u kATVEDEkLQGkIND
0 7 K561-m1 EDEkLQGkINDEDkQ
0 1 K561-m2 EDEkLQGkINDEDkQ
1 6 K561-m3 EDEkLQGkINDEDkQ
0 2 K561-u EDEkLQGkINDEDkQ
0 4 K567-m2 GkINDEDkQkILDkC
0 4 K569-m2 INDEDkQkILDkCNE
0 2 K573-u DkQkILDkCNEIINW
0 1 N579 DkCNEIINWLDkNQT
0 110 K583-u EIINWLDkNQTAEkE
0 1 K589-a DkNQTAEkEEFEHQQ
0 39 K589-u DkNQTAEkEEFEHQQ
0 7 K597-a EEFEHQQkELEkVCN
0 41 K597-u EEFEHQQkELEkVCN
0 7 K601-a HQQkELEkVCNPIIT
0 99 K601-u HQQkELEkVCNPIIT
0 2 K609 VCNPIITKLYQsAGG
0 1 S613-p IITKLYQsAGGMPGG
  mouse

 
K3 _____MSKGPAVGID
K3-u _____MSkGPAVGID
Y15-p GIDLGTTySCVGVFQ
S16 IDLGTTySCVGVFQH
K25 VGVFQHGKVEIIAND
S40-p QGNRTTPsyVAFTDT
Y41-p GNRTTPsyVAFTDTE
K56-a RLIGDAAkNQVAMNP
K56-u RLIGDAAkNQVAMNP
T66 VAMNPTNTVFDAkRL
K71-a TNTVFDAkRLIGRRF
K71-u TNTVFDAkRLIGRRF
K88-a AVVQSDMkHWPFMVV
K88-u AVVQSDMkHWPFMVV
Y107-p RPKVQVEykGEtkSF
K108-a PKVQVEykGEtkSFY
K108-u PKVQVEykGEtkSFY
T111-p QVEykGEtkSFYPEE
K112 VEykGEtKSFYPEEV
K112-u VEykGEtkSFYPEEV
K126-u VSSMVLTkMkEIAEA
K128-u SMVLTkMkEIAEAYL
Y134 MkEIAEAYLGkTVTN
K137-u IAEAYLGkTVTNAVV
T138 AEAYLGkTVTNAVVT
S153 VPAYFNDSQRQATkD
T158 NDSQRQATkDAGTIA
K159-u DSQRQATkDAGTIAG
T163 QATkDAGTIAGLNVL
T177 LRIINEPTAAAIAYG
K187-a AIAYGLDkkVGAERN
K187-u AIAYGLDkkVGAERN
K188-u IAYGLDkkVGAERNV
S221-p DGIFEVKsTAGDtHL
T226-p VKsTAGDtHLGGEDF
K246-a NHFIAEFkRKHKKDI
K246-u NHFIAEFkRKHKKDI
K251 EFkRKHKKDIsENkR
S254-p RKHKKDIsENkRAVR
K257-a KKDIsENkRAVRRLR
K257-u KKDIsENkRAVRRLR
T265-p RAVRRLRtACERAKR
S277 AKRTLSSSTQASIEI
T313 NADLFRGTLDPVEkA
K319 GTLDPVEKALRDAkL
K319-u GTLDPVEkALRDAkL
K325-u EkALRDAkLDksQIH
K328-u LRDAkLDksQIHDIV
S329-p RDAkLDksQIHDIVL
T341 IVLVGGSTRIPkIQk
K345-u GGSTRIPkIQkLLQD
K348-a TRIPkIQkLLQDFFN
K348-u TRIPkIQkLLQDFFN
K357-u LQDFFNGkELNkSIN
K361-u FNGkELNkSINPDEA
S362 NGkELNkSINPDEAV
S400 LLDVTPLSLGIETAG
T405 PLSLGIETAGGVMTV
T411 ETAGGVMTVLIKRNT
K423-u RNTTIPTkQTQTFTT
K451-u EGERAMTkDNNLLGk
K458-u kDNNLLGkFELTGIP
R469-m1 TGIPPAPrGVPQIEV
T477 GVPQIEVTFDIDANG
K500-u KSTGKENkITITNDk
T502 TGKENkITITNDkGR
K507-u kITITNDkGRLSkED
S511 TNDkGRLSkEDIERM
K512 NDkGRLSKEDIERMV
K512-u NDkGRLSkEDIERMV
K524 RMVQEAEKykAEDEk
K524-u RMVQEAEkykAEDEk
Y525-p MVQEAEkykAEDEkQ
K526-u VQEAEkykAEDEkQR
K531-u kykAEDEkQRDKVSS
K535 EDEkQRDKVSSkNsL
K539-u QRDKVSSkNsLESYA
S541-p DKVSSkNsLESYAFN
S544 SSkNsLESYAFNMkA
K550-u ESYAFNMkATVEDEk
K557 kATVEDEKLQGkIND
K557 kATVEDEKLQGkIND
K557-u kATVEDEkLQGkIND
K561-m1 EDEkLQGkINDEDKQ
K561 EDEkLQGKINDEDKQ
K561 EDEkLQGKINDEDKQ
K561 EDEkLQGKINDEDKQ
K567 GkINDEDKQKILDkC
K569 INDEDKQKILDkCNE
K573-u DKQKILDkCNEIIsW
S579-p DkCNEIIsWLDkNQT
K583-u EIIsWLDkNQTAEkE
K589 DkNQTAEKEEFEHQQ
K589-u DkNQTAEkEEFEHQQ
K597-a EEFEHQQkELEkVCN
K597-u EEFEHQQkELEkVCN
K601-a HQQkELEkVCNPIIT
K601-u HQQkELEkVCNPIIT
K609-u VCNPIITkLYQSAGG
S613 IITkLYQSAGGMPGG
  rat

 
K3 _____MSKGPAVGID
K3 _____MSKGPAVGID
Y15 GIDLGTTYSCVGVFQ
S16 IDLGTTYSCVGVFQH
K25 VGVFQHGKVEIIAND
S40 QGNRTTPSyVAFTDT
Y41-p GNRTTPSyVAFTDTE
K56 RLIGDAAKNQVAMNP
K56 RLIGDAAKNQVAMNP
T66 VAMNPTNTVFDAKRL
K71 TNTVFDAKRLIGRRF
K71 TNTVFDAKRLIGRRF
K88 AVVQSDMKHWPFMVV
K88 AVVQSDMKHWPFMVV
Y107-p RPKVQVEyKGETKSF
K108 PKVQVEyKGETKSFY
K108 PKVQVEyKGETKSFY
T111 QVEyKGETKSFYPEE
K112 VEyKGETKSFYPEEV
K112 VEyKGETKSFYPEEV
K126 VSSMVLTKMKEIAEA
K128 SMVLTKMKEIAEAyL
Y134-p MKEIAEAyLGKTVTN
K137 IAEAyLGKTVTNAVV
T138 AEAyLGKTVTNAVVT
S153 VPAYFNDSQRQATKD
T158 NDSQRQATKDAGTIA
K159 DSQRQATKDAGTIAG
T163 QATKDAGTIAGLNVL
T177 LRIINEPTAAAIAYG
K187 AIAYGLDKKVGAERN
K187 AIAYGLDKKVGAERN
K188 IAYGLDKKVGAERNV
S221 DGIFEVKSTAGDTHL
T226 VKSTAGDTHLGGEDF
K246-a NHFIAEFkRKHKKDI
K246-u NHFIAEFkRKHKKDI
K251 EFkRKHKKDISENKR
S254 RKHKKDISENKRAVR
K257 KKDISENKRAVRRLR
K257 KKDISENKRAVRRLR
T265 RAVRRLRTACERAKR
S277 AKRTLSSSTQASIEI
T313 NADLFRGTLDPVEKA
K319 GTLDPVEKALRDAkL
K319 GTLDPVEKALRDAkL
K325-u EKALRDAkLDkSQIH
K328-u LRDAkLDkSQIHDIV
S329 RDAkLDkSQIHDIVL
T341 IVLVGGSTRIPkIQk
K345-u GGSTRIPkIQkLLQD
K348 TRIPkIQKLLQDFFN
K348-u TRIPkIQkLLQDFFN
K357 LQDFFNGKELNKSIN
K361 FNGKELNKSINPDEA
S362 NGKELNKSINPDEAV
S400 LLDVTPLSLGIEtAG
T405-p PLSLGIEtAGGVMtV
T411-p EtAGGVMtVLIKRNT
K423 RNTTIPTKQTQTFTT
K451 EGERAMTKDNNLLGK
K458 KDNNLLGKFELTGIP
R469-m1 TGIPPAPrGVPQIEV
T477 GVPQIEVTFDIDANG
K500 KSTGKENKITITNDk
T502 TGKENKITITNDkGR
K507-u KITITNDkGRLSkED
S511 TNDkGRLSkEDIERM
K512 NDkGRLSKEDIERMV
K512-u NDkGRLSkEDIERMV
K524 RMVQEAEKykAEDEk
K524-u RMVQEAEkykAEDEk
Y525-p MVQEAEkykAEDEkQ
K526-u VQEAEkykAEDEkQR
K531-u kykAEDEkQRDKVSS
K535 EDEkQRDKVSSkNSL
K539-u QRDKVSSkNSLESYA
S541 DKVSSkNSLESYAFN
S544 SSkNSLESYAFNMKA
K550 ESYAFNMKATVEDEK
K557 KATVEDEKLQGKIND
K557 KATVEDEKLQGKIND
K557 KATVEDEKLQGKIND
K561 EDEKLQGKINDEDKQ
K561 EDEKLQGKINDEDKQ
K561 EDEKLQGKINDEDKQ
K561 EDEKLQGKINDEDKQ
K567 GKINDEDKQKILDKC
K569 INDEDKQKILDKCNE
K573 DKQKILDKCNEIISW
S579 DKCNEIISWLDKNQT
K583 EIISWLDKNQTAEkE
K589 DKNQTAEKEEFEHQQ
K589-u DKNQTAEkEEFEHQQ
K597 EEFEHQQKELEKVCN
K597 EEFEHQQKELEKVCN
K601 HQQKELEKVCNPIIT
K601 HQQKELEKVCNPIIT
K609 VCNPIITKLYQSAGG
S613 IITKLYQSAGGMPGG
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