Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. Interacts with HRAS. Interacts with HBV protein X and HTLV-1 protein p40tax. Belongs to the chaperonin (HSP60) family. Note: This description may include information from UniProtKB.
Molecular Function: protease binding; lipopolysaccharide binding; p53 binding; unfolded protein binding; ATPase activity; misfolded protein binding; insulin binding; protein binding; protein heterodimerization activity; ubiquitin protein ligase binding; chaperone binding; double-stranded RNA binding; protein complex binding; DNA replication origin binding; single-stranded DNA binding; ATP binding
Biological Process: B cell proliferation; T cell activation; viral reproduction; positive regulation of interleukin-12 production; positive regulation of apoptosis; protein maturation; isotype switching to IgG isotypes; response to lipopolysaccharide; positive regulation of interleukin-10 production; protein refolding; positive regulation of T cell mediated immune response to tumor cell; negative regulation of neuron apoptosis; chaperone-mediated protein complex assembly; positive regulation of interferon-alpha production; positive regulation of macrophage activation; caspase activation; response to drug; B cell activation; protein stabilization; chaperone cofactor-dependent protein folding; positive regulation of interleukin-6 production; B cell cytokine production; detection of misfolded protein; response to cocaine; response to ATP; response to unfolded protein; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-gamma production; 'de novo' protein folding; response to hydrogen peroxide; response to heat; response to estrogen stimulus; response to hypoxia; positive regulation of T cell activation; response to cold; negative regulation of apoptosis; positive regulation of inflammatory response
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.