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Protein Page:
HSP60 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
HSP60 Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. Interacts with HRAS. Interacts with HBV protein X and HTLV-1 protein p40tax. Belongs to the chaperonin (HSP60) family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Chaperone
Cellular Component: extracellular space; protein complex; cell surface; mitochondrion; early endosome; coated pit; cytosol; secretory granule; mitochondrial matrix; cytoplasm; mitochondrial inner membrane; plasma membrane; lipopolysaccharide receptor complex; cyclin-dependent protein kinase activating kinase holoenzyme complex
Molecular Function: protein binding; lipopolysaccharide binding; p53 binding; chaperone binding; ATPase activity; double-stranded RNA binding; unfolded protein binding; DNA replication origin binding; ATP binding; single-stranded DNA binding
Biological Process: B cell proliferation; T cell activation; viral reproduction; positive regulation of interleukin-12 production; positive regulation of apoptosis; protein maturation; isotype switching to IgG isotypes; positive regulation of interleukin-10 production; protein refolding; positive regulation of T cell mediated immune response to tumor cell; chaperone-mediated protein complex assembly; positive regulation of interferon-alpha production; positive regulation of macrophage activation; caspase activation; ATP catabolic process; protein stabilization; B cell activation; positive regulation of interleukin-6 production; B cell cytokine production; response to unfolded protein; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-gamma production; 'de novo' protein folding; positive regulation of T cell activation; negative regulation of apoptosis
Reference #:  P10809 (UniProtKB)
Alt. Names/Synonyms: 60 kDa chaperonin; 60 kDa heat shock protein, mitochondrial; CH60; Chaperonin 60; CPN60; GROEL; heat shock 60kDa protein 1 (chaperonin); Heat shock protein 60; heat shock protein 65; HLD4; HSP-60; HSP60; HSP65; HSPD1; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein; short heat shock protein 60 Hsp60s1; SPG13
Gene Symbols: HSPD1
Molecular weight: 61,055 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
CST Pathways:  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HSP60

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K31-a RAYAKDVkFGADARA
0 2 K31-u RAYAKDVkFGADARA
0 3 K58-u VAVTMGPkGRTVIIE
0 30 S70-p IIEQSWGsPkVTkDG
0 2 K72-u EQSWGsPkVTkDGVt
0 1 T74 SWGsPkVTkDGVtVA
0 3 K75-u WGsPkVTkDGVtVAk
0 2 T79-p kVTkDGVtVAksIDL
0 2 K82-a kDGVtVAksIDLkDK
0 2 K82-u kDGVtVAksIDLkDK
0 1 S83-p DGVtVAksIDLkDKy
0 10 K87-a VAksIDLkDKyKNIG
0 2 K87-u VAksIDLkDKyKNIG
0 1 K89 ksIDLkDKyKNIGAk
0 4 Y90-p sIDLkDKyKNIGAkL
0 2 K96-u KyKNIGAkLVQDVAN
0 1 T105-p VQDVANNtNEEAGDG
0 5 K125-a VLARSIAkEGFEkIS
0 3 K125-u VLARSIAkEGFEkIS
0 3 K130-a IAkEGFEkISkGANP
0 2 K133 EGFEkISKGANPVEI
0 6 K133-u EGFEkISkGANPVEI
0 66 K156-a DAVIAELkkQskPVT
0 3 K157-a AVIAELkkQskPVTT
0 1 S159-p IAELkkQskPVTTPE
0 1 K160-u AELkkQskPVTTPEE
0 3 K180-a TISANGDkEIGNIIS
0 1 S187 kEIGNIISDAMkkVG
0 66 K191-a NIISDAMkkVGRKGV
0 2 K191-u NIISDAMkkVGRKGV
0 31 K192-a IISDAMkkVGRKGVI
0 2 T200-p VGRKGVItVkDGKTL
0 9 K202-a RKGVItVkDGKTLND
0 1 D203 KGVItVkDGKTLNDE
0 1 K205 VItVkDGKTLNDELE
0 6 K218-a LEIIEGMkFDRGYIS
0 2 K218-u LEIIEGMkFDRGYIS
0 1 Y223 GMkFDRGYISPyFIN
0 99 Y227-p DRGYISPyFINTskG
0 1 S232-p SPyFINTskGQkCEF
0 2 K233-a PyFINTskGQkCEFQ
0 1 K233 PyFINTsKGQkCEFQ
0 5 K236-a INTskGQkCEFQDAy
0 2 K236-u INTskGQkCEFQDAy
0 61 Y243-p kCEFQDAyVLLSEkk
0 69 K249-a AyVLLSEkkISsIQS
0 1 K250-u yVLLSEkkISsIQSI
0 2 S253-p LSEkkISsIQSIVPA
0 2 K269-a EIANAHRkPLVIIAE
0 1 D279 VIIAEDVDGEALSTL
0 8 K292-u TLVLNRLkVGLQVVA
0 2 K301 GLQVVAVKAPGFGDN
0 1 K301 GLQVVAVKAPGFGDN
0 11 K352-a VGEVIVTkDDAMLLk
0 4 K352-u VGEVIVTkDDAMLLk
0 2 K359-a kDDAMLLkGKGDKAQ
0 1 K359-u kDDAMLLkGKGDKAQ
0 2 K361 DAMLLkGKGDKAQIE
0 3 K364 LLkGKGDKAQIEkRI
0 11 K369-a GDKAQIEkRIQEIIE
0 1 I375 EkRIQEIIEQLDVTT
0 1 T381 IIEQLDVTTSEyEkE
0 1 T382 IEQLDVTTSEyEkEk
0 1 S383 EQLDVTTSEyEkEkL
0 2 Y385-p LDVTTSEyEkEkLNE
0 2 K387-a VTTSEyEkEkLNERL
0 16 K389-a TSEyEkEkLNERLAk
0 2 K396-a kLNERLAkLSDGVAV
0 1 K396 kLNERLAKLSDGVAV
0 2 T409-p AVLKVGGtsDVEVNE
0 3 S410-p VLKVGGtsDVEVNEk
0 3 K417-u sDVEVNEkKDRVTDA
0 6 K418 DVEVNEkKDRVTDAL
0 2 T455 IPALDSLTPANEDQk
0 3 K462-a TPANEDQkIGIEIIk
0 28 K469-a kIGIEIIkRTLkIPA
0 2 K469-u kIGIEIIkRTLkIPA
0 3 K473-a EIIkRTLkIPAMTIA
0 3 K481-u IPAMTIAkNAGVEGs
0 2 S488-p kNAGVEGsLIVEKIM
0 1 K516 DFVNMVEKGIIDPTk
0 1 K516-m1 DFVNMVEkGIIDPTk
0 1 K523-a kGIIDPTkVVRTALL
0 1 D531 VVRTALLDAAGVASL
  mouse

 
K31 RAYAKDVKFGADARA
K31-u RAYAKDVkFGADARA
K58-u VAVTMGPkGRTVIIE
S70-p IIEQSWGsPkVtkDG
K72-u EQSWGsPkVtkDGVt
T74-p SWGsPkVtkDGVtVA
K75-u WGsPkVtkDGVtVAk
T79-p kVtkDGVtVAkSIDL
K82 kDGVtVAKSIDLkDk
K82-u kDGVtVAkSIDLkDk
S83 DGVtVAkSIDLkDkY
K87-a VAkSIDLkDkYKNIG
K87 VAkSIDLKDkYKNIG
K89-a kSIDLkDkYKNIGAk
Y90 SIDLkDkYKNIGAkL
K96-u kYKNIGAkLVQDVAN
T105 VQDVANNTNEEAGDG
K125-a VLARSIAkEGFEkIS
K125-u VLARSIAkEGFEkIS
K130-a IAkEGFEkISkGANP
K133-a EGFEkISkGANPVEI
K133-u EGFEkISkGANPVEI
K156-a DAVIAELkKQSKPVT
K157 AVIAELkKQSKPVTT
S159 IAELkKQSKPVTTPE
K160 AELkKQSKPVTTPEE
K180 TISANGDKDIGNIIs
S187-p KDIGNIIsDAMkkVG
K191-a NIIsDAMkkVGRKGV
K191-u NIIsDAMkkVGRKGV
K192-a IIsDAMkkVGRKGVI
T200-p VGRKGVItVkdGkTL
K202-a RKGVItVkdGkTLND
D203-ca KGVItVkdGkTLNDE
K205-a VItVkdGkTLNDELE
K218-a LEIIEGMkFDRGyIS
K218-u LEIIEGMkFDRGyIS
Y223-p GMkFDRGyISPyFIN
Y227-p DRGyISPyFINTskG
S232-p SPyFINTskGQkCEF
K233-a PyFINTskGQkCEFQ
K233-u PyFINTskGQkCEFQ
K236-a INTskGQkCEFQDAY
K236-u INTskGQkCEFQDAY
Y243 kCEFQDAYVLLSEkK
K249-a AYVLLSEkKISsVQS
K250 YVLLSEkKISsVQSI
S253-p LSEkKISsVQSIVPA
K269-a EIANAHRkPLVIIAE
D279-ca VIIAEDVdGEALSTL
K292 TLVLNRLKVGLQVVA
K301-a GLQVVAVkAPGFGDN
K301-u GLQVVAVkAPGFGDN
K352-a VGEVIVTkDDAMLLk
K352-u VGEVIVTkDDAMLLk
K359-a kDDAMLLkGkGDkAH
K359 kDDAMLLKGkGDkAH
K361-a DAMLLkGkGDkAHIE
K364-a LLkGkGDkAHIEkRI
K369-a GDkAHIEkRIQEItE
T375-p EkRIQEItEQLDItt
T381-p ItEQLDIttsEYEKE
T382-p tEQLDIttsEYEKEk
S383-p EQLDIttsEYEKEkL
Y385 LDIttsEYEKEkLNE
K387 IttsEYEKEkLNERL
K389-a tsEYEKEkLNERLAk
K396-a kLNERLAkLSDGVAV
K396-u kLNERLAkLSDGVAV
T409-p AVLKVGGtsDVEVNE
S410-p VLKVGGtsDVEVNEk
K417-u sDVEVNEkkDRVTDA
K418-a DVEVNEkkDRVTDAL
K455-a IPALDSLkPANEDQk
K462-a kPANEDQkIGIEIIk
K469-a kIGIEIIkRALKIPA
K469 kIGIEIIKRALKIPA
K473 EIIkRALKIPAMTIA
K481-u IPAMTIAkNAGVEGs
S488-p kNAGVEGsLIVEKIL
K516-a DFVNMVEkGIIDPTK
K516 DFVNMVEKGIIDPTK
K523 kGIIDPTKVVRTALL
D531-ca VVRTALLdAAGVASL
  rat

 
K31 RAYAKDVKFGADARA
K31 RAYAKDVKFGADARA
K58 VAVTMGPKGRTVIIE
S70-p IIEQSWGsPKVTKDG
K72 EQSWGsPKVTKDGVT
T74 SWGsPKVTKDGVTVA
K75 WGsPKVTKDGVTVAK
T79 KVTKDGVTVAKSIDL
K82 KDGVTVAKSIDLKDK
K82 KDGVTVAKSIDLKDK
S83 DGVTVAKSIDLKDKY
K87 VAKSIDLKDKYKNIG
K87 VAKSIDLKDKYKNIG
K89 KSIDLKDKYKNIGAK
Y90 SIDLKDKYKNIGAKL
K96 KYKNIGAKLVQDVAN
T105 VQDVANNTNEEAGDG
K125 VLARSIAKEGFEKIS
K125 VLARSIAKEGFEKIS
K130 IAKEGFEKISKGANP
K133 EGFEKISKGANPVEI
K133 EGFEKISKGANPVEI
K156-a DAVIAELkKQSKPVT
K157 AVIAELkKQSKPVTT
S159 IAELkKQSKPVTTPE
K160 AELkKQSKPVTTPEE
K180 TISANGDKDIGNIIS
S187 KDIGNIISDAMKKVG
K191 NIISDAMKKVGRKGV
K191 NIISDAMKKVGRKGV
K192 IISDAMKKVGRKGVI
T200 VGRKGVITVKDGKTL
K202 RKGVITVKDGKTLND
D203 KGVITVKDGKTLNDE
K205 VITVKDGKTLNDELE
K218 LEIIEGMKFDRGYIS
K218 LEIIEGMKFDRGYIS
Y223 GMKFDRGYISPYFIN
Y227 DRGYISPYFINTSKG
S232 SPYFINTSKGQKCEF
K233 PYFINTSKGQKCEFQ
K233 PYFINTSKGQKCEFQ
K236 INTSKGQKCEFQDAy
K236 INTSKGQKCEFQDAy
Y243-p KCEFQDAyVLLSEKK
K249 AyVLLSEKKISSVQS
K250 yVLLSEKKISSVQSI
S253 LSEKKISSVQSIVPA
K269 EIANAHRKPLVIIAE
D279 VIIAEDVDGEALSTL
K292 TLVLNRLKVGLQVVA
K301 GLQVVAVKAPGFGDN
K301 GLQVVAVKAPGFGDN
K352 VGEVIVTKDDAMLLK
K352 VGEVIVTKDDAMLLK
K359 KDDAMLLKGKGDKAH
K359 KDDAMLLKGKGDKAH
K361 DAMLLKGKGDKAHIE
K364 LLKGKGDKAHIEKRI
K369 GDKAHIEKRIQEITE
T375 EKRIQEITEQLDITT
T381 ITEQLDITTSEYEKE
T382 TEQLDITTSEYEKEK
S383 EQLDITTSEYEKEKL
Y385 LDITTSEYEKEKLNE
K387 ITTSEYEKEKLNERL
K389 TSEYEKEKLNERLAK
K396 KLNERLAKLSDGVAV
K396 KLNERLAKLSDGVAV
T409 AVLKVGGTSDVEVNE
S410 VLKVGGTSDVEVNEK
K417 SDVEVNEKKDRVTDA
K418 DVEVNEKKDRVTDAL
K455 IPALDSLKPANEDQK
K462 KPANEDQKIGIEIIk
K469-a KIGIEIIkRALKIPA
K469 KIGIEIIKRALKIPA
K473 EIIkRALKIPAMTIA
K481 IPAMTIAKNAGVEGS
S488 KNAGVEGSLIVEKIL
K516 DFVNMVEKGIIDPTK
K516 DFVNMVEKGIIDPTK
K523 KGIIDPTKVVRTALL
D531 VVRTALLDAAGVASL
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