Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. Interacts with HRAS. Interacts with HBV protein X and HTLV-1 protein p40tax. Belongs to the chaperonin (HSP60) family. Note: This description may include information from UniProtKB.
Molecular Function: protease binding; p53 binding; lipopolysaccharide binding; ATPase activity; unfolded protein binding; misfolded protein binding; insulin binding; protein binding; protein heterodimerization activity; chaperone binding; ubiquitin protein ligase binding; double-stranded RNA binding; protein complex binding; DNA replication origin binding; single-stranded DNA binding; ATP binding
Biological Process: B cell proliferation; T cell activation; viral reproduction; positive regulation of apoptosis; positive regulation of interleukin-12 production; protein maturation; isotype switching to IgG isotypes; response to lipopolysaccharide; positive regulation of interleukin-10 production; protein refolding; positive regulation of T cell mediated immune response to tumor cell; negative regulation of neuron apoptosis; chaperone-mediated protein complex assembly; positive regulation of interferon-alpha production; positive regulation of macrophage activation; caspase activation; response to drug; chaperone cofactor-dependent protein folding; protein stabilization; B cell activation; positive regulation of interleukin-6 production; detection of misfolded protein; B cell cytokine production; response to cocaine; response to ATP; response to unfolded protein; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-gamma production; 'de novo' protein folding; response to hydrogen peroxide; response to estrogen stimulus; response to heat; response to hypoxia; positive regulation of T cell activation; response to cold; positive regulation of inflammatory response; negative regulation of apoptosis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.